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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genetic Determinants of Dyslipidemia in African-Based Populations: A Systematic Review</title><author><name sortKey="Noubiap, Jean Jacques" sort="Noubiap, Jean Jacques" uniqKey="Noubiap J" first="Jean Jacques" last="Noubiap">Jean Jacques Noubiap</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Mato, Edith Pascale M" sort="Mato, Edith Pascale M" uniqKey="Mato E" first="Edith Pascale M." last="Mato">Edith Pascale M. Mato</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Guewo Fokeng, Magellan" sort="Guewo Fokeng, Magellan" uniqKey="Guewo Fokeng M" first="Magellan" last="Guewo-Fokeng">Magellan Guewo-Fokeng</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Kaze, Arnaud D" sort="Kaze, Arnaud D" uniqKey="Kaze A" first="Arnaud D." last="Kaze">Arnaud D. Kaze</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Boulenouar, Houssam" sort="Boulenouar, Houssam" uniqKey="Boulenouar H" first="Houssam" last="Boulenouar">Houssam Boulenouar</name><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"></nlm:aff></affiliation><affiliation><nlm:aff id="aff7"></nlm:aff></affiliation></author><author><name sortKey="Wonkam, Ambroise" sort="Wonkam, Ambroise" uniqKey="Wonkam A" first="Ambroise" last="Wonkam">Ambroise Wonkam</name><affiliation><nlm:aff id="aff8"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">30571611</idno><idno type="pmc">7001384</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001384</idno><idno type="RBID">PMC:7001384</idno><idno type="doi">10.1089/omi.2018.0158</idno><date when="2018">2018</date><idno type="wicri:Area/Pmc/Corpus">000293</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000293</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genetic Determinants of Dyslipidemia in African-Based Populations: A Systematic Review</title><author><name sortKey="Noubiap, Jean Jacques" sort="Noubiap, Jean Jacques" uniqKey="Noubiap J" first="Jean Jacques" last="Noubiap">Jean Jacques Noubiap</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Mato, Edith Pascale M" sort="Mato, Edith Pascale M" uniqKey="Mato E" first="Edith Pascale M." last="Mato">Edith Pascale M. Mato</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Guewo Fokeng, Magellan" sort="Guewo Fokeng, Magellan" uniqKey="Guewo Fokeng M" first="Magellan" last="Guewo-Fokeng">Magellan Guewo-Fokeng</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Kaze, Arnaud D" sort="Kaze, Arnaud D" uniqKey="Kaze A" first="Arnaud D." last="Kaze">Arnaud D. Kaze</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Boulenouar, Houssam" sort="Boulenouar, Houssam" uniqKey="Boulenouar H" first="Houssam" last="Boulenouar">Houssam Boulenouar</name><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"></nlm:aff></affiliation><affiliation><nlm:aff id="aff7"></nlm:aff></affiliation></author><author><name sortKey="Wonkam, Ambroise" sort="Wonkam, Ambroise" uniqKey="Wonkam A" first="Ambroise" last="Wonkam">Ambroise Wonkam</name><affiliation><nlm:aff id="aff8"></nlm:aff></affiliation></author></analytic><series><title level="j">OMICS : a Journal of Integrative Biology</title><idno type="ISSN">1536-2310</idno><idno type="eISSN">1557-8100</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Identification of genetic/genomic factors contributing to dyslipidemia is of great interest to prevention and reduction of the onset and burden of cardiovascular diseases in Africa. This systematic review summarizes available data on genetic variants associated with dyslipidemia in populations within Africa. A PubMed and EMBASE database search was conducted to identify all studies published until June 2018 on genetic susceptibility to dyslipidemia in African-based populations, excluding familial hypercholesterolemia. All studies on genetic predispositions of dyslipidemia and respecting the preestablished inclusion criteria were included in this systematic review. Because of high heterogeneity, the data were summarized narratively. Twenty-two studies investigated mostly the targeted genetic variants. A total of 51 polymorphisms in 28 susceptibility genes to dyslipidemia have been associated with a particular trait in the African populations, and through variable effects. Most polymorphisms investigated in Northern Africa seemed to have consistent effects on increasing the level of low-density lipoprotein cholesterol (LDL-C), total cholesterol, and triglycerides in patients with diabetes, myocardial infarction, coronary artery disease, and metabolic syndrome. By contrast, only Ser447Ter and C49620T variants were associated with increased LDL-C in sub-Saharan Africa. Despite few studies available in this context in the literature, certain genetic variants were consistently associated with dyslipidemia especially in Northern Africa as highlighted in this analysis. Further data, particularly from genome-wide association studies, would help establish an African-specific reference for genetic susceptibility markers of dyslipidemia.</p></div></front></TEI><pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">OMICS</journal-id><journal-id journal-id-type="iso-abbrev">OMICS</journal-id><journal-id journal-id-type="publisher-id">omi</journal-id><journal-title-group><journal-title>OMICS : a Journal of Integrative Biology</journal-title></journal-title-group><issn pub-type="ppub">1536-2310</issn><issn pub-type="epub">1557-8100</issn><publisher><publisher-name>Mary Ann Liebert, Inc., publishers</publisher-name><publisher-loc>140 Huguenot Street, 3rd FloorNew Rochelle, NY 10801USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">30571611</article-id><article-id pub-id-type="pmc">7001384</article-id><article-id pub-id-type="publisher-id">10.1089/omi.2018.0158</article-id><article-id pub-id-type="doi">10.1089/omi.2018.0158</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review Articles</subject></subj-group></article-categories><title-group><article-title>Genetic Determinants of Dyslipidemia in African-Based Populations: A Systematic Review</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Noubiap</surname><given-names>Jean Jacques</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="corr1"></xref></contrib><contrib contrib-type="author"><name><surname>Mato</surname><given-names>Edith Pascale M.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Guewo-Fokeng</surname><given-names>Magellan</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kaze</surname><given-names>Arnaud D.</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Boulenouar</surname><given-names>Houssam</given-names></name><xref ref-type="aff" rid="aff5"><sup>5,</sup></xref><xref ref-type="aff" rid="aff6"><sup>6,</sup></xref><xref ref-type="aff" rid="aff7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wonkam</surname><given-names>Ambroise</given-names></name><xref ref-type="aff" rid="aff8"><sup>8</sup></xref></contrib><aff id="aff1"><label><sup>1</sup></label>Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa.</aff><aff id="aff2"><label><sup>2</sup></label>Molecular and Clinical Research Laboratory, Department of Pharmacology, University of Kwazulu-Natal, Durban, South Africa.</aff><aff id="aff3"><label><sup>3</sup></label>Department of Biochemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.</aff><aff id="aff4"><label><sup>4</sup></label>Department of Medicine, University of Maryland Medical Center Midtown Campus, Baltimore, Maryland.</aff><aff id="aff5"><label><sup>5</sup></label>Laboratoire de Génétique Moléculaire et Cellulaire, Université des Sciences et de Technologie d'Oran Mohamed Boudiaf, Oran, Algeria.</aff><aff id="aff6"><label><sup>6</sup></label>Département de Médecine, Faculté de Médecine Dr Benzerdjeb Benaouda, Université Aboubekr Belkaid-Tlemcen, Tlemcen, Algeria.</aff><aff id="aff7"><label><sup>7</sup></label>Laboratoire Cancer Lab No. 30, Faculté de Médecine Dr. Benzerdjeb Benaouda Université Aboubekr Belkaid-Tlemcen, Tlemcen, Algeria.</aff><aff id="aff8"><label><sup>8</sup></label>Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.</aff></contrib-group><author-notes><corresp id="corr1">Address correspondence to: Jean Jacques N. Noubiap, MD, Department of Medicine, University of Cape Town and Groote Schuur Hospital, 7925 Observatory, Cape Town, South Africa <email>noubiapjj@yahoo.fr</email></corresp></author-notes><pub-date pub-type="ppub"><day>01</day><month>12</month><year>2018</year><pmc-comment>string-date: December 2018</pmc-comment>
</pub-date><pub-date pub-type="epub"><day>19</day><month>12</month><year>2018</year></pub-date><volume>22</volume><issue>12</issue><fpage>749</fpage><lpage>758</lpage><permissions><copyright-statement>Copyright 2018, Mary Ann Liebert, Inc., publishers</copyright-statement><copyright-year>2018</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="omi.2018.0158.pdf"></self-uri><abstract><title>Abstract</title><p>Identification of genetic/genomic factors contributing to dyslipidemia is of great interest to prevention and reduction of the onset and burden of cardiovascular diseases in Africa. This systematic review summarizes available data on genetic variants associated with dyslipidemia in populations within Africa. A PubMed and EMBASE database search was conducted to identify all studies published until June 2018 on genetic susceptibility to dyslipidemia in African-based populations, excluding familial hypercholesterolemia. All studies on genetic predispositions of dyslipidemia and respecting the preestablished inclusion criteria were included in this systematic review. Because of high heterogeneity, the data were summarized narratively. Twenty-two studies investigated mostly the targeted genetic variants. A total of 51 polymorphisms in 28 susceptibility genes to dyslipidemia have been associated with a particular trait in the African populations, and through variable effects. Most polymorphisms investigated in Northern Africa seemed to have consistent effects on increasing the level of low-density lipoprotein cholesterol (LDL-C), total cholesterol, and triglycerides in patients with diabetes, myocardial infarction, coronary artery disease, and metabolic syndrome. By contrast, only Ser447Ter and C49620T variants were associated with increased LDL-C in sub-Saharan Africa. Despite few studies available in this context in the literature, certain genetic variants were consistently associated with dyslipidemia especially in Northern Africa as highlighted in this analysis. Further data, particularly from genome-wide association studies, would help establish an African-specific reference for genetic susceptibility markers of dyslipidemia.</p></abstract><kwd-group kwd-group-type="author"><title>Keywords</title><kwd>biomarkers</kwd><kwd>cardiovascular health and disease</kwd><kwd>dyslipidemia</kwd><kwd>genetics</kwd><kwd>genomics</kwd><kwd>polymorphism</kwd><kwd>Africa</kwd></kwd-group><counts><fig-count count="1"></fig-count><table-count count="2"></table-count><ref-count count="53"></ref-count><page-count count="10"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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