Activation of RNA Polymerase III Transcription of Human Alu Elements by Herpes Simplex Virus
Identifieur interne : 001B23 ( Istex/Checkpoint ); précédent : 001B22; suivant : 001B24Activation of RNA Polymerase III Transcription of Human Alu Elements by Herpes Simplex Virus
Auteurs : Barbara Panning [Canada] ; James R. Smiley [Canada]Source :
- Virology [ 0042-6822 ] ; 1994.
Abstract
Abstract: We found that HSV infection of HeLa cells strongly induces RNA polymerase III transcription of endogenous human Alu elements, resulting in the accumulation of high levels of cytoplasmic RNAs initiated from Alu pol III promoters. Induction required viral protein synthesis and occurred during infection with a viral mutant bearing a null mutation in the immediate--early (IE) gene encoding ICP4, suggesting that one or more IE proteins are sufficient for activation. However, mutations in each of the other four IE genes had no effect on activation of Alu expression. We therefore conclude that HSV most likely encodes at least two proteins that are each sufficient to activate Alu transcription and that at least one of these is an IE protein other than ICP4.
Url:
DOI: 10.1006/viro.1994.1357
Affiliations:
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Activation of RNA Polymerase III Transcription of Human Alu Elements by Herpes Simplex Virus</title><author><name sortKey="Panning, Barbara" sort="Panning, Barbara" uniqKey="Panning B" first="Barbara" last="Panning">Barbara Panning</name></author><author><name sortKey="Smiley, James R" sort="Smiley, James R" uniqKey="Smiley J" first="James R." last="Smiley">James R. Smiley</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8492169BAA95830A93923E2DF21691E66BDE0610</idno><date when="1994" year="1994">1994</date><idno type="doi">10.1006/viro.1994.1357</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-H90VV9GW-S/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002118</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002118</idno><idno type="wicri:Area/Istex/Curation">002118</idno><idno type="wicri:Area/Istex/Checkpoint">001B23</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001B23</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Activation of RNA Polymerase III Transcription of Human Alu Elements by Herpes Simplex Virus</title><author><name sortKey="Panning, Barbara" sort="Panning, Barbara" uniqKey="Panning B" first="Barbara" last="Panning">Barbara Panning</name><affiliation wicri:level="4"><country>Canada</country><wicri:regionArea>Molecular Virology and Immunology Program, Pathology Department, McMaster University, Hamilton Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Smiley, James R" sort="Smiley, James R" uniqKey="Smiley J" first="James R." last="Smiley">James R. Smiley</name><affiliation wicri:level="4"><country>Canada</country><wicri:regionArea>Molecular Virology and Immunology Program, Pathology Department, McMaster University, Hamilton Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Virology</title><title level="j" type="abbrev">YVIRO</title><idno type="ISSN">0042-6822</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994">1994</date><biblScope unit="volume">202</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="408">408</biblScope><biblScope unit="page" to="417">417</biblScope></imprint><idno type="ISSN">0042-6822</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0042-6822</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: We found that HSV infection of HeLa cells strongly induces RNA polymerase III transcription of endogenous human Alu elements, resulting in the accumulation of high levels of cytoplasmic RNAs initiated from Alu pol III promoters. Induction required viral protein synthesis and occurred during infection with a viral mutant bearing a null mutation in the immediate--early (IE) gene encoding ICP4, suggesting that one or more IE proteins are sufficient for activation. However, mutations in each of the other four IE genes had no effect on activation of Alu expression. We therefore conclude that HSV most likely encodes at least two proteins that are each sufficient to activate Alu transcription and that at least one of these is an IE protein other than ICP4.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Hamilton (Ontario)</li></settlement><orgName><li>Université McMaster</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Panning, Barbara" sort="Panning, Barbara" uniqKey="Panning B" first="Barbara" last="Panning">Barbara Panning</name></region><name sortKey="Smiley, James R" sort="Smiley, James R" uniqKey="Smiley J" first="James R." last="Smiley">James R. Smiley</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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