Detection of HBV DNA in non-A, non-B hepatic tissues using the polymerase chain reaction assay
Identifieur interne : 000991 ( Istex/Corpus ); précédent : 000990; suivant : 000992Detection of HBV DNA in non-A, non-B hepatic tissues using the polymerase chain reaction assay
Auteurs : Showgo OhkoshiSource :
- Gastroenterologia Japonica [ 0435-1339 ] ; 1991-12-01.
English descriptors
- KwdEn :
- Teeft :
- Alcoholic liver disease, Author thanks, Carcinoma, Causative agent, Chronic hepatitis, Chronic liver disease, Core antigen, Enzymatic amplification, Hbcag region, Hbsag, Hbsag region, Hepatic tissue, Hepatic tissues, Hepatitis, Hepatocellular, Hepatocellular carcinoma, Human hepatitis, Hybridization, Kodak film, Liver disease, Liver specimens, Liver tissue, Normal liver, Polymerase, Polymerase chain reaction, Posttransfusion hepatitis, Primers hbcp1, Primers hbsp1, Proc natl acad, Reaction mixture, Several reports, Southern blot analysis, Southern blot hybridization, Surface antigen, Surgical resection.
Abstract
Summary: The polymerase chain reaction (PCR) followed by Southern blotting was used to examine the presence of hepatitis B virus (HBV) DNA in non-cancerous liver tissue specimens from 22 Japanese hepatocellular carcinoma (HCC) patients, who were negative for HBV surface antigen (HBsAg). By Southern blot analysis, HBV DNA was negative in all 22 patients, but it was detected by the PCR in 8 of the 15 patients who were positive for antibodies against HBsAg or HBV core antigen. Seven patients who were negative for those antibodies were also negative for HBV DNA by the PCR. These results suggest that HBV may be involved in the etiology of the liver disease of some patients with what is presently classified as non-A, non-B hepatitis, if they are positive for HBV antibodies.
Url:
DOI: 10.1007/BF02782860
Links to Exploration step
ISTEX:4E307F30F829015F07010490BD4A80C2A57A1AD8Le document en format XML
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By Southern blot analysis, HBV DNA was negative in all 22 patients, but it was detected by the PCR in 8 of the 15 patients who were positive for antibodies against HBsAg or HBV core antigen. Seven patients who were negative for those antibodies were also negative for HBV DNA by the PCR. 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By Southern blot analysis, HBV DNA was negative in all 22 patients, but it was detected by the PCR in 8 of the 15 patients who were positive for antibodies against HBsAg or HBV core antigen. Seven patients who were negative for those antibodies were also negative for HBV DNA by the PCR. These results suggest that HBV may be involved in the etiology of the liver disease of some patients with what is presently classified as non-A, non-B hepatitis, if they are positive for HBV antibodies.</abstract><qualityIndicators><refBibsNative>false</refBibsNative><abstractWordCount>129</abstractWordCount><abstractCharCount>778</abstractCharCount><keywordCount>3</keywordCount><score>6.321</score><pdfWordCount>2773</pdfWordCount><pdfCharCount>16834</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>6</pdfPageCount><pdfPageSize>554.28 x 806.28 pts</pdfPageSize></qualityIndicators><title>Detection of HBV DNA in non-A, non-B hepatic tissues using the polymerase chain reaction assay</title><genre><json:string>research-article</json:string></genre><host><title>Gastroenterologia Japonica</title><language><json:string>unknown</json:string></language><publicationDate>1991</publicationDate><copyrightDate>1991</copyrightDate><issn><json:string>0435-1339</json:string></issn><eissn><json:string>1435-5922</json:string></eissn><journalId><json:string>535</json:string></journalId><volume>26</volume><issue>6</issue><pages><first>728</first><last>733</last></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Medicine & Public Health</value></json:item><json:item><value>Gastroenterology</value></json:item><json:item><value>Oncology</value></json:item><json:item><value>Surgical Oncology</value></json:item><json:item><value>Hepatology</value></json:item><json:item><value>Internal Medicine</value></json:item><json:item><value>Colorectal Surgery</value></json:item></subject></host><namedEntities><unitex><date></date><geogName></geogName><orgName></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName></persName><placeName></placeName><ref_url></ref_url><ref_bibl></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/1BB-9D9QKJJW-Z</json:string></ark><categories><wos></wos><scienceMetrix></scienceMetrix><scopus><json:string>1 - 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By Southern blot analysis, HBV DNA was negative in all 22 patients, but it was detected by the PCR in 8 of the 15 patients who were positive for antibodies against HBsAg or HBV core antigen. Seven patients who were negative for those antibodies were also negative for HBV DNA by the PCR. These results suggest that HBV may be involved in the etiology of the liver disease of some patients with what is presently classified as non-A, non-B hepatitis, if they are positive for HBV antibodies.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Key words</head><item><term>HBV DNA</term></item><item><term>non-A, non-B hepatic tissue</term></item><item><term>polymerase chain reaction</term></item></list></keywords></textClass><textClass><keywords scheme="Journal-Subject-Group"><list><label>H</label><item><term>Medicine & Public Health</term></item><label>H33061</label><item><term>Gastroenterology</term></item><label>H43008</label><item><term>Oncology</term></item><label>H43016</label><item><term>Surgical Oncology</term></item><label>H33088</label><item><term>Hepatology</term></item><label>H33002</label><item><term>Internal Medicine</term></item><label>H59036</label><item><term>Colorectal 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Tract</ArticleCategory><ArticleFirstPage>728</ArticleFirstPage><ArticleLastPage>733</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2007</Year><Month>12</Month><Day>10</Day></RegistrationDate><Received><Year>1990</Year><Month>12</Month><Day>17</Day></Received><Accepted><Year>1991</Year><Month>3</Month><Day>15</Day></Accepted></ArticleHistory><ArticleCopyright><CopyrightHolderName>The Japanese Society of Gastroenterology</CopyrightHolderName><CopyrightYear>1991</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant 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Language="En"><Heading>Summary</Heading><Para>The polymerase chain reaction (PCR) followed by Southern blotting was used to examine the presence of hepatitis B virus (HBV) DNA in non-cancerous liver tissue specimens from 22 Japanese hepatocellular carcinoma (HCC) patients, who were negative for HBV surface antigen (HBsAg). By Southern blot analysis, HBV DNA was negative in all 22 patients, but it was detected by the PCR in 8 of the 15 patients who were positive for antibodies against HBsAg or HBV core antigen. Seven patients who were negative for those antibodies were also negative for HBV DNA by the PCR. These results suggest that HBV may be involved in the etiology of the liver disease of some patients with what is presently classified as non-A, non-B hepatitis, if they are positive for HBV antibodies.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>HBV DNA</Keyword><Keyword>non-A, non-B hepatic tissue</Keyword><Keyword>polymerase chain reaction</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Detection of HBV DNA in non-A, non-B hepatic tissues using the polymerase chain reaction assay</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Detection of HBV DNA in non-A, non-B hepatic tissues using the polymerase chain reaction assay</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">Showgo</namePart><namePart type="family">Ohkoshi</namePart><namePart type="termsOfAddress">M.D.</namePart><affiliation>Virology Division, National Cancer Center Research Institute, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Tokyo</placeTerm></place><dateCreated encoding="w3cdtf">1990-12-17</dateCreated><dateIssued encoding="w3cdtf">1991-12-01</dateIssued><copyrightDate encoding="w3cdtf">1991</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Summary: The polymerase chain reaction (PCR) followed by Southern blotting was used to examine the presence of hepatitis B virus (HBV) DNA in non-cancerous liver tissue specimens from 22 Japanese hepatocellular carcinoma (HCC) patients, who were negative for HBV surface antigen (HBsAg). By Southern blot analysis, HBV DNA was negative in all 22 patients, but it was detected by the PCR in 8 of the 15 patients who were positive for antibodies against HBsAg or HBV core antigen. Seven patients who were negative for those antibodies were also negative for HBV DNA by the PCR. These results suggest that HBV may be involved in the etiology of the liver disease of some patients with what is presently classified as non-A, non-B hepatitis, if they are positive for HBV antibodies.</abstract><note>Liver, Pancreas, and Biliary Tract</note><subject lang="en"><genre>Key words</genre><topic>HBV DNA</topic><topic>non-A, non-B hepatic tissue</topic><topic>polymerase chain reaction</topic></subject><relatedItem type="host"><titleInfo><title>Gastroenterologia Japonica</title></titleInfo><titleInfo type="abbreviated"><title>Gastroenterol Jpn</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">1991-12-01</dateIssued><copyrightDate encoding="w3cdtf">1991</copyrightDate></originInfo><subject><genre>Journal-Subject-Group</genre><topic authority="SpringerSubjectCodes" authorityURI="H">Medicine & Public Health</topic><topic authority="SpringerSubjectCodes" authorityURI="H33061">Gastroenterology</topic><topic authority="SpringerSubjectCodes" authorityURI="H43008">Oncology</topic><topic authority="SpringerSubjectCodes" authorityURI="H43016">Surgical Oncology</topic><topic authority="SpringerSubjectCodes" authorityURI="H33088">Hepatology</topic><topic authority="SpringerSubjectCodes" authorityURI="H33002">Internal Medicine</topic><topic authority="SpringerSubjectCodes" authorityURI="H59036">Colorectal Surgery</topic></subject><identifier type="ISSN">0435-1339</identifier><identifier type="eISSN">1435-5922</identifier><identifier type="JournalID">535</identifier><identifier type="IssueArticleCount">21</identifier><identifier type="VolumeIssueCount">6</identifier><part><date>1991</date><detail type="volume"><number>26</number><caption>vol.</caption></detail><detail type="issue"><number>6</number><caption>no.</caption></detail><extent unit="pages"><start>728</start><end>733</end></extent></part><recordInfo><recordOrigin>The Japanese Society of Gastroenterology, 1991</recordOrigin></recordInfo></relatedItem><identifier type="istex">4E307F30F829015F07010490BD4A80C2A57A1AD8</identifier><identifier type="ark">ark:/67375/1BB-9D9QKJJW-Z</identifier><identifier type="DOI">10.1007/BF02782860</identifier><identifier type="ArticleID">BF02782860</identifier><identifier type="ArticleID">Art5</identifier><accessCondition type="use and reproduction" contentType="copyright">The Japanese Society of Gastroenterology, 1991</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>The Japanese Society of Gastroenterology, 1991</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-9D9QKJJW-Z/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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