A common molecular signature of patients with sickle cell disease revealed by microarray meta-analysis and a genome-wide association study.
Identifieur interne : 000337 ( PubMed/Corpus ); précédent : 000336; suivant : 000338A common molecular signature of patients with sickle cell disease revealed by microarray meta-analysis and a genome-wide association study.
Auteurs : Cherif Ben Hamda ; Raphael Sangeda ; Liberata Mwita ; Ayton Meintjes ; Siana Nkya ; Sumir Panji ; Nicola Mulder ; Lamia Guizani-Tabbane ; Alia Benkahla ; Julie Makani ; Kais GhediraSource :
- PloS one [ 1932-6203 ] ; 2018.
English descriptors
- KwdEn :
- Alleles (MeSH), Anemia, Sickle Cell (genetics), Computational Biology (methods), Data Mining (MeSH), Databases, Genetic (MeSH), Gene Expression Profiling (MeSH), Gene Ontology (MeSH), Gene Regulatory Networks (MeSH), Genome-Wide Association Study (MeSH), Genotype (MeSH), Humans (MeSH), Polymorphism, Single Nucleotide (MeSH), Transcriptome (MeSH).
- MESH :
Abstract
A chronic inflammatory state to a large extent explains sickle cell disease (SCD) pathophysiology. Nonetheless, the principal dysregulated factors affecting this major pathway and their mechanisms of action still have to be fully identified and elucidated. Integrating gene expression and genome-wide association study (GWAS) data analysis represents a novel approach to refining the identification of key mediators and functions in complex diseases. Here, we performed gene expression meta-analysis of five independent publicly available microarray datasets related to homozygous SS patients with SCD to identify a consensus SCD transcriptomic profile. The meta-analysis conducted using the MetaDE R package based on combining p values (maxP approach) identified 335 differentially expressed genes (DEGs; 224 upregulated and 111 downregulated). Functional gene set enrichment revealed the importance of several metabolic pathways, of innate immune responses, erythrocyte development, and hemostasis pathways. Advanced analyses of GWAS data generated within the framework of this study by means of the atSNP R package and SIFT tool identified 60 regulatory single-nucleotide polymorphisms (rSNPs) occurring in the promoter of 20 DEGs and a deleterious SNP, affecting CAMKK2 protein function. This novel database of candidate genes, transcription factors, and rSNPs associated with SCD provides new markers that may help to identify new therapeutic targets.
DOI: 10.1371/journal.pone.0199461
PubMed: 29979707
PubMed Central: PMC6034806
Links to Exploration step
pubmed:29979707Le document en format XML
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Tunisia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>University of Tunis El Manar, Tunis, Tunisia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Faculty of Science of Bizerte, Jarzouna, University of Carthage, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Sangeda, Raphael" sort="Sangeda, Raphael" uniqKey="Sangeda R" first="Raphael" last="Sangeda">Raphael Sangeda</name><affiliation><nlm:affiliation>Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.</nlm:affiliation></affiliation></author><author><name sortKey="Mwita, Liberata" sort="Mwita, Liberata" uniqKey="Mwita L" first="Liberata" last="Mwita">Liberata Mwita</name><affiliation><nlm:affiliation>Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.</nlm:affiliation></affiliation></author><author><name sortKey="Meintjes, Ayton" sort="Meintjes, Ayton" uniqKey="Meintjes A" first="Ayton" last="Meintjes">Ayton Meintjes</name><affiliation><nlm:affiliation>University of Cape Town, Cape Town, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Nkya, Siana" sort="Nkya, Siana" uniqKey="Nkya S" first="Siana" last="Nkya">Siana Nkya</name><affiliation><nlm:affiliation>Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.</nlm:affiliation></affiliation></author><author><name sortKey="Panji, Sumir" sort="Panji, Sumir" uniqKey="Panji S" first="Sumir" last="Panji">Sumir Panji</name><affiliation><nlm:affiliation>University of Cape Town, Cape Town, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Mulder, Nicola" sort="Mulder, Nicola" uniqKey="Mulder N" first="Nicola" last="Mulder">Nicola Mulder</name><affiliation><nlm:affiliation>University of Cape Town, Cape Town, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Guizani Tabbane, Lamia" sort="Guizani Tabbane, Lamia" uniqKey="Guizani Tabbane L" first="Lamia" last="Guizani-Tabbane">Lamia Guizani-Tabbane</name><affiliation><nlm:affiliation>University of Tunis El Manar, Tunis, Tunisia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Laboratory of Medical Parasitology, Biotechnology and Biomolecules, Institute Pasteur of Tunis, Tunis, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Benkahla, Alia" sort="Benkahla, Alia" uniqKey="Benkahla A" first="Alia" last="Benkahla">Alia Benkahla</name><affiliation><nlm:affiliation>Laboratory of Bioinformatics, Biomathematics and Biostatistics, Institute Pasteur of Tunis, Tunis, Tunisia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>University of Tunis El Manar, Tunis, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Makani, Julie" sort="Makani, Julie" uniqKey="Makani J" first="Julie" last="Makani">Julie Makani</name><affiliation><nlm:affiliation>Faculty of Science of Bizerte, Jarzouna, University of Carthage, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Ghedira, Kais" sort="Ghedira, Kais" uniqKey="Ghedira K" first="Kais" last="Ghedira">Kais Ghedira</name><affiliation><nlm:affiliation>Laboratory of Bioinformatics, Biomathematics and Biostatistics, Institute Pasteur of Tunis, Tunis, Tunisia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>University of Tunis El Manar, Tunis, Tunisia.</nlm:affiliation></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alleles (MeSH)</term><term>Anemia, Sickle Cell (genetics)</term><term>Computational Biology (methods)</term><term>Data Mining (MeSH)</term><term>Databases, Genetic (MeSH)</term><term>Gene Expression Profiling (MeSH)</term><term>Gene Ontology (MeSH)</term><term>Gene Regulatory Networks (MeSH)</term><term>Genome-Wide Association Study (MeSH)</term><term>Genotype (MeSH)</term><term>Humans (MeSH)</term><term>Polymorphism, Single Nucleotide (MeSH)</term><term>Transcriptome (MeSH)</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Anemia, Sickle Cell</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Computational Biology</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Alleles</term><term>Data Mining</term><term>Databases, Genetic</term><term>Gene Expression Profiling</term><term>Gene Ontology</term><term>Gene Regulatory Networks</term><term>Genome-Wide Association Study</term><term>Genotype</term><term>Humans</term><term>Polymorphism, Single Nucleotide</term><term>Transcriptome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A chronic inflammatory state to a large extent explains sickle cell disease (SCD) pathophysiology. Nonetheless, the principal dysregulated factors affecting this major pathway and their mechanisms of action still have to be fully identified and elucidated. Integrating gene expression and genome-wide association study (GWAS) data analysis represents a novel approach to refining the identification of key mediators and functions in complex diseases. Here, we performed gene expression meta-analysis of five independent publicly available microarray datasets related to homozygous SS patients with SCD to identify a consensus SCD transcriptomic profile. The meta-analysis conducted using the MetaDE R package based on combining p values (maxP approach) identified 335 differentially expressed genes (DEGs; 224 upregulated and 111 downregulated). Functional gene set enrichment revealed the importance of several metabolic pathways, of innate immune responses, erythrocyte development, and hemostasis pathways. Advanced analyses of GWAS data generated within the framework of this study by means of the atSNP R package and SIFT tool identified 60 regulatory single-nucleotide polymorphisms (rSNPs) occurring in the promoter of 20 DEGs and a deleterious SNP, affecting CAMKK2 protein function. This novel database of candidate genes, transcription factors, and rSNPs associated with SCD provides new markers that may help to identify new therapeutic targets.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29979707</PMID><DateCompleted><Year>2018</Year><Month>12</Month><Day>31</Day></DateCompleted><DateRevised><Year>2019</Year><Month>04</Month><Day>26</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>13</Volume><Issue>7</Issue><PubDate><Year>2018</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS One</ISOAbbreviation></Journal><ArticleTitle>A common molecular signature of patients with sickle cell disease revealed by microarray meta-analysis and a genome-wide association study.</ArticleTitle><Pagination><MedlinePgn>e0199461</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0199461</ELocationID><Abstract><AbstractText>A chronic inflammatory state to a large extent explains sickle cell disease (SCD) pathophysiology. Nonetheless, the principal dysregulated factors affecting this major pathway and their mechanisms of action still have to be fully identified and elucidated. Integrating gene expression and genome-wide association study (GWAS) data analysis represents a novel approach to refining the identification of key mediators and functions in complex diseases. Here, we performed gene expression meta-analysis of five independent publicly available microarray datasets related to homozygous SS patients with SCD to identify a consensus SCD transcriptomic profile. The meta-analysis conducted using the MetaDE R package based on combining p values (maxP approach) identified 335 differentially expressed genes (DEGs; 224 upregulated and 111 downregulated). Functional gene set enrichment revealed the importance of several metabolic pathways, of innate immune responses, erythrocyte development, and hemostasis pathways. Advanced analyses of GWAS data generated within the framework of this study by means of the atSNP R package and SIFT tool identified 60 regulatory single-nucleotide polymorphisms (rSNPs) occurring in the promoter of 20 DEGs and a deleterious SNP, affecting CAMKK2 protein function. This novel database of candidate genes, transcription factors, and rSNPs associated with SCD provides new markers that may help to identify new therapeutic targets.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ben Hamda</LastName><ForeName>Cherif</ForeName><Initials>C</Initials><Identifier Source="ORCID">0000-0003-0985-4881</Identifier><AffiliationInfo><Affiliation>Laboratory of Bioinformatics, Biomathematics and Biostatistics, Institute Pasteur of Tunis, Tunis, Tunisia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Tunis El Manar, Tunis, Tunisia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculty of Science of Bizerte, Jarzouna, University of Carthage, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sangeda</LastName><ForeName>Raphael</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mwita</LastName><ForeName>Liberata</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meintjes</LastName><ForeName>Ayton</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>University of Cape Town, Cape Town, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nkya</LastName><ForeName>Siana</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Panji</LastName><ForeName>Sumir</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>University of Cape Town, Cape Town, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mulder</LastName><ForeName>Nicola</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>University of Cape Town, Cape Town, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guizani-Tabbane</LastName><ForeName>Lamia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>University of Tunis El Manar, Tunis, Tunisia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Medical Parasitology, Biotechnology and Biomolecules, Institute Pasteur of Tunis, Tunis, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Benkahla</LastName><ForeName>Alia</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Laboratory of Bioinformatics, Biomathematics and Biostatistics, Institute Pasteur of Tunis, Tunis, Tunisia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Tunis El Manar, Tunis, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Makani</LastName><ForeName>Julie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Faculty of Science of Bizerte, Jarzouna, University of Carthage, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ghedira</LastName><ForeName>Kais</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Laboratory of Bioinformatics, Biomathematics and Biostatistics, Institute Pasteur of Tunis, Tunis, Tunisia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Tunis El Manar, Tunis, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>H3ABioNet Consortium</CollectiveName></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>U24 HG006941</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U41 HG006941</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D017418">Meta-Analysis</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>07</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000483" MajorTopicYN="N">Alleles</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000755" MajorTopicYN="N">Anemia, Sickle Cell</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019295" MajorTopicYN="N">Computational Biology</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D057225" MajorTopicYN="N">Data Mining</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D030541" MajorTopicYN="N">Databases, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020869" MajorTopicYN="Y">Gene Expression Profiling</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D063990" MajorTopicYN="N">Gene Ontology</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053263" MajorTopicYN="N">Gene Regulatory Networks</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055106" MajorTopicYN="Y">Genome-Wide Association Study</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020641" MajorTopicYN="N">Polymorphism, Single Nucleotide</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D059467" MajorTopicYN="Y">Transcriptome</DescriptorName></MeshHeading></MeshHeadingList><CoiStatement>The authors declare that they have no competing interests.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>01</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>06</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>7</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>7</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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Dec;12(4):1085-95</Citation><ArticleIdList><ArticleId IdType="pubmed">597858</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2005 Jan 14;280(2):872-7</Citation><ArticleIdList><ArticleId IdType="pubmed">15546873</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Rep. 2015 Dec 09;5:17822</Citation><ArticleIdList><ArticleId IdType="pubmed">26648000</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Pharmacol. 2012 Jul 19;3:119</Citation><ArticleIdList><ArticleId IdType="pubmed">22833723</ArticleId></ArticleIdList></Reference><Reference><Citation>Cytometry B Clin Cytom. 2007 Jul;72(4):276-80</Citation><ArticleIdList><ArticleId IdType="pubmed">17111385</ArticleId></ArticleIdList></Reference><Reference><Citation>J Exp Med. 2012 Jan 16;209(1):35-50</Citation><ArticleIdList><ArticleId IdType="pubmed">22231305</ArticleId></ArticleIdList></Reference><Reference><Citation>Circ Res. 2007 Oct 26;101(9):919-27</Citation><ArticleIdList><ArticleId IdType="pubmed">17823375</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Med Genomics. 2012 Jun 29;5:28</Citation><ArticleIdList><ArticleId IdType="pubmed">22747986</ArticleId></ArticleIdList></Reference><Reference><Citation>Semin Immunol. 2002 Feb;14(1):7-18</Citation><ArticleIdList><ArticleId IdType="pubmed">11884226</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Bioinformatics. 2016 Jun 06;17 Suppl 5:181</Citation><ArticleIdList><ArticleId IdType="pubmed">27295045</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioinformatics. 2010 Feb 1;26(3):333-40</Citation><ArticleIdList><ArticleId IdType="pubmed">19965884</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 2017 Jun 1;129(22):3009-3016</Citation><ArticleIdList><ArticleId IdType="pubmed">28373264</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2015 Jan;43(Database issue):D447-52</Citation><ArticleIdList><ArticleId IdType="pubmed">25352553</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 2013 Oct 10;122(15):2535-6</Citation><ArticleIdList><ArticleId IdType="pubmed">24113796</ArticleId></ArticleIdList></Reference><Reference><Citation>J Leukoc Biol. 2009 Feb;85(2):235-42</Citation><ArticleIdList><ArticleId IdType="pubmed">19004988</ArticleId></ArticleIdList></Reference><Reference><Citation>Genome Res. 2003 Nov;13(11):2498-504</Citation><ArticleIdList><ArticleId IdType="pubmed">14597658</ArticleId></ArticleIdList></Reference><Reference><Citation>J Am Heart Assoc. 2015 Jul 31;4(8):e002272</Citation><ArticleIdList><ArticleId IdType="pubmed">26231844</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Hum Genet. 2013 Jan 10;92(1):126-30</Citation><ArticleIdList><ArticleId IdType="pubmed">23246294</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Genet. 2016 Oct 13;7:183</Citation><ArticleIdList><ArticleId IdType="pubmed">27790248</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2010 Dec 11;376(9757):2018-31</Citation><ArticleIdList><ArticleId IdType="pubmed">21131035</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2013 Jan 12;381(9861):142-51</Citation><ArticleIdList><ArticleId IdType="pubmed">23103089</ArticleId></ArticleIdList></Reference><Reference><Citation>Circ Res. 2015 Jan 16;116(2):298-306</Citation><ArticleIdList><ArticleId IdType="pubmed">25378535</ArticleId></ArticleIdList></Reference><Reference><Citation>BMJ. 2009 Jul 21;339:b2535</Citation><ArticleIdList><ArticleId IdType="pubmed">19622551</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 2001 Sep 15;98(6):1802-11</Citation><ArticleIdList><ArticleId IdType="pubmed">11535514</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2016 Jul 28;11(7):e0158101</Citation><ArticleIdList><ArticleId IdType="pubmed">27467239</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncogene. 1999 Nov 22;18(49):6853-66</Citation><ArticleIdList><ArticleId IdType="pubmed">10602461</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Comput Biol. 2012;8(12):e1002822</Citation><ArticleIdList><ArticleId IdType="pubmed">23300413</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Cell Biol. 2001 Aug;3(8):E190-5</Citation><ArticleIdList><ArticleId IdType="pubmed">11483980</ArticleId></ArticleIdList></Reference><Reference><Citation>Comput Biol Chem. 2008 Feb;32(1):38-46</Citation><ArticleIdList><ArticleId IdType="pubmed">17988949</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2013 Jul;41(Web Server issue):W63-70</Citation><ArticleIdList><ArticleId IdType="pubmed">23766290</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioinformatics. 2009 Apr 15;25(8):1091-3</Citation><ArticleIdList><ArticleId IdType="pubmed">19237447</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Genet. 2014 Feb 14;5:26</Citation><ArticleIdList><ArticleId IdType="pubmed">24592274</ArticleId></ArticleIdList></Reference><Reference><Citation>Antioxid Redox Signal. 2010 Feb;12(2):233-48</Citation><ArticleIdList><ArticleId IdType="pubmed">19697995</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 2016 Feb 18;127(7):801-9</Citation><ArticleIdList><ArticleId IdType="pubmed">26758915</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Invest. 2006 Mar;116(3):808-16</Citation><ArticleIdList><ArticleId IdType="pubmed">16485041</ArticleId></ArticleIdList></Reference><Reference><Citation>Stat Appl Genet Mol Biol. 2006;5:Article15</Citation><ArticleIdList><ArticleId IdType="pubmed">17049026</ArticleId></ArticleIdList></Reference><Reference><Citation>Circulation. 2007 Mar 27;115(12):1551-62</Citation><ArticleIdList><ArticleId IdType="pubmed">17353439</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 2007 Mar 15;109(6):2622-9</Citation><ArticleIdList><ArticleId IdType="pubmed">17138828</ArticleId></ArticleIdList></Reference><Reference><Citation>Nutrients. 2013 Aug 02;5(8):3034-61</Citation><ArticleIdList><ArticleId IdType="pubmed">23917168</ArticleId></ArticleIdList></Reference><Reference><Citation>Hematol Oncol Clin North Am. 2014 Apr;28(2):265-86</Citation><ArticleIdList><ArticleId IdType="pubmed">24589266</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2012 Jan;40(2):e15</Citation><ArticleIdList><ArticleId IdType="pubmed">22116060</ArticleId></ArticleIdList></Reference><Reference><Citation>Stat Appl Genet Mol Biol. 2004;3:Article3</Citation><ArticleIdList><ArticleId IdType="pubmed">16646809</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Clin Lab Sci. 1980 Jan-Feb;10(1):9-12</Citation><ArticleIdList><ArticleId IdType="pubmed">6965833</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2009 Aug 04;4(8):e6511</Citation><ArticleIdList><ArticleId IdType="pubmed">19652704</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Genet. 2015 Jan 08;11(1):e1004857</Citation><ArticleIdList><ArticleId IdType="pubmed">25569255</ArticleId></ArticleIdList></Reference><Reference><Citation>Hemoglobin. 2009;33(1):1-16</Citation><ArticleIdList><ArticleId IdType="pubmed">19205968</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Rep. 2016 Nov 28;6:37099</Citation><ArticleIdList><ArticleId IdType="pubmed">27892526</ArticleId></ArticleIdList></Reference><Reference><Citation>Tumour Biol. 2016 Sep;37(9):12755-12766</Citation><ArticleIdList><ArticleId IdType="pubmed">27448818</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2003 Jan 1;31(1):97-100</Citation><ArticleIdList><ArticleId IdType="pubmed">12519957</ArticleId></ArticleIdList></Reference><Reference><Citation>Haematologica. 2012 Mar;97(3):340-3</Citation><ArticleIdList><ArticleId IdType="pubmed">22102705</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Med. 2007 Sep-Oct;13(9-10):527-41</Citation><ArticleIdList><ArticleId IdType="pubmed">17660860</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 2013 Oct 10;122(15):2757-64</Citation><ArticleIdList><ArticleId IdType="pubmed">23908468</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mol Diagn. 2006 Nov;8(5):551-8</Citation><ArticleIdList><ArticleId IdType="pubmed">17065423</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Protoc. 2015 Jun;10(6):823-44</Citation><ArticleIdList><ArticleId IdType="pubmed">25950236</ArticleId></ArticleIdList></Reference><Reference><Citation>Hematol Oncol Clin North Am. 2014 Apr;28(2):181-98</Citation><ArticleIdList><ArticleId IdType="pubmed">24589261</ArticleId></ArticleIdList></Reference><Reference><Citation>Med Hypotheses. 2001 Jul;57(1):46-50</Citation><ArticleIdList><ArticleId IdType="pubmed">11421623</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Appl Thromb Hemost. 2012 Mar-Apr;18(2):195-200</Citation><ArticleIdList><ArticleId IdType="pubmed">21949038</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 1999 Jun 1;93(11):3824-30</Citation><ArticleIdList><ArticleId IdType="pubmed">10339489</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Bioinformatics. 2013 Apr 15;14:128</Citation><ArticleIdList><ArticleId IdType="pubmed">23586463</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Hematol. 2014 Mar;89(3):261-6</Citation><ArticleIdList><ArticleId IdType="pubmed">24779034</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Med. 2008 Sep 30;5(9):e184</Citation><ArticleIdList><ArticleId IdType="pubmed">18767902</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Genomics. 2008 Nov;9(7):466-74</Citation><ArticleIdList><ArticleId IdType="pubmed">19506735</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Cancer Res. 2004 May 1;10(9):2922-7</Citation><ArticleIdList><ArticleId IdType="pubmed">15131026</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Hematol Oncol Stem Cell Res. 2017 Jan 1;11(1):1-12</Citation><ArticleIdList><ArticleId IdType="pubmed">28286608</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2016 Aug 23;7(34):54616-54626</Citation><ArticleIdList><ArticleId IdType="pubmed">27409348</ArticleId></ArticleIdList></Reference><Reference><Citation>Haematologica. 2014 Jun;99(6):973-83</Citation><ArticleIdList><ArticleId IdType="pubmed">24881043</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Hematol. 2016 Sep;91(9):938-46</Citation><ArticleIdList><ArticleId IdType="pubmed">27237467</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioinformatics. 2003;19 Suppl 1:i84-90</Citation><ArticleIdList><ArticleId IdType="pubmed">12855442</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Genet. 2013 Feb;14(2):89-99</Citation><ArticleIdList><ArticleId IdType="pubmed">23269463</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Pathol. 2001 Mar;158(3):893-903</Citation><ArticleIdList><ArticleId IdType="pubmed">11238038</ArticleId></ArticleIdList></Reference><Reference><Citation>Cytokine. 2015 Mar;72(1):43-7</Citation><ArticleIdList><ArticleId IdType="pubmed">25569375</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2012 Sep 7;337(6099):1190-5</Citation><ArticleIdList><ArticleId IdType="pubmed">22955828</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2014 Nov 05;9(11):e111464</Citation><ArticleIdList><ArticleId IdType="pubmed">25372704</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 2007 Oct 15;110(8):2940-7</Citation><ArticleIdList><ArticleId IdType="pubmed">17626838</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioinformatics. 2012 Oct 1;28(19):2534-6</Citation><ArticleIdList><ArticleId IdType="pubmed">22863766</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2012 Mar 30;287(14):11579-91</Citation><ArticleIdList><ArticleId IdType="pubmed">22334678</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioinformatics. 2003 Nov 1;19(16):2065-71</Citation><ArticleIdList><ArticleId IdType="pubmed">14594711</ArticleId></ArticleIdList></Reference><Reference><Citation>Diabetes. 2015 Mar;64(3):867-75</Citation><ArticleIdList><ArticleId IdType="pubmed">25294945</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2012 May;40(9):3785-99</Citation><ArticleIdList><ArticleId IdType="pubmed">22262733</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Infect Dis. 2010 May;10(5):329-37</Citation><ArticleIdList><ArticleId IdType="pubmed">20417415</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2009 Aug 03;4(8):e6484</Citation><ArticleIdList><ArticleId IdType="pubmed">19649296</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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