On the Origin of Primitive Cells: From Nutrient Intake to Elongation of Encapsulated Nucleotides
Identifieur interne : 000163 ( France/Analysis ); précédent : 000162; suivant : 000164On the Origin of Primitive Cells: From Nutrient Intake to Elongation of Encapsulated Nucleotides
Auteurs : Uwe Meierhenrich [France] ; Jean-Jacques Filippi ; Cornelia Meinert ; Pierre Vierling ; Jason Dworkin [États-Unis]Source :
- Angewandte Chemie International Edition [ 1433-7851 ] ; 2010-05-17.
Abstract
Recent major discoveries in membrane biophysics hold the key to a modern understanding of the origin of life on Earth. Membrane bilayer vesicles have been shown to provide a multifaceted microenvironment in which protometabolic reactions could have developed. Cell‐membrane‐like aggregates of amphiphilic molecules capable of retaining encapsulated oligonucleotides have been successfully created in the laboratory. Sophisticated laboratory studies on the origin of life now show that elongation of the DNA primer takes place inside fatty acid vesicles when activated nucleotide nutrients are added to the external medium. These studies demonstrate that cell‐like vesicles can be sufficiently permeable to allow for the intake of charged molecules such as activated nucleotides, which can then take part in copying templates in the protocell interior. In this Review we summarize recent experiments in this area and describe a possible scenario for the origin of primitive cells, with an emphasis on the elongation of encapsulated nucleotides.
A primitive cell remodeled: Bilayer membrane vesicles (see picture) provide a multifaceted microenvironment in which protometabolic reactions could have been triggered. This Review summarizes experiments carried out to form vesicles by the aggregation of amphiphiles. The addition of nucleotides to the extravesicular medium results in them being taken up and their participation in non‐enzymatic elongation of the DNA primer within the vesicular interior.
Url:
DOI: 10.1002/anie.200905465
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002440
- to stream Istex, to step Curation: 002440
- to stream Istex, to step Checkpoint: 000567
- to stream Main, to step Merge: 002721
- to stream Main, to step Curation: 002696
- to stream Main, to step Exploration: 002696
- to stream France, to step Extraction: 000163
Links to Exploration step
ISTEX:F038F32111F0E7DE2B2A8A9D9C0D7E892B3A7385Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">On the Origin of Primitive Cells: From Nutrient Intake to Elongation of Encapsulated Nucleotides</title><author><name sortKey="Meierhenrich, Uwe" sort="Meierhenrich, Uwe" uniqKey="Meierhenrich U" first="Uwe" last="Meierhenrich">Uwe Meierhenrich</name></author><author><name sortKey="Filippi, Jean Acques" sort="Filippi, Jean Acques" uniqKey="Filippi J" first="Jean-Jacques" last="Filippi">Jean-Jacques Filippi</name></author><author><name sortKey="Meinert, Cornelia" sort="Meinert, Cornelia" uniqKey="Meinert C" first="Cornelia" last="Meinert">Cornelia Meinert</name></author><author><name sortKey="Vierling, Pierre" sort="Vierling, Pierre" uniqKey="Vierling P" first="Pierre" last="Vierling">Pierre Vierling</name></author><author><name sortKey="Dworkin, Jason" sort="Dworkin, Jason" uniqKey="Dworkin J" first="Jason" last="Dworkin">Jason Dworkin</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:F038F32111F0E7DE2B2A8A9D9C0D7E892B3A7385</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1002/anie.200905465</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-T8B5ZQ26-D/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002440</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002440</idno><idno type="wicri:Area/Istex/Curation">002440</idno><idno type="wicri:Area/Istex/Checkpoint">000567</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000567</idno><idno type="wicri:doubleKey">1433-7851:2010:Meierhenrich U:on:the:origin</idno><idno type="wicri:Area/Main/Merge">002721</idno><idno type="wicri:Area/Main/Curation">002696</idno><idno type="wicri:Area/Main/Exploration">002696</idno><idno type="wicri:Area/France/Extraction">000163</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">On the Origin of Primitive Cells: From Nutrient Intake to Elongation of Encapsulated Nucleotides</title><author><name sortKey="Meierhenrich, Uwe" sort="Meierhenrich, Uwe" uniqKey="Meierhenrich U" first="Uwe" last="Meierhenrich">Uwe Meierhenrich</name><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">France</country></affiliation></author><author><name sortKey="Filippi, Jean Acques" sort="Filippi, Jean Acques" uniqKey="Filippi J" first="Jean-Jacques" last="Filippi">Jean-Jacques Filippi</name><affiliation><wicri:noCountry code="subField">http://www.unice.fr/lcmba/meierhenrich/</wicri:noCountry></affiliation></author><author><name sortKey="Meinert, Cornelia" sort="Meinert, Cornelia" uniqKey="Meinert C" first="Cornelia" last="Meinert">Cornelia Meinert</name><affiliation><wicri:noCountry code="subField">http://www.unice.fr/lcmba/meierhenrich/</wicri:noCountry></affiliation></author><author><name sortKey="Vierling, Pierre" sort="Vierling, Pierre" uniqKey="Vierling P" first="Pierre" last="Vierling">Pierre Vierling</name><affiliation><wicri:noCountry code="subField">http://www.unice.fr/lcmba/meierhenrich/</wicri:noCountry></affiliation></author><author><name sortKey="Dworkin, Jason" sort="Dworkin, Jason" uniqKey="Dworkin J" first="Jason" last="Dworkin">Jason Dworkin</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Astrochemistry Laboratory, Code 691.0, NASA Goddard Flight Space Center, Greenbelt MD 20771</wicri:regionArea><wicri:noRegion>Greenbelt MD 20771</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Angewandte Chemie International Edition</title><title level="j" type="alt">ANGEWANDTE CHEMIE INTERNATIONAL EDITION</title><idno type="ISSN">1433-7851</idno><idno type="eISSN">1521-3773</idno><imprint><biblScope unit="vol">49</biblScope><biblScope unit="issue">22</biblScope><biblScope unit="page" from="3738">3738</biblScope><biblScope unit="page" to="3750">3750</biblScope><biblScope unit="page-count">13</biblScope><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><date type="published" when="2010-05-17">2010-05-17</date></imprint><idno type="ISSN">1433-7851</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1433-7851</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent major discoveries in membrane biophysics hold the key to a modern understanding of the origin of life on Earth. Membrane bilayer vesicles have been shown to provide a multifaceted microenvironment in which protometabolic reactions could have developed. Cell‐membrane‐like aggregates of amphiphilic molecules capable of retaining encapsulated oligonucleotides have been successfully created in the laboratory. Sophisticated laboratory studies on the origin of life now show that elongation of the DNA primer takes place inside fatty acid vesicles when activated nucleotide nutrients are added to the external medium. These studies demonstrate that cell‐like vesicles can be sufficiently permeable to allow for the intake of charged molecules such as activated nucleotides, which can then take part in copying templates in the protocell interior. In this Review we summarize recent experiments in this area and describe a possible scenario for the origin of primitive cells, with an emphasis on the elongation of encapsulated nucleotides.</div><div type="abstract" xml:lang="en">A primitive cell remodeled: Bilayer membrane vesicles (see picture) provide a multifaceted microenvironment in which protometabolic reactions could have been triggered. This Review summarizes experiments carried out to form vesicles by the aggregation of amphiphiles. The addition of nucleotides to the extravesicular medium results in them being taken up and their participation in non‐enzymatic elongation of the DNA primer within the vesicular interior.</div></front></TEI><affiliations><list><country><li>France</li><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Filippi, Jean Acques" sort="Filippi, Jean Acques" uniqKey="Filippi J" first="Jean-Jacques" last="Filippi">Jean-Jacques Filippi</name><name sortKey="Meinert, Cornelia" sort="Meinert, Cornelia" uniqKey="Meinert C" first="Cornelia" last="Meinert">Cornelia Meinert</name><name sortKey="Vierling, Pierre" sort="Vierling, Pierre" uniqKey="Vierling P" first="Pierre" last="Vierling">Pierre Vierling</name></noCountry><country name="France"><noRegion><name sortKey="Meierhenrich, Uwe" sort="Meierhenrich, Uwe" uniqKey="Meierhenrich U" first="Uwe" last="Meierhenrich">Uwe Meierhenrich</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Dworkin, Jason" sort="Dworkin, Jason" uniqKey="Dworkin J" first="Jason" last="Dworkin">Jason Dworkin</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000163 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000163 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= France
|étape= Analysis
|type= RBID
|clé= ISTEX:F038F32111F0E7DE2B2A8A9D9C0D7E892B3A7385
|texte= On the Origin of Primitive Cells: From Nutrient Intake to Elongation of Encapsulated Nucleotides
}}
| This area was generated with Dilib version V0.6.33. |  |