Sequence Analysis of Two Genomic Regions Containing the KIT and the FMS Receptor Tyrosine Kinase Genes
Identifieur interne : 000550 ( Istex/Corpus ); précédent : 000549; suivant : 000551Sequence Analysis of Two Genomic Regions Containing the KIT and the FMS Receptor Tyrosine Kinase Genes
Auteurs : Catherine Andre ; Annie Hampe ; Philippe Lachaume ; Emmanuel Martin ; Xao-Ping Wang ; Vladimir Manus ; Wei-Xin Hu ; Francis GalibertSource :
- Genomics [ 0888-7543 ] ; 1997.
English descriptors
- Teeft :
- Additional exons, Analogous sequences, Andre, Antisense, Antisense strand, Casein kinase, Cdna, Cdna sequences, Cell growth, Cell growth factor receptor, Chromosomal location, Chromosome, Coding, Coding exons, Common ancestor, Common ancestor gene, Computer analysis, Consensus sequence, Database, Deletion, Dense clusters, Different chromosomes, Different sizes, Dnastar package, Exon, Exon predictions, Falu, Feline retrovirus, Gene, Gene region, Gene regions, Genefinder, Genefinder programs, Genefinder software, Geno, Genomic, Genomic regions, Genomic sequence, Genomic sequences, Genomic structure, Gnma, Grail, Hexon program, Higher proportion, Human gene, Human genomic, Internal duplications, Intron, Intron expansion, Intron sequences, Kalu, Kinase, Local similarities, Mstb element, Noncoding region, Nucleic acids, Nucleotide, Nucleotide sequence, Oncogene, Opposite orientation, Paris cedex, Polyadenylation signal, Present address, Promoter, Promoter region, Promoter regions, Putative, Putative exon, Putative exons, Receptor, Region coding, Region encoding, Repetitive sequences, Respective size, Sense strand, Sequencing, Splice, Structural analysis, Structural organization, Subclass iiia, Such sequences, Tyrosine, White boxes.
Abstract
Abstract: The KIT and FMS tyrosine kinase receptors, which are implicated in the control of cell growth and differentiation, stem through duplications from a common ancestor. We have conducted a detailed structural analysis of the two loci containing the KIT and FMS genes. The sequence of the ∼90-kb KIT locus reveals the position and size of the 21 introns and of the 5′ regulatory region of the KIT gene. The introns and the 3′-untranslated parts of KIT and FMS have been analyzed in parallel. Comparison of the two sequences shows that, while introns of both genes have extensively diverged in size and sequence, this divergence is, at least in part, due to intron expansion through internal duplications, as suggested by the discrete extant analogies. Repetitive elements as well as exon predictions obtained using the GRAIL and GENEFINDER programs are described in detail. These programs led us to identify a novel gene, designated SMF, immediately downstream of FMS, in the opposite orientation. This finding emphasizes the gene-rich characteristic of this genomic region.
Url:
DOI: 10.1006/geno.1996.4482
Links to Exploration step
ISTEX:C025792FDF082DC3F9493EDA9E0782B6341C68D6Le document en format XML
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Xao Ping" uniqKey="Wang X" first="Xao-Ping" last="Wang">Xao-Ping Wang</name><affiliation><mods:affiliation>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex, France</mods:affiliation></affiliation></author><author><name sortKey="Manus, Vladimir" sort="Manus, Vladimir" uniqKey="Manus V" first="Vladimir" last="Manus">Vladimir Manus</name><affiliation><mods:affiliation>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex, France</mods:affiliation></affiliation></author><author><name sortKey="Hu, Wei Xin" sort="Hu, Wei Xin" uniqKey="Hu W" first="Wei-Xin" last="Hu">Wei-Xin Hu</name><affiliation><mods:affiliation>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex, France</mods:affiliation></affiliation></author><author><name sortKey="Galibert, Francis" sort="Galibert, Francis" uniqKey="Galibert F" first="Francis" last="Galibert">Francis Galibert</name><affiliation><mods:affiliation>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Genomics</title><title level="j" type="abbrev">YGENO</title><idno type="ISSN">0888-7543</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997">1997</date><biblScope unit="volume">39</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="216">216</biblScope><biblScope unit="page" to="226">226</biblScope></imprint><idno type="ISSN">0888-7543</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0888-7543</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Additional exons</term><term>Analogous sequences</term><term>Andre</term><term>Antisense</term><term>Antisense strand</term><term>Casein kinase</term><term>Cdna</term><term>Cdna sequences</term><term>Cell growth</term><term>Cell growth factor receptor</term><term>Chromosomal location</term><term>Chromosome</term><term>Coding</term><term>Coding exons</term><term>Common ancestor</term><term>Common ancestor gene</term><term>Computer analysis</term><term>Consensus sequence</term><term>Database</term><term>Deletion</term><term>Dense clusters</term><term>Different chromosomes</term><term>Different sizes</term><term>Dnastar package</term><term>Exon</term><term>Exon predictions</term><term>Falu</term><term>Feline retrovirus</term><term>Gene</term><term>Gene region</term><term>Gene regions</term><term>Genefinder</term><term>Genefinder programs</term><term>Genefinder software</term><term>Geno</term><term>Genomic</term><term>Genomic regions</term><term>Genomic sequence</term><term>Genomic sequences</term><term>Genomic structure</term><term>Gnma</term><term>Grail</term><term>Hexon program</term><term>Higher proportion</term><term>Human gene</term><term>Human genomic</term><term>Internal duplications</term><term>Intron</term><term>Intron expansion</term><term>Intron sequences</term><term>Kalu</term><term>Kinase</term><term>Local similarities</term><term>Mstb element</term><term>Noncoding region</term><term>Nucleic acids</term><term>Nucleotide</term><term>Nucleotide sequence</term><term>Oncogene</term><term>Opposite orientation</term><term>Paris cedex</term><term>Polyadenylation signal</term><term>Present address</term><term>Promoter</term><term>Promoter region</term><term>Promoter regions</term><term>Putative</term><term>Putative exon</term><term>Putative exons</term><term>Receptor</term><term>Region coding</term><term>Region encoding</term><term>Repetitive sequences</term><term>Respective size</term><term>Sense strand</term><term>Sequencing</term><term>Splice</term><term>Structural analysis</term><term>Structural organization</term><term>Subclass iiia</term><term>Such sequences</term><term>Tyrosine</term><term>White boxes</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The KIT and FMS tyrosine kinase receptors, which are implicated in the control of cell growth and differentiation, stem through duplications from a common ancestor. We have conducted a detailed structural analysis of the two loci containing the KIT and FMS genes. The sequence of the ∼90-kb KIT locus reveals the position and size of the 21 introns and of the 5′ regulatory region of the KIT gene. The introns and the 3′-untranslated parts of KIT and FMS have been analyzed in parallel. Comparison of the two sequences shows that, while introns of both genes have extensively diverged in size and sequence, this divergence is, at least in part, due to intron expansion through internal duplications, as suggested by the discrete extant analogies. Repetitive elements as well as exon predictions obtained using the GRAIL and GENEFINDER programs are described in detail. These programs led us to identify a novel gene, designated SMF, immediately downstream of FMS, in the opposite orientation. This finding emphasizes the gene-rich characteristic of this genomic region.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>exon</json:string><json:string>intron</json:string><json:string>receptor</json:string><json:string>kalu</json:string><json:string>genomic</json:string><json:string>genefinder</json:string><json:string>kinase</json:string><json:string>falu</json:string><json:string>gnma</json:string><json:string>cdna</json:string><json:string>geno</json:string><json:string>putative</json:string><json:string>chromosome</json:string><json:string>additional exons</json:string><json:string>oncogene</json:string><json:string>sequencing</json:string><json:string>deletion</json:string><json:string>antisense</json:string><json:string>database</json:string><json:string>promoter</json:string><json:string>gene</json:string><json:string>coding exons</json:string><json:string>grail</json:string><json:string>genefinder 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France</json:string></affiliations></json:item><json:item><name>Philippe Lachaume</name><affiliations><json:string>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex, France</json:string></affiliations></json:item><json:item><name>Emmanuel Martin</name><affiliations><json:string>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex, France</json:string></affiliations></json:item><json:item><name>Xao-Ping Wang</name><affiliations><json:string>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex, France</json:string></affiliations></json:item><json:item><name>Vladimir Manus</name><affiliations><json:string>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex, France</json:string></affiliations></json:item><json:item><name>Wei-Xin Hu</name><affiliations><json:string>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex, France</json:string></affiliations></json:item><json:item><name>Francis Galibert</name><affiliations><json:string>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex, France</json:string></affiliations></json:item></author><arkIstex>ark:/67375/6H6-R4PC618V-9</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: The KIT and FMS tyrosine kinase receptors, which are implicated in the control of cell growth and differentiation, stem through duplications from a common ancestor. We have conducted a detailed structural analysis of the two loci containing the KIT and FMS genes. The sequence of the ∼90-kb KIT locus reveals the position and size of the 21 introns and of the 5′ regulatory region of the KIT gene. The introns and the 3′-untranslated parts of KIT and FMS have been analyzed in parallel. Comparison of the two sequences shows that, while introns of both genes have extensively diverged in size and sequence, this divergence is, at least in part, due to intron expansion through internal duplications, as suggested by the discrete extant analogies. Repetitive elements as well as exon predictions obtained using the GRAIL and GENEFINDER programs are described in detail. These programs led us to identify a novel gene, designated SMF, immediately downstream of FMS, in the opposite orientation. This finding emphasizes the gene-rich characteristic of this genomic region.</abstract><qualityIndicators><refBibsNative>false</refBibsNative><abstractWordCount>171</abstractWordCount><abstractCharCount>1079</abstractCharCount><keywordCount>0</keywordCount><score>9.052</score><pdfWordCount>6424</pdfWordCount><pdfCharCount>38640</pdfCharCount><pdfVersion>1.1</pdfVersion><pdfPageCount>11</pdfPageCount><pdfPageSize>541 x 727 pts</pdfPageSize></qualityIndicators><title>Sequence Analysis of Two Genomic Regions Containing the KIT and the FMS Receptor Tyrosine Kinase Genes</title><pmid><json:string>9027509</json:string></pmid><pii><json:string>S0888-7543(96)94482-1</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Genomics</title><language><json:string>unknown</json:string></language><publicationDate>1997</publicationDate><issn><json:string>0888-7543</json:string></issn><pii><json:string>S0888-7543(00)X0105-X</json:string></pii><volume>39</volume><issue>2</issue><pages><first>216</first><last>226</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1912</json:string><json:string>1997</json:string><json:string>35S</json:string><json:string>1255</json:string></date><geogName></geogName><orgName><json:string>DNASTAR, Inc.</json:string><json:string>University of Arkansas</json:string><json:string>Laboratory of Enzyme Engineering, Jilin University, Changchun, China</json:string><json:string>CNRS</json:string></orgName><orgName_funder><json:string>CNRS</json:string></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Francois Agnes</json:string><json:string>Paris Cedex</json:string><json:string>Jean-Claude Chuat</json:string><json:string>Nicolas Soriano</json:string><json:string>KIT Gene</json:string><json:string>D. Mathieu</json:string><json:string>KIT Intron</json:string><json:string>Ma</json:string><json:string>Roux</json:string></persName><placeName><json:string>Ulm</json:string><json:string>France</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Sanger et al., 1977</json:string><json:string>Prestridge, 1995</json:string><json:string>De Sepulveda et al., 1995</json:string><json:string>Agnes et al.</json:string><json:string>Jurka and Milosavljevic, 1991</json:string><json:string>Burset and Guigo (1996)</json:string><json:string>Smit et al., 1995</json:string><json:string>Roberts et al., 1988</json:string><json:string>Uberbacher and Mural, 1991</json:string><json:string>Huang et al., 1990</json:string><json:string>Rosnet and Birnbaum, 1993</json:string><json:string>Lopez et al. 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(1993)</json:string><json:string>Wingender, 1994</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-R4PC618V-9</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - genetics & heredity</json:string><json:string>2 - biotechnology & applied microbiology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - biomedical research</json:string><json:string>3 - genetics & heredity</json:string></scienceMetrix><scopus><json:string>1 - Life Sciences</json:string><json:string>2 - Biochemistry, Genetics and Molecular Biology</json:string><json:string>3 - Genetics</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences biologiques fondamentales et appliquees. psychologie</json:string><json:string>4 - vertebres: systeme digestif</json:string></inist></categories><publicationDate>1997</publicationDate><copyrightDate>1997</copyrightDate><doi><json:string>10.1006/geno.1996.4482</json:string></doi><id>C025792FDF082DC3F9493EDA9E0782B6341C68D6</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-R4PC618V-9/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-R4PC618V-9/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-R4PC618V-9/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Sequence Analysis of Two Genomic Regions Containing the KIT and the FMS Receptor Tyrosine Kinase Genes</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>©1997 Academic Press</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</p></availability><date>1997</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note>Sequence data from this article have been deposited with the GenBank/EMBL Data Libraries under Accession Nos. U63834 for the KIT gene region and U63963 for the tandem FMS and SMF genes.</note><note type="content">Section title: Regular Article</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Sequence Analysis of Two Genomic Regions Containing the KIT and the FMS Receptor Tyrosine Kinase Genes</title><author xml:id="author-0000"><persName><forename type="first">Catherine</forename><surname>Andre</surname></persName><affiliation>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex, France</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Annie</forename><surname>Hampe</surname></persName><affiliation>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex, France</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Philippe</forename><surname>Lachaume</surname></persName><affiliation>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex, France</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Emmanuel</forename><surname>Martin</surname></persName><note type="biography">Present address: Laboratoire de Transfert, Institut Curie, 26 Rue d'Ulm, 75231 Paris Cedex 05, France.</note><affiliation>Present address: Laboratoire de Transfert, Institut Curie, 26 Rue d'Ulm, 75231 Paris Cedex 05, France.</affiliation><affiliation>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex, France</affiliation></author><author xml:id="author-0004"><persName><forename type="first">Xao-Ping</forename><surname>Wang</surname></persName><note type="biography">Present address: Laboratory of Enzyme Engineering, Jilin University, Changchun, China.</note><affiliation>Present address: Laboratory of Enzyme Engineering, Jilin University, Changchun, China.</affiliation><affiliation>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex, France</affiliation></author><author xml:id="author-0005"><persName><forename type="first">Vladimir</forename><surname>Manus</surname></persName><note type="biography">Present address: URA 1149 CNRS, Institut Pasteur, 25 Rue du Dr Roux, 75724 Paris Cedex 15, France.</note><affiliation>Present address: URA 1149 CNRS, Institut Pasteur, 25 Rue du Dr Roux, 75724 Paris Cedex 15, France.</affiliation><affiliation>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex, France</affiliation></author><author xml:id="author-0006"><persName><forename type="first">Wei-Xin</forename><surname>Hu</surname></persName><note type="biography">Present address: University of Arkansas for Medical Sciences, 4301 W Markam, Little Rock, Arkansas 72205.</note><affiliation>Present address: University of Arkansas for Medical Sciences, 4301 W Markam, Little Rock, Arkansas 72205.</affiliation><affiliation>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex, France</affiliation></author><author xml:id="author-0007"><persName><forename type="first">Francis</forename><surname>Galibert</surname></persName><affiliation>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex, France</affiliation></author><idno type="istex">C025792FDF082DC3F9493EDA9E0782B6341C68D6</idno><idno type="ark">ark:/67375/6H6-R4PC618V-9</idno><idno type="DOI">10.1006/geno.1996.4482</idno><idno type="PII">S0888-7543(96)94482-1</idno></analytic><monogr><title level="j">Genomics</title><title level="j" type="abbrev">YGENO</title><idno type="pISSN">0888-7543</idno><idno type="PII">S0888-7543(00)X0105-X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997"></date><biblScope unit="volume">39</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="216">216</biblScope><biblScope unit="page" to="226">226</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1997</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: The KIT and FMS tyrosine kinase receptors, which are implicated in the control of cell growth and differentiation, stem through duplications from a common ancestor. We have conducted a detailed structural analysis of the two loci containing the KIT and FMS genes. The sequence of the ∼90-kb KIT locus reveals the position and size of the 21 introns and of the 5′ regulatory region of the KIT gene. The introns and the 3′-untranslated parts of KIT and FMS have been analyzed in parallel. Comparison of the two sequences shows that, while introns of both genes have extensively diverged in size and sequence, this divergence is, at least in part, due to intron expansion through internal duplications, as suggested by the discrete extant analogies. Repetitive elements as well as exon predictions obtained using the GRAIL and GENEFINDER programs are described in detail. These programs led us to identify a novel gene, designated SMF, immediately downstream of FMS, in the opposite orientation. This finding emphasizes the gene-rich characteristic of this genomic region.</p></abstract></profileDesc><revisionDesc><change when="1997">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-R4PC618V-9/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier converted-article found"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla" xml:lang="en"><item-info><jid>YGENO</jid><aid>94482</aid><ce:pii>S0888-7543(96)94482-1</ce:pii><ce:doi>10.1006/geno.1996.4482</ce:doi><ce:copyright type="full-transfer" year="1997">Academic Press</ce:copyright></item-info><head><ce:article-footnote><ce:label>☆</ce:label><ce:note-para>Sequence data from this article have been deposited with the GenBank/EMBL Data Libraries under Accession Nos. U63834 for the KIT gene region and U63963 for the tandem FMS and SMF genes.</ce:note-para></ce:article-footnote><ce:dochead><ce:textfn>Regular Article</ce:textfn></ce:dochead><ce:title>Sequence Analysis of Two Genomic Regions Containing the KIT and the FMS Receptor Tyrosine Kinase Genes</ce:title><ce:author-group><ce:author><ce:given-name>Catherine</ce:given-name><ce:surname>Andre</ce:surname><ce:cross-ref refid="GE964482FN1">1</ce:cross-ref></ce:author><ce:author><ce:given-name>Annie</ce:given-name><ce:surname>Hampe</ce:surname></ce:author><ce:author><ce:given-name>Philippe</ce:given-name><ce:surname>Lachaume</ce:surname></ce:author><ce:author><ce:given-name>Emmanuel</ce:given-name><ce:surname>Martin</ce:surname><ce:cross-ref refid="GE964482FN2">2</ce:cross-ref></ce:author><ce:author><ce:given-name>Xao-Ping</ce:given-name><ce:surname>Wang</ce:surname><ce:cross-ref refid="GE964482FN3">3</ce:cross-ref></ce:author><ce:author><ce:given-name>Vladimir</ce:given-name><ce:surname>Manus</ce:surname><ce:cross-ref refid="GE964482FN4">4</ce:cross-ref></ce:author><ce:author><ce:given-name>Wei-Xin</ce:given-name><ce:surname>Hu</ce:surname><ce:cross-ref refid="GE964482FN5">5</ce:cross-ref></ce:author><ce:author><ce:given-name>Francis</ce:given-name><ce:surname>Galibert</ce:surname></ce:author><ce:affiliation><ce:textfn>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex, France</ce:textfn></ce:affiliation><ce:footnote id="GE964482FN1"><ce:label>1</ce:label><ce:note-para>To whom correspondence should be addressed. Telephone: (33) 02 99 33 62 47. Fax: (33) 02 99 33 62 00. E-mail: candre@univ-rennes1.fr.</ce:note-para></ce:footnote><ce:footnote id="GE964482FN2"><ce:label>2</ce:label><ce:note-para>Present address: Laboratoire de Transfert, Institut Curie, 26 Rue d'Ulm, 75231 Paris Cedex 05, France.</ce:note-para></ce:footnote><ce:footnote id="GE964482FN3"><ce:label>3</ce:label><ce:note-para>Present address: Laboratory of Enzyme Engineering, Jilin University, Changchun, China.</ce:note-para></ce:footnote><ce:footnote id="GE964482FN4"><ce:label>4</ce:label><ce:note-para>Present address: URA 1149 CNRS, Institut Pasteur, 25 Rue du Dr Roux, 75724 Paris Cedex 15, France.</ce:note-para></ce:footnote><ce:footnote id="GE964482FN5"><ce:label>5</ce:label><ce:note-para>Present address: University of Arkansas for Medical Sciences, 4301 W Markam, Little Rock, Arkansas 72205.</ce:note-para></ce:footnote></ce:author-group><ce:date-received day="29" month="7" year="1996"></ce:date-received><ce:date-accepted day="30" month="10" year="1996"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The KIT and FMS tyrosine kinase receptors, which are implicated in the control of cell growth and differentiation, stem through duplications from a common ancestor. We have conducted a detailed structural analysis of the two loci containing the KIT and FMS genes. The sequence of the ∼90-kb KIT locus reveals the position and size of the 21 introns and of the 5′ regulatory region of the KIT gene. The introns and the 3′-untranslated parts of KIT and FMS have been analyzed in parallel. Comparison of the two sequences shows that, while introns of both genes have extensively diverged in size and sequence, this divergence is, at least in part, due to intron expansion through internal duplications, as suggested by the discrete extant analogies. Repetitive elements as well as exon predictions obtained using the GRAIL and GENEFINDER programs are described in detail. These programs led us to identify a novel gene, designated SMF, immediately downstream of FMS, in the opposite orientation. This finding emphasizes the gene-rich characteristic of this genomic region.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Sequence Analysis of Two Genomic Regions Containing the KIT and the FMS Receptor Tyrosine Kinase Genes</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Sequence Analysis of Two Genomic Regions Containing the KIT and the FMS Receptor Tyrosine Kinase Genes</title></titleInfo><name type="personal"><namePart type="given">Catherine</namePart><namePart type="family">Andre</namePart><affiliation>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex, France</affiliation><description>To whom correspondence should be addressed. Telephone: (33) 02 99 33 62 47. Fax: (33) 02 99 33 62 00. E-mail: candre@univ-rennes1.fr.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Annie</namePart><namePart type="family">Hampe</namePart><affiliation>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Philippe</namePart><namePart type="family">Lachaume</namePart><affiliation>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Emmanuel</namePart><namePart type="family">Martin</namePart><affiliation>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex, France</affiliation><description>Present address: Laboratoire de Transfert, Institut Curie, 26 Rue d'Ulm, 75231 Paris Cedex 05, France.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Xao-Ping</namePart><namePart type="family">Wang</namePart><affiliation>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex, France</affiliation><description>Present address: Laboratory of Enzyme Engineering, Jilin University, Changchun, China.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Vladimir</namePart><namePart type="family">Manus</namePart><affiliation>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex, France</affiliation><description>Present address: URA 1149 CNRS, Institut Pasteur, 25 Rue du Dr Roux, 75724 Paris Cedex 15, France.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wei-Xin</namePart><namePart type="family">Hu</namePart><affiliation>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex, France</affiliation><description>Present address: University of Arkansas for Medical Sciences, 4301 W Markam, Little Rock, Arkansas 72205.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Francis</namePart><namePart type="family">Galibert</namePart><affiliation>Laboratoire de Biochimie et Biologie Moléculaire, UPR41 CNRS, 2, Avenue du Professeur Léon Bernard, 35043, Rennes Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1997</dateIssued><copyrightDate encoding="w3cdtf">1997</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: The KIT and FMS tyrosine kinase receptors, which are implicated in the control of cell growth and differentiation, stem through duplications from a common ancestor. We have conducted a detailed structural analysis of the two loci containing the KIT and FMS genes. The sequence of the ∼90-kb KIT locus reveals the position and size of the 21 introns and of the 5′ regulatory region of the KIT gene. The introns and the 3′-untranslated parts of KIT and FMS have been analyzed in parallel. Comparison of the two sequences shows that, while introns of both genes have extensively diverged in size and sequence, this divergence is, at least in part, due to intron expansion through internal duplications, as suggested by the discrete extant analogies. Repetitive elements as well as exon predictions obtained using the GRAIL and GENEFINDER programs are described in detail. These programs led us to identify a novel gene, designated SMF, immediately downstream of FMS, in the opposite orientation. This finding emphasizes the gene-rich characteristic of this genomic region.</abstract><note>Sequence data from this article have been deposited with the GenBank/EMBL Data Libraries under Accession Nos. U63834 for the KIT gene region and U63963 for the tandem FMS and SMF genes.</note><note type="content">Section title: Regular Article</note><relatedItem type="host"><titleInfo><title>Genomics</title></titleInfo><titleInfo type="abbreviated"><title>YGENO</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1997</dateIssued></originInfo><identifier type="ISSN">0888-7543</identifier><identifier type="PII">S0888-7543(00)X0105-X</identifier><part><date>1997</date><detail type="volume"><number>39</number><caption>vol.</caption></detail><detail type="issue"><number>2</number><caption>no.</caption></detail><extent unit="issue-pages"><start>127</start><end>237</end></extent><extent unit="pages"><start>216</start><end>226</end></extent></part></relatedItem><identifier type="istex">C025792FDF082DC3F9493EDA9E0782B6341C68D6</identifier><identifier type="ark">ark:/67375/6H6-R4PC618V-9</identifier><identifier type="DOI">10.1006/geno.1996.4482</identifier><identifier type="PII">S0888-7543(96)94482-1</identifier><accessCondition type="use and reproduction" contentType="copyright">©1997 Academic Press</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource><recordOrigin>Academic Press, ©1997</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-R4PC618V-9/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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