DALIA- a comprehensive resource of Disease Alleles in Arab population
Identifieur interne : 000261 ( Pmc/Curation ); précédent : 000260; suivant : 000262DALIA- a comprehensive resource of Disease Alleles in Arab population
Auteurs : Aastha Vatsyayan [Inde] ; Parul Sharma [Inde] ; Shrey Gupta [Inde] ; Sumiti Sandhu [Inde] ; Seetha Lakshmi Venu [Inde] ; Vandana Sharma [Inde] ; Bouabid Badaoui [Maroc] ; Kaidi Azedine [Maroc] ; Serti Youssef [Maroc] ; Anna Rajab [Oman] ; Alaaeldin Fayez [Égypte] ; Seema Madinur [Inde] ; Anop Ranawat [Inde] ; Kavita Pandhare [Inde] ; Srinivasan Ramachandran [Inde] ; Sridhar Sivasubbu [Inde] ; Vinod Scaria [Inde]Source :
- PLoS ONE [ 1932-6203 ] ; 2021.
Abstract
The Arab population encompasses over 420 million people characterized by genetic admixture and a consequent rich genetic diversity. A number of genetic diseases have been reported for the first time from the population. Additionally a high prevalence of some genetic diseases including autosomal recessive disorders such as hemoglobinopathies and familial mediterranean fever have been found in the population and across the region. There is a paucity of databases cataloguing genetic variants of clinical relevance from the population. The availability of such a catalog could have implications in precise diagnosis, genetic epidemiology and prevention of disease. To fill in the gap, we have compiled DALIA, a comprehensive compendium of genetic variants reported in literature and implicated in genetic diseases reported from the Arab population. The database aims to act as an effective resource for population-scale and sub-population specific variant analyses, enabling a ready reference aiding clinical interpretation of genetic variants, genetic epidemiology, as well as facilitating rapid screening and a quick reference for evaluating evidence on genetic diseases.
Url:
DOI: 10.1371/journal.pone.0244567
PubMed: 33439861
PubMed Central: 7806169
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id="aff002"><addr-line>Amity University, Noida, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Amity University, Noida</wicri:regionArea></affiliation></author><author><name sortKey="Sharma, Parul" sort="Sharma, Parul" uniqKey="Sharma P" first="Parul" last="Sharma">Parul Sharma</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Indraprastha Institute of Information Technology Delhi (IIIT-D), Delhi, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Indraprastha Institute of Information Technology Delhi (IIIT-D), Delhi</wicri:regionArea></affiliation></author><author><name sortKey="Gupta, Shrey" sort="Gupta, Shrey" uniqKey="Gupta S" first="Shrey" last="Gupta">Shrey Gupta</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Indraprastha Institute of Information Technology Delhi (IIIT-D), Delhi, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Indraprastha Institute of Information Technology Delhi (IIIT-D), Delhi</wicri:regionArea></affiliation></author><author><name sortKey="Sandhu, Sumiti" sort="Sandhu, Sumiti" uniqKey="Sandhu S" first="Sumiti" last="Sandhu">Sumiti Sandhu</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Amity University, Rajasthan, Jaipur, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Amity University, Rajasthan, Jaipur</wicri:regionArea></affiliation></author><author><name sortKey="Venu, Seetha Lakshmi" sort="Venu, Seetha Lakshmi" uniqKey="Venu S" first="Seetha Lakshmi" last="Venu">Seetha Lakshmi Venu</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>ACBR, Delhi, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>ACBR, Delhi</wicri:regionArea></affiliation></author><author><name sortKey="Sharma, Vandana" sort="Sharma, Vandana" uniqKey="Sharma V" first="Vandana" last="Sharma">Vandana Sharma</name><affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>Kalindi College, University of Delhi, New Delhi, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Kalindi College, University of Delhi, New Delhi</wicri:regionArea></affiliation></author><author><name sortKey="Badaoui, Bouabid" sort="Badaoui, Bouabid" uniqKey="Badaoui B" first="Bouabid" last="Badaoui">Bouabid Badaoui</name><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Mohammed V University, Rabat, Morocco</addr-line></nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Mohammed V University, Rabat</wicri:regionArea></affiliation></author><author><name sortKey="Azedine, Kaidi" sort="Azedine, Kaidi" uniqKey="Azedine K" first="Kaidi" last="Azedine">Kaidi Azedine</name><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Mohammed V University, Rabat, Morocco</addr-line></nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Mohammed V University, Rabat</wicri:regionArea></affiliation></author><author><name sortKey="Youssef, Serti" sort="Youssef, Serti" uniqKey="Youssef S" first="Serti" last="Youssef">Serti Youssef</name><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Mohammed V University, Rabat, Morocco</addr-line></nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Mohammed V University, Rabat</wicri:regionArea></affiliation></author><author><name sortKey="Rajab, Anna" sort="Rajab, Anna" uniqKey="Rajab A" first="Anna" last="Rajab">Anna Rajab</name><affiliation wicri:level="1"><nlm:aff id="aff008"><addr-line>National Genetic Center, Ministry of Health, Muscat, Oman</addr-line></nlm:aff><country xml:lang="fr">Oman</country><wicri:regionArea>National Genetic Center, Ministry of Health, Muscat</wicri:regionArea></affiliation></author><author><name sortKey="Fayez, Alaaeldin" sort="Fayez, Alaaeldin" uniqKey="Fayez A" first="Alaaeldin" last="Fayez">Alaaeldin Fayez</name><affiliation wicri:level="1"><nlm:aff id="aff009"><addr-line>Human Genetics and Genome Research Division, Center of Excellence for Human Genetics, National Research Center, Cairo, Egypt</addr-line></nlm:aff><country xml:lang="fr">Égypte</country><wicri:regionArea>Human Genetics and Genome Research Division, Center of Excellence for Human Genetics, National Research Center, Cairo</wicri:regionArea></affiliation></author><author><name sortKey="Madinur, Seema" sort="Madinur, Seema" uniqKey="Madinur S" first="Seema" last="Madinur">Seema Madinur</name><affiliation wicri:level="1"><nlm:aff id="aff010"><addr-line>Independent Researcher, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Independent Researcher</wicri:regionArea></affiliation></author><author><name sortKey="Ranawat, Anop" sort="Ranawat, Anop" uniqKey="Ranawat A" first="Anop" last="Ranawat">Anop Ranawat</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi</wicri:regionArea></affiliation></author><author><name sortKey="Pandhare, Kavita" sort="Pandhare, Kavita" uniqKey="Pandhare K" first="Kavita" last="Pandhare">Kavita Pandhare</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi</wicri:regionArea></affiliation></author><author><name sortKey="Ramachandran, Srinivasan" sort="Ramachandran, Srinivasan" uniqKey="Ramachandran S" first="Srinivasan" last="Ramachandran">Srinivasan Ramachandran</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff011"><addr-line>Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Academy of Scientific and Innovative Research (AcSIR), Ghaziabad</wicri:regionArea></affiliation></author><author><name sortKey="Sivasubbu, Sridhar" sort="Sivasubbu, Sridhar" uniqKey="Sivasubbu S" first="Sridhar" last="Sivasubbu">Sridhar Sivasubbu</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff011"><addr-line>Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Academy of Scientific and Innovative Research (AcSIR), Ghaziabad</wicri:regionArea></affiliation></author><author><name sortKey="Scaria, Vinod" sort="Scaria, Vinod" uniqKey="Scaria V" first="Vinod" last="Scaria">Vinod Scaria</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff011"><addr-line>Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Academy of Scientific and Innovative Research (AcSIR), Ghaziabad</wicri:regionArea></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2021">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The Arab population encompasses over 420 million people characterized by genetic admixture and a consequent rich genetic diversity. A number of genetic diseases have been reported for the first time from the population. Additionally a high prevalence of some genetic diseases including autosomal recessive disorders such as hemoglobinopathies and familial mediterranean fever have been found in the population and across the region. There is a paucity of databases cataloguing genetic variants of clinical relevance from the population. The availability of such a catalog could have implications in precise diagnosis, genetic epidemiology and prevention of disease. To fill in the gap, we have compiled DALIA, a comprehensive compendium of genetic variants reported in literature and implicated in genetic diseases reported from the Arab population. The database aims to act as an effective resource for population-scale and sub-population specific variant analyses, enabling a ready reference aiding clinical interpretation of genetic variants, genetic epidemiology, as well as facilitating rapid screening and a quick reference for evaluating evidence on genetic diseases.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Tadmouri, Go" uniqKey="Tadmouri G">GO Tadmouri</name></author><author><name sortKey="Sastry, Ks" uniqKey="Sastry K">KS Sastry</name></author><author><name sortKey="Chouchane, L" uniqKey="Chouchane L">L Chouchane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Gazali, L" uniqKey="Al Gazali L">L Al-Gazali</name></author><author><name sortKey="Hamamy, H" uniqKey="Hamamy H">H Hamamy</name></author><author><name sortKey="Al Arrayad, S" uniqKey="Al Arrayad S">S 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<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS One</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, CA USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">33439861</article-id><article-id pub-id-type="pmc">7806169</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0244567</article-id><article-id pub-id-type="publisher-id">PONE-D-20-26943</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Epidemiology</subject><subj-group><subject>Genetic Epidemiology</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Genetics</subject><subj-group><subject>Genetic Loci</subject><subj-group><subject>Alleles</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Genetics</subject><subj-group><subject>Genetics of Disease</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Research and Analysis Methods</subject><subj-group><subject>Database and Informatics Methods</subject><subj-group><subject>Biological Databases</subject><subj-group><subject>Genomic Databases</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Computational Biology</subject><subj-group><subject>Genome Analysis</subject><subj-group><subject>Genomic Databases</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Genetics</subject><subj-group><subject>Genomics</subject><subj-group><subject>Genome Analysis</subject><subj-group><subject>Genomic Databases</subject></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Evolutionary Biology</subject><subj-group><subject>Population Genetics</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Genetics</subject><subj-group><subject>Population Genetics</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Population Biology</subject><subj-group><subject>Population Genetics</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>People and Places</subject><subj-group><subject>Geographical Locations</subject><subj-group><subject>Asia</subject><subj-group><subject>Qatar</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Medical Conditions</subject><subj-group><subject>Genetic Diseases</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Clinical Genetics</subject><subj-group><subject>Genetic Diseases</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Computational Biology</subject><subj-group><subject>Genome Analysis</subject><subj-group><subject>Genome Annotation</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Genetics</subject><subj-group><subject>Genomics</subject><subj-group><subject>Genome Analysis</subject><subj-group><subject>Genome Annotation</subject></subj-group></subj-group></subj-group></subj-group></subj-group></article-categories><title-group><article-title>DALIA- a comprehensive resource of Disease Alleles in Arab population</article-title><alt-title alt-title-type="running-head">DALIA: Disease Alleles in Arabs</alt-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Vatsyayan</surname><given-names>Aastha</given-names></name><role content-type="https://casrai.org/credit/">Data curation</role><role content-type="https://casrai.org/credit/">Formal analysis</role><role content-type="https://casrai.org/credit/">Investigation</role><role content-type="https://casrai.org/credit/">Project administration</role><role content-type="https://casrai.org/credit/">Validation</role><role content-type="https://casrai.org/credit/">Visualization</role><role content-type="https://casrai.org/credit/">Writing – original draft</role><role content-type="https://casrai.org/credit/">Writing – review & editing</role><xref ref-type="aff" rid="aff001"><sup>1</sup></xref><xref ref-type="aff" rid="aff002"><sup>2</sup></xref><xref ref-type="author-notes" rid="econtrib001"><sup>‡</sup></xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Sharma</surname><given-names>Parul</given-names></name><role content-type="https://casrai.org/credit/">Supervision</role><xref ref-type="aff" rid="aff003"><sup>3</sup></xref><xref ref-type="author-notes" rid="econtrib001"><sup>‡</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gupta</surname><given-names>Shrey</given-names></name><role content-type="https://casrai.org/credit/">Data curation</role><xref ref-type="aff" rid="aff003"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sandhu</surname><given-names>Sumiti</given-names></name><role content-type="https://casrai.org/credit/">Data curation</role><xref ref-type="aff" rid="aff004"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Venu</surname><given-names>Seetha Lakshmi</given-names></name><role content-type="https://casrai.org/credit/">Data curation</role><xref ref-type="aff" rid="aff005"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sharma</surname><given-names>Vandana</given-names></name><role content-type="https://casrai.org/credit/">Data curation</role><xref ref-type="aff" rid="aff006"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Badaoui</surname><given-names>Bouabid</given-names></name><role content-type="https://casrai.org/credit/">Data curation</role><xref ref-type="aff" rid="aff007"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Azedine</surname><given-names>Kaidi</given-names></name><role content-type="https://casrai.org/credit/">Data curation</role><xref ref-type="aff" rid="aff007"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Youssef</surname><given-names>Serti</given-names></name><role content-type="https://casrai.org/credit/">Data curation</role><xref ref-type="aff" rid="aff007"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rajab</surname><given-names>Anna</given-names></name><role content-type="https://casrai.org/credit/">Data curation</role><xref ref-type="aff" rid="aff008"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fayez</surname><given-names>Alaaeldin</given-names></name><role content-type="https://casrai.org/credit/">Data curation</role><xref ref-type="aff" rid="aff009"><sup>9</sup></xref></contrib><contrib contrib-type="author"><name><surname>Madinur</surname><given-names>Seema</given-names></name><role content-type="https://casrai.org/credit/">Data curation</role><xref ref-type="aff" rid="aff010"><sup>10</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ranawat</surname><given-names>Anop</given-names></name><role content-type="https://casrai.org/credit/">Resources</role><role content-type="https://casrai.org/credit/">Software</role><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pandhare</surname><given-names>Kavita</given-names></name><role content-type="https://casrai.org/credit/">Software</role><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ramachandran</surname><given-names>Srinivasan</given-names></name><role content-type="https://casrai.org/credit/">Resources</role><role content-type="https://casrai.org/credit/">Software</role><xref ref-type="aff" rid="aff001"><sup>1</sup></xref><xref ref-type="aff" rid="aff011"><sup>11</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sivasubbu</surname><given-names>Sridhar</given-names></name><role content-type="https://casrai.org/credit/">Conceptualization</role><xref ref-type="aff" rid="aff001"><sup>1</sup></xref><xref ref-type="aff" rid="aff011"><sup>11</sup></xref></contrib><contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">https://orcid.org/0000-0001-7644-7181</contrib-id><name><surname>Scaria</surname><given-names>Vinod</given-names></name><role content-type="https://casrai.org/credit/">Conceptualization</role><role content-type="https://casrai.org/credit/">Funding acquisition</role><role content-type="https://casrai.org/credit/">Investigation</role><role content-type="https://casrai.org/credit/">Methodology</role><role content-type="https://casrai.org/credit/">Project administration</role><role content-type="https://casrai.org/credit/">Resources</role><role content-type="https://casrai.org/credit/">Software</role><role content-type="https://casrai.org/credit/">Supervision</role><role content-type="https://casrai.org/credit/">Writing – review & editing</role><xref ref-type="aff" rid="aff001"><sup>1</sup></xref><xref ref-type="aff" rid="aff011"><sup>11</sup></xref><xref ref-type="corresp" rid="cor001">*</xref></contrib></contrib-group><aff id="aff001"><label>1</label><addr-line>CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, India</addr-line></aff><aff id="aff002"><label>2</label><addr-line>Amity University, Noida, India</addr-line></aff><aff id="aff003"><label>3</label><addr-line>Indraprastha Institute of Information Technology Delhi (IIIT-D), Delhi, India</addr-line></aff><aff id="aff004"><label>4</label><addr-line>Amity University, Rajasthan, Jaipur, India</addr-line></aff><aff id="aff005"><label>5</label><addr-line>ACBR, Delhi, India</addr-line></aff><aff id="aff006"><label>6</label><addr-line>Kalindi College, University of Delhi, New Delhi, India</addr-line></aff><aff id="aff007"><label>7</label><addr-line>Mohammed V University, Rabat, Morocco</addr-line></aff><aff id="aff008"><label>8</label><addr-line>National Genetic Center, Ministry of Health, Muscat, Oman</addr-line></aff><aff id="aff009"><label>9</label><addr-line>Human Genetics and Genome Research Division, Center of Excellence for Human Genetics, National Research Center, Cairo, Egypt</addr-line></aff><aff id="aff010"><label>10</label><addr-line>Independent Researcher, India</addr-line></aff><aff id="aff011"><label>11</label><addr-line>Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Bandapalli</surname><given-names>Obul Reddy</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>German Cancer Research Center (DKFZ), GERMANY</addr-line></aff><author-notes><fn fn-type="COI-statement" id="coi001"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="other" id="econtrib001"><p>‡ These authors share first authorship on this work.</p></fn><corresp id="cor001">* E-mail: <email>vinods@igib.in</email></corresp></author-notes><pub-date pub-type="epub"><day>13</day><month>1</month><year>2021</year></pub-date><pub-date pub-type="collection"><year>2021</year></pub-date><volume>16</volume><issue>1</issue><elocation-id>e0244567</elocation-id><history><date date-type="received"><day>27</day><month>8</month><year>2020</year></date><date date-type="accepted"><day>11</day><month>12</month><year>2020</year></date></history><permissions><copyright-statement>© 2021 Vatsyayan et al</copyright-statement><copyright-year>2021</copyright-year><copyright-holder>Vatsyayan et al</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="pone.0244567.pdf"></self-uri><abstract><p>The Arab population encompasses over 420 million people characterized by genetic admixture and a consequent rich genetic diversity. A number of genetic diseases have been reported for the first time from the population. Additionally a high prevalence of some genetic diseases including autosomal recessive disorders such as hemoglobinopathies and familial mediterranean fever have been found in the population and across the region. There is a paucity of databases cataloguing genetic variants of clinical relevance from the population. The availability of such a catalog could have implications in precise diagnosis, genetic epidemiology and prevention of disease. To fill in the gap, we have compiled DALIA, a comprehensive compendium of genetic variants reported in literature and implicated in genetic diseases reported from the Arab population. The database aims to act as an effective resource for population-scale and sub-population specific variant analyses, enabling a ready reference aiding clinical interpretation of genetic variants, genetic epidemiology, as well as facilitating rapid screening and a quick reference for evaluating evidence on genetic diseases.</p></abstract><funding-group><award-group id="award001"><funding-source><institution>Council of Scientific and Industrial Research, India (IN)</institution></funding-source><award-id>RareGen Grant</award-id><principal-award-recipient><contrib-id authenticated="true" contrib-id-type="orcid">https://orcid.org/0000-0001-7644-7181</contrib-id><name><surname>Scaria</surname><given-names>Vinod</given-names></name></principal-award-recipient></award-group><funding-statement>The work was funded by the Council of Scientific and Industrial Research, India [RareGen Grant]. The funding body had no role in the preparation of the manuscript or decision to publish. AV acknowledges a Senior Research Fellowship from the Indian Council for Medical Research.</funding-statement></funding-group><counts><fig-count count="5"></fig-count><table-count count="1"></table-count><page-count count="14"></page-count></counts><custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name><meta-value>The data used in the analysis is accessible at: <ext-link ext-link-type="uri" xlink:href="https://clingen.igib.res.in/dalia/DALIA_Table.xlsx">https://clingen.igib.res.in/dalia/DALIA_Table.xlsx</ext-link>.</meta-value></custom-meta></custom-meta-group></article-meta><notes><title>Data Availability</title><p>The data used in the analysis is accessible at: <ext-link ext-link-type="uri" xlink:href="https://clingen.igib.res.in/dalia/DALIA_Table.xlsx">https://clingen.igib.res.in/dalia/DALIA_Table.xlsx</ext-link>.</p></notes></front><sub-article id="pone.0244567.r001" article-type="aggregated-review-documents"><front-stub><article-id pub-id-type="doi">10.1371/journal.pone.0244567.r001</article-id><title-group><article-title>Decision Letter 0</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bandapalli</surname><given-names>Obul Reddy</given-names></name><role>Academic Editor</role></contrib></contrib-group><permissions><copyright-statement>© 2021 Obul Reddy Bandapalli</copyright-statement><copyright-year>2021</copyright-year><copyright-holder>Obul Reddy Bandapalli</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><related-article id="rel-obj001" ext-link-type="doi" xlink:href="10.1371/journal.pone.0244567" related-article-type="reviewed-article"></related-article><custom-meta-group><custom-meta><meta-name>Submission Version</meta-name><meta-value>0</meta-value></custom-meta></custom-meta-group></front-stub><body><p><named-content content-type="letter-date">8 Oct 2020</named-content></p><p>PONE-D-20-26943</p><p>DALIA- a Comprehensive Resource of Disease Alleles in Arab Population</p><p>PLOS ONE</p><p>Dear Dr. Scaria,</p><p>Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.</p><p>One of the reviewers raised concerns on the way the population is described and the rationale for this study is not clear. Please make those points clear and also the other points raised by the reviewers. Also explain your reasons for the interpretation that large family size results in genetic disorders. Not clear why that would be the case, and what is the evidence that family sizes are large among Arabs providing supporting references also for the source of information on the population size.</p><p>Please submit your revised manuscript by Nov 22 2020 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at <email>plosone@plos.org</email>. When you're ready to submit your revision, log on to <ext-link ext-link-type="uri" xlink:href="https://www.editorialmanager.com/pone/">https://www.editorialmanager.com/pone/</ext-link> and select the 'Submissions Needing Revision' folder to locate your manuscript file.</p><p>Please include the following items when submitting your revised manuscript:</p><p><list list-type="bullet"><list-item><p>A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'.</p></list-item><list-item><p>A marked-up copy of your manuscript that highlights changes made to the original version. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'.</p></list-item><list-item><p>An unmarked version of your revised paper without tracked changes. You should upload this as a separate file labeled 'Manuscript'.</p></list-item></list></p><p>If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter.</p><p>If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. 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The PLOS ONE style templates can be found at</p><p><ext-link ext-link-type="uri" xlink:href="https://journals.plos.org/plosone/s/file?id=wjVg/PLOSOne_formatting_sample_main_body.pdf">https://journals.plos.org/plosone/s/file?id=wjVg/PLOSOne_formatting_sample_main_body.pdf</ext-link> and</p><p><ext-link ext-link-type="uri" xlink:href="https://journals.plos.org/plosone/s/file?id=ba62/PLOSOne_formatting_sample_title_authors_affiliations.pdf">https://journals.plos.org/plosone/s/file?id=ba62/PLOSOne_formatting_sample_title_authors_affiliations.pdf</ext-link></p><p>[Note: HTML markup is below. Please do not edit.]</p><p>Reviewers' comments:</p><p>Reviewer's Responses to Questions</p><p><bold>Comments to the Author</bold></p><p>1. Is the manuscript technically sound, and do the data support the conclusions?</p><p>The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented. </p><p>Reviewer #1: No</p><p>Reviewer #2: Yes</p><p>**********</p><p>2. Has the statistical analysis been performed appropriately and rigorously? </p><p>Reviewer #1: I Don't Know</p><p>Reviewer #2: Yes</p><p>**********</p><p>3. Have the authors made all data underlying the findings in their manuscript fully available?</p><p>The <ext-link ext-link-type="uri" xlink:href="http://www.plosone.org/static/policies.action#sharing">PLOS Data policy</ext-link> requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.</p><p>Reviewer #1: Yes</p><p>Reviewer #2: Yes</p><p>**********</p><p>4. Is the manuscript presented in an intelligible fashion and written in standard English?</p><p>PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.</p><p>Reviewer #1: No</p><p>Reviewer #2: Yes</p><p>**********</p><p>5. Review Comments to the Author</p><p>Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)</p><p>Reviewer #1: This paper seeks to describe how a comprehensive database for genetic information on Arab populations was formed, and it's characteristics. The rationale for data base need is strong: heavy burden of genetic disorders in the region underscores the need for genome data analyses. However, the purpose of the paper is not clear. The authors need to state with more clarity what the paper aims to do, and why that aim is important for advancing the field. Other details are elaborated below.</p><p>1. There is no source of information in terms of the basic statement that there are twenty-three Arab States with a total population of around 420 million individuals and roughly encompassing 5% of the world population. What are the 23 countries? How is Arab defined?</p><p>2. The authors seem to conflate Arab with Middle Eastern. Need to distinguish Arab from Middle Eastern.</p><p>3. The authors state that large family size results in genetic disorders. Not clear why that would be the case, and what is the evidence that family sizes are large among Arabs?</p><p>4. Supporting information is difficult to make sense of. What does it support and how does that information advance the aims of the paper?</p><p>Reviewer #2: DALIA- a Comprehensive Resource of Disease Alleles in Arab Population by Aastha Vatsyayan et al has compiled and made the resource important for genetic analysis of Arab population.</p><p>It is quite an impressive work done. The features in the database have been incorporated thoughtfully.</p><p>**********</p><p>6. PLOS authors have the option to publish the peer review history of their article (<ext-link ext-link-type="uri" xlink:href="https://journals.plos.org/plosone/s/editorial-and-peer-review-process#loc-peer-review-history">what does this mean?</ext-link>). 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If this link does not appear, there are no attachment files.]</p><p>While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, <ext-link ext-link-type="uri" xlink:href="https://pacev2.apexcovantage.com/">https://pacev2.apexcovantage.com/</ext-link>. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at <email>figures@plos.org</email>. Please note that Supporting Information files do not need this step.</p></body></sub-article><sub-article id="pone.0244567.r002" article-type="author-comment"><front-stub><article-id pub-id-type="doi">10.1371/journal.pone.0244567.r002</article-id><title-group><article-title>Author response to Decision Letter 0</article-title></title-group><related-article id="rel-obj002" ext-link-type="doi" xlink:href="10.1371/journal.pone.0244567" related-article-type="editor-report"></related-article><custom-meta-group><custom-meta><meta-name>Submission Version</meta-name><meta-value>1</meta-value></custom-meta></custom-meta-group></front-stub><body><p><named-content content-type="author-response-date">25 Nov 2020</named-content></p><p>Response to Reviewers</p><p>RESPONSE TO REVIEWER 1</p><p>Reviewer #1: This paper seeks to describe how a comprehensive database for genetic information on Arab populations was formed, and it's characteristics. The rationale for data base need is strong: heavy burden of genetic disorders in the region underscores the need for genome data analyses. However, the purpose of the paper is not clear. The authors need to state with more clarity what the paper aims to do, and why that aim is important for advancing the field. Other details are elaborated below.</p><p>ANS: We thank the reviewers for the prompt review and suggestions. </p><p>The aim of creating the data collection is to provide a ready reference to genetic variants reported from Arab populations. This is relevant as a significant number of genetic variants with clinical implications are not readily curated and available in global databases like ClinVar, which necessitates the creation of focussed and local databases relevant to the populations. The database as its name suggests, encompasses genetic variants reported from the 23 Arab countries. </p><p>1. There is no source of information in terms of the basic statement that there are twenty-three Arab States with a total population of around 420 million individuals and roughly encompassing 5% of the world population. What are the 23 countries? How is Arab defined?</p><p>ANS: We thank the reviewer for asking for the clarifications. The 23 Arab countries are defined as per the Arab League [1]. We have now updated the manuscript with more details as well as relevant citations. </p><p>The Arab League is an alliance of Arab countries that aims to foster cooperation in economics, communication, culture, nationality, social welfare, and health and military affairs among its 22 members, namely: Algeria, Bahrain, the Comoros Islands, Djibouti, Egypt, Iraq, Jordan, Kuwait, Lebanon, Libya, Morocco, Mauritania, Oman, Palestine, Qatar, Saudi Arabia, Somalia, Sudan, Syria, Tunisia, the United Arab Emirates, and Yemen [1–4]. Israel, though not a part of this alliance, has a portion of population that comprises Arabs [5,6], however the exact reported total figures vary. These 23 countries are represented in the DALIA database. Though estimates vary, the Arab League has a population of about 427.87 million people, and is home to about 5.6% of the world population [7,8]. All 22 countries form a part of the Arabic speaking world, as does the Arabic population in Israel.</p><p>2. The authors seem to conflate Arab with Middle Eastern. Need to distinguish Arab from Middle Eastern.</p><p>ANS: We apologise for any confusion regarding this. The data encompasses genetic variants reported in Arab populations. The Allele frequency estimates use the Middle Eastern datasets, as no population scale data for the Arab populations exist in public domain. We have now clarified this in the revised manuscript. </p><p>3. The authors state that large family size results in genetic disorders. Not clear why that would be the case, and what is the evidence that family sizes are large among Arabs?</p><p>ANS: We apologise for the confusion. We have now removed the statement in the revised manuscript and added references wherever appropriate to clarify the statements.</p><p>4. Supporting information is difficult to make sense of. What does it support and how does that information advance the aims of the paper?</p><p>ANS: While the manuscript provides a detailed overview of the DALIA database, The supporting information provides the detailed metrics for the Allele frequencies as well as FST calculations, for the interest of clinicians and genetic epidemiologists with a ready dataset and reference. </p><p>An example of such use would be the analysis of allele frequencies as shown in our paper, in which we compared the variant allele frequencies in Qatar and GME with those in global populations reported in 1000 Genomes and ExAC databases. We obtained 142 statistically significant variants (Fisher’s Exact Test, p-value < 0.01) as a result of this analysis (S1 Fig), 94 of which (Fig 3) were selected for ease of study after applying Bonferroni correction. All significant variants represent potential targets that could be pathogenic for specific populations, and thus make ideal targets for screening in those populations, and consequently for genetic counselling. As evidence, we performed the ACMG annotation of 4 G6PD variants, two of which were found to have evidence to qualify being annotated as pathogenic or likely pathogenic. </p><p>Further, iHS and Fst are two widely used tests to determine positive selection, which can help map changing allele frequencies at population scale. In our work, we found 10 genes that had extreme iHS scores, indicating selection. Each of then 10 plots (Fig 4, S2-S10 Figs) also depicts all known variants along the length of the gene, along with its exon structure. These genes could be linked with diseases of interest - e.g., MEFV is linked to Familial Mediterranean Fever, ABCA4 to Stargardt macular dystrophy [9] and CLDN deafness (OMIM 605608), and would help researchers visualize whether a variant in a positively selected gene is selected, and also lies in the coding region, and what its scores are. </p><p>RESPONSE TO REVIEWER 2</p><p>Reviewer #2: DALIA- a Comprehensive Resource of Disease Alleles in Arab Population by Aastha Vatsyayan et al has compiled and made the resource important for genetic analysis of Arab population.</p><p>It is quite an impressive work done. The features in the database have been incorporated thoughtfully.</p><p>ANS: We thank the reviewer. </p><p>References</p><p>1. The state of health in the Arab world, 1990–2010: an analysis of the burden of diseases, injuries, and risk factors. Lancet. 2014;383: 309–320.</p><p>2. The Arab League. [cited 21 Nov 2020]. Available: <ext-link ext-link-type="uri" xlink:href="https://www.cfr.org/backgrounder/arab-league">https://www.cfr.org/backgrounder/arab-league</ext-link></p><p>3. Geography of the Modern Middle East and North Africa. [cited 21 Nov 2020]. Available: <ext-link ext-link-type="uri" xlink:href="http://www.middleeastpdx.org/resources/original/geography-of-the-modern-middle-east-and-north-africa/">http://www.middleeastpdx.org/resources/original/geography-of-the-modern-middle-east-and-north-africa/</ext-link></p><p>4. Khachfe HH, Refaat MM. Bibliometric analysis of Cardiovascular Disease Research Activity in the Arab World. International Cardiovascular Forum Journal. 2019. doi:10.17987/icfj.v15i0.554</p><p>5. Danial-Farran N, Brownstein Z, Gulsuner S, Tammer L, Khayat M, Aleme O, et al. Genetics of hearing loss in the Arab population of Northern Israel. Eur J Hum Genet. 2018;26: 1840–1847.</p><p>6. Brunstein Klomek A, Nakash O, Goldberger N, Haklai Z, Geraisy N, Yatzkar U, et al. Completed suicide and suicide attempts in the Arab population in Israel. Soc Psychiatry Psychiatr Epidemiol. 2016;51: 869–876.</p><p>7. Arab Countries 2020. [cited 21 Oct 2020]. Available: <ext-link ext-link-type="uri" xlink:href="https://worldpopulationreview.com/country-rankings/arab-countries">https://worldpopulationreview.com/country-rankings/arab-countries</ext-link></p><p>8. Member states of the Arab League. [cited 21 Nov 2020]. Available: <ext-link ext-link-type="uri" xlink:href="https://www.worlddata.info/alliances/arab-league.php">https://www.worlddata.info/alliances/arab-league.php</ext-link></p><p>9. Piccardi M, Fadda A, Martelli F, Marangoni D, Magli A, Minnella AM, et al. Antioxidant Saffron and Central Retinal Function in ABCA4-Related Stargardt Macular Dystrophy. Nutrients. 2019;11. doi:10.3390/nu11102461</p><supplementary-material content-type="local-data" id="pone.0244567.s012"><label>Attachment</label><caption><p>Submitted filename: <named-content content-type="submitted-filename">Response_to_Reviewers_DALIA.docx</named-content></p></caption><media xlink:href="pone.0244567.s012.docx"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material></body></sub-article><sub-article id="pone.0244567.r003" article-type="aggregated-review-documents"><front-stub><article-id pub-id-type="doi">10.1371/journal.pone.0244567.r003</article-id><title-group><article-title>Decision Letter 1</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bandapalli</surname><given-names>Obul Reddy</given-names></name><role>Academic Editor</role></contrib></contrib-group><permissions><copyright-statement>© 2021 Obul Reddy Bandapalli</copyright-statement><copyright-year>2021</copyright-year><copyright-holder>Obul Reddy Bandapalli</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><related-article id="rel-obj003" ext-link-type="doi" xlink:href="10.1371/journal.pone.0244567" related-article-type="reviewed-article"></related-article><custom-meta-group><custom-meta><meta-name>Submission Version</meta-name><meta-value>1</meta-value></custom-meta></custom-meta-group></front-stub><body><p><named-content content-type="letter-date">14 Dec 2020</named-content></p><p>DALIA- A Comprehensive Resource of Disease Alleles in Arab Population</p><p>PONE-D-20-26943R1</p><p>Dear Dr. Scaria,</p><p>We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.</p><p>Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.</p><p>An invoice for payment will follow shortly after the formal acceptance. To ensure an efficient process, please log into Editorial Manager at <ext-link ext-link-type="uri" xlink:href="http://www.editorialmanager.com/pone/">http://www.editorialmanager.com/pone/</ext-link>, click the 'Update My Information' link at the top of the page, and double check that your user information is up-to-date. If you have any billing related questions, please contact our Author Billing department directly at <email>authorbilling@plos.org</email>.</p><p>If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact <email>onepress@plos.org</email>.</p><p>Kind regards,</p><p>Obul Reddy Bandapalli, MSc, PhD</p><p>Academic Editor</p><p>PLOS ONE</p><p>Additional Editor Comments (optional):</p><p>Reviewers' comments:</p><p>Reviewer's Responses to Questions</p><p><bold>Comments to the Author</bold></p><p>1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.</p><p>Reviewer #2: All comments have been addressed</p><p>**********</p><p>2. Is the manuscript technically sound, and do the data support the conclusions?</p><p>The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented. </p><p>Reviewer #2: Yes</p><p>**********</p><p>3. Has the statistical analysis been performed appropriately and rigorously? </p><p>Reviewer #2: Yes</p><p>**********</p><p>4. Have the authors made all data underlying the findings in their manuscript fully available?</p><p>The <ext-link ext-link-type="uri" xlink:href="http://www.plosone.org/static/policies.action#sharing">PLOS Data policy</ext-link> requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.</p><p>Reviewer #2: Yes</p><p>**********</p><p>5. Is the manuscript presented in an intelligible fashion and written in standard English?</p><p>PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.</p><p>Reviewer #2: Yes</p><p>**********</p><p>6. Review Comments to the Author</p><p>Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)</p><p>Reviewer #2: The authors have answered the reviewers concern. No additional comments. Also the data related to database has been included</p><p>**********</p><p>7. PLOS authors have the option to publish the peer review history of their article (<ext-link ext-link-type="uri" xlink:href="https://journals.plos.org/plosone/s/editorial-and-peer-review-process#loc-peer-review-history">what does this mean?</ext-link>). If published, this will include your full peer review and any attached files.</p><p>If you choose “no”, your identity will remain anonymous but your review may still be made public.</p><p><bold>Do you want your identity to be public for this peer review?</bold> For information about this choice, including consent withdrawal, please see our <ext-link ext-link-type="uri" xlink:href="https://www.plos.org/privacy-policy">Privacy Policy</ext-link>.</p><p>Reviewer #2: No</p></body></sub-article><sub-article id="pone.0244567.r004" article-type="editor-report"><front-stub><article-id pub-id-type="doi">10.1371/journal.pone.0244567.r004</article-id><title-group><article-title>Acceptance letter</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bandapalli</surname><given-names>Obul Reddy</given-names></name><role>Academic Editor</role></contrib></contrib-group><permissions><copyright-statement>© 2021 Obul Reddy Bandapalli</copyright-statement><copyright-year>2021</copyright-year><copyright-holder>Obul Reddy Bandapalli</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><related-article id="rel-obj004" ext-link-type="doi" xlink:href="10.1371/journal.pone.0244567" related-article-type="reviewed-article"></related-article></front-stub><body><p><named-content content-type="letter-date">4 Jan 2021</named-content></p><p>PONE-D-20-26943R1 </p><p>DALIA- a Comprehensive Resource of Disease Alleles in Arab Population </p><p>Dear Dr. Scaria:</p><p>I'm pleased to inform you that your manuscript has been deemed suitable for publication in PLOS ONE. Congratulations! Your manuscript is now with our production department. </p><p>If your institution or institutions have a press office, please let them know about your upcoming paper now to help maximize its impact. If they'll be preparing press materials, please inform our press team within the next 48 hours. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information please contact <email>onepress@plos.org</email>.</p><p>If we can help with anything else, please email us at <email>plosone@plos.org</email>. </p><p>Thank you for submitting your work to PLOS ONE and supporting open access. </p><p>Kind regards, </p><p>PLOS ONE Editorial Office Staff</p><p>on behalf of</p><p>Dr. Obul Reddy Bandapalli </p><p>Academic Editor</p><p>PLOS ONE</p></body></sub-article></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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