MersV1, Istex, Corpus, bibRecord, 000C88

Studies on binding of toromycin, an antitumor antibiotic, to DNA

Identifieur interne : 000C88 ( Istex/Corpus ); précédent : 000C87; suivant : 000C89

Studies on binding of toromycin, an antitumor antibiotic, to DNA

Auteurs : Kazuo Shishido ; Ken-Ichi Joho ; Masakazu Uramoto ; Kiyoshi Isono ; Tikam Jain

Source :

Biochemical and Biophysical Research Communications [ 0006-291X ] ; 1986.

RBID : ISTEX:F49733B5597015630C5E0430A1D6D30B47203AE6

English descriptors

Teeft :
- Academic press, Agarose, Antibiotic, Capital letters, Chem, Copolymer, Electrophoretic, Electrophoretic patterns, Gilvocarcin, Helix, Limited condition, Linear pns1, Nuclease, Nucleic acids, Plasmid, Pns1, Riken institute, Supercoiled, Supercoiled forms, Tokyo institute, Toromycin.

Abstract

Abstract: Toromycin, an antitumor, bactericidal and antiviral compound, was found to bind to DNA in such a way as to interfere with the dissociation of double helix at an elevated temperature. The antibiotic did not introduce strand scission into DNA. Single-strand-specific nuclease S1-susceptibility of negatively supercoiled DNA was not influenced by its binding. The antibiotic was shown to bind to both of the alternating purine-pyrimidine copolymers, poly(dG-dC):poly(dG-dC) and poly(dA-dT):poly(dA-dT). The unique C-glycoside molecule of toromycin interacted with single-stranded DNA, but was found to have no affinity for RNA.

Url:

https://api.istex.fr/ark:/67375/6H6-DXP0B204-2/fulltext.pdf

DOI: 10.1016/0006-291X(86)90415-8

Links to Exploration step

ISTEX:F49733B5597015630C5E0430A1D6D30B47203AE6

Le document en format XML

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<name type="personal"><namePart type="given">Kazuo</namePart>
<namePart type="family">Shishido</namePart>
<affiliation>Laboratory of Natural Products Chemistry, Tokyo Institute of Technology, Nagatsuta, Yokohama, Kanagawa 227, Japan</affiliation>
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<name type="personal"><namePart type="given">Ken-ichi</namePart>
<namePart type="family">Joho</namePart>
<affiliation>Laboratory of Natural Products Chemistry, Tokyo Institute of Technology, Nagatsuta, Yokohama, Kanagawa 227, Japan</affiliation>
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<name type="personal"><namePart type="given">Masakazu</namePart>
<namePart type="family">Uramoto</namePart>
<affiliation>Laboratory of Antibiotics, Riken Institute, Wako-shi, Saitama 351, Japan</affiliation>
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<name type="personal"><namePart type="given">Kiyoshi</namePart>
<namePart type="family">Isono</namePart>
<affiliation>Laboratory of Antibiotics, Riken Institute, Wako-shi, Saitama 351, Japan</affiliation>
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<name type="personal"><namePart type="given">Tikam</namePart>
<namePart type="family">Jain</namePart>
<affiliation>Research and Development Division, Smith Kline and French Laboratories, Philadelphia, PA 19101 USA</affiliation>
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<abstract lang="en">Abstract: Toromycin, an antitumor, bactericidal and antiviral compound, was found to bind to DNA in such a way as to interfere with the dissociation of double helix at an elevated temperature. The antibiotic did not introduce strand scission into DNA. Single-strand-specific nuclease S1-susceptibility of negatively supercoiled DNA was not influenced by its binding. The antibiotic was shown to bind to both of the alternating purine-pyrimidine copolymers, poly(dG-dC):poly(dG-dC) and poly(dA-dT):poly(dA-dT). The unique C-glycoside molecule of toromycin interacted with single-stranded DNA, but was found to have no affinity for RNA.</abstract>
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<identifier type="ISSN">0006-291X</identifier>
<identifier type="PII">S0006-291X(00)X0583-9</identifier>
<part><date>1986</date>
<detail type="volume"><number>136</number>
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<detail type="issue"><number>3</number>
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<extent unit="issue-pages"><start>845</start>
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<identifier type="DOI">10.1016/0006-291X(86)90415-8</identifier>
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Studies on binding of toromycin, an antitumor antibiotic, to DNA

Studies on binding of toromycin, an antitumor antibiotic, to DNA

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