Development of Bioinformatics Infrastructure for Genomics Research.
Identifieur interne : 000440 ( PubMed/Corpus ); précédent : 000439; suivant : 000441Development of Bioinformatics Infrastructure for Genomics Research.
Auteurs : Nicola J. Mulder ; Ezekiel Adebiyi ; Marion Adebiyi ; Seun Adeyemi ; Azza Ahmed ; Rehab Ahmed ; Bola Akanle ; Mohamed Alibi ; Don L. Armstrong ; Shaun Aron ; Efejiro Ashano ; Shakuntala Baichoo ; Alia Benkahla ; David K. Brown ; Emile R. Chimusa ; Faisal M. Fadlelmola ; Dare Falola ; Segun Fatumo ; Kais Ghedira ; Amel Ghouila ; Scott Hazelhurst ; Itunuoluwa Isewon ; Segun Jung ; Samar Kamal Kassim ; Jonathan K. Kayondo ; Mamana Mbiyavanga ; Ayton Meintjes ; Somia Mohammed ; Abayomi Mosaku ; Ahmed Moussa ; Mustafa Muhammd ; Zahra Mungloo-Dilmohamud ; Oyekanmi Nashiru ; Trust Odia ; Adaobi Okafor ; Olaleye Oladipo ; Victor Osamor ; Jellili Oyelade ; Khalid Sadki ; Samson Pandam Salifu ; Jumoke Soyemi ; Sumir Panji ; Fouzia Radouani ; Oussama Souiai ; Özlem Tastan BishopSource :
- Global heart [ 2211-8179 ] ; 2017.
English descriptors
- KwdEn :
- MESH :
- methods : Biomedical Research, Genomics.
- trends : Computational Biology.
- Africa, Humans.
Abstract
BACKGROUND
Although pockets of bioinformatics excellence have developed in Africa, generally, large-scale genomic data analysis has been limited by the availability of expertise and infrastructure. H3ABioNet, a pan-African bioinformatics network, was established to build capacity specifically to enable H3Africa (Human Heredity and Health in Africa) researchers to analyze their data in Africa. Since the inception of the H3Africa initiative, H3ABioNet's role has evolved in response to changing needs from the consortium and the African bioinformatics community.
OBJECTIVES
H3ABioNet set out to develop core bioinformatics infrastructure and capacity for genomics research in various aspects of data collection, transfer, storage, and analysis.
METHODS AND RESULTS
Various resources have been developed to address genomic data management and analysis needs of H3Africa researchers and other scientific communities on the continent. NetMap was developed and used to build an accurate picture of network performance within Africa and between Africa and the rest of the world, and Globus Online has been rolled out to facilitate data transfer. A participant recruitment database was developed to monitor participant enrollment, and data is being harmonized through the use of ontologies and controlled vocabularies. The standardized metadata will be integrated to provide a search facility for H3Africa data and biospecimens. Because H3Africa projects are generating large-scale genomic data, facilities for analysis and interpretation are critical. H3ABioNet is implementing several data analysis platforms that provide a large range of bioinformatics tools or workflows, such as Galaxy, the Job Management System, and eBiokits. A set of reproducible, portable, and cloud-scalable pipelines to support the multiple H3Africa data types are also being developed and dockerized to enable execution on multiple computing infrastructures. In addition, new tools have been developed for analysis of the uniquely divergent African data and for downstream interpretation of prioritized variants. To provide support for these and other bioinformatics queries, an online bioinformatics helpdesk backed by broad consortium expertise has been established. Further support is provided by means of various modes of bioinformatics training.
CONCLUSIONS
For the past 4 years, the development of infrastructure support and human capacity through H3ABioNet, have significantly contributed to the establishment of African scientific networks, data analysis facilities, and training programs. Here, we describe the infrastructure and how it has affected genomics and bioinformatics research in Africa.
DOI: 10.1016/j.gheart.2017.01.005
PubMed: 28302555
PubMed Central: PMC5582980
Links to Exploration step
pubmed:28302555Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Development of Bioinformatics Infrastructure for Genomics Research.</title><author><name sortKey="Mulder, Nicola J" sort="Mulder, Nicola J" uniqKey="Mulder N" first="Nicola J" last="Mulder">Nicola J. Mulder</name><affiliation><nlm:affiliation>Computational Biology Division, Department of Integrative Biomedical Sciences, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa. Electronic address: Nicola.mulder@uct.ac.za.</nlm:affiliation></affiliation></author><author><name sortKey="Adebiyi, Ezekiel" sort="Adebiyi, Ezekiel" uniqKey="Adebiyi E" first="Ezekiel" last="Adebiyi">Ezekiel Adebiyi</name><affiliation><nlm:affiliation>Department of Computer and Information Sciences, Covenant University, Ota, Nigeria; Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Adebiyi, Marion" sort="Adebiyi, Marion" uniqKey="Adebiyi M" first="Marion" last="Adebiyi">Marion Adebiyi</name><affiliation><nlm:affiliation>Department of Computer and Information Sciences, Covenant University, Ota, Nigeria; Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Adeyemi, Seun" sort="Adeyemi, Seun" uniqKey="Adeyemi S" first="Seun" last="Adeyemi">Seun Adeyemi</name><affiliation><nlm:affiliation>Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria; Center for System and Information Service, Covenant University, Ota, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Ahmed, Azza" sort="Ahmed, Azza" uniqKey="Ahmed A" first="Azza" last="Ahmed">Azza Ahmed</name><affiliation><nlm:affiliation>Centre for Bioinformatics and Systems Biology, Faculty of Science, University of Khartoum, Khartoum, Sudan.</nlm:affiliation></affiliation></author><author><name sortKey="Ahmed, Rehab" sort="Ahmed, Rehab" uniqKey="Ahmed R" first="Rehab" last="Ahmed">Rehab Ahmed</name><affiliation><nlm:affiliation>Centre for Bioinformatics and Systems Biology, Faculty of Science, University of Khartoum, Khartoum, Sudan.</nlm:affiliation></affiliation></author><author><name sortKey="Akanle, Bola" sort="Akanle, Bola" uniqKey="Akanle B" first="Bola" last="Akanle">Bola Akanle</name><affiliation><nlm:affiliation>Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria; Center for System and Information Service, Covenant University, Ota, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Alibi, Mohamed" sort="Alibi, Mohamed" uniqKey="Alibi M" first="Mohamed" last="Alibi">Mohamed Alibi</name><affiliation><nlm:affiliation>Laboratory of Bioinformatics, Biomathematics and Biostatistics (BIMS), Institut Pasteur de Tunis, Tunis, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Armstrong, Don L" sort="Armstrong, Don L" uniqKey="Armstrong D" first="Don L" last="Armstrong">Don L. Armstrong</name><affiliation><nlm:affiliation>Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Champaign, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Aron, Shaun" sort="Aron, Shaun" uniqKey="Aron S" first="Shaun" last="Aron">Shaun Aron</name><affiliation><nlm:affiliation>Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Ashano, Efejiro" sort="Ashano, Efejiro" uniqKey="Ashano E" first="Efejiro" last="Ashano">Efejiro Ashano</name><affiliation><nlm:affiliation>Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria; H3Africa Bioinformatics Network (H3ABioNet) Node, National Biotechnology Development Agency (NABDA), Federal Ministry of Science and Technology (FMST), Abuja, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Baichoo, Shakuntala" sort="Baichoo, Shakuntala" uniqKey="Baichoo S" first="Shakuntala" last="Baichoo">Shakuntala Baichoo</name><affiliation><nlm:affiliation>University of Mauritius, Moka, Mauritius.</nlm:affiliation></affiliation></author><author><name sortKey="Benkahla, Alia" sort="Benkahla, Alia" uniqKey="Benkahla A" first="Alia" last="Benkahla">Alia Benkahla</name><affiliation><nlm:affiliation>Laboratory of Bioinformatics, Biomathematics and Biostatistics (BIMS), Institut Pasteur de Tunis, Tunis, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Brown, David K" sort="Brown, David K" uniqKey="Brown D" first="David K" last="Brown">David K. Brown</name><affiliation><nlm:affiliation>Research Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Chimusa, Emile R" sort="Chimusa, Emile R" uniqKey="Chimusa E" first="Emile R" last="Chimusa">Emile R. Chimusa</name><affiliation><nlm:affiliation>Computational Biology Division, Department of Integrative Biomedical Sciences, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Fadlelmola, Faisal M" sort="Fadlelmola, Faisal M" uniqKey="Fadlelmola F" first="Faisal M" last="Fadlelmola">Faisal M. Fadlelmola</name><affiliation><nlm:affiliation>Centre for Bioinformatics and Systems Biology, Faculty of Science, University of Khartoum, Khartoum, Sudan; Future University of Sudan, Khartoum, Sudan.</nlm:affiliation></affiliation></author><author><name sortKey="Falola, Dare" sort="Falola, Dare" uniqKey="Falola D" first="Dare" last="Falola">Dare Falola</name><affiliation><nlm:affiliation>Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Fatumo, Segun" sort="Fatumo, Segun" uniqKey="Fatumo S" first="Segun" last="Fatumo">Segun Fatumo</name><affiliation><nlm:affiliation>H3Africa Bioinformatics Network (H3ABioNet) Node, National Biotechnology Development Agency (NABDA), Federal Ministry of Science and Technology (FMST), Abuja, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Ghedira, Kais" sort="Ghedira, Kais" uniqKey="Ghedira K" first="Kais" last="Ghedira">Kais Ghedira</name><affiliation><nlm:affiliation>Laboratory of Bioinformatics, Biomathematics and Biostatistics (BIMS), Institut Pasteur de Tunis, Tunis, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Ghouila, Amel" sort="Ghouila, Amel" uniqKey="Ghouila A" first="Amel" last="Ghouila">Amel Ghouila</name><affiliation><nlm:affiliation>Institut Pasteur de Tunis, LR11IPT02, Laboratory of Transmission, Control and Immunobiology of Infections (LTCII), Tunis-Belvédère, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Hazelhurst, Scott" sort="Hazelhurst, Scott" uniqKey="Hazelhurst S" first="Scott" last="Hazelhurst">Scott Hazelhurst</name><affiliation><nlm:affiliation>Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Isewon, Itunuoluwa" sort="Isewon, Itunuoluwa" uniqKey="Isewon I" first="Itunuoluwa" last="Isewon">Itunuoluwa Isewon</name><affiliation><nlm:affiliation>Department of Computer and Information Sciences, Covenant University, Ota, Nigeria; Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Jung, Segun" sort="Jung, Segun" uniqKey="Jung S" first="Segun" last="Jung">Segun Jung</name><affiliation><nlm:affiliation>Computation Institute, University of Chicago and Argonne National Laboratory, Chicago, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kassim, Samar Kamal" sort="Kassim, Samar Kamal" uniqKey="Kassim S" first="Samar Kamal" last="Kassim">Samar Kamal Kassim</name><affiliation><nlm:affiliation>Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Abbaseya, Cairo, Egypt.</nlm:affiliation></affiliation></author><author><name sortKey="Kayondo, Jonathan K" sort="Kayondo, Jonathan K" uniqKey="Kayondo J" first="Jonathan K" last="Kayondo">Jonathan K. Kayondo</name><affiliation><nlm:affiliation>Uganda Virus Research Institute (UVRI), Entebbe, Uganda.</nlm:affiliation></affiliation></author><author><name sortKey="Mbiyavanga, Mamana" sort="Mbiyavanga, Mamana" uniqKey="Mbiyavanga M" first="Mamana" last="Mbiyavanga">Mamana Mbiyavanga</name><affiliation><nlm:affiliation>Computational Biology Division, Department of Integrative Biomedical Sciences, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Meintjes, Ayton" sort="Meintjes, Ayton" uniqKey="Meintjes A" first="Ayton" last="Meintjes">Ayton Meintjes</name><affiliation><nlm:affiliation>Computational Biology Division, Department of Integrative Biomedical Sciences, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Mohammed, Somia" sort="Mohammed, Somia" uniqKey="Mohammed S" first="Somia" last="Mohammed">Somia Mohammed</name><affiliation><nlm:affiliation>Centre for Bioinformatics and Systems Biology, Faculty of Science, University of Khartoum, Khartoum, Sudan.</nlm:affiliation></affiliation></author><author><name sortKey="Mosaku, Abayomi" sort="Mosaku, Abayomi" uniqKey="Mosaku A" first="Abayomi" last="Mosaku">Abayomi Mosaku</name><affiliation><nlm:affiliation>Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Moussa, Ahmed" sort="Moussa, Ahmed" uniqKey="Moussa A" first="Ahmed" last="Moussa">Ahmed Moussa</name><affiliation><nlm:affiliation>LAbTIC Laboratory, ENSA, Abdelmalek Essaadi University, Tangier, Morocco.</nlm:affiliation></affiliation></author><author><name sortKey="Muhammd, Mustafa" sort="Muhammd, Mustafa" uniqKey="Muhammd M" first="Mustafa" last="Muhammd">Mustafa Muhammd</name><affiliation><nlm:affiliation>Centre for Bioinformatics and Systems Biology, Faculty of Science, University of Khartoum, Khartoum, Sudan.</nlm:affiliation></affiliation></author><author><name sortKey="Mungloo Dilmohamud, Zahra" sort="Mungloo Dilmohamud, Zahra" uniqKey="Mungloo Dilmohamud Z" first="Zahra" last="Mungloo-Dilmohamud">Zahra Mungloo-Dilmohamud</name><affiliation><nlm:affiliation>University of Mauritius, Moka, Mauritius.</nlm:affiliation></affiliation></author><author><name sortKey="Nashiru, Oyekanmi" sort="Nashiru, Oyekanmi" uniqKey="Nashiru O" first="Oyekanmi" last="Nashiru">Oyekanmi Nashiru</name><affiliation><nlm:affiliation>H3Africa Bioinformatics Network (H3ABioNet) Node, National Biotechnology Development Agency (NABDA), Federal Ministry of Science and Technology (FMST), Abuja, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Odia, Trust" sort="Odia, Trust" uniqKey="Odia T" first="Trust" last="Odia">Trust Odia</name><affiliation><nlm:affiliation>Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Okafor, Adaobi" sort="Okafor, Adaobi" uniqKey="Okafor A" first="Adaobi" last="Okafor">Adaobi Okafor</name><affiliation><nlm:affiliation>Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Oladipo, Olaleye" sort="Oladipo, Olaleye" uniqKey="Oladipo O" first="Olaleye" last="Oladipo">Olaleye Oladipo</name><affiliation><nlm:affiliation>Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria; Center for System and Information Service, Landmark University, Omu-Aran, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Osamor, Victor" sort="Osamor, Victor" uniqKey="Osamor V" first="Victor" last="Osamor">Victor Osamor</name><affiliation><nlm:affiliation>Department of Computer and Information Sciences, Covenant University, Ota, Nigeria; Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Oyelade, Jellili" sort="Oyelade, Jellili" uniqKey="Oyelade J" first="Jellili" last="Oyelade">Jellili Oyelade</name><affiliation><nlm:affiliation>Department of Computer and Information Sciences, Covenant University, Ota, Nigeria; Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Sadki, Khalid" sort="Sadki, Khalid" uniqKey="Sadki K" first="Khalid" last="Sadki">Khalid Sadki</name><affiliation><nlm:affiliation>School of Sciences, Mohammed V University of Rabat, Rabat, Morocco.</nlm:affiliation></affiliation></author><author><name sortKey="Salifu, Samson Pandam" sort="Salifu, Samson Pandam" uniqKey="Salifu S" first="Samson Pandam" last="Salifu">Samson Pandam Salifu</name><affiliation><nlm:affiliation>Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Kumasi Centre for Collaborative Research, South End Asougya Road, KNUST Campus, Kumasi, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Soyemi, Jumoke" sort="Soyemi, Jumoke" uniqKey="Soyemi J" first="Jumoke" last="Soyemi">Jumoke Soyemi</name><affiliation><nlm:affiliation>Department of Computer Science, Ilaro Polytechnic, Ilaro, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Panji, Sumir" sort="Panji, Sumir" uniqKey="Panji S" first="Sumir" last="Panji">Sumir Panji</name><affiliation><nlm:affiliation>Computational Biology Division, Department of Integrative Biomedical Sciences, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Radouani, Fouzia" sort="Radouani, Fouzia" uniqKey="Radouani F" first="Fouzia" last="Radouani">Fouzia Radouani</name><affiliation><nlm:affiliation>Chlamydiae and Mycoplasma Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco.</nlm:affiliation></affiliation></author><author><name sortKey="Souiai, Oussama" sort="Souiai, Oussama" uniqKey="Souiai O" first="Oussama" last="Souiai">Oussama Souiai</name><affiliation><nlm:affiliation>Laboratory of Bioinformatics, Biomathematics and Biostatistics (BIMS), Institut Pasteur de Tunis, Tunis, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Tastan Bishop, Ozlem" sort="Tastan Bishop, Ozlem" uniqKey="Tastan Bishop O" first="Özlem" last="Tastan Bishop">Özlem Tastan Bishop</name><affiliation><nlm:affiliation>Research Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, South Africa.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28302555</idno><idno type="pmid">28302555</idno><idno type="doi">10.1016/j.gheart.2017.01.005</idno><idno type="pmc">PMC5582980</idno><idno type="wicri:Area/PubMed/Corpus">000440</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000440</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Development of Bioinformatics Infrastructure for Genomics Research.</title><author><name sortKey="Mulder, Nicola J" sort="Mulder, Nicola J" uniqKey="Mulder N" first="Nicola J" last="Mulder">Nicola J. Mulder</name><affiliation><nlm:affiliation>Computational Biology Division, Department of Integrative Biomedical Sciences, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa. Electronic address: Nicola.mulder@uct.ac.za.</nlm:affiliation></affiliation></author><author><name sortKey="Adebiyi, Ezekiel" sort="Adebiyi, Ezekiel" uniqKey="Adebiyi E" first="Ezekiel" last="Adebiyi">Ezekiel Adebiyi</name><affiliation><nlm:affiliation>Department of Computer and Information Sciences, Covenant University, Ota, Nigeria; Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Adebiyi, Marion" sort="Adebiyi, Marion" uniqKey="Adebiyi M" first="Marion" last="Adebiyi">Marion Adebiyi</name><affiliation><nlm:affiliation>Department of Computer and Information Sciences, Covenant University, Ota, Nigeria; Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Adeyemi, Seun" sort="Adeyemi, Seun" uniqKey="Adeyemi S" first="Seun" last="Adeyemi">Seun Adeyemi</name><affiliation><nlm:affiliation>Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria; Center for System and Information Service, Covenant University, Ota, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Ahmed, Azza" sort="Ahmed, Azza" uniqKey="Ahmed A" first="Azza" last="Ahmed">Azza Ahmed</name><affiliation><nlm:affiliation>Centre for Bioinformatics and Systems Biology, Faculty of Science, University of Khartoum, Khartoum, Sudan.</nlm:affiliation></affiliation></author><author><name sortKey="Ahmed, Rehab" sort="Ahmed, Rehab" uniqKey="Ahmed R" first="Rehab" last="Ahmed">Rehab Ahmed</name><affiliation><nlm:affiliation>Centre for Bioinformatics and Systems Biology, Faculty of Science, University of Khartoum, Khartoum, Sudan.</nlm:affiliation></affiliation></author><author><name sortKey="Akanle, Bola" sort="Akanle, Bola" uniqKey="Akanle B" first="Bola" last="Akanle">Bola Akanle</name><affiliation><nlm:affiliation>Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria; Center for System and Information Service, Covenant University, Ota, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Alibi, Mohamed" sort="Alibi, Mohamed" uniqKey="Alibi M" first="Mohamed" last="Alibi">Mohamed Alibi</name><affiliation><nlm:affiliation>Laboratory of Bioinformatics, Biomathematics and Biostatistics (BIMS), Institut Pasteur de Tunis, Tunis, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Armstrong, Don L" sort="Armstrong, Don L" uniqKey="Armstrong D" first="Don L" last="Armstrong">Don L. Armstrong</name><affiliation><nlm:affiliation>Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Champaign, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Aron, Shaun" sort="Aron, Shaun" uniqKey="Aron S" first="Shaun" last="Aron">Shaun Aron</name><affiliation><nlm:affiliation>Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Ashano, Efejiro" sort="Ashano, Efejiro" uniqKey="Ashano E" first="Efejiro" last="Ashano">Efejiro Ashano</name><affiliation><nlm:affiliation>Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria; H3Africa Bioinformatics Network (H3ABioNet) Node, National Biotechnology Development Agency (NABDA), Federal Ministry of Science and Technology (FMST), Abuja, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Baichoo, Shakuntala" sort="Baichoo, Shakuntala" uniqKey="Baichoo S" first="Shakuntala" last="Baichoo">Shakuntala Baichoo</name><affiliation><nlm:affiliation>University of Mauritius, Moka, Mauritius.</nlm:affiliation></affiliation></author><author><name sortKey="Benkahla, Alia" sort="Benkahla, Alia" uniqKey="Benkahla A" first="Alia" last="Benkahla">Alia Benkahla</name><affiliation><nlm:affiliation>Laboratory of Bioinformatics, Biomathematics and Biostatistics (BIMS), Institut Pasteur de Tunis, Tunis, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Brown, David K" sort="Brown, David K" uniqKey="Brown D" first="David K" last="Brown">David K. Brown</name><affiliation><nlm:affiliation>Research Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Chimusa, Emile R" sort="Chimusa, Emile R" uniqKey="Chimusa E" first="Emile R" last="Chimusa">Emile R. Chimusa</name><affiliation><nlm:affiliation>Computational Biology Division, Department of Integrative Biomedical Sciences, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Fadlelmola, Faisal M" sort="Fadlelmola, Faisal M" uniqKey="Fadlelmola F" first="Faisal M" last="Fadlelmola">Faisal M. Fadlelmola</name><affiliation><nlm:affiliation>Centre for Bioinformatics and Systems Biology, Faculty of Science, University of Khartoum, Khartoum, Sudan; Future University of Sudan, Khartoum, Sudan.</nlm:affiliation></affiliation></author><author><name sortKey="Falola, Dare" sort="Falola, Dare" uniqKey="Falola D" first="Dare" last="Falola">Dare Falola</name><affiliation><nlm:affiliation>Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Fatumo, Segun" sort="Fatumo, Segun" uniqKey="Fatumo S" first="Segun" last="Fatumo">Segun Fatumo</name><affiliation><nlm:affiliation>H3Africa Bioinformatics Network (H3ABioNet) Node, National Biotechnology Development Agency (NABDA), Federal Ministry of Science and Technology (FMST), Abuja, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Ghedira, Kais" sort="Ghedira, Kais" uniqKey="Ghedira K" first="Kais" last="Ghedira">Kais Ghedira</name><affiliation><nlm:affiliation>Laboratory of Bioinformatics, Biomathematics and Biostatistics (BIMS), Institut Pasteur de Tunis, Tunis, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Ghouila, Amel" sort="Ghouila, Amel" uniqKey="Ghouila A" first="Amel" last="Ghouila">Amel Ghouila</name><affiliation><nlm:affiliation>Institut Pasteur de Tunis, LR11IPT02, Laboratory of Transmission, Control and Immunobiology of Infections (LTCII), Tunis-Belvédère, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Hazelhurst, Scott" sort="Hazelhurst, Scott" uniqKey="Hazelhurst S" first="Scott" last="Hazelhurst">Scott Hazelhurst</name><affiliation><nlm:affiliation>Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Isewon, Itunuoluwa" sort="Isewon, Itunuoluwa" uniqKey="Isewon I" first="Itunuoluwa" last="Isewon">Itunuoluwa Isewon</name><affiliation><nlm:affiliation>Department of Computer and Information Sciences, Covenant University, Ota, Nigeria; Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Jung, Segun" sort="Jung, Segun" uniqKey="Jung S" first="Segun" last="Jung">Segun Jung</name><affiliation><nlm:affiliation>Computation Institute, University of Chicago and Argonne National Laboratory, Chicago, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kassim, Samar Kamal" sort="Kassim, Samar Kamal" uniqKey="Kassim S" first="Samar Kamal" last="Kassim">Samar Kamal Kassim</name><affiliation><nlm:affiliation>Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Abbaseya, Cairo, Egypt.</nlm:affiliation></affiliation></author><author><name sortKey="Kayondo, Jonathan K" sort="Kayondo, Jonathan K" uniqKey="Kayondo J" first="Jonathan K" last="Kayondo">Jonathan K. Kayondo</name><affiliation><nlm:affiliation>Uganda Virus Research Institute (UVRI), Entebbe, Uganda.</nlm:affiliation></affiliation></author><author><name sortKey="Mbiyavanga, Mamana" sort="Mbiyavanga, Mamana" uniqKey="Mbiyavanga M" first="Mamana" last="Mbiyavanga">Mamana Mbiyavanga</name><affiliation><nlm:affiliation>Computational Biology Division, Department of Integrative Biomedical Sciences, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Meintjes, Ayton" sort="Meintjes, Ayton" uniqKey="Meintjes A" first="Ayton" last="Meintjes">Ayton Meintjes</name><affiliation><nlm:affiliation>Computational Biology Division, Department of Integrative Biomedical Sciences, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Mohammed, Somia" sort="Mohammed, Somia" uniqKey="Mohammed S" first="Somia" last="Mohammed">Somia Mohammed</name><affiliation><nlm:affiliation>Centre for Bioinformatics and Systems Biology, Faculty of Science, University of Khartoum, Khartoum, Sudan.</nlm:affiliation></affiliation></author><author><name sortKey="Mosaku, Abayomi" sort="Mosaku, Abayomi" uniqKey="Mosaku A" first="Abayomi" last="Mosaku">Abayomi Mosaku</name><affiliation><nlm:affiliation>Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Moussa, Ahmed" sort="Moussa, Ahmed" uniqKey="Moussa A" first="Ahmed" last="Moussa">Ahmed Moussa</name><affiliation><nlm:affiliation>LAbTIC Laboratory, ENSA, Abdelmalek Essaadi University, Tangier, Morocco.</nlm:affiliation></affiliation></author><author><name sortKey="Muhammd, Mustafa" sort="Muhammd, Mustafa" uniqKey="Muhammd M" first="Mustafa" last="Muhammd">Mustafa Muhammd</name><affiliation><nlm:affiliation>Centre for Bioinformatics and Systems Biology, Faculty of Science, University of Khartoum, Khartoum, Sudan.</nlm:affiliation></affiliation></author><author><name sortKey="Mungloo Dilmohamud, Zahra" sort="Mungloo Dilmohamud, Zahra" uniqKey="Mungloo Dilmohamud Z" first="Zahra" last="Mungloo-Dilmohamud">Zahra Mungloo-Dilmohamud</name><affiliation><nlm:affiliation>University of Mauritius, Moka, Mauritius.</nlm:affiliation></affiliation></author><author><name sortKey="Nashiru, Oyekanmi" sort="Nashiru, Oyekanmi" uniqKey="Nashiru O" first="Oyekanmi" last="Nashiru">Oyekanmi Nashiru</name><affiliation><nlm:affiliation>H3Africa Bioinformatics Network (H3ABioNet) Node, National Biotechnology Development Agency (NABDA), Federal Ministry of Science and Technology (FMST), Abuja, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Odia, Trust" sort="Odia, Trust" uniqKey="Odia T" first="Trust" last="Odia">Trust Odia</name><affiliation><nlm:affiliation>Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Okafor, Adaobi" sort="Okafor, Adaobi" uniqKey="Okafor A" first="Adaobi" last="Okafor">Adaobi Okafor</name><affiliation><nlm:affiliation>Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Oladipo, Olaleye" sort="Oladipo, Olaleye" uniqKey="Oladipo O" first="Olaleye" last="Oladipo">Olaleye Oladipo</name><affiliation><nlm:affiliation>Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria; Center for System and Information Service, Landmark University, Omu-Aran, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Osamor, Victor" sort="Osamor, Victor" uniqKey="Osamor V" first="Victor" last="Osamor">Victor Osamor</name><affiliation><nlm:affiliation>Department of Computer and Information Sciences, Covenant University, Ota, Nigeria; Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Oyelade, Jellili" sort="Oyelade, Jellili" uniqKey="Oyelade J" first="Jellili" last="Oyelade">Jellili Oyelade</name><affiliation><nlm:affiliation>Department of Computer and Information Sciences, Covenant University, Ota, Nigeria; Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Sadki, Khalid" sort="Sadki, Khalid" uniqKey="Sadki K" first="Khalid" last="Sadki">Khalid Sadki</name><affiliation><nlm:affiliation>School of Sciences, Mohammed V University of Rabat, Rabat, Morocco.</nlm:affiliation></affiliation></author><author><name sortKey="Salifu, Samson Pandam" sort="Salifu, Samson Pandam" uniqKey="Salifu S" first="Samson Pandam" last="Salifu">Samson Pandam Salifu</name><affiliation><nlm:affiliation>Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Kumasi Centre for Collaborative Research, South End Asougya Road, KNUST Campus, Kumasi, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Soyemi, Jumoke" sort="Soyemi, Jumoke" uniqKey="Soyemi J" first="Jumoke" last="Soyemi">Jumoke Soyemi</name><affiliation><nlm:affiliation>Department of Computer Science, Ilaro Polytechnic, Ilaro, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Panji, Sumir" sort="Panji, Sumir" uniqKey="Panji S" first="Sumir" last="Panji">Sumir Panji</name><affiliation><nlm:affiliation>Computational Biology Division, Department of Integrative Biomedical Sciences, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Radouani, Fouzia" sort="Radouani, Fouzia" uniqKey="Radouani F" first="Fouzia" last="Radouani">Fouzia Radouani</name><affiliation><nlm:affiliation>Chlamydiae and Mycoplasma Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco.</nlm:affiliation></affiliation></author><author><name sortKey="Souiai, Oussama" sort="Souiai, Oussama" uniqKey="Souiai O" first="Oussama" last="Souiai">Oussama Souiai</name><affiliation><nlm:affiliation>Laboratory of Bioinformatics, Biomathematics and Biostatistics (BIMS), Institut Pasteur de Tunis, Tunis, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Tastan Bishop, Ozlem" sort="Tastan Bishop, Ozlem" uniqKey="Tastan Bishop O" first="Özlem" last="Tastan Bishop">Özlem Tastan Bishop</name><affiliation><nlm:affiliation>Research Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, South Africa.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Global heart</title><idno type="eISSN">2211-8179</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Africa (MeSH)</term><term>Biomedical Research (methods)</term><term>Computational Biology (trends)</term><term>Genomics (methods)</term><term>Humans (MeSH)</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Biomedical Research</term><term>Genomics</term></keywords><keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Computational Biology</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Africa</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Although pockets of bioinformatics excellence have developed in Africa, generally, large-scale genomic data analysis has been limited by the availability of expertise and infrastructure. H3ABioNet, a pan-African bioinformatics network, was established to build capacity specifically to enable H3Africa (Human Heredity and Health in Africa) researchers to analyze their data in Africa. Since the inception of the H3Africa initiative, H3ABioNet's role has evolved in response to changing needs from the consortium and the African bioinformatics community.</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b></p><p>H3ABioNet set out to develop core bioinformatics infrastructure and capacity for genomics research in various aspects of data collection, transfer, storage, and analysis.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS AND RESULTS</b></p><p>Various resources have been developed to address genomic data management and analysis needs of H3Africa researchers and other scientific communities on the continent. NetMap was developed and used to build an accurate picture of network performance within Africa and between Africa and the rest of the world, and Globus Online has been rolled out to facilitate data transfer. A participant recruitment database was developed to monitor participant enrollment, and data is being harmonized through the use of ontologies and controlled vocabularies. The standardized metadata will be integrated to provide a search facility for H3Africa data and biospecimens. Because H3Africa projects are generating large-scale genomic data, facilities for analysis and interpretation are critical. H3ABioNet is implementing several data analysis platforms that provide a large range of bioinformatics tools or workflows, such as Galaxy, the Job Management System, and eBiokits. A set of reproducible, portable, and cloud-scalable pipelines to support the multiple H3Africa data types are also being developed and dockerized to enable execution on multiple computing infrastructures. In addition, new tools have been developed for analysis of the uniquely divergent African data and for downstream interpretation of prioritized variants. To provide support for these and other bioinformatics queries, an online bioinformatics helpdesk backed by broad consortium expertise has been established. Further support is provided by means of various modes of bioinformatics training.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>For the past 4 years, the development of infrastructure support and human capacity through H3ABioNet, have significantly contributed to the establishment of African scientific networks, data analysis facilities, and training programs. Here, we describe the infrastructure and how it has affected genomics and bioinformatics research in Africa.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28302555</PMID><DateCompleted><Year>2018</Year><Month>06</Month><Day>11</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2211-8179</ISSN><JournalIssue CitedMedium="Internet"><Volume>12</Volume><Issue>2</Issue><PubDate><Year>2017</Year><Month>06</Month></PubDate></JournalIssue><Title>Global heart</Title><ISOAbbreviation>Glob Heart</ISOAbbreviation></Journal><ArticleTitle>Development of Bioinformatics Infrastructure for Genomics Research.</ArticleTitle><Pagination><MedlinePgn>91-98</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S2211-8160(17)30005-4</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.gheart.2017.01.005</ELocationID><Abstract><AbstractText Label="BACKGROUND">Although pockets of bioinformatics excellence have developed in Africa, generally, large-scale genomic data analysis has been limited by the availability of expertise and infrastructure. H3ABioNet, a pan-African bioinformatics network, was established to build capacity specifically to enable H3Africa (Human Heredity and Health in Africa) researchers to analyze their data in Africa. Since the inception of the H3Africa initiative, H3ABioNet's role has evolved in response to changing needs from the consortium and the African bioinformatics community.</AbstractText><AbstractText Label="OBJECTIVES">H3ABioNet set out to develop core bioinformatics infrastructure and capacity for genomics research in various aspects of data collection, transfer, storage, and analysis.</AbstractText><AbstractText Label="METHODS AND RESULTS">Various resources have been developed to address genomic data management and analysis needs of H3Africa researchers and other scientific communities on the continent. NetMap was developed and used to build an accurate picture of network performance within Africa and between Africa and the rest of the world, and Globus Online has been rolled out to facilitate data transfer. A participant recruitment database was developed to monitor participant enrollment, and data is being harmonized through the use of ontologies and controlled vocabularies. The standardized metadata will be integrated to provide a search facility for H3Africa data and biospecimens. Because H3Africa projects are generating large-scale genomic data, facilities for analysis and interpretation are critical. H3ABioNet is implementing several data analysis platforms that provide a large range of bioinformatics tools or workflows, such as Galaxy, the Job Management System, and eBiokits. A set of reproducible, portable, and cloud-scalable pipelines to support the multiple H3Africa data types are also being developed and dockerized to enable execution on multiple computing infrastructures. In addition, new tools have been developed for analysis of the uniquely divergent African data and for downstream interpretation of prioritized variants. To provide support for these and other bioinformatics queries, an online bioinformatics helpdesk backed by broad consortium expertise has been established. Further support is provided by means of various modes of bioinformatics training.</AbstractText><AbstractText Label="CONCLUSIONS">For the past 4 years, the development of infrastructure support and human capacity through H3ABioNet, have significantly contributed to the establishment of African scientific networks, data analysis facilities, and training programs. Here, we describe the infrastructure and how it has affected genomics and bioinformatics research in Africa.</AbstractText><CopyrightInformation>Copyright © 2017 World Heart Federation (Geneva). Published by Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mulder</LastName><ForeName>Nicola J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>Computational Biology Division, Department of Integrative Biomedical Sciences, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa. Electronic address: Nicola.mulder@uct.ac.za.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adebiyi</LastName><ForeName>Ezekiel</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Computer and Information Sciences, Covenant University, Ota, Nigeria; Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adebiyi</LastName><ForeName>Marion</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Computer and Information Sciences, Covenant University, Ota, Nigeria; Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adeyemi</LastName><ForeName>Seun</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria; Center for System and Information Service, Covenant University, Ota, Nigeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ahmed</LastName><ForeName>Azza</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Centre for Bioinformatics and Systems Biology, Faculty of Science, University of Khartoum, Khartoum, Sudan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ahmed</LastName><ForeName>Rehab</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Centre for Bioinformatics and Systems Biology, Faculty of Science, University of Khartoum, Khartoum, Sudan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Akanle</LastName><ForeName>Bola</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria; Center for System and Information Service, Covenant University, Ota, Nigeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alibi</LastName><ForeName>Mohamed</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratory of Bioinformatics, Biomathematics and Biostatistics (BIMS), Institut Pasteur de Tunis, Tunis, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Armstrong</LastName><ForeName>Don L</ForeName><Initials>DL</Initials><AffiliationInfo><Affiliation>Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Champaign, IL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aron</LastName><ForeName>Shaun</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ashano</LastName><ForeName>Efejiro</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria; H3Africa Bioinformatics Network (H3ABioNet) Node, National Biotechnology Development Agency (NABDA), Federal Ministry of Science and Technology (FMST), Abuja, Nigeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baichoo</LastName><ForeName>Shakuntala</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>University of Mauritius, Moka, Mauritius.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Benkahla</LastName><ForeName>Alia</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Laboratory of Bioinformatics, Biomathematics and Biostatistics (BIMS), Institut Pasteur de Tunis, Tunis, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brown</LastName><ForeName>David K</ForeName><Initials>DK</Initials><AffiliationInfo><Affiliation>Research Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chimusa</LastName><ForeName>Emile R</ForeName><Initials>ER</Initials><AffiliationInfo><Affiliation>Computational Biology Division, Department of Integrative Biomedical Sciences, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fadlelmola</LastName><ForeName>Faisal M</ForeName><Initials>FM</Initials><AffiliationInfo><Affiliation>Centre for Bioinformatics and Systems Biology, Faculty of Science, University of Khartoum, Khartoum, Sudan; Future University of Sudan, Khartoum, Sudan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Falola</LastName><ForeName>Dare</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fatumo</LastName><ForeName>Segun</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>H3Africa Bioinformatics Network (H3ABioNet) Node, National Biotechnology Development Agency (NABDA), Federal Ministry of Science and Technology (FMST), Abuja, Nigeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ghedira</LastName><ForeName>Kais</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Laboratory of Bioinformatics, Biomathematics and Biostatistics (BIMS), Institut Pasteur de Tunis, Tunis, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ghouila</LastName><ForeName>Amel</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institut Pasteur de Tunis, LR11IPT02, Laboratory of Transmission, Control and Immunobiology of Infections (LTCII), Tunis-Belvédère, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hazelhurst</LastName><ForeName>Scott</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Isewon</LastName><ForeName>Itunuoluwa</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Computer and Information Sciences, Covenant University, Ota, Nigeria; Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jung</LastName><ForeName>Segun</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Computation Institute, University of Chicago and Argonne National Laboratory, Chicago, IL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kassim</LastName><ForeName>Samar Kamal</ForeName><Initials>SK</Initials><AffiliationInfo><Affiliation>Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Abbaseya, Cairo, Egypt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kayondo</LastName><ForeName>Jonathan K</ForeName><Initials>JK</Initials><AffiliationInfo><Affiliation>Uganda Virus Research Institute (UVRI), Entebbe, Uganda.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mbiyavanga</LastName><ForeName>Mamana</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Computational Biology Division, Department of Integrative Biomedical Sciences, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meintjes</LastName><ForeName>Ayton</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Computational Biology Division, Department of Integrative Biomedical Sciences, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mohammed</LastName><ForeName>Somia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Centre for Bioinformatics and Systems Biology, Faculty of Science, University of Khartoum, Khartoum, Sudan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mosaku</LastName><ForeName>Abayomi</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Covenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Nigeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moussa</LastName><ForeName>Ahmed</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>LAbTIC Laboratory, ENSA, Abdelmalek Essaadi University, Tangier, Morocco.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muhammd</LastName><ForeName>Mustafa</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Centre for Bioinformatics and Systems Biology, Faculty of Science, University of Khartoum, Khartoum, Sudan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mungloo-Dilmohamud</LastName><ForeName>Zahra</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>University of Mauritius, Moka, Mauritius.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nashiru</LastName><ForeName>Oyekanmi</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>H3Africa Bioinformatics Network (H3ABioNet) Node, National Biotechnology Development Agency (NABDA), Federal Ministry of Science and Technology 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