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Genetic Distribution of the LTA +252 A>G and TNFA -308 G > A Polymorphisms in the Moroccan Population.

Identifieur interne : 000196 ( PubMed/Corpus ); précédent : 000195; suivant : 000197

Genetic Distribution of the LTA +252 A>G and TNFA -308 G > A Polymorphisms in the Moroccan Population.

Auteurs : Fatima Zahra Aznag ; Mohamed Taha Moutaoufik ; Amal Korrida ; El Hassan Izaabel

Source :

RBID : pubmed:31738572

English descriptors

Abstract

Introduction: The LTA and TNFA genes encode key proinflammatory cytokines with diverse activities in the immune responses. Single nucleotide polymorphisms (SNPs) in the LTA rs909253 (+252 A > G) and TNFA rs1800629 (-308 G > A) genes have been associated with susceptibility to many complex diseases. The aim of this study was to assess the frequency for these two key polymorphisms in the Moroccan population. Materials and Methods: A total of 338 unrelated healthy Moroccan subjects were genotyped for the two alleles using a restriction fragment length polymorphism-polymerase chain reaction method. Results: The LTA (+252 A > G) and TNFA (-308 G > A) were the most common alleles with 67.9% and 74.8% frequencies, respectively. In addition to the linkage disequilibrium between the two SNPs, significant differences in allele frequencies were observed in Moroccan population compared with Mediterraneans, Europeans, Africans, South Americans, and Asians (p < 0.05). Finally, genetic proximities between Moroccan, European, and West African populations were found by means of the principal component analysis. Conclusion: The LTA +252 A>G and TNFA -308 G > A polymorphisms among Moroccan population follow the patterns commonly encountered in other Mediterranean, European, and African populations. The result of this study could contribute in developing a genetic database on the healthy Moroccan population.

DOI: 10.1089/gtmb.2019.0116
PubMed: 31738572

Links to Exploration step

pubmed:31738572

Le document en format XML

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<title xml:lang="en">Genetic Distribution of the
<i>LTA</i>
+252 A>G and
<i>TNFA</i>
-308 G > A Polymorphisms in the Moroccan Population.</title>
<author>
<name sortKey="Aznag, Fatima Zahra" sort="Aznag, Fatima Zahra" uniqKey="Aznag F" first="Fatima Zahra" last="Aznag">Fatima Zahra Aznag</name>
<affiliation>
<nlm:affiliation>Laboratory of Cellular Biology and Molecular Genetics, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Moutaoufik, Mohamed Taha" sort="Moutaoufik, Mohamed Taha" uniqKey="Moutaoufik M" first="Mohamed Taha" last="Moutaoufik">Mohamed Taha Moutaoufik</name>
<affiliation>
<nlm:affiliation>Department of Biochemistry, University of Regina, Regina, SK, Canada.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Korrida, Amal" sort="Korrida, Amal" uniqKey="Korrida A" first="Amal" last="Korrida">Amal Korrida</name>
<affiliation>
<nlm:affiliation>Laboratory of Cellular Biology and Molecular Genetics, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco.</nlm:affiliation>
</affiliation>
<affiliation>
<nlm:affiliation>Higher Institute of Nursing Professions and Health Techniques of Agadir, Ministry of Health, Agadir, Morocco.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Izaabel, El Hassan" sort="Izaabel, El Hassan" uniqKey="Izaabel E" first="El Hassan" last="Izaabel">El Hassan Izaabel</name>
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<nlm:affiliation>Laboratory of Cellular Biology and Molecular Genetics, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco.</nlm:affiliation>
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+252 A>G and
<i>TNFA</i>
-308 G > A Polymorphisms in the Moroccan Population.</title>
<author>
<name sortKey="Aznag, Fatima Zahra" sort="Aznag, Fatima Zahra" uniqKey="Aznag F" first="Fatima Zahra" last="Aznag">Fatima Zahra Aznag</name>
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<name sortKey="Moutaoufik, Mohamed Taha" sort="Moutaoufik, Mohamed Taha" uniqKey="Moutaoufik M" first="Mohamed Taha" last="Moutaoufik">Mohamed Taha Moutaoufik</name>
<affiliation>
<nlm:affiliation>Department of Biochemistry, University of Regina, Regina, SK, Canada.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Korrida, Amal" sort="Korrida, Amal" uniqKey="Korrida A" first="Amal" last="Korrida">Amal Korrida</name>
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</affiliation>
<affiliation>
<nlm:affiliation>Higher Institute of Nursing Professions and Health Techniques of Agadir, Ministry of Health, Agadir, Morocco.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Izaabel, El Hassan" sort="Izaabel, El Hassan" uniqKey="Izaabel E" first="El Hassan" last="Izaabel">El Hassan Izaabel</name>
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<nlm:affiliation>Laboratory of Cellular Biology and Molecular Genetics, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco.</nlm:affiliation>
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<title level="j">Genetic testing and molecular biomarkers</title>
<idno type="eISSN">1945-0257</idno>
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<term>Adult (MeSH)</term>
<term>Alleles (MeSH)</term>
<term>Case-Control Studies (MeSH)</term>
<term>Cytokines (genetics)</term>
<term>Female (MeSH)</term>
<term>Gene Frequency (genetics)</term>
<term>Genetic Predisposition to Disease (MeSH)</term>
<term>Genotype (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Linkage Disequilibrium (genetics)</term>
<term>Lymphotoxin-alpha (blood)</term>
<term>Lymphotoxin-alpha (genetics)</term>
<term>Lymphotoxin-alpha (metabolism)</term>
<term>Male (MeSH)</term>
<term>Morocco (epidemiology)</term>
<term>Polymorphism, Single Nucleotide (genetics)</term>
<term>Tumor Necrosis Factor-alpha (blood)</term>
<term>Tumor Necrosis Factor-alpha (genetics)</term>
<term>Tumor Necrosis Factor-alpha (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en">
<term>Lymphotoxin-alpha</term>
<term>Tumor Necrosis Factor-alpha</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en">
<term>Cytokines</term>
<term>Lymphotoxin-alpha</term>
<term>Tumor Necrosis Factor-alpha</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en">
<term>Morocco</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en">
<term>Gene Frequency</term>
<term>Linkage Disequilibrium</term>
<term>Polymorphism, Single Nucleotide</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en">
<term>Lymphotoxin-alpha</term>
<term>Tumor Necrosis Factor-alpha</term>
</keywords>
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<term>Adult</term>
<term>Alleles</term>
<term>Case-Control Studies</term>
<term>Female</term>
<term>Genetic Predisposition to Disease</term>
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<front>
<div type="abstract" xml:lang="en">
<b>
<i>Introduction:</i>
</b>
The
<i>LTA</i>
and
<i>TNFA</i>
genes encode key proinflammatory cytokines with diverse activities in the immune responses. Single nucleotide polymorphisms (SNPs) in the
<i>LTA</i>
rs909253 (+252 A > G) and
<i>TNFA</i>
rs1800629 (-308 G > A) genes have been associated with susceptibility to many complex diseases. The aim of this study was to assess the frequency for these two key polymorphisms in the Moroccan population.
<b>
<i>Materials and Methods:</i>
</b>
A total of 338 unrelated healthy Moroccan subjects were genotyped for the two alleles using a restriction fragment length polymorphism-polymerase chain reaction method.
<b>
<i>Results:</i>
</b>
The
<i>LTA</i>
(+252 A > G) and
<i>TNFA</i>
(-308 G > A) were the most common alleles with 67.9% and 74.8% frequencies, respectively. In addition to the linkage disequilibrium between the two SNPs, significant differences in allele frequencies were observed in Moroccan population compared with Mediterraneans, Europeans, Africans, South Americans, and Asians (
<i>p</i>
 < 0.05). Finally, genetic proximities between Moroccan, European, and West African populations were found by means of the principal component analysis.
<b>
<i>Conclusion:</i>
</b>
The
<i>LTA</i>
+252 A>G and
<i>TNFA</i>
-308 G > A polymorphisms among Moroccan population follow the patterns commonly encountered in other Mediterranean, European, and African populations. The result of this study could contribute in developing a genetic database on the healthy Moroccan population.</div>
</front>
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<Day>13</Day>
</DateRevised>
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<ISSN IssnType="Electronic">1945-0257</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>23</Volume>
<Issue>12</Issue>
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<Month>Dec</Month>
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<Title>Genetic testing and molecular biomarkers</Title>
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<ArticleTitle>Genetic Distribution of the
<i>LTA</i>
+252 A>G and
<i>TNFA</i>
-308 G > A Polymorphisms in the Moroccan Population.</ArticleTitle>
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<b>
<i>Introduction:</i>
</b>
The
<i>LTA</i>
and
<i>TNFA</i>
genes encode key proinflammatory cytokines with diverse activities in the immune responses. Single nucleotide polymorphisms (SNPs) in the
<i>LTA</i>
rs909253 (+252 A > G) and
<i>TNFA</i>
rs1800629 (-308 G > A) genes have been associated with susceptibility to many complex diseases. The aim of this study was to assess the frequency for these two key polymorphisms in the Moroccan population.
<b>
<i>Materials and Methods:</i>
</b>
A total of 338 unrelated healthy Moroccan subjects were genotyped for the two alleles using a restriction fragment length polymorphism-polymerase chain reaction method.
<b>
<i>Results:</i>
</b>
The
<i>LTA</i>
(+252 A > G) and
<i>TNFA</i>
(-308 G > A) were the most common alleles with 67.9% and 74.8% frequencies, respectively. In addition to the linkage disequilibrium between the two SNPs, significant differences in allele frequencies were observed in Moroccan population compared with Mediterraneans, Europeans, Africans, South Americans, and Asians (
<i>p</i>
 < 0.05). Finally, genetic proximities between Moroccan, European, and West African populations were found by means of the principal component analysis.
<b>
<i>Conclusion:</i>
</b>
The
<i>LTA</i>
+252 A>G and
<i>TNFA</i>
-308 G > A polymorphisms among Moroccan population follow the patterns commonly encountered in other Mediterranean, European, and African populations. The result of this study could contribute in developing a genetic database on the healthy Moroccan population.</AbstractText>
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<Affiliation>Department of Biochemistry, University of Regina, Regina, SK, Canada.</Affiliation>
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<ForeName>Amal</ForeName>
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