Primary central nervous system malignant non–Hodgkin's lymphomas from HIV‐infected and non‐infected patients:expression of cellular surface proteins and Epstein‐Barr viral markers
Identifieur interne : 000351 ( France/Analysis ); précédent : 000350; suivant : 000352Primary central nervous system malignant non–Hodgkin's lymphomas from HIV‐infected and non‐infected patients:expression of cellular surface proteins and Epstein‐Barr viral markers
Auteurs : I. Auperin ; J. Mikol [France] ; E. Oksenhendler ; J. B. Thiebaut [France] ; M. Brunet ; B. Dupont [France] ; F. MorinetSource :
- Neuropathology and Applied Neurobiology [ 0305-1846 ] ; 1994-06.
Abstract
The increased incidence of primary central nervous system malignant non–Hodgkin's lymphomas (PCNSL) in HIV– and non–HIV–infected patients and the demonstration of Epstein–Barr virus (EBV) in these tumours may indicate relationships between PCNSL and EBV. Consequently expression of EBV–induced antigens and cellular markers were studied in 11 HIV–infected and seven non–infected patients by in situ hybridization (ISH) and immunocytochemistry in monoclonal B cell PCNSL. In HIV–infected patients EBV genome was present in 9/11 cases, LMP in 11/11 cases and EBNA2 in 10/11 cases. The expression of adhesion and activation molecules was low or absent. In HIV non–infected patients, EBV genome was present in 5/7 cases, with LMP in 4/7 cases. EBNA2 was never detected. All these lymphomas expressed LFAlbeta. Whatever the population, no lytic cycle EBV markers were detected. Compared with other types of EBV lymphomas, our results suggest a different EBV latency state in primary B cell lymphomas of the CNS from HIV–infected or non–infected patients.
Url:
DOI: 10.1111/j.1365-2990.1994.tb00966.x
Affiliations:
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Thiebaut</name><affiliation wicri:level="3"><country>France</country><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName><wicri:orgArea>§Department of Neurosurgery, Henry Dunant Hospital</wicri:orgArea></affiliation></author><author><name sortKey="Brunet, M" sort="Brunet, M" uniqKey="Brunet M" first="M." last="Brunet">M. Brunet</name><affiliation><wicri:noCountry code="subField">University</wicri:noCountry></affiliation></author><author><name sortKey="Dupont, B" sort="Dupont, B" uniqKey="Dupont B" first="B." last="Dupont">B. Dupont</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>|Department of Internal Medicine, Pasteur Hospital, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Morinet, F" sort="Morinet, F" uniqKey="Morinet F" first="F." last="Morinet">F. Morinet</name><affiliation><wicri:noCountry code="subField">University</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Neuropathology and Applied Neurobiology</title><title level="j" type="alt">NEUROPATHOLOGY APPLIED NEUROBIOLOGY</title><idno type="ISSN">0305-1846</idno><idno type="eISSN">1365-2990</idno><imprint><biblScope unit="vol">20</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="243">243</biblScope><biblScope unit="page" to="252">252</biblScope><biblScope unit="page-count">10</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1994-06">1994-06</date></imprint><idno type="ISSN">0305-1846</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0305-1846</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The increased incidence of primary central nervous system malignant non–Hodgkin's lymphomas (PCNSL) in HIV– and non–HIV–infected patients and the demonstration of Epstein–Barr virus (EBV) in these tumours may indicate relationships between PCNSL and EBV. Consequently expression of EBV–induced antigens and cellular markers were studied in 11 HIV–infected and seven non–infected patients by in situ hybridization (ISH) and immunocytochemistry in monoclonal B cell PCNSL. In HIV–infected patients EBV genome was present in 9/11 cases, LMP in 11/11 cases and EBNA2 in 10/11 cases. The expression of adhesion and activation molecules was low or absent. In HIV non–infected patients, EBV genome was present in 5/7 cases, with LMP in 4/7 cases. EBNA2 was never detected. All these lymphomas expressed LFAlbeta. Whatever the population, no lytic cycle EBV markers were detected. Compared with other types of EBV lymphomas, our results suggest a different EBV latency state in primary B cell lymphomas of the CNS from HIV–infected or non–infected patients.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><noCountry><name sortKey="Auperin, I" sort="Auperin, I" uniqKey="Auperin I" first="I." last="Auperin">I. Auperin</name><name sortKey="Brunet, M" sort="Brunet, M" uniqKey="Brunet M" first="M." last="Brunet">M. Brunet</name><name sortKey="Morinet, F" sort="Morinet, F" uniqKey="Morinet F" first="F." last="Morinet">F. Morinet</name><name sortKey="Oksenhendler, E" sort="Oksenhendler, E" uniqKey="Oksenhendler E" first="E." last="Oksenhendler">E. Oksenhendler</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Mikol, J" sort="Mikol, J" uniqKey="Mikol J" first="J." last="Mikol">J. 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