Expression of c-fos and c-jun mRNA in the developing chicken lens: Relationship to cell proliferation, quiescence, and differentiation
Identifieur interne : 001D58 ( Istex/Checkpoint ); précédent : 001D57; suivant : 001D59Expression of c-fos and c-jun mRNA in the developing chicken lens: Relationship to cell proliferation, quiescence, and differentiation
Auteurs : Jo Ann Spiewak Rinaudo [États-Unis] ; Peggy S. Zelenka [États-Unis]Source :
- Experimental Cell Research [ 0014-4827 ] ; 1992.
English descriptors
- Teeft :
- Academic press, Annular, Autoradiogram, Cell basis, Cell cycle, Cell cycle arrest, Cell proliferation, Central epithelium, Chicken lens, Crystallin genes, Cultured cells, Early stages, Embryonic, Embryonic chicken lens, Epithelial, Epithelium, Equatorial, Equatorial epithelium, Fiber cells, Fiber mass, High levels, Inner epithelium, Internal standards, Lens, Lens epithelial cells, Lens fiber cells, Mrna, Mrna expression, Oligonucleotide, Other members, Personal communication, Piatigorsky, Postmitotic cells, Quiescent, Quiescent cells, Relative concentrations, Terminal differentiation, Terminally, Transcription, Zelenka.
Abstract
Abstract: The in vivo developmental pattern of c-fos and c-jun mRNA expression has been examined in the embryonic chicken lens using a coupled reverse transcription/ polymerase chain reaction assay. Levels of each mRNA were measured in the central epithelium, equatorial epithelium, and fiber cell mass at 6, 10, 14, and 19 days of development. The results showed that c-fos and c-jun mRNAs accumulated during development of the embryonic chicken lens epithelium as the proportion of proliferating cells decreased, suggesting that quiescent epithelial cells express high levels of both protooncogene mRNAs. Cells in the early stages of terminal differentiation near the lens equator also contained relatively high levels of c-fos and c-jun mRNA. As lens fiber cells matured, the number of copies of c-fos mRNA per cell decreased markedly, while c-jun mRNA increased. These findings demonstrate that c-fos and c-jun are differentially regulated during terminal differentiation of lens fiber cells and suggest that these protooncogenes are expressed in lens epithelial cells following cell cycle arrest.
Url:
DOI: 10.1016/0014-4827(92)90472-K
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
ISTEX:E1F0B327C4EBE10F2FE86738DA9F73E3C07C2AA1Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Expression of c-fos and c-jun mRNA in the developing chicken lens: Relationship to cell proliferation, quiescence, and differentiation</title><author><name sortKey="Rinaudo, Jo Ann Spiewak" sort="Rinaudo, Jo Ann Spiewak" uniqKey="Rinaudo J" first="Jo Ann Spiewak" last="Rinaudo">Jo Ann Spiewak Rinaudo</name></author><author><name sortKey="Zelenka, Peggy S" sort="Zelenka, Peggy S" uniqKey="Zelenka P" first="Peggy S." last="Zelenka">Peggy S. Zelenka</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E1F0B327C4EBE10F2FE86738DA9F73E3C07C2AA1</idno><date when="1992" year="1992">1992</date><idno type="doi">10.1016/0014-4827(92)90472-K</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-CNVQPMWW-6/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001666</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001666</idno><idno type="wicri:Area/Istex/Curation">001666</idno><idno type="wicri:Area/Istex/Checkpoint">001D58</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001D58</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Expression of c-fos and c-jun mRNA in the developing chicken lens: Relationship to cell proliferation, quiescence, and differentiation</title><author><name sortKey="Rinaudo, Jo Ann Spiewak" sort="Rinaudo, Jo Ann Spiewak" uniqKey="Rinaudo J" first="Jo Ann Spiewak" last="Rinaudo">Jo Ann Spiewak Rinaudo</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Zelenka, Peggy S" sort="Zelenka, Peggy S" uniqKey="Zelenka P" first="Peggy S." last="Zelenka">Peggy S. Zelenka</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Experimental Cell Research</title><title level="j" type="abbrev">YEXCR</title><idno type="ISSN">0014-4827</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992">1992</date><biblScope unit="volume">199</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="147">147</biblScope><biblScope unit="page" to="153">153</biblScope></imprint><idno type="ISSN">0014-4827</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0014-4827</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Academic press</term><term>Annular</term><term>Autoradiogram</term><term>Cell basis</term><term>Cell cycle</term><term>Cell cycle arrest</term><term>Cell proliferation</term><term>Central epithelium</term><term>Chicken lens</term><term>Crystallin genes</term><term>Cultured cells</term><term>Early stages</term><term>Embryonic</term><term>Embryonic chicken lens</term><term>Epithelial</term><term>Epithelium</term><term>Equatorial</term><term>Equatorial epithelium</term><term>Fiber cells</term><term>Fiber mass</term><term>High levels</term><term>Inner epithelium</term><term>Internal standards</term><term>Lens</term><term>Lens epithelial cells</term><term>Lens fiber cells</term><term>Mrna</term><term>Mrna expression</term><term>Oligonucleotide</term><term>Other members</term><term>Personal communication</term><term>Piatigorsky</term><term>Postmitotic cells</term><term>Quiescent</term><term>Quiescent cells</term><term>Relative concentrations</term><term>Terminal differentiation</term><term>Terminally</term><term>Transcription</term><term>Zelenka</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The in vivo developmental pattern of c-fos and c-jun mRNA expression has been examined in the embryonic chicken lens using a coupled reverse transcription/ polymerase chain reaction assay. Levels of each mRNA were measured in the central epithelium, equatorial epithelium, and fiber cell mass at 6, 10, 14, and 19 days of development. The results showed that c-fos and c-jun mRNAs accumulated during development of the embryonic chicken lens epithelium as the proportion of proliferating cells decreased, suggesting that quiescent epithelial cells express high levels of both protooncogene mRNAs. Cells in the early stages of terminal differentiation near the lens equator also contained relatively high levels of c-fos and c-jun mRNA. As lens fiber cells matured, the number of copies of c-fos mRNA per cell decreased markedly, while c-jun mRNA increased. These findings demonstrate that c-fos and c-jun are differentially regulated during terminal differentiation of lens fiber cells and suggest that these protooncogenes are expressed in lens epithelial cells following cell cycle arrest.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Rinaudo, Jo Ann Spiewak" sort="Rinaudo, Jo Ann Spiewak" uniqKey="Rinaudo J" first="Jo Ann Spiewak" last="Rinaudo">Jo Ann Spiewak Rinaudo</name></region><name sortKey="Zelenka, Peggy S" sort="Zelenka, Peggy S" uniqKey="Zelenka P" first="Peggy S." last="Zelenka">Peggy S. Zelenka</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Istex/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001D58 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Checkpoint/biblio.hfd -nk 001D58 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Istex
|étape= Checkpoint
|type= RBID
|clé= ISTEX:E1F0B327C4EBE10F2FE86738DA9F73E3C07C2AA1
|texte= Expression of c-fos and c-jun mRNA in the developing chicken lens: Relationship to cell proliferation, quiescence, and differentiation
}}
| This area was generated with Dilib version V0.6.33. |  |