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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Factor V <styled-content style="fixed-case">L</styled-content>eiden, Prothrombin 20210<styled-content style="fixed-case">G</styled-content>><styled-content style="fixed-case">A</styled-content>, MTHFR 677<styled-content style="fixed-case">C</styled-content>><styled-content style="fixed-case">T</styled-content> and 1298<styled-content style="fixed-case">A</styled-content>><styled-content style="fixed-case">C</styled-content>, and Homocysteinemia in <styled-content style="fixed-case">T</styled-content>unisian Blood Donors</title><author><name sortKey="Hadhri, Samira" sort="Hadhri, Samira" uniqKey="Hadhri S" first="Samira" last="Hadhri">Samira Hadhri</name><affiliation><nlm:aff id="jcla21506-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Rejab, Mohamed Ben" sort="Rejab, Mohamed Ben" uniqKey="Rejab M" first="Mohamed Ben" last="Rejab">Mohamed Ben Rejab</name><affiliation><nlm:aff id="jcla21506-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Guedria, Hajer" sort="Guedria, Hajer" uniqKey="Guedria H" first="Hajer" last="Guedria">Hajer Guedria</name><affiliation><nlm:aff id="jcla21506-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Ifa, Lamia" sort="Ifa, Lamia" uniqKey="Ifa L" first="Lamia" last="Ifa">Lamia Ifa</name><affiliation><nlm:aff id="jcla21506-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Chatti, Noureddine" sort="Chatti, Noureddine" uniqKey="Chatti N" first="Noureddine" last="Chatti">Noureddine Chatti</name><affiliation><nlm:aff id="jcla21506-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Skouri, Hadef" sort="Skouri, Hadef" uniqKey="Skouri H" first="Hadef" last="Skouri">Hadef Skouri</name><affiliation><nlm:aff id="jcla21506-aff-0001"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22628232</idno><idno type="pmc">6807485</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6807485</idno><idno type="RBID">PMC:6807485</idno><idno type="doi">10.1002/jcla.21506</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000134</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000134</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Factor V <styled-content style="fixed-case">L</styled-content>eiden, Prothrombin 20210<styled-content style="fixed-case">G</styled-content>><styled-content style="fixed-case">A</styled-content>, MTHFR 677<styled-content style="fixed-case">C</styled-content>><styled-content style="fixed-case">T</styled-content> and 1298<styled-content style="fixed-case">A</styled-content>><styled-content style="fixed-case">C</styled-content>, and Homocysteinemia in <styled-content style="fixed-case">T</styled-content>unisian Blood Donors</title><author><name sortKey="Hadhri, Samira" sort="Hadhri, Samira" uniqKey="Hadhri S" first="Samira" last="Hadhri">Samira Hadhri</name><affiliation><nlm:aff id="jcla21506-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Rejab, Mohamed Ben" sort="Rejab, Mohamed Ben" uniqKey="Rejab M" first="Mohamed Ben" last="Rejab">Mohamed Ben Rejab</name><affiliation><nlm:aff id="jcla21506-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Guedria, Hajer" sort="Guedria, Hajer" uniqKey="Guedria H" first="Hajer" last="Guedria">Hajer Guedria</name><affiliation><nlm:aff id="jcla21506-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Ifa, Lamia" sort="Ifa, Lamia" uniqKey="Ifa L" first="Lamia" last="Ifa">Lamia Ifa</name><affiliation><nlm:aff id="jcla21506-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Chatti, Noureddine" sort="Chatti, Noureddine" uniqKey="Chatti N" first="Noureddine" last="Chatti">Noureddine Chatti</name><affiliation><nlm:aff id="jcla21506-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Skouri, Hadef" sort="Skouri, Hadef" uniqKey="Skouri H" first="Hadef" last="Skouri">Hadef Skouri</name><affiliation><nlm:aff id="jcla21506-aff-0001"></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Clinical Laboratory Analysis</title><idno type="ISSN">0887-8013</idno><idno type="eISSN">1098-2825</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Specific genetic conditions are known to be associated with high risk of venous thromboembolism. This genetic basis varies widely between ethnic groups. We investigated the distribution of four inherited polymorphisms in 113 unselected <styled-content style="fixed-case">T</styled-content>unisian blood donors by using polymerase chain reaction‐restriction fragment length polymorphism (<styled-content style="fixed-case">PCR</styled-content>‐<styled-content style="fixed-case">RFLP</styled-content>) method. The allele frequencies of Factor V <styled-content style="fixed-case">L</styled-content>eiden (<styled-content style="fixed-case">FVL</styled-content>), prothrombin 20210G><styled-content style="fixed-case">A</styled-content>, methylenetetrahydrofolate reductase (<styled-content style="fixed-case">MTHFR</styled-content>) 677<styled-content style="fixed-case">C</styled-content>><styled-content style="fixed-case">T</styled-content>, and <styled-content style="fixed-case">MTHFR</styled-content> 1298<styled-content style="fixed-case">A</styled-content>><styled-content style="fixed-case">C</styled-content> mutations were 3, 0.9, 30, and 31%, respectively. The <styled-content style="fixed-case">MTHFR</styled-content> 677<styled-content style="fixed-case">C</styled-content>><styled-content style="fixed-case">T</styled-content> polymorphism was influenced by age. Twenty‐nine of the 113 blood donors demonstrated more than one genetic markers. Hyperhomocysteinemia was found in 12 subjects, and it was statistically associated to the <styled-content style="fixed-case">MTHFR</styled-content> 677<styled-content style="fixed-case">TT</styled-content> genotype. Principal component analysis allowed disclosing the resemblance between <styled-content style="fixed-case">M</styled-content>editerranean populations. Our findings may be helpful for population genetics study, and provide epidemiologic database for further studies in thrombosis field among <styled-content style="fixed-case">T</styled-content>unisians. J. Clin. Lab. Anal. 26:167‐173, 2012. © 2012 Wiley Periodicals, Inc.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Lab Anal</journal-id><journal-id journal-id-type="iso-abbrev">J. Clin. Lab. Anal</journal-id><journal-id journal-id-type="doi">10.1002/(ISSN)1098-2825</journal-id><journal-id journal-id-type="publisher-id">JCLA</journal-id><journal-title-group><journal-title>Journal of Clinical Laboratory Analysis</journal-title></journal-title-group><issn pub-type="ppub">0887-8013</issn><issn pub-type="epub">1098-2825</issn><publisher><publisher-name>John Wiley and Sons Inc.</publisher-name><publisher-loc>Hoboken</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22628232</article-id><article-id pub-id-type="pmc">6807485</article-id><article-id pub-id-type="doi">10.1002/jcla.21506</article-id><article-id pub-id-type="publisher-id">JCLA21506</article-id><article-categories><subj-group subj-group-type="overline"><subject>Research Article</subject></subj-group><subj-group subj-group-type="heading"><subject>Research Articles</subject></subj-group></article-categories><title-group><article-title>Factor V <styled-content style="fixed-case">L</styled-content>eiden, Prothrombin 20210<styled-content style="fixed-case">G</styled-content>><styled-content style="fixed-case">A</styled-content>, MTHFR 677<styled-content style="fixed-case">C</styled-content>><styled-content style="fixed-case">T</styled-content> and 1298<styled-content style="fixed-case">A</styled-content>><styled-content style="fixed-case">C</styled-content>, and Homocysteinemia in <styled-content style="fixed-case">T</styled-content>unisian Blood Donors</article-title><alt-title alt-title-type="left-running-head">Hadhri et al.</alt-title><alt-title alt-title-type="right-running-head">Inherited Thrombophilia in Tunisia</alt-title></title-group><contrib-group><contrib id="jcla21506-cr-0001" contrib-type="author"><name><surname>Hadhri</surname><given-names>Samira</given-names></name><xref ref-type="aff" rid="jcla21506-aff-0001"><sup>1</sup></xref></contrib><contrib id="jcla21506-cr-0002" contrib-type="author"><name><surname>Rejab</surname><given-names>Mohamed Ben</given-names></name><xref ref-type="aff" rid="jcla21506-aff-0002"><sup>2</sup></xref></contrib><contrib id="jcla21506-cr-0003" contrib-type="author"><name><surname>Guedria</surname><given-names>Hajer</given-names></name><xref ref-type="aff" rid="jcla21506-aff-0001"><sup>1</sup></xref></contrib><contrib id="jcla21506-cr-0004" contrib-type="author"><name><surname>Ifa</surname><given-names>Lamia</given-names></name><xref ref-type="aff" rid="jcla21506-aff-0001"><sup>1</sup></xref></contrib><contrib id="jcla21506-cr-0005" contrib-type="author"><name><surname>Chatti</surname><given-names>Noureddine</given-names></name><xref ref-type="aff" rid="jcla21506-aff-0003"><sup>3</sup></xref></contrib><contrib id="jcla21506-cr-0006" contrib-type="author" corresp="yes"><name><surname>Skouri</surname><given-names>Hadef</given-names></name><xref ref-type="aff" rid="jcla21506-aff-0001"><sup>1</sup></xref></contrib></contrib-group><aff id="jcla21506-aff-0001"><label><sup>1</sup></label><institution>Laboratoire d'Hématologie et Banque du Sang</institution><named-content content-type="city">CHU Sahloul</named-content><named-content content-type="country-part">Sousse</named-content><country country="TN">Tunisia</country></aff><aff id="jcla21506-aff-0002"><label><sup>2</sup></label><institution>Laboratoire d'Hygiène Hospitalière CHU Sahloul</institution><named-content content-type="city">Sousse</named-content><country country="TN">Tunisia</country></aff><aff id="jcla21506-aff-0003"><label><sup>3</sup></label><institution>Institut Supérieur de Biotechnologie</institution><named-content content-type="city">Monastir</named-content><country country="TN">Tunisia</country></aff><author-notes><corresp id="correspondenceTo"><label>*</label>Correspondence to: Hadef Skouri, Laboratoire d'Hématologie et Banque du Sang, CHU Sahloul, 4000 Sousse, Tunisie. E‐Mail: <email>hadef.skouri@rns.tn</email></corresp></author-notes><pub-date pub-type="epub"><day>24</day><month>5</month><year>2012</year></pub-date><pub-date pub-type="collection"><month>5</month><year>2012</year></pub-date><volume>26</volume><issue>3</issue><issue-id pub-id-type="doi">10.1002/jcla.2012.26.issue-3</issue-id><fpage>167</fpage><lpage>173</lpage><history><date date-type="received"><day>02</day><month>11</month><year>2011</year></date><date date-type="accepted"><day>24</day><month>2</month><year>2012</year></date></history><permissions><pmc-comment> © 2012 Wiley Periodicals, Inc. </pmc-comment>
<copyright-statement content-type="article-copyright">© 2012 Wiley Periodicals, Inc.</copyright-statement></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="file:JCLA-26-167.pdf"></self-uri><abstract><p>Specific genetic conditions are known to be associated with high risk of venous thromboembolism. This genetic basis varies widely between ethnic groups. We investigated the distribution of four inherited polymorphisms in 113 unselected <styled-content style="fixed-case">T</styled-content>unisian blood donors by using polymerase chain reaction‐restriction fragment length polymorphism (<styled-content style="fixed-case">PCR</styled-content>‐<styled-content style="fixed-case">RFLP</styled-content>) method. The allele frequencies of Factor V <styled-content style="fixed-case">L</styled-content>eiden (<styled-content style="fixed-case">FVL</styled-content>), prothrombin 20210G><styled-content style="fixed-case">A</styled-content>, methylenetetrahydrofolate reductase (<styled-content style="fixed-case">MTHFR</styled-content>) 677<styled-content style="fixed-case">C</styled-content>><styled-content style="fixed-case">T</styled-content>, and <styled-content style="fixed-case">MTHFR</styled-content> 1298<styled-content style="fixed-case">A</styled-content>><styled-content style="fixed-case">C</styled-content> mutations were 3, 0.9, 30, and 31%, respectively. The <styled-content style="fixed-case">MTHFR</styled-content> 677<styled-content style="fixed-case">C</styled-content>><styled-content style="fixed-case">T</styled-content> polymorphism was influenced by age. Twenty‐nine of the 113 blood donors demonstrated more than one genetic markers. Hyperhomocysteinemia was found in 12 subjects, and it was statistically associated to the <styled-content style="fixed-case">MTHFR</styled-content> 677<styled-content style="fixed-case">TT</styled-content> genotype. Principal component analysis allowed disclosing the resemblance between <styled-content style="fixed-case">M</styled-content>editerranean populations. Our findings may be helpful for population genetics study, and provide epidemiologic database for further studies in thrombosis field among <styled-content style="fixed-case">T</styled-content>unisians. J. Clin. Lab. Anal. 26:167‐173, 2012. © 2012 Wiley Periodicals, Inc.</p></abstract><kwd-group kwd-group-type="author-generated"><kwd id="jcla21506-kwd-0001">Factor V gene</kwd><kwd id="jcla21506-kwd-0002">prothrombin gene</kwd><kwd id="jcla21506-kwd-0003">methylenetetrahydrofolate reductase</kwd><kwd id="jcla21506-kwd-0004">homocysteine</kwd><kwd id="jcla21506-kwd-0005"><styled-content style="fixed-case">T</styled-content>unisia</kwd></kwd-group><counts><page-count count="7"></page-count></counts><custom-meta-group><custom-meta><meta-name>source-schema-version-number</meta-name><meta-value>2.0</meta-value></custom-meta><custom-meta><meta-name>component-id</meta-name><meta-value>JCLA21506</meta-value></custom-meta><custom-meta><meta-name>cover-date</meta-name><meta-value>May 2012</meta-value></custom-meta><custom-meta><meta-name>details-of-publishers-convertor</meta-name><meta-value>Converter:WILEY_ML3GV2_TO_NLMPMC version:5.7.0 mode:remove_FC converted:23.10.2019</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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