Oligonucleotide micro‐arrays for identification of unknown mutations: how far from reality?
Identifieur interne : 000308 ( France/Analysis ); précédent : 000307; suivant : 000309Oligonucleotide micro‐arrays for identification of unknown mutations: how far from reality?
Auteurs : Frédéric Ginot [France]Source :
- Human Mutation [ 1059-7794 ] ; 1997.
English descriptors
- Teeft :
- Adsorption, Array, Beattie, Chee, Combinatorial synthesis, Conventional format, Destabilisation effect, Different bases, Different oligonucleotides, Drmanac, Duplex, Duplex form, Duplex stability, Electric field, Electric field intensity, Evry cedex, Flat surface, Fodor, Footprint detection, Genome, Ginot, Glass slide, Hybridisation, Hybridisation data, Hybridisation experiments, Hybridisation specificity, Hybridization, Immobilised, Immobilised oligonucleotides, Internal mismatches, Khrapko, Latex particles, Main problem, Mirzabekov, Mismatch, More oligonucleotides, Mutation, Mutation detection, Nanogen solution, Nonspecific adsorption, Normalisation method, Nucleic, Nucleic acids, Oligonucleotide, Oligonucleotide array, Oligonucleotide arrays, Oligonucleotide concentrations, Oligonucleotide hybridisations, Oligonucleotide length, Oligonucleotide matrix, Oligonucleotide synthesis, Oligonucleotides, Oligonucleotides immobilised, Pharmaceutical business news, Polymorphism, Proc natl acad, Qualitative hybridisation, Quantitative hybridisation, Reference sequence, Sample fragments, Sample sequence, Santa clara, Sequence analysis, Sequencing, Short oligonucleotides, Single hybridisation, Single hybridisation experiment, Solid support, Stability differences, Synthesis cycle, Target sequence, Terminal mismatch discrimination, Terminal mismatches, Theoretical power, Thin film, Tiled array, Universal array, Universal oligonucleotide array, Universal tool, Unknown mutation detection, Unknown mutations, Wild type sequence, Yershov.
Abstract
The present review examines critically what has been published on oligonucleotide micro‐arrays, from the point of view of detection of unknown mutations. We will first demonstrate the theoretical power of this new technique, and then argue that it is experimentally realistic. However, technical difficulties remain, and the proposed solutions for controlling the hybridisation specificity and for manufacturing the micro‐arrays will be reviewed. Some are promising, but a complete integration of several of these solutions must be achieved before oligonucleotide micro‐arrays become a universal tool for routine detection of unknown mutations. Nevertheless, sequence specific arrays should be available in the short term for the most frequently studied genes. Hum Mutat 10:1–10, 1997. © 1997 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/(SICI)1098-1004(1997)10:1<1::AID-HUMU1>3.0.CO;2-P
Affiliations:
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Cedex</wicri:noRegion><wicri:noRegion>91 000 Evry Cedex</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Human Mutation</title><title level="j" type="alt">HUMAN MUTATION</title><idno type="ISSN">1059-7794</idno><idno type="eISSN">1098-1004</idno><imprint><biblScope unit="vol">10</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="1">1</biblScope><biblScope unit="page" to="10">10</biblScope><biblScope unit="page-count">10</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="1997">1997</date></imprint><idno type="ISSN">1059-7794</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1059-7794</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adsorption</term><term>Array</term><term>Beattie</term><term>Chee</term><term>Combinatorial 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adsorption</term><term>Normalisation method</term><term>Nucleic</term><term>Nucleic acids</term><term>Oligonucleotide</term><term>Oligonucleotide array</term><term>Oligonucleotide arrays</term><term>Oligonucleotide concentrations</term><term>Oligonucleotide hybridisations</term><term>Oligonucleotide length</term><term>Oligonucleotide matrix</term><term>Oligonucleotide synthesis</term><term>Oligonucleotides</term><term>Oligonucleotides immobilised</term><term>Pharmaceutical business news</term><term>Polymorphism</term><term>Proc natl acad</term><term>Qualitative hybridisation</term><term>Quantitative hybridisation</term><term>Reference sequence</term><term>Sample fragments</term><term>Sample sequence</term><term>Santa clara</term><term>Sequence analysis</term><term>Sequencing</term><term>Short oligonucleotides</term><term>Single hybridisation</term><term>Single hybridisation experiment</term><term>Solid support</term><term>Stability differences</term><term>Synthesis cycle</term><term>Target sequence</term><term>Terminal mismatch discrimination</term><term>Terminal mismatches</term><term>Theoretical power</term><term>Thin film</term><term>Tiled array</term><term>Universal array</term><term>Universal oligonucleotide array</term><term>Universal tool</term><term>Unknown mutation detection</term><term>Unknown mutations</term><term>Wild type sequence</term><term>Yershov</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The present review examines critically what has been published on oligonucleotide micro‐arrays, from the point of view of detection of unknown mutations. We will first demonstrate the theoretical power of this new technique, and then argue that it is experimentally realistic. However, technical difficulties remain, and the proposed solutions for controlling the hybridisation specificity and for manufacturing the micro‐arrays will be reviewed. Some are promising, but a complete integration of several of these solutions must be achieved before oligonucleotide micro‐arrays become a universal tool for routine detection of unknown mutations. Nevertheless, sequence specific arrays should be available in the short term for the most frequently studied genes. 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