Clinical management of respiratory syndrome in patients hospitalized for suspected Middle East respiratory syndrome coronavirus infection in the Paris area from 2013 to 2016
Identifieur interne : 000038 ( France/Analysis ); précédent : 000037; suivant : 000039Clinical management of respiratory syndrome in patients hospitalized for suspected Middle East respiratory syndrome coronavirus infection in the Paris area from 2013 to 2016
Auteurs : A. Bleibtreu [France] ; S. Jaureguiberry [France] ; N. Houhou [France] ; D. Boutolleau [France] ; H. Guillot [France] ; D. Vallois [France] ; J. C. Lucet [France] ; J. Robert [France] ; B. Mourvillier [France] ; J. Delemazure [France] ; M. Jaspard [France] ; F. X. Lescure [France] ; C. Rioux [France] ; E. Caumes [France] ; Y. Yazdanapanah [France]Source :
- BMC Infectious Diseases [ 1471-2334 ] ; 2018.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Antibactériens (usage thérapeutique), Antiviraux (usage thérapeutique), Arabie saoudite, Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Femelle, Hospitalisation, Humains, Infections à coronavirus (), Infections à coronavirus (diagnostic), Infections à coronavirus (virologie), Isolement du patient, Mâle, Oséltamivir (usage thérapeutique), Oxygénothérapie, Paris, Résultat thérapeutique, Streptococcus pneumoniae, Sujet âgé, Voyage, Études rétrospectives.
- MESH :
- diagnostic : Infections à coronavirus.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- usage thérapeutique : Antibactériens, Antiviraux, Oséltamivir.
- virologie : Infections à coronavirus.
- Adulte d'âge moyen, Arabie saoudite, Femelle, Hospitalisation, Humains, Infections à coronavirus, Isolement du patient, Mâle, Oxygénothérapie, Paris, Résultat thérapeutique, Streptococcus pneumoniae, Sujet âgé, Voyage, Études rétrospectives.
- Wicri :
- geographic : Arabie saoudite.
English descriptors
- KwdEn :
- Aged, Anti-Bacterial Agents (therapeutic use), Antiviral Agents (therapeutic use), Coronavirus Infections (diagnosis), Coronavirus Infections (therapy), Coronavirus Infections (virology), Female, Hospitalization, Humans, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (isolation & purification), Oseltamivir (therapeutic use), Oxygen Inhalation Therapy, Paris, Patient Isolation, Retrospective Studies, Saudi Arabia, Streptococcus pneumoniae, Travel, Treatment Outcome.
- MESH :
- chemical , therapeutic use : Anti-Bacterial Agents, Antiviral Agents, Oseltamivir.
- geographic : Paris, Saudi Arabia.
- diagnosis : Coronavirus Infections.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- therapy : Coronavirus Infections.
- virology : Coronavirus Infections.
- Aged, Female, Hospitalization, Humans, Male, Middle Aged, Oxygen Inhalation Therapy, Patient Isolation, Retrospective Studies, Streptococcus pneumoniae, Travel, Treatment Outcome.
- mix :
Abstract
Patients with suspected Middle East respiratory syndrome coronavirus (MERS-CoV) infection should be hospitalized in isolation wards to avoid transmission. This suspicion can also lead to medical confusion and inappropriate management of acute respiratory syndrome due to causes other than MERS-CoV.
We studied the characteristics and outcome of patients hospitalized for suspected MERS-CoV infection in the isolation wards of two referral infectious disease departments in the Paris area between January 2013 and December 2016.
Of 93 adult patients (49 male (52.6%), median age 63.4 years) hospitalized, 82 out of 93 adult patients had returned from Saudi Arabia, and 74 of them were pilgrims (Hajj). Chest X-ray findings were abnormal in 72 (77%) patients. The 93 patients were negative for MERS-CoV RT-PCR, and 70 (75.2%) patients had documented infection, 47 (50.5%) viral, 22 (23.6%) bacterial and one
The management of patients with possible MERS-CoV infection requires medical facilities with trained personnel, and rapid access to virological results. Empirical treatment with neuraminidase inhibitors and an association of antibiotics effective against
The online version of this article (10.1186/s12879-018-3223-5) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s12879-018-3223-5
PubMed: 30012113
PubMed Central: 6048819
Affiliations:
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PMC:6048819Le document en format XML
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Bleibtreu</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2217 0017</institution-id><institution-id institution-id-type="GRID">grid.7452.4</institution-id><institution>APHP, Hôpital Bichat Claude Bernard,</institution><institution>Service des Maladies Infectieuses et Tropicales, Paris Diderot University,</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.50550.35</institution-id><institution-id institution-id-type="ISNI">0000 0001 2175 4109</institution-id><institution>APHP, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix,</institution><institution>Service des Maladies Infectieuses et Tropicales,</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000000121866389</institution-id><institution-id institution-id-type="GRID">grid.7429.8</institution-id><institution>INSERM, IAME, UMR 1137,</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2217 0017</institution-id><institution-id institution-id-type="GRID">grid.7452.4</institution-id><institution>Univ Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité,</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation></author><author><name sortKey="Jaureguiberry, S" sort="Jaureguiberry, S" uniqKey="Jaureguiberry S" first="S." last="Jaureguiberry">S. Jaureguiberry</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.50550.35</institution-id><institution-id institution-id-type="ISNI">0000 0001 2175 4109</institution-id><institution>APHP, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix,</institution><institution>Service des Maladies Infectieuses et Tropicales,</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation></author><author><name sortKey="Houhou, N" sort="Houhou, N" uniqKey="Houhou N" first="N." last="Houhou">N. Houhou</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8588 831X</institution-id><institution-id institution-id-type="GRID">grid.411119.d</institution-id><institution>Virology Department,</institution><institution>APHP-Bichat-Claude Bernard Hospital,</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation></author><author><name sortKey="Boutolleau, D" sort="Boutolleau, D" uniqKey="Boutolleau D" first="D." last="Boutolleau">D. Boutolleau</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2175 4109</institution-id><institution-id institution-id-type="GRID">grid.50550.35</institution-id><institution>AP-HP, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Service de Virologie, et Sorbonne Universités, UPMC Univ Paris 06, CR7, CIMI, INSERM U1135,</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation></author><author><name sortKey="Guillot, H" sort="Guillot, H" uniqKey="Guillot H" first="H." last="Guillot">H. Guillot</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.50550.35</institution-id><institution-id institution-id-type="ISNI">0000 0001 2175 4109</institution-id><institution>APHP, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix,</institution><institution>Service des Maladies Infectieuses et Tropicales,</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation></author><author><name sortKey="Vallois, D" sort="Vallois, D" uniqKey="Vallois D" first="D." last="Vallois">D. Vallois</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2217 0017</institution-id><institution-id institution-id-type="GRID">grid.7452.4</institution-id><institution>APHP, Hôpital Bichat Claude Bernard,</institution><institution>Service des Maladies Infectieuses et Tropicales, Paris Diderot University,</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation></author><author><name sortKey="Lucet, J C" sort="Lucet, J C" uniqKey="Lucet J" first="J. C." last="Lucet">J. C. Lucet</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2217 0017</institution-id><institution-id institution-id-type="GRID">grid.7452.4</institution-id><institution>APHP, Infection control unit, Bichat Claude Bernard hospital,</institution><institution>Paris Diderot University,</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000000121866389</institution-id><institution-id institution-id-type="GRID">grid.7429.8</institution-id><institution>INSERM, IAME, UMR 1137,</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2217 0017</institution-id><institution-id institution-id-type="GRID">grid.7452.4</institution-id><institution>Univ Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité,</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation></author><author><name sortKey="Robert, J" sort="Robert, J" uniqKey="Robert J" first="J." last="Robert">J. Robert</name><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2175 4109</institution-id><institution-id institution-id-type="GRID">grid.50550.35</institution-id><institution>AP-HP, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Bactériologie-Hygiène Hospitalière,</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="GRID">grid.463810.8</institution-id><institution>Faculté de Médecine P. & M. Curie Paris-6 - Site Pitié,</institution><institution>Centre d’Immunologie et des Maladies Infectieuses (CIMI) - E13,</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation></author><author><name sortKey="Mourvillier, B" sort="Mourvillier, B" uniqKey="Mourvillier B" first="B." last="Mourvillier">B. Mourvillier</name><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000000121866389</institution-id><institution-id institution-id-type="GRID">grid.7429.8</institution-id><institution>INSERM, IAME, UMR 1137,</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2217 0017</institution-id><institution-id institution-id-type="GRID">grid.7452.4</institution-id><institution>Univ Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité,</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="GRID">grid.411119.d</institution-id><institution-id institution-id-type="ISNI">0000 0000 8588 831X</institution-id><institution>APHP- Hôpital Bichat Claude Bernard,</institution><institution>Service de Réanimation médicale et Infectieuse,</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation></author><author><name sortKey="Delemazure, J" sort="Delemazure, J" uniqKey="Delemazure J" first="J." last="Delemazure">J. Delemazure</name><affiliation wicri:level="1"><nlm:aff id="Aff11"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2175 4109</institution-id><institution-id institution-id-type="GRID">grid.50550.35</institution-id><institution>Service de pneumologie et réanimation Département R3S,</institution><institution>AP-HP, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, unité de Soin de Réadaptation Post Réanimation (SRPR),</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation></author><author><name sortKey="Jaspard, M" sort="Jaspard, M" uniqKey="Jaspard M" first="M." last="Jaspard">M. Jaspard</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.50550.35</institution-id><institution-id institution-id-type="ISNI">0000 0001 2175 4109</institution-id><institution>APHP, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix,</institution><institution>Service des Maladies Infectieuses et Tropicales,</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation></author><author><name sortKey="Lescure, F X" sort="Lescure, F X" uniqKey="Lescure F" first="F. X." last="Lescure">F. X. Lescure</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2217 0017</institution-id><institution-id institution-id-type="GRID">grid.7452.4</institution-id><institution>APHP, Hôpital Bichat Claude Bernard,</institution><institution>Service des Maladies Infectieuses et Tropicales, Paris Diderot University,</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000000121866389</institution-id><institution-id institution-id-type="GRID">grid.7429.8</institution-id><institution>INSERM, IAME, UMR 1137,</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2217 0017</institution-id><institution-id institution-id-type="GRID">grid.7452.4</institution-id><institution>Univ Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité,</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation></author><author><name sortKey="Rioux, C" sort="Rioux, C" uniqKey="Rioux C" first="C." last="Rioux">C. Rioux</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2217 0017</institution-id><institution-id institution-id-type="GRID">grid.7452.4</institution-id><institution>APHP, Hôpital Bichat Claude Bernard,</institution><institution>Service des Maladies Infectieuses et Tropicales, Paris Diderot University,</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation></author><author><name sortKey="Caumes, E" sort="Caumes, E" uniqKey="Caumes E" first="E." last="Caumes">E. Caumes</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.50550.35</institution-id><institution-id institution-id-type="ISNI">0000 0001 2175 4109</institution-id><institution>APHP, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix,</institution><institution>Service des Maladies Infectieuses et Tropicales,</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation></author><author><name sortKey="Yazdanapanah, Y" sort="Yazdanapanah, Y" uniqKey="Yazdanapanah Y" first="Y." last="Yazdanapanah">Y. Yazdanapanah</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2217 0017</institution-id><institution-id institution-id-type="GRID">grid.7452.4</institution-id><institution>APHP, Hôpital Bichat Claude Bernard,</institution><institution>Service des Maladies Infectieuses et Tropicales, Paris Diderot University,</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000000121866389</institution-id><institution-id institution-id-type="GRID">grid.7429.8</institution-id><institution>INSERM, IAME, UMR 1137,</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2217 0017</institution-id><institution-id institution-id-type="GRID">grid.7452.4</institution-id><institution>Univ Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité,</institution></institution-wrap>Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation></author></analytic><series><title level="j">BMC Infectious Diseases</title><idno type="eISSN">1471-2334</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Anti-Bacterial Agents (therapeutic use)</term><term>Antiviral Agents (therapeutic use)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (therapy)</term><term>Coronavirus Infections (virology)</term><term>Female</term><term>Hospitalization</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term><term>Oseltamivir (therapeutic use)</term><term>Oxygen Inhalation Therapy</term><term>Paris</term><term>Patient Isolation</term><term>Retrospective Studies</term><term>Saudi Arabia</term><term>Streptococcus pneumoniae</term><term>Travel</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Antibactériens (usage thérapeutique)</term><term>Antiviraux (usage thérapeutique)</term><term>Arabie saoudite</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term><term>Femelle</term><term>Hospitalisation</term><term>Humains</term><term>Infections à coronavirus ()</term><term>Infections à coronavirus (diagnostic)</term><term>Infections à coronavirus (virologie)</term><term>Isolement du patient</term><term>Mâle</term><term>Oséltamivir (usage thérapeutique)</term><term>Oxygénothérapie</term><term>Paris</term><term>Résultat thérapeutique</term><term>Streptococcus pneumoniae</term><term>Sujet âgé</term><term>Voyage</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Antiviral Agents</term><term>Oseltamivir</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Paris</term><term>Saudi Arabia</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antibactériens</term><term>Antiviraux</term><term>Oséltamivir</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Hospitalization</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Oxygen Inhalation Therapy</term><term>Patient Isolation</term><term>Retrospective Studies</term><term>Streptococcus pneumoniae</term><term>Travel</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Arabie saoudite</term><term>Femelle</term><term>Hospitalisation</term><term>Humains</term><term>Infections à coronavirus</term><term>Isolement du patient</term><term>Mâle</term><term>Oxygénothérapie</term><term>Paris</term><term>Résultat thérapeutique</term><term>Streptococcus pneumoniae</term><term>Sujet âgé</term><term>Voyage</term><term>Études rétrospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Arabie saoudite</term></keywords><keywords scheme="mix" xml:lang="en"><term> Legionella</term><term> Middle East respiratory syndrome coronavirus (MERS-CoV)</term><term> Pilgrims</term><term> Respiratory tract infection</term><term> Saudi Arabia</term><term>Isolation ward</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">Patients with suspected Middle East respiratory syndrome coronavirus (MERS-CoV) infection should be hospitalized in isolation wards to avoid transmission. This suspicion can also lead to medical confusion and inappropriate management of acute respiratory syndrome due to causes other than MERS-CoV.</p></sec><sec><title>Methods</title><p id="Par2">We studied the characteristics and outcome of patients hospitalized for suspected MERS-CoV infection in the isolation wards of two referral infectious disease departments in the Paris area between January 2013 and December 2016.</p></sec><sec><title>Results</title><p id="Par3">Of 93 adult patients (49 male (52.6%), median age 63.4 years) hospitalized, 82 out of 93 adult patients had returned from Saudi Arabia, and 74 of them were pilgrims (Hajj). Chest X-ray findings were abnormal in 72 (77%) patients. The 93 patients were negative for MERS-CoV RT-PCR, and 70 (75.2%) patients had documented infection, 47 (50.5%) viral, 22 (23.6%) bacterial and one <italic>Plasmodium falciparum</italic> malaria. Microbiological analysis identified <italic>Rhinovirus</italic> (27.9%), <italic>Influenza</italic> virus (26.8%), <italic>Legionella pneumophila</italic> (7.5%), <italic>Streptococcus pneumoniae</italic> (7.5%), and non-MERS-coronavirus (6.4%). Antibiotics were initiated in 81 (87%) cases, with two antibiotics in 63 patients (67.7%). The median duration of hospitalization and isolation was 3 days (1–33) and 24 h (8–92), respectively. Time of isolation decreased over time (<italic>P</italic> < 0.01). Two patients (2%) died.</p></sec><sec><title>Conclusion</title><p id="Par4">The management of patients with possible MERS-CoV infection requires medical facilities with trained personnel, and rapid access to virological results. 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Yazdanapanah</name><name sortKey="Yazdanapanah, Y" sort="Yazdanapanah, Y" uniqKey="Yazdanapanah Y" first="Y." last="Yazdanapanah">Y. Yazdanapanah</name><name sortKey="Yazdanapanah, Y" sort="Yazdanapanah, Y" uniqKey="Yazdanapanah Y" first="Y." last="Yazdanapanah">Y. Yazdanapanah</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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