Polymorphisms in XRCC1, ERCC2, and ERCC3 DNA repair genes, CYP1A1 xenobiotic metabolism gene, and tobacco are associated with bladder cancer susceptibility in Tunisian population.
Identifieur interne : 000409 ( PubMed/Corpus ); précédent : 000408; suivant : 000410Polymorphisms in XRCC1, ERCC2, and ERCC3 DNA repair genes, CYP1A1 xenobiotic metabolism gene, and tobacco are associated with bladder cancer susceptibility in Tunisian population.
Auteurs : Molka Feki-Tounsi ; Rim Khlifi ; Ibtihel Louati ; Mohamed Fourati ; Mohamed-Nabil Mhiri ; Amel Hamza-Chaffai ; Ahmed RebaiSource :
- Environmental science and pollution research international [ 1614-7499 ] ; 2017.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Arylamine N-Acetyltransferase (MeSH), Case-Control Studies (MeSH), Cytochrome P-450 CYP1A1 (genetics), DNA Helicases (genetics), DNA Repair (MeSH), DNA-Binding Proteins (genetics), Female (MeSH), Genetic Predisposition to Disease (MeSH), Genotype (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Polymorphism, Restriction Fragment Length (MeSH), Polymorphism, Single Nucleotide (MeSH), Smoking (MeSH), Tobacco (MeSH), Tunisia (MeSH), Urinary Bladder Neoplasms (genetics), X-ray Repair Cross Complementing Protein 1 (genetics), Xeroderma Pigmentosum Group D Protein (genetics), Young Adult (MeSH).
- MESH :
- chemical , genetics : Cytochrome P-450 CYP1A1, DNA Helicases, DNA-Binding Proteins, X-ray Repair Cross Complementing Protein 1, Xeroderma Pigmentosum Group D Protein.
- chemical : Arylamine N-Acetyltransferase.
- genetics : Urinary Bladder Neoplasms.
- Adult, Aged, Aged, 80 and over, Case-Control Studies, DNA Repair, Female, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Polymorphism, Restriction Fragment Length, Polymorphism, Single Nucleotide, Smoking, Tobacco, Tunisia, Young Adult.
Abstract
Other than the established environmental risk factors associated with bladder cancer (BC), little is known about the genetic variations determining the individual susceptibility of this complex disease. This study aimed to investigate the relationship of BC with environmental agents and polymorphisms in XRCC1, ERCC2, and ERCC3 DNA repair genes and CYP1A1, CYP2D6, NAT1, and NAT2 xenobiotic metabolism genes through a hospital-based case-control study in Tunisia. The selection of the single nucleotide polymorphisms (SNPs) (rs25487, rs 13181, rs415407, rs446421, rs1058172, rs4921880, and rs1208) was performed using the dbSNP database. DNA genotyping was determined by PCR-RFLP after DNA extraction from whole blood. The risks of BC associated with every polymorphism as well as the studied environmental factors were estimated by multivariate-adjusted logistic regression using R software. In addition, gene-gene interactions were analyzed using generalized multifactor dimensionality reduction (GMDR) methods. Results showed that tobacco smoking and chewing parameters were significantly associated with BC risk. Single-gene variant analysis showed significant associations of the TT genotype of CYP1A1 and the rare GG genotype of ERCC2 with bladder cancer susceptibility (OR = 1.34, 95% CI 1.22-1.40, P < 0.0001). According to GMDR analysis, our findings indicated a significant association between BC and gene-gene interaction among the CYP1A1, ERCC3, and XRCC1. The present results suggest a potential role of XRCC1, ERCC2, ERCC3, and CYP1A1 besides tobacco intake in susceptibility to BC.
DOI: 10.1007/s11356-017-9767-x
PubMed: 28803404
Links to Exploration step
pubmed:28803404Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Polymorphisms in XRCC1, ERCC2, and ERCC3 DNA repair genes, CYP1A1 xenobiotic metabolism gene, and tobacco are associated with bladder cancer susceptibility in Tunisian population.</title><author><name sortKey="Feki Tounsi, Molka" sort="Feki Tounsi, Molka" uniqKey="Feki Tounsi M" first="Molka" last="Feki-Tounsi">Molka Feki-Tounsi</name><affiliation><nlm:affiliation>Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, Po Box 1177, 3018, Sfax, Tunisia. molkafekitounsi@yahoo.fr.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Unit of Marine and Environmental Toxicology, UR 09-03, Sfax University, IPEIS, BP 1172, 3018, Sfax, Tunisia. molkafekitounsi@yahoo.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Khlifi, Rim" sort="Khlifi, Rim" uniqKey="Khlifi R" first="Rim" last="Khlifi">Rim Khlifi</name><affiliation><nlm:affiliation>Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, Po Box 1177, 3018, Sfax, Tunisia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Unit of Marine and Environmental Toxicology, UR 09-03, Sfax University, IPEIS, BP 1172, 3018, Sfax, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Louati, Ibtihel" sort="Louati, Ibtihel" uniqKey="Louati I" first="Ibtihel" last="Louati">Ibtihel Louati</name><affiliation><nlm:affiliation>Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, Po Box 1177, 3018, Sfax, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Fourati, Mohamed" sort="Fourati, Mohamed" uniqKey="Fourati M" first="Mohamed" last="Fourati">Mohamed Fourati</name><affiliation><nlm:affiliation>Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, Po Box 1177, 3018, Sfax, Tunisia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Unit of Marine and Environmental Toxicology, UR 09-03, Sfax University, IPEIS, BP 1172, 3018, Sfax, Tunisia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Mhiri, Mohamed Nabil" sort="Mhiri, Mohamed Nabil" uniqKey="Mhiri M" first="Mohamed-Nabil" last="Mhiri">Mohamed-Nabil Mhiri</name><affiliation><nlm:affiliation>Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Hamza Chaffai, Amel" sort="Hamza Chaffai, Amel" uniqKey="Hamza Chaffai A" first="Amel" last="Hamza-Chaffai">Amel Hamza-Chaffai</name><affiliation><nlm:affiliation>Unit of Marine and Environmental Toxicology, UR 09-03, Sfax University, IPEIS, BP 1172, 3018, Sfax, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Rebai, Ahmed" sort="Rebai, Ahmed" uniqKey="Rebai A" first="Ahmed" last="Rebai">Ahmed Rebai</name><affiliation><nlm:affiliation>Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, Po Box 1177, 3018, Sfax, Tunisia.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28803404</idno><idno type="pmid">28803404</idno><idno type="doi">10.1007/s11356-017-9767-x</idno><idno type="wicri:Area/PubMed/Corpus">000409</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000409</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Polymorphisms in XRCC1, ERCC2, and ERCC3 DNA repair genes, CYP1A1 xenobiotic metabolism gene, and tobacco are associated with bladder cancer susceptibility in Tunisian population.</title><author><name sortKey="Feki Tounsi, Molka" sort="Feki Tounsi, Molka" uniqKey="Feki Tounsi M" first="Molka" last="Feki-Tounsi">Molka Feki-Tounsi</name><affiliation><nlm:affiliation>Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, Po Box 1177, 3018, Sfax, Tunisia. molkafekitounsi@yahoo.fr.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Unit of Marine and Environmental Toxicology, UR 09-03, Sfax University, IPEIS, BP 1172, 3018, Sfax, Tunisia. molkafekitounsi@yahoo.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Khlifi, Rim" sort="Khlifi, Rim" uniqKey="Khlifi R" first="Rim" last="Khlifi">Rim Khlifi</name><affiliation><nlm:affiliation>Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, Po Box 1177, 3018, Sfax, Tunisia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Unit of Marine and Environmental Toxicology, UR 09-03, Sfax University, IPEIS, BP 1172, 3018, Sfax, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Louati, Ibtihel" sort="Louati, Ibtihel" uniqKey="Louati I" first="Ibtihel" last="Louati">Ibtihel Louati</name><affiliation><nlm:affiliation>Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, Po Box 1177, 3018, Sfax, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Fourati, Mohamed" sort="Fourati, Mohamed" uniqKey="Fourati M" first="Mohamed" last="Fourati">Mohamed Fourati</name><affiliation><nlm:affiliation>Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, Po Box 1177, 3018, Sfax, Tunisia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Unit of Marine and Environmental Toxicology, UR 09-03, Sfax University, IPEIS, BP 1172, 3018, Sfax, Tunisia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Mhiri, Mohamed Nabil" sort="Mhiri, Mohamed Nabil" uniqKey="Mhiri M" first="Mohamed-Nabil" last="Mhiri">Mohamed-Nabil Mhiri</name><affiliation><nlm:affiliation>Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Hamza Chaffai, Amel" sort="Hamza Chaffai, Amel" uniqKey="Hamza Chaffai A" first="Amel" last="Hamza-Chaffai">Amel Hamza-Chaffai</name><affiliation><nlm:affiliation>Unit of Marine and Environmental Toxicology, UR 09-03, Sfax University, IPEIS, BP 1172, 3018, Sfax, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Rebai, Ahmed" sort="Rebai, Ahmed" uniqKey="Rebai A" first="Ahmed" last="Rebai">Ahmed Rebai</name><affiliation><nlm:affiliation>Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, Po Box 1177, 3018, Sfax, Tunisia.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Environmental science and pollution research international</title><idno type="eISSN">1614-7499</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Arylamine N-Acetyltransferase (MeSH)</term><term>Case-Control Studies (MeSH)</term><term>Cytochrome P-450 CYP1A1 (genetics)</term><term>DNA Helicases (genetics)</term><term>DNA Repair (MeSH)</term><term>DNA-Binding Proteins (genetics)</term><term>Female (MeSH)</term><term>Genetic Predisposition to Disease (MeSH)</term><term>Genotype (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Polymorphism, Restriction Fragment Length (MeSH)</term><term>Polymorphism, Single Nucleotide (MeSH)</term><term>Smoking (MeSH)</term><term>Tobacco (MeSH)</term><term>Tunisia (MeSH)</term><term>Urinary Bladder Neoplasms (genetics)</term><term>X-ray Repair Cross Complementing Protein 1 (genetics)</term><term>Xeroderma Pigmentosum Group D Protein (genetics)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cytochrome P-450 CYP1A1</term><term>DNA Helicases</term><term>DNA-Binding Proteins</term><term>X-ray Repair Cross Complementing Protein 1</term><term>Xeroderma Pigmentosum Group D Protein</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Arylamine N-Acetyltransferase</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Urinary Bladder Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>DNA Repair</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Restriction Fragment Length</term><term>Polymorphism, Single Nucleotide</term><term>Smoking</term><term>Tobacco</term><term>Tunisia</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Other than the established environmental risk factors associated with bladder cancer (BC), little is known about the genetic variations determining the individual susceptibility of this complex disease. This study aimed to investigate the relationship of BC with environmental agents and polymorphisms in XRCC1, ERCC2, and ERCC3 DNA repair genes and CYP1A1, CYP2D6, NAT1, and NAT2 xenobiotic metabolism genes through a hospital-based case-control study in Tunisia. The selection of the single nucleotide polymorphisms (SNPs) (rs25487, rs 13181, rs415407, rs446421, rs1058172, rs4921880, and rs1208) was performed using the dbSNP database. DNA genotyping was determined by PCR-RFLP after DNA extraction from whole blood. The risks of BC associated with every polymorphism as well as the studied environmental factors were estimated by multivariate-adjusted logistic regression using R software. In addition, gene-gene interactions were analyzed using generalized multifactor dimensionality reduction (GMDR) methods. Results showed that tobacco smoking and chewing parameters were significantly associated with BC risk. Single-gene variant analysis showed significant associations of the TT genotype of CYP1A1 and the rare GG genotype of ERCC2 with bladder cancer susceptibility (OR = 1.34, 95% CI 1.22-1.40, P < 0.0001). According to GMDR analysis, our findings indicated a significant association between BC and gene-gene interaction among the CYP1A1, ERCC3, and XRCC1. The present results suggest a potential role of XRCC1, ERCC2, ERCC3, and CYP1A1 besides tobacco intake in susceptibility to BC.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">28803404</PMID><DateCompleted><Year>2018</Year><Month>09</Month><Day>27</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1614-7499</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>28</Issue><PubDate><Year>2017</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Environmental science and pollution research international</Title><ISOAbbreviation>Environ Sci Pollut Res Int</ISOAbbreviation></Journal><ArticleTitle>Polymorphisms in XRCC1, ERCC2, and ERCC3 DNA repair genes, CYP1A1 xenobiotic metabolism gene, and tobacco are associated with bladder cancer susceptibility in Tunisian population.</ArticleTitle><Pagination><MedlinePgn>22476-22484</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s11356-017-9767-x</ELocationID><Abstract><AbstractText>Other than the established environmental risk factors associated with bladder cancer (BC), little is known about the genetic variations determining the individual susceptibility of this complex disease. This study aimed to investigate the relationship of BC with environmental agents and polymorphisms in XRCC1, ERCC2, and ERCC3 DNA repair genes and CYP1A1, CYP2D6, NAT1, and NAT2 xenobiotic metabolism genes through a hospital-based case-control study in Tunisia. The selection of the single nucleotide polymorphisms (SNPs) (rs25487, rs 13181, rs415407, rs446421, rs1058172, rs4921880, and rs1208) was performed using the dbSNP database. DNA genotyping was determined by PCR-RFLP after DNA extraction from whole blood. The risks of BC associated with every polymorphism as well as the studied environmental factors were estimated by multivariate-adjusted logistic regression using R software. In addition, gene-gene interactions were analyzed using generalized multifactor dimensionality reduction (GMDR) methods. Results showed that tobacco smoking and chewing parameters were significantly associated with BC risk. Single-gene variant analysis showed significant associations of the TT genotype of CYP1A1 and the rare GG genotype of ERCC2 with bladder cancer susceptibility (OR = 1.34, 95% CI 1.22-1.40, P < 0.0001). According to GMDR analysis, our findings indicated a significant association between BC and gene-gene interaction among the CYP1A1, ERCC3, and XRCC1. The present results suggest a potential role of XRCC1, ERCC2, ERCC3, and CYP1A1 besides tobacco intake in susceptibility to BC.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Feki-Tounsi</LastName><ForeName>Molka</ForeName><Initials>M</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-9095-7839</Identifier><AffiliationInfo><Affiliation>Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, Po Box 1177, 3018, Sfax, Tunisia. molkafekitounsi@yahoo.fr.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Unit of Marine and Environmental Toxicology, UR 09-03, Sfax University, IPEIS, BP 1172, 3018, Sfax, Tunisia. molkafekitounsi@yahoo.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khlifi</LastName><ForeName>Rim</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, Po Box 1177, 3018, Sfax, Tunisia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Unit of Marine and Environmental Toxicology, UR 09-03, Sfax University, IPEIS, BP 1172, 3018, Sfax, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Louati</LastName><ForeName>Ibtihel</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, Po Box 1177, 3018, Sfax, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fourati</LastName><ForeName>Mohamed</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, Po Box 1177, 3018, Sfax, Tunisia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Unit of Marine and Environmental Toxicology, UR 09-03, Sfax University, IPEIS, BP 1172, 3018, Sfax, Tunisia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mhiri</LastName><ForeName>Mohamed-Nabil</ForeName><Initials>MN</Initials><AffiliationInfo><Affiliation>Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hamza-Chaffai</LastName><ForeName>Amel</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Unit of Marine and Environmental Toxicology, UR 09-03, Sfax University, IPEIS, BP 1172, 3018, Sfax, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rebai</LastName><ForeName>Ahmed</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, Po Box 1177, 3018, Sfax, Tunisia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>08</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Environ Sci Pollut Res Int</MedlineTA><NlmUniqueID>9441769</NlmUniqueID><ISSNLinking>0944-1344</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004268">DNA-Binding Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000076105">X-ray Repair Cross Complementing Protein 1</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C000619371">XRCC1 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>146045-44-5</RegistryNumber><NameOfSubstance UI="C072022">XPBC-ERCC-3 protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.14.14.1</RegistryNumber><NameOfSubstance UI="C569463">CYP1A1 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.14.14.1</RegistryNumber><NameOfSubstance UI="D019363">Cytochrome P-450 CYP1A1</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.3.1.5</RegistryNumber><NameOfSubstance UI="D001191">Arylamine N-Acetyltransferase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.3.1.5</RegistryNumber><NameOfSubstance UI="C478900">NAT2 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.6.4.-</RegistryNumber><NameOfSubstance UI="D004265">DNA Helicases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.6.4.12</RegistryNumber><NameOfSubstance UI="D051759">Xeroderma Pigmentosum Group D Protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 5.99.-</RegistryNumber><NameOfSubstance UI="C497292">ERCC2 protein, human</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001191" MajorTopicYN="N">Arylamine N-Acetyltransferase</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019363" MajorTopicYN="N">Cytochrome P-450 CYP1A1</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004265" MajorTopicYN="N">DNA Helicases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004260" MajorTopicYN="N">DNA Repair</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004268" MajorTopicYN="N">DNA-Binding Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020022" MajorTopicYN="N">Genetic Predisposition to Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012150" MajorTopicYN="N">Polymorphism, Restriction Fragment Length</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020641" MajorTopicYN="Y">Polymorphism, Single Nucleotide</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012907" MajorTopicYN="Y">Smoking</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014026" MajorTopicYN="N">Tobacco</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014416" MajorTopicYN="N">Tunisia</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001749" MajorTopicYN="N">Urinary Bladder Neoplasms</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000076105" MajorTopicYN="N">X-ray Repair Cross Complementing Protein 1</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051759" MajorTopicYN="N">Xeroderma Pigmentosum Group D 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