pH‐Responsive Polymers as Gene Carriers
Identifieur interne : 000B88 ( Istex/Corpus ); précédent : 000B87; suivant : 000B89pH‐Responsive Polymers as Gene Carriers
Auteurs : In-Kyu Park ; Kaushik Singha ; Rohidas B. Arote ; Yun-Jaie Choi ; Won Jong Kim ; Chong-Su ChoSource :
- Macromolecular Rapid Communications [ 1022-1336 ] ; 2010-07-01.
English descriptors
- Teeft :
- Acetal linkage, Acidic, Acrylic acid, Agricultural biotechnology, Aminated, Amine, Amine functionalities, Amino groups, Arote, Binary complexes, Biocompatible sirna delivery, Bioconjug chem, Bioconjugate chem, Biomolecular engineering, Blood components, Blood stream, Buffering, Buffering capacity, Carboxylic groups, Cationic, Cationic polyplexes, Cellular compartments, Cellular uptake, Chem, Chitosan, Chitosan derivatives, Choi, Commun, Conformational change, Copolymer, Delivery process, Delivery system, Diblock copolymers, Different cell lines, Dmaema, Drug delivery, Endosomal, Endosomal compartment, Endosomal compartments, Endosomal destabilization, Endosomal membrane, Endosomal release, Endosomal rupture, Figure complexes, Functional features, Functional traits, Fusion ability, Fusion capability, Fusogenic, Fusogenic peptide, Fusogenic peptides, Fusogenic polymers, Gala peptide, Gene, Gene carriers, Gene delivery, Gene expression, Gene transfer, Gmbh, Hemolytic activity, High buffering capacity, Higher transfection, Histidine, Hydrazone, Hydrophilic, Hydrophobic, Imidazole, Imidazole group, Imidazole groups, Intracellular, Intracellular delivery, Kaushik singha, Ketal branches, Kgaa, Liposome, Macromol, Major disadvantage, Maleimide moiety, Membrane, Membrane disruption, Membrane fusion, Membrane fusion activity, Natl acad, Nucleic, Nucleic acid delivery, Nucleic acids, Pdna, Pdpa chains, Peptide, Pohang university, Polymer, Polymeric, Polymeric vectors, Polyplexes, Positive charge, Postdoctoral researcher, Potential candidates, Proton sponge effect, Protonated, Rapid commun, Reversible shielding, Secondary amines, Seoul, Seoul republic, Singha, Sirna, Target cells, Ternary complexes, Tokyo institute, Transfection, Transfection activity, Unfavorable interactions, Uorescent protein, Various kinds, Verlag, Verlag gmbh, Vesicle, Weinheim.
Abstract
Despite the immense potential of non‐viral delivery system in gene therapy its application has been impaired greatly by various impediments having contrasting traits. Therefore it is an absolute necessity to develop some non‐viral vectors which are endowed with special characteristics to act differently in intracellular as well as extracellular compartments to surmount these inter‐conflicting hurdles. Such smart polymers should serve some specific purposes by adjusting their structural or functional traits under the influence of stimuli such as temperature, light, salt concentration or pH. Among all these stimuli‐responsive polymers pH‐responsive polymers have attracted major attention and great impetus has been directed towards utilizing the subtle yet significant change in pH value within the cellular compartments. This review is intended to provide a comprehensive account of the development of pH‐responsive polymeric vectors based on their structural features and consequent functional attributes to achieve efficient transfection. The underlying modes of actions relating to structure and differential pH environment have also been discussed in this review.
pH‐responsive polymers are successfully designed and developed to achieve efficient gene delivery by exploiting the subtle pH differences within the cellular compartments. Installation of appropriate functional as well as structural attributes into the basic polymeric framework could trigger favorable pH‐responsive transformations which provide enhanced gene delivery as well as higher biocompatibility.
Url:
DOI: 10.1002/marc.200900867
Links to Exploration step
ISTEX:B2F95833A76259317CE3347740875D9D170565E8Le document en format XML
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Arote</name><affiliation><mods:affiliation>Department of Agricultural Biotechnology, Seoul National University, Seoul 151‐921, Republic of Korea</mods:affiliation></affiliation><affiliation><mods:affiliation>Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151‐921, Republic of Korea</mods:affiliation></affiliation></author><author><name sortKey="Choi, Yun Aie" sort="Choi, Yun Aie" uniqKey="Choi Y" first="Yun-Jaie" last="Choi">Yun-Jaie Choi</name><affiliation><mods:affiliation>Department of Agricultural Biotechnology, Seoul National University, Seoul 151‐921, Republic of Korea</mods:affiliation></affiliation></author><author><name sortKey="Kim, Won Jong" sort="Kim, Won Jong" uniqKey="Kim W" first="Won Jong" last="Kim">Won Jong Kim</name><affiliation><mods:affiliation>Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, Kyungbuk, 790‐784, Korea</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: wjkim@postech.ac.kr</mods:affiliation></affiliation><affiliation><mods:affiliation>Won Jong Kim, Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, Kyungbuk, 790‐784, Korea Fax: +82‐54‐279‐3399.Chong‐Su Cho, Department of Agricultural Biotechnology, Seoul National University, Seoul 151‐921, Republic of Korea Fax: +82‐54‐279‐3399.</mods:affiliation></affiliation></author><author><name sortKey="Cho, Chong U" sort="Cho, Chong U" uniqKey="Cho C" first="Chong-Su" last="Cho">Chong-Su Cho</name><affiliation><mods:affiliation>Department of Agricultural Biotechnology, Seoul National University, Seoul 151‐921, Republic of Korea</mods:affiliation></affiliation><affiliation><mods:affiliation>Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151‐921, Republic of Korea</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: chocs@plaza.snu.ac.kr</mods:affiliation></affiliation><affiliation><mods:affiliation>Won Jong Kim, Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, Kyungbuk, 790‐784, Korea Fax: +82‐54‐279‐3399.Chong‐Su Cho, Department of Agricultural Biotechnology, Seoul National University, Seoul 151‐921, Republic of Korea Fax: +82‐54‐279‐3399.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Macromolecular Rapid Communications</title><title level="j" type="sub">Synthetic Biomacromolecules for Delivery of Therapeutics, Tissue Engineering, and Imaging</title><title level="j" type="alt">MACROMOLECULAR RAPID COMMUNICATIONS</title><idno type="ISSN">1022-1336</idno><idno type="eISSN">1521-3927</idno><imprint><biblScope unit="vol">31</biblScope><biblScope unit="issue">13</biblScope><biblScope unit="page" from="1122">1122</biblScope><biblScope unit="page" to="1133">1133</biblScope><biblScope unit="page-count">12</biblScope><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><date type="published" when="2010-07-01">2010-07-01</date></imprint><idno type="ISSN">1022-1336</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1022-1336</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acetal linkage</term><term>Acidic</term><term>Acrylic acid</term><term>Agricultural biotechnology</term><term>Aminated</term><term>Amine</term><term>Amine functionalities</term><term>Amino groups</term><term>Arote</term><term>Binary complexes</term><term>Biocompatible sirna delivery</term><term>Bioconjug chem</term><term>Bioconjugate chem</term><term>Biomolecular engineering</term><term>Blood components</term><term>Blood stream</term><term>Buffering</term><term>Buffering capacity</term><term>Carboxylic groups</term><term>Cationic</term><term>Cationic polyplexes</term><term>Cellular compartments</term><term>Cellular uptake</term><term>Chem</term><term>Chitosan</term><term>Chitosan 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effect</term><term>Protonated</term><term>Rapid commun</term><term>Reversible shielding</term><term>Secondary amines</term><term>Seoul</term><term>Seoul republic</term><term>Singha</term><term>Sirna</term><term>Target cells</term><term>Ternary complexes</term><term>Tokyo institute</term><term>Transfection</term><term>Transfection activity</term><term>Unfavorable interactions</term><term>Uorescent protein</term><term>Various kinds</term><term>Verlag</term><term>Verlag gmbh</term><term>Vesicle</term><term>Weinheim</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite the immense potential of non‐viral delivery system in gene therapy its application has been impaired greatly by various impediments having contrasting traits. Therefore it is an absolute necessity to develop some non‐viral vectors which are endowed with special characteristics to act differently in intracellular as well as extracellular compartments to surmount these inter‐conflicting hurdles. Such smart polymers should serve some specific purposes by adjusting their structural or functional traits under the influence of stimuli such as temperature, light, salt concentration or pH. Among all these stimuli‐responsive polymers pH‐responsive polymers have attracted major attention and great impetus has been directed towards utilizing the subtle yet significant change in pH value within the cellular compartments. This review is intended to provide a comprehensive account of the development of pH‐responsive polymeric vectors based on their structural features and consequent functional attributes to achieve efficient transfection. The underlying modes of actions relating to structure and differential pH environment have also been discussed in this review.</div><div type="abstract" xml:lang="en">pH‐responsive polymers are successfully designed and developed to achieve efficient gene delivery by exploiting the subtle pH differences within the cellular compartments. 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complexes</json:string><json:string>positive charge</json:string><json:string>endosomal destabilization</json:string><json:string>endosomal rupture</json:string><json:string>agricultural biotechnology</json:string><json:string>high buffering capacity</json:string><json:string>blood stream</json:string><json:string>kaushik singha</json:string><json:string>amine functionalities</json:string><json:string>buffering capacity</json:string><json:string>target cells</json:string><json:string>endosomal membrane</json:string><json:string>fusogenic peptide</json:string><json:string>gala peptide</json:string><json:string>maleimide moiety</json:string><json:string>fusogenic polymers</json:string><json:string>fusion capability</json:string><json:string>gene transfer</json:string><json:string>different cell lines</json:string><json:string>diblock copolymers</json:string><json:string>pdpa chains</json:string><json:string>seoul republic</json:string><json:string>carboxylic 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Arote</name><affiliations><json:string>Department of Agricultural Biotechnology, Seoul National University, Seoul 151‐921, Republic of Korea</json:string><json:string>Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151‐921, Republic of Korea</json:string></affiliations></json:item><json:item><name>Yun‐Jaie Choi</name><affiliations><json:string>Department of Agricultural Biotechnology, Seoul National University, Seoul 151‐921, Republic of Korea</json:string></affiliations></json:item><json:item><name>Won Jong Kim</name><affiliations><json:string>Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, Kyungbuk, 790‐784, Korea</json:string><json:string>E-mail: wjkim@postech.ac.kr</json:string><json:string>Won Jong Kim, Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, Kyungbuk, 790‐784, Korea Fax: +82‐54‐279‐3399.Chong‐Su Cho, Department of Agricultural Biotechnology, Seoul National University, Seoul 151‐921, Republic of Korea Fax: +82‐54‐279‐3399.</json:string></affiliations></json:item><json:item><name>Chong‐Su Cho</name><affiliations><json:string>Department of Agricultural Biotechnology, Seoul National University, Seoul 151‐921, Republic of Korea</json:string><json:string>Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151‐921, Republic of Korea</json:string><json:string>E-mail: chocs@plaza.snu.ac.kr</json:string><json:string>Won Jong Kim, Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, Kyungbuk, 790‐784, Korea Fax: +82‐54‐279‐3399.Chong‐Su Cho, Department of Agricultural Biotechnology, Seoul National University, Seoul 151‐921, Republic of Korea Fax: +82‐54‐279‐3399.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>biodegradable materials</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>conjugated polymers</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>gene delivery</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>nonviral vectors</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>pH‐responsive materials</value></json:item></subject><articleId><json:string>MARC200900867</json:string></articleId><arkIstex>ark:/67375/WNG-K76L13V4-B</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>reviewArticle</json:string></originalGenre><abstract>Despite the immense potential of non‐viral delivery system in gene therapy its application has been impaired greatly by various impediments having contrasting traits. Therefore it is an absolute necessity to develop some non‐viral vectors which are endowed with special characteristics to act differently in intracellular as well as extracellular compartments to surmount these inter‐conflicting hurdles. Such smart polymers should serve some specific purposes by adjusting their structural or functional traits under the influence of stimuli such as temperature, light, salt concentration or pH. Among all these stimuli‐responsive polymers pH‐responsive polymers have attracted major attention and great impetus has been directed towards utilizing the subtle yet significant change in pH value within the cellular compartments. This review is intended to provide a comprehensive account of the development of pH‐responsive polymeric vectors based on their structural features and consequent functional attributes to achieve efficient transfection. The underlying modes of actions relating to structure and differential pH environment have also been discussed in this review.</abstract><qualityIndicators><score>8.944</score><pdfWordCount>6904</pdfWordCount><pdfCharCount>46478</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>12</pdfPageCount><pdfPageSize>595 x 794 pts</pdfPageSize><pdfWordsPerPage>575</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>162</abstractWordCount><abstractCharCount>1175</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>pH‐Responsive Polymers as Gene Carriers</title><pmid><json:string>21590865</json:string></pmid><genre><json:string>review-article</json:string></genre><host><title>Macromolecular Rapid Communications</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1521-3927</json:string></doi><issn><json:string>1022-1336</json:string></issn><eissn><json:string>1521-3927</json:string></eissn><publisherId><json:string>MARC</json:string></publisherId><volume>31</volume><issue>13</issue><pages><first>1122</first><last>1133</last><total>12</total></pages><genre><json:string>journal</json:string></genre><author><json:item><name>Y.‐Y. 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KGaA, Weinheim</licence></availability><date type="published" when="2010-07-01"></date></publicationStmt><notesStmt><note type="content-type" subtype="review-article" source="reviewArticle" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="review-article"><analytic><title level="a" type="main">pH‐Responsive Polymers as Gene Carriers</title><title level="a" type="short" xml:lang="en">pH‐Responsive Polymers as Gene Carriers</title><author xml:id="author-0000"><persName><forename type="first">In‐Kyu</forename><surname>Park</surname></persName><affiliation><orgName type="division">Department of Biomedical Sciences</orgName><orgName type="institution">Chonnam National University Medical School</orgName><orgName type="institution">Chonnam National University</orgName><address><addrLine>Gwangju 501‐746</addrLine><addrLine>Korea</addrLine><country key="KR" xml:lang="en">KOREA, REPUBLIC OF</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Kaushik</forename><surname>Singha</surname></persName><affiliation><orgName type="division">Department of Chemistry</orgName><orgName type="institution">Pohang University of Science and Technology (POSTECH)</orgName><address><addrLine>Pohang</addrLine><addrLine>Kyungbuk, 790‐784, Korea</addrLine><country key="KR" xml:lang="en">KOREA, REPUBLIC OF</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Rohidas B.</forename><surname>Arote</surname></persName><affiliation><orgName type="department">Department of Agricultural Biotechnology</orgName><orgName type="institution">Seoul National University</orgName><address><addrLine>Seoul 151‐921</addrLine><addrLine>Republic of Korea</addrLine><country key="KR" xml:lang="en">KOREA, REPUBLIC OF</country></address></affiliation><affiliation><orgName type="institution">Research Institute for Agriculture and Life Sciences</orgName><orgName type="institution">Seoul National University</orgName><address><addrLine>Seoul 151‐921</addrLine><addrLine>Republic of Korea</addrLine><country key="KR" xml:lang="en">KOREA, REPUBLIC OF</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Yun‐Jaie</forename><surname>Choi</surname></persName><affiliation><orgName type="department">Department of Agricultural Biotechnology</orgName><orgName type="institution">Seoul National University</orgName><address><addrLine>Seoul 151‐921</addrLine><addrLine>Republic of Korea</addrLine><country key="KR" xml:lang="en">KOREA, REPUBLIC OF</country></address></affiliation></author><author xml:id="author-0004" role="corresp"><persName><forename type="first">Won Jong</forename><surname>Kim</surname></persName><email>wjkim@postech.ac.kr</email><affiliation><orgName type="division">Department of Chemistry</orgName><orgName type="institution">Pohang University of Science and Technology (POSTECH)</orgName><address><addrLine>Pohang</addrLine><addrLine>Kyungbuk, 790‐784, Korea</addrLine><country key="KR" xml:lang="en">KOREA, REPUBLIC OF</country></address></affiliation></author><author xml:id="author-0005" role="corresp"><persName><forename type="first">Chong‐Su</forename><surname>Cho</surname></persName><email>chocs@plaza.snu.ac.kr</email><affiliation><orgName type="department">Department of Agricultural Biotechnology</orgName><orgName type="institution">Seoul National University</orgName><address><addrLine>Seoul 151‐921</addrLine><addrLine>Republic of Korea</addrLine><country key="KR" xml:lang="en">KOREA, REPUBLIC OF</country></address></affiliation><affiliation><orgName type="institution">Research Institute for Agriculture and Life Sciences</orgName><orgName type="institution">Seoul National University</orgName><address><addrLine>Seoul 151‐921</addrLine><addrLine>Republic of Korea</addrLine><country key="KR" xml:lang="en">KOREA, REPUBLIC OF</country></address></affiliation></author><idno type="istex">B2F95833A76259317CE3347740875D9D170565E8</idno><idno type="ark">ark:/67375/WNG-K76L13V4-B</idno><idno type="DOI">10.1002/marc.200900867</idno><idno type="unit">MARC200900867</idno><idno type="toTypesetVersion">file:MARC.MARC200900867.pdf</idno></analytic><monogr><editor xml:id="editor-0000"><persName><forename type="first">Y.‐Y.</forename><surname>Yang</surname></persName></editor><editor xml:id="editor-0001"><persName><forename type="first">A. J. T.</forename><surname>George</surname></persName></editor><editor xml:id="editor-0002"><persName><forename type="first">K.</forename><surname>Kataoka</surname></persName></editor><editor xml:id="editor-0003"><persName><forename type="first">D.</forename><surname>Luo</surname></persName></editor><editor xml:id="editor-0004"><persName><forename type="first">S.</forename><surname>Wang</surname></persName></editor><title level="j" type="main">Macromolecular Rapid Communications</title><title level="j" type="sub">Synthetic Biomacromolecules for Delivery of Therapeutics, Tissue Engineering, and Imaging</title><title level="j" type="alt">MACROMOLECULAR RAPID COMMUNICATIONS</title><idno type="pISSN">1022-1336</idno><idno type="eISSN">1521-3927</idno><idno type="book-DOI">10.1002/(ISSN)1521-3927</idno><idno type="book-part-DOI">10.1002/marc.v31:13</idno><idno type="product">MARC</idno><imprint><biblScope unit="vol">31</biblScope><biblScope unit="issue">13</biblScope><biblScope unit="page" from="1122">1122</biblScope><biblScope unit="page" to="1133">1133</biblScope><biblScope unit="page-count">12</biblScope><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><date type="published" when="2010-07-01"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef><appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-20"><label>pub2TEI-ISTEX</label><desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p>Despite the immense potential of non‐viral delivery system in gene therapy its application has been impaired greatly by various impediments having contrasting traits. Therefore it is an absolute necessity to develop some non‐viral vectors which are endowed with special characteristics to act differently in intracellular as well as extracellular compartments to surmount these inter‐conflicting hurdles. Such smart polymers should serve some specific purposes by adjusting their structural or functional traits under the influence of stimuli such as temperature, light, salt concentration or pH. Among all these stimuli‐responsive polymers pH‐responsive polymers have attracted major attention and great impetus has been directed towards utilizing the subtle yet significant change in pH value within the cellular compartments. This review is intended to provide a comprehensive account of the development of pH‐responsive polymeric vectors based on their structural features and consequent functional attributes to achieve efficient transfection. The underlying modes of actions relating to structure and differential pH environment have also been discussed in this review.</p><p><figure type="box"><media mimeType="image" url="urn:x-wiley:10221336:media:MARC200900867:gra001"></media><media mimeType="image/gif" url="" rendition="webLoRes"></media><media mimeType="image/gif" url="" rendition="webOriginal"></media><media mimeType="image/gif" url="" rendition="webHiRes"></media></figure></p></abstract><abstract xml:lang="en" style="graphical"><p><hi rend="bold">pH‐responsive polymers are successfully designed and developed</hi> to achieve efficient gene delivery by exploiting the subtle pH differences within the cellular compartments. Installation of appropriate functional as well as structural attributes into the basic polymeric framework could trigger favorable pH‐responsive transformations which provide enhanced gene delivery as well as higher biocompatibility. <figure type="box"><media mimeType="image" url="urn:x-wiley:10221336:media:MARC200900867:content"></media><media mimeType="image/gif" url="" rendition="webLoRes"></media><media mimeType="image/gif" url="" rendition="webOriginal"></media><media mimeType="image/gif" url="" rendition="webHiRes"></media></figure></p></abstract><textClass><keywords xml:lang="en"><term xml:id="kwd1">biodegradable materials</term><term xml:id="kwd2">conjugated polymers</term><term xml:id="kwd3">gene delivery</term><term xml:id="kwd4">nonviral vectors</term><term xml:id="kwd5">pH‐responsive materials</term></keywords><keywords rend="articleCategory"><term>Review</term></keywords><keywords rend="tocHeading1"><term>Reviews</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-K76L13V4-B/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>WILEY‐VCH Verlag</publisherName><publisherLoc>Weinheim</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1521-3927</doi><issn type="print">1022-1336</issn><issn type="electronic">1521-3927</issn><idGroup><id type="product" value="MARC"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MACROMOLECULAR RAPID COMMUNICATIONS">Macromolecular Rapid Communications</title><title type="short">Macromol. Rapid Commun.</title></titleGroup></publicationMeta><publicationMeta level="part" position="130"><doi origin="wiley" registered="yes">10.1002/marc.v31:13</doi><titleGroup><title type="specialIssueTitle">Synthetic Biomacromolecules for Delivery of Therapeutics, Tissue Engineering, and Imaging</title></titleGroup><numberingGroup><numbering type="journalVolume" number="31">31</numbering><numbering type="journalIssue">13</numbering></numberingGroup><creators><creator xml:id="sped1" creatorRole="sponsoringEditor"><personName><givenNames>Y.‐Y.</givenNames><familyName>Yang</familyName></personName></creator><creator xml:id="sped2" creatorRole="sponsoringEditor"><personName><givenNames>A. J. 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KGaA, Weinheim</copyright><eventGroup><event type="manuscriptReceived" date="2009-12-08"></event><event type="manuscriptRevised" date="2010-02-05"></event><event type="firstOnline" date="2010-05-04"></event><event type="publishedOnlineFinalForm" date="2010-06-30"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.15 mode:FullText source:FullText result:FullText mathml2tex" date="2010-07-21"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">1122</numbering><numbering type="pageLast">1133</numbering></numberingGroup><correspondenceTo><lineatedText><line>Won Jong Kim, Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, Kyungbuk, 790‐784, Korea Fax: +82‐54‐279‐3399.</line><line>Chong‐Su Cho, Department of Agricultural Biotechnology, Seoul National University, Seoul 151‐921, Republic of Korea Fax: +82‐54‐279‐3399.</line></lineatedText></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MARC.MARC200900867.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="6"></count><count type="tableTotal" number="0"></count><count type="referenceTotal" number="51"></count><count type="wordTotal" number="7161"></count></countGroup><titleGroup><title type="main" xml:lang="en">pH‐Responsive Polymers as Gene Carriers</title><title type="short" xml:lang="en">pH‐Responsive Polymers as Gene Carriers</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af3"><personName><givenNames>In‐Kyu</givenNames><familyName>Park</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Kaushik</givenNames><familyName>Singha</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2 #af4"><personName><givenNames>Rohidas B.</givenNames><familyName>Arote</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Yun‐Jaie</givenNames><familyName>Choi</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Won Jong</givenNames><familyName>Kim</familyName></personName><contactDetails><email>wjkim@postech.ac.kr</email></contactDetails></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af2 #af4" corresponding="yes"><personName><givenNames>Chong‐Su</givenNames><familyName>Cho</familyName></personName><contactDetails><email>chocs@plaza.snu.ac.kr</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="KR" type="organization"><unparsedAffiliation>Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, Kyungbuk, 790‐784, Korea</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="KR" type="organization"><unparsedAffiliation>Department of Agricultural Biotechnology, Seoul National University, Seoul 151‐921, Republic of Korea</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="KR" type="organization"><unparsedAffiliation>Department of Biomedical Sciences, Chonnam National University Medical School, Chonnam National University, Gwangju 501‐746, Korea</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="KR" type="organization"><unparsedAffiliation>Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151‐921, Republic of Korea</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">biodegradable materials</keyword><keyword xml:id="kwd2">conjugated polymers</keyword><keyword xml:id="kwd3">gene delivery</keyword><keyword xml:id="kwd4">nonviral vectors</keyword><keyword xml:id="kwd5">pH‐responsive materials</keyword></keywordGroup><fundingInfo><fundingAgency>The Korea–Japan Joint Research Project, Korea Healthcare Technology R&D Project</fundingAgency><fundingNumber>F01‐2008‐000‐10004‐0</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Ministry for Health, Welfare and Family Affairs, Republic of Korea</fundingAgency><fundingNumber>A084869</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Regional Technology Innovation Program of the Ministry of Knowledge Economy (MKE)</fundingAgency><fundingNumber>RTI05‐01‐01</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Nano‐Biotechnology Project, Ministry of Education, Science and Technology</fundingAgency><fundingNumber>20090065528</fundingNumber></fundingInfo><fundingInfo><fundingAgency>NRL</fundingAgency><fundingNumber>ROA‐2009‐000‐83151‐0</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Despite the immense potential of non‐viral delivery system in gene therapy its application has been impaired greatly by various impediments having contrasting traits. Therefore it is an absolute necessity to develop some non‐viral vectors which are endowed with special characteristics to act differently in intracellular as well as extracellular compartments to surmount these inter‐conflicting hurdles. Such smart polymers should serve some specific purposes by adjusting their structural or functional traits under the influence of stimuli such as temperature, light, salt concentration or pH. Among all these stimuli‐responsive polymers pH‐responsive polymers have attracted major attention and great impetus has been directed towards utilizing the subtle yet significant change in pH value within the cellular compartments. This review is intended to provide a comprehensive account of the development of pH‐responsive polymeric vectors based on their structural features and consequent functional attributes to achieve efficient transfection. The underlying modes of actions relating to structure and differential pH environment have also been discussed in this review.</p><p><blockFixed type="graphic"><mediaResourceGroup><mediaResource alt="image" eRights="yes" copyright="WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim" href="urn:x-wiley:10221336:media:MARC200900867:gra001"></mediaResource><mediaResource alt="thumbnail image" rendition="webLoRes" mimeType="image/gif" href=""></mediaResource><mediaResource alt="original image" rendition="webOriginal" mimeType="image/gif" href=""></mediaResource><mediaResource alt="magnified image" rendition="webHiRes" mimeType="image/gif" href=""></mediaResource></mediaResourceGroup></blockFixed></p></abstract><abstract type="graphical" xml:lang="en"><p><b>pH‐responsive polymers are successfully designed and developed</b> to achieve efficient gene delivery by exploiting the subtle pH differences within the cellular compartments. Installation of appropriate functional as well as structural attributes into the basic polymeric framework could trigger favorable pH‐responsive transformations which provide enhanced gene delivery as well as higher biocompatibility. <blockFixed type="graphic"><mediaResourceGroup><mediaResource alt="image" eRights="yes" copyright="WILEY-VCH" href="urn:x-wiley:10221336:media:MARC200900867:content"></mediaResource><mediaResource alt="thumbnail image" rendition="webLoRes" mimeType="image/gif" href=""></mediaResource><mediaResource alt="original image" rendition="webOriginal" mimeType="image/gif" href=""></mediaResource><mediaResource alt="magnified image" rendition="webHiRes" mimeType="image/gif" href=""></mediaResource></mediaResourceGroup></blockFixed></p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>pH‐Responsive Polymers as Gene Carriers</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>pH‐Responsive Polymers as Gene Carriers</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>pH‐Responsive Polymers as Gene Carriers</title></titleInfo><name type="personal"><namePart type="given">In‐Kyu</namePart><namePart type="family">Park</namePart><affiliation>Department of Biomedical Sciences, Chonnam National University Medical School, Chonnam National University, Gwangju 501‐746, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kaushik</namePart><namePart type="family">Singha</namePart><affiliation>Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, Kyungbuk, 790‐784, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rohidas B.</namePart><namePart type="family">Arote</namePart><affiliation>Department of Agricultural Biotechnology, Seoul National University, Seoul 151‐921, Republic of Korea</affiliation><affiliation>Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151‐921, Republic of Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yun‐Jaie</namePart><namePart type="family">Choi</namePart><affiliation>Department of Agricultural Biotechnology, Seoul National University, Seoul 151‐921, Republic of Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Won Jong</namePart><namePart type="family">Kim</namePart><affiliation>Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, Kyungbuk, 790‐784, Korea</affiliation><affiliation>E-mail: wjkim@postech.ac.kr</affiliation><affiliation>Won Jong Kim, Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, Kyungbuk, 790‐784, Korea Fax: +82‐54‐279‐3399.Chong‐Su Cho, Department of Agricultural Biotechnology, Seoul National University, Seoul 151‐921, Republic of Korea Fax: +82‐54‐279‐3399.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chong‐Su</namePart><namePart type="family">Cho</namePart><affiliation>Department of Agricultural Biotechnology, Seoul National University, Seoul 151‐921, Republic of Korea</affiliation><affiliation>Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151‐921, Republic of Korea</affiliation><affiliation>E-mail: chocs@plaza.snu.ac.kr</affiliation><affiliation>Won Jong Kim, Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, Kyungbuk, 790‐784, Korea Fax: +82‐54‐279‐3399.Chong‐Su Cho, Department of Agricultural Biotechnology, Seoul National University, Seoul 151‐921, Republic of Korea Fax: +82‐54‐279‐3399.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="reviewArticle" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>WILEY‐VCH Verlag</publisher><place><placeTerm type="text">Weinheim</placeTerm></place><dateIssued encoding="w3cdtf">2010-07-01</dateIssued><dateCaptured encoding="w3cdtf">2009-12-08</dateCaptured><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">6</extent><extent unit="tables">0</extent><extent unit="references">51</extent><extent unit="words">7161</extent></physicalDescription><abstract lang="en">Despite the immense potential of non‐viral delivery system in gene therapy its application has been impaired greatly by various impediments having contrasting traits. Therefore it is an absolute necessity to develop some non‐viral vectors which are endowed with special characteristics to act differently in intracellular as well as extracellular compartments to surmount these inter‐conflicting hurdles. Such smart polymers should serve some specific purposes by adjusting their structural or functional traits under the influence of stimuli such as temperature, light, salt concentration or pH. Among all these stimuli‐responsive polymers pH‐responsive polymers have attracted major attention and great impetus has been directed towards utilizing the subtle yet significant change in pH value within the cellular compartments. This review is intended to provide a comprehensive account of the development of pH‐responsive polymeric vectors based on their structural features and consequent functional attributes to achieve efficient transfection. The underlying modes of actions relating to structure and differential pH environment have also been discussed in this review.</abstract><abstract type="graphical" lang="en">pH‐responsive polymers are successfully designed and developed to achieve efficient gene delivery by exploiting the subtle pH differences within the cellular compartments. Installation of appropriate functional as well as structural attributes into the basic polymeric framework could trigger favorable pH‐responsive transformations which provide enhanced gene delivery as well as higher biocompatibility.</abstract><note type="funding">The Korea–Japan Joint Research Project, Korea Healthcare Technology R&D Project - No. F01‐2008‐000‐10004‐0; </note><note type="funding">Ministry for Health, Welfare and Family Affairs, Republic of Korea - No. A084869; </note><note type="funding">Regional Technology Innovation Program of the Ministry of Knowledge Economy (MKE) - No. RTI05‐01‐01; </note><note type="funding">Nano‐Biotechnology Project, Ministry of Education, Science and Technology - No. 20090065528; </note><note type="funding">NRL - No. ROA‐2009‐000‐83151‐0; </note><subject lang="en"><genre>keywords</genre><topic>biodegradable materials</topic><topic>conjugated polymers</topic><topic>gene delivery</topic><topic>nonviral vectors</topic><topic>pH‐responsive materials</topic></subject><relatedItem type="host"><titleInfo><title>Macromolecular Rapid Communications</title></titleInfo><titleInfo type="abbreviated"><title>Macromol. 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