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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neuroendocrine Testicular Tumors: A Systematic Review and Meta-Analysis</title><author><name sortKey="Amine, Mseddi M" sort="Amine, Mseddi M" uniqKey="Amine M" first="Mseddi M." last="Amine">Mseddi M. Amine</name><affiliation><nlm:aff id="aff1">Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff></affiliation></author><author><name sortKey="Mohamed, Bouzguenda" sort="Mohamed, Bouzguenda" uniqKey="Mohamed B" first="Bouzguenda" last="Mohamed">Bouzguenda Mohamed</name><affiliation><nlm:aff id="aff2">Faculty of Medicine, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff></affiliation></author><author><name sortKey="Mourad, Hadjslimane" sort="Mourad, Hadjslimane" uniqKey="Mourad H" first="Hadjslimane" last="Mourad">Hadjslimane Mourad</name><affiliation><nlm:aff id="aff1">Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff></affiliation></author><author><name sortKey="Majed, Hamza" sort="Majed, Hamza" uniqKey="Majed H" first="Hamza" last="Majed">Hamza Majed</name><affiliation><nlm:aff id="aff1">Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff></affiliation></author><author><name sortKey="Slim, Charfi" sort="Slim, Charfi" uniqKey="Slim C" first="Charfi" last="Slim">Charfi Slim</name><affiliation><nlm:aff id="aff3">Department of anatomic pathology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff></affiliation></author><author><name sortKey="Mehdi, Bouassida" sort="Mehdi, Bouassida" uniqKey="Mehdi B" first="Bouassida" last="Mehdi">Bouassida Mehdi</name><affiliation><nlm:aff id="aff1">Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff></affiliation></author><author><name sortKey="Hela, Mnif" sort="Hela, Mnif" uniqKey="Hela M" first="Mnif" last="Hela">Mnif Hela</name><affiliation><nlm:aff id="aff3">Department of anatomic pathology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff></affiliation></author><author><name sortKey="Nouri, Rebai" sort="Nouri, Rebai" uniqKey="Nouri R" first="Rebai" last="Nouri">Rebai Nouri</name><affiliation><nlm:aff id="aff1">Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff></affiliation></author><author><name sortKey="Rim, Kallel" sort="Rim, Kallel" uniqKey="Rim K" first="Kallel" last="Rim">Kallel Rim</name><affiliation><nlm:aff id="aff3">Department of anatomic pathology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff></affiliation></author><author><name sortKey="Tahya, Boudaouara" sort="Tahya, Boudaouara" uniqKey="Tahya B" first="Boudaouara" last="Tahya">Boudaouara Tahya</name><affiliation><nlm:aff id="aff3">Department of anatomic pathology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff></affiliation></author><author><name sortKey="Nabil, Mhiri M" sort="Nabil, Mhiri M" uniqKey="Nabil M" first="Mhiri M." last="Nabil">Mhiri M. Nabil</name><affiliation><nlm:aff id="aff1">Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28559773</idno><idno type="pmc">5436018</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436018</idno><idno type="RBID">PMC:5436018</idno><idno type="doi">10.1159/000447146</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000291</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000291</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Neuroendocrine Testicular Tumors: A Systematic Review and Meta-Analysis</title><author><name sortKey="Amine, Mseddi M" sort="Amine, Mseddi M" uniqKey="Amine M" first="Mseddi M." last="Amine">Mseddi M. Amine</name><affiliation><nlm:aff id="aff1">Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff></affiliation></author><author><name sortKey="Mohamed, Bouzguenda" sort="Mohamed, Bouzguenda" uniqKey="Mohamed B" first="Bouzguenda" last="Mohamed">Bouzguenda Mohamed</name><affiliation><nlm:aff id="aff2">Faculty of Medicine, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff></affiliation></author><author><name sortKey="Mourad, Hadjslimane" sort="Mourad, Hadjslimane" uniqKey="Mourad H" first="Hadjslimane" last="Mourad">Hadjslimane Mourad</name><affiliation><nlm:aff id="aff1">Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff></affiliation></author><author><name sortKey="Majed, Hamza" sort="Majed, Hamza" uniqKey="Majed H" first="Hamza" last="Majed">Hamza Majed</name><affiliation><nlm:aff id="aff1">Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff></affiliation></author><author><name sortKey="Slim, Charfi" sort="Slim, Charfi" uniqKey="Slim C" first="Charfi" last="Slim">Charfi Slim</name><affiliation><nlm:aff id="aff3">Department of anatomic pathology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff></affiliation></author><author><name sortKey="Mehdi, Bouassida" sort="Mehdi, Bouassida" uniqKey="Mehdi B" first="Bouassida" last="Mehdi">Bouassida Mehdi</name><affiliation><nlm:aff id="aff1">Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff></affiliation></author><author><name sortKey="Hela, Mnif" sort="Hela, Mnif" uniqKey="Hela M" first="Mnif" last="Hela">Mnif Hela</name><affiliation><nlm:aff id="aff3">Department of anatomic pathology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff></affiliation></author><author><name sortKey="Nouri, Rebai" sort="Nouri, Rebai" uniqKey="Nouri R" first="Rebai" last="Nouri">Rebai Nouri</name><affiliation><nlm:aff id="aff1">Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff></affiliation></author><author><name sortKey="Rim, Kallel" sort="Rim, Kallel" uniqKey="Rim K" first="Kallel" last="Rim">Kallel Rim</name><affiliation><nlm:aff id="aff3">Department of anatomic pathology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff></affiliation></author><author><name sortKey="Tahya, Boudaouara" sort="Tahya, Boudaouara" uniqKey="Tahya B" first="Boudaouara" last="Tahya">Boudaouara Tahya</name><affiliation><nlm:aff id="aff3">Department of anatomic pathology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff></affiliation></author><author><name sortKey="Nabil, Mhiri M" sort="Nabil, Mhiri M" uniqKey="Nabil M" first="Mhiri M." last="Nabil">Mhiri M. Nabil</name><affiliation><nlm:aff id="aff1">Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff></affiliation></author></analytic><series><title level="j">Current Urology</title><idno type="ISSN">1661-7649</idno><idno type="eISSN">1661-7657</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>The purpose of this study is to study the main epidemiological, clinical, para clinical, pathological, therapeutic, and evolutionary features of patients with testicular neuroendocrine tumors (TNET).</p></sec><sec><title>Materials and Methods</title><p>Nine case series and sixteen case reports were identified by searching PubMed database and qualified for inclusion in this study. We added the data of one case treated in the department of urology in Habib Bourguiba Hospital in Sfax, to the published cases.</p></sec><sec><title>Results</title><p>A total of 132 cases were collected. Median age at diagnosis was 39 years old (range 10- 83 years). The most common presenting symptom was either a testicular mass or a swelling in 38.46% of cases. Carcinoid syndrome was documented in 10.60% of patients. The clinical examination revealed a palpable mass in 44.70% of patients. This mass was painless and firm in most cases. Serum tumor markers (β-gonadotrophine chorionique humaine, α-feto protein, and lactate dehydrogenase) were within normal limits in all patients except in one case. Most testicular neuroendocrine tumors (76.52%) were primary and pure. The tumors were positive for chromogranin (100%), synaptophysin (100%) and cytokeratin (93.10%). Metastases were detected at time of diagnosis in eight cases (6.06%). The main treatment was radical orchiectomy performed in 127 patients (96.21%). The 5-year overall survival rate was 78.70% and the 5-year specific survival rate was 84.30%.</p></sec><sec><title>Conclusion</title><p>The diagnosis of testicular carcinoids is based on the immunohistochemistry study. The treatment of choice for these tumors is radical orchiectomy. Somatostatin analogues were reported to be effective in patients with carcinoid syndrome.</p></sec></div></front></TEI><pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Curr Urol</journal-id><journal-id journal-id-type="iso-abbrev">Curr Urol</journal-id><journal-id journal-id-type="publisher-id">CUR</journal-id><journal-title-group><journal-title>Current Urology</journal-title></journal-title-group><issn pub-type="ppub">1661-7649</issn><issn pub-type="epub">1661-7657</issn><publisher><publisher-name>S. Karger AG</publisher-name><publisher-loc>Allschwilerstrasse 10, P.O. Box · Postfach · Case postale, CH–4009, Basel, Switzerland · Schweiz · Suisse, Phone: +41 61 306 11 11, Fax: +41 61 306 12 34, karger@karger.ch</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28559773</article-id><article-id pub-id-type="pmc">5436018</article-id><article-id pub-id-type="doi">10.1159/000447146</article-id><article-id pub-id-type="publisher-id">cur-0010-0015</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Neuroendocrine Testicular Tumors: A Systematic Review and Meta-Analysis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Amine</surname><given-names>Mseddi M.</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mohamed</surname><given-names>Bouzguenda</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mourad</surname><given-names>Hadjslimane</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Majed</surname><given-names>Hamza</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Slim</surname><given-names>Charfi</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mehdi</surname><given-names>Bouassida</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hela</surname><given-names>Mnif</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nouri</surname><given-names>Rebai</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rim</surname><given-names>Kallel</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tahya</surname><given-names>Boudaouara</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nabil</surname><given-names>Mhiri M.</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib></contrib-group><aff id="aff1"><sup>a</sup>Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia</aff><aff id="aff2"><sup>b</sup>Faculty of Medicine, Habib Bourguiba Hospital, Sfax, Tunisia</aff><aff id="aff3"><sup>c</sup>Department of anatomic pathology, Habib Bourguiba Hospital, Sfax, Tunisia</aff><author-notes><corresp id="cor1">*Hamza Majed, Soukra street KM1, 5, 3052, Sfax (Tunisia), E-Mail <email>mojmed@live.fr/majedhamza@gmail.com</email></corresp></author-notes><pub-date pub-type="ppub"><month>4</month><year>2017</year></pub-date><pub-date pub-type="epub"><day>30</day><month>3</month><year>2017</year></pub-date><pub-date pub-type="pmc-release"><day>30</day><month>3</month><year>2017</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>10</volume><issue>1</issue><fpage>15</fpage><lpage>25</lpage><history><date date-type="received"><day>13</day><month>6</month><year>2016</year></date><date date-type="accepted"><day>6</day><month>7</month><year>2016</year></date></history><permissions><copyright-statement>Copyright © 2016 by S. Karger AG, Basel</copyright-statement><copyright-year>2016</copyright-year></permissions><abstract><sec><title>Purpose</title><p>The purpose of this study is to study the main epidemiological, clinical, para clinical, pathological, therapeutic, and evolutionary features of patients with testicular neuroendocrine tumors (TNET).</p></sec><sec><title>Materials and Methods</title><p>Nine case series and sixteen case reports were identified by searching PubMed database and qualified for inclusion in this study. We added the data of one case treated in the department of urology in Habib Bourguiba Hospital in Sfax, to the published cases.</p></sec><sec><title>Results</title><p>A total of 132 cases were collected. Median age at diagnosis was 39 years old (range 10- 83 years). The most common presenting symptom was either a testicular mass or a swelling in 38.46% of cases. Carcinoid syndrome was documented in 10.60% of patients. The clinical examination revealed a palpable mass in 44.70% of patients. This mass was painless and firm in most cases. Serum tumor markers (β-gonadotrophine chorionique humaine, α-feto protein, and lactate dehydrogenase) were within normal limits in all patients except in one case. Most testicular neuroendocrine tumors (76.52%) were primary and pure. The tumors were positive for chromogranin (100%), synaptophysin (100%) and cytokeratin (93.10%). Metastases were detected at time of diagnosis in eight cases (6.06%). The main treatment was radical orchiectomy performed in 127 patients (96.21%). The 5-year overall survival rate was 78.70% and the 5-year specific survival rate was 84.30%.</p></sec><sec><title>Conclusion</title><p>The diagnosis of testicular carcinoids is based on the immunohistochemistry study. The treatment of choice for these tumors is radical orchiectomy. Somatostatin analogues were reported to be effective in patients with carcinoid syndrome.</p></sec></abstract><kwd-group><title>Key Words</title><kwd>Testicular cancer</kwd><kwd>Neuroendocrine tumors</kwd><kwd>Meta-analysis</kwd></kwd-group><counts><fig-count count="5"></fig-count><table-count count="5"></table-count><ref-count count="58"></ref-count><page-count count="11"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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