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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ethylzingerone, a Novel Compound with Antifungal Activity</title><author><name sortKey="Rossignol, Tristan" sort="Rossignol, Tristan" uniqKey="Rossignol T" first="Tristan" last="Rossignol">Tristan Rossignol</name><affiliation><nlm:aff id="aff1"><addr-line>Unité Biologie et Pathogénicité Fongiques, USC2019 INRA, Institut Pasteur, Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Znaidi, Sadri" sort="Znaidi, Sadri" uniqKey="Znaidi S" first="Sadri" last="Znaidi">Sadri Znaidi</name><affiliation><nlm:aff id="aff1"><addr-line>Unité Biologie et Pathogénicité Fongiques, USC2019 INRA, Institut Pasteur, Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><addr-line>Laboratoire de Microbiologie Moléculaire, Vaccinologie et Développement Biotechnologique, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis-Belvédère, Tunisia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chauvel, Murielle" sort="Chauvel, Murielle" uniqKey="Chauvel M" first="Murielle" last="Chauvel">Murielle Chauvel</name><affiliation><nlm:aff id="aff1"><addr-line>Unité Biologie et Pathogénicité Fongiques, USC2019 INRA, Institut Pasteur, Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wesgate, Rebecca" sort="Wesgate, Rebecca" uniqKey="Wesgate R" first="Rebecca" last="Wesgate">Rebecca Wesgate</name><affiliation><nlm:aff id="aff3"><addr-line>Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Decourty, Laurence" sort="Decourty, Laurence" uniqKey="Decourty L" first="Laurence" last="Decourty">Laurence Decourty</name><affiliation><nlm:aff id="aff4"><addr-line>Unité Génétique des Interactions Macromoléculaires, UMR3525 CNRS, Institut Pasteur, Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Menard Szczebara, Florence" sort="Menard Szczebara, Florence" uniqKey="Menard Szczebara F" first="Florence" last="Menard-Szczebara">Florence Menard-Szczebara</name><affiliation><nlm:aff id="aff5"><addr-line>L’Oréal Research and Innovation, Aulnay sous Bois, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cupferman, Sylvie" sort="Cupferman, Sylvie" uniqKey="Cupferman S" first="Sylvie" last="Cupferman">Sylvie Cupferman</name><affiliation><nlm:aff id="aff5"><addr-line>L’Oréal Research and Innovation, Aulnay sous Bois, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dalko Sciba, Maria" sort="Dalko Sciba, Maria" uniqKey="Dalko Sciba M" first="Maria" last="Dalko-Sciba">Maria Dalko-Sciba</name><affiliation><nlm:aff id="aff5"><addr-line>L’Oréal Research and Innovation, Aulnay sous Bois, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Barnes, Rosemary" sort="Barnes, Rosemary" uniqKey="Barnes R" first="Rosemary" last="Barnes">Rosemary Barnes</name><affiliation><nlm:aff id="aff6"><addr-line>University Hospital of Wales, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Maillard, Jean Yves" sort="Maillard, Jean Yves" uniqKey="Maillard J" first="Jean-Yves" last="Maillard">Jean-Yves Maillard</name><affiliation><nlm:aff id="aff6"><addr-line>University Hospital of Wales, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Saveanu, Cosmin" sort="Saveanu, Cosmin" uniqKey="Saveanu C" first="Cosmin" last="Saveanu">Cosmin Saveanu</name><affiliation><nlm:aff id="aff4"><addr-line>Unité Génétique des Interactions Macromoléculaires, UMR3525 CNRS, Institut Pasteur, Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="D Nfert, Christophe" sort="D Nfert, Christophe" uniqKey="D Nfert C" first="Christophe" last="D Nfert">Christophe D Nfert</name><affiliation><nlm:aff id="aff1"><addr-line>Unité Biologie et Pathogénicité Fongiques, USC2019 INRA, Institut Pasteur, Paris, France</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">33468481</idno><idno type="pmc">8097443</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097443</idno><idno type="RBID">PMC:8097443</idno><idno type="doi">10.1128/AAC.02711-20</idno><date when="2021">2021</date><idno type="wicri:Area/Pmc/Corpus">000130</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000130</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Ethylzingerone, a Novel Compound with Antifungal Activity</title><author><name sortKey="Rossignol, Tristan" sort="Rossignol, Tristan" uniqKey="Rossignol T" first="Tristan" last="Rossignol">Tristan Rossignol</name><affiliation><nlm:aff id="aff1"><addr-line>Unité Biologie et Pathogénicité Fongiques, USC2019 INRA, Institut Pasteur, Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Znaidi, Sadri" sort="Znaidi, Sadri" uniqKey="Znaidi S" first="Sadri" last="Znaidi">Sadri Znaidi</name><affiliation><nlm:aff id="aff1"><addr-line>Unité Biologie et Pathogénicité Fongiques, USC2019 INRA, Institut Pasteur, Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><addr-line>Laboratoire de Microbiologie Moléculaire, Vaccinologie et Développement Biotechnologique, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis-Belvédère, Tunisia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chauvel, Murielle" sort="Chauvel, Murielle" uniqKey="Chauvel M" first="Murielle" last="Chauvel">Murielle Chauvel</name><affiliation><nlm:aff id="aff1"><addr-line>Unité Biologie et Pathogénicité Fongiques, USC2019 INRA, Institut Pasteur, Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wesgate, Rebecca" sort="Wesgate, Rebecca" uniqKey="Wesgate R" first="Rebecca" last="Wesgate">Rebecca Wesgate</name><affiliation><nlm:aff id="aff3"><addr-line>Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Decourty, Laurence" sort="Decourty, Laurence" uniqKey="Decourty L" first="Laurence" last="Decourty">Laurence Decourty</name><affiliation><nlm:aff id="aff4"><addr-line>Unité Génétique des Interactions Macromoléculaires, UMR3525 CNRS, Institut Pasteur, Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Menard Szczebara, Florence" sort="Menard Szczebara, Florence" uniqKey="Menard Szczebara F" first="Florence" last="Menard-Szczebara">Florence Menard-Szczebara</name><affiliation><nlm:aff id="aff5"><addr-line>L’Oréal Research and Innovation, Aulnay sous Bois, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cupferman, Sylvie" sort="Cupferman, Sylvie" uniqKey="Cupferman S" first="Sylvie" last="Cupferman">Sylvie Cupferman</name><affiliation><nlm:aff id="aff5"><addr-line>L’Oréal Research and Innovation, Aulnay sous Bois, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Dalko Sciba, Maria" sort="Dalko Sciba, Maria" uniqKey="Dalko Sciba M" first="Maria" last="Dalko-Sciba">Maria Dalko-Sciba</name><affiliation><nlm:aff id="aff5"><addr-line>L’Oréal Research and Innovation, Aulnay sous Bois, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Barnes, Rosemary" sort="Barnes, Rosemary" uniqKey="Barnes R" first="Rosemary" last="Barnes">Rosemary Barnes</name><affiliation><nlm:aff id="aff6"><addr-line>University Hospital of Wales, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Maillard, Jean Yves" sort="Maillard, Jean Yves" uniqKey="Maillard J" first="Jean-Yves" last="Maillard">Jean-Yves Maillard</name><affiliation><nlm:aff id="aff6"><addr-line>University Hospital of Wales, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff></affiliation></author><author><name sortKey="Saveanu, Cosmin" sort="Saveanu, Cosmin" uniqKey="Saveanu C" first="Cosmin" last="Saveanu">Cosmin Saveanu</name><affiliation><nlm:aff id="aff4"><addr-line>Unité Génétique des Interactions Macromoléculaires, UMR3525 CNRS, Institut Pasteur, Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="D Nfert, Christophe" sort="D Nfert, Christophe" uniqKey="D Nfert C" first="Christophe" last="D Nfert">Christophe D Nfert</name><affiliation><nlm:aff id="aff1"><addr-line>Unité Biologie et Pathogénicité Fongiques, USC2019 INRA, Institut Pasteur, Paris, France</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">Antimicrobial Agents and Chemotherapy</title><idno type="ISSN">0066-4804</idno><idno type="eISSN">1098-6596</idno><imprint><date when="2021">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Preservatives increase the shelf life of cosmetic products by preventing growth of contaminating microbes, including bacteria and fungi. In recent years, the Scientific Committee on Consumer Safety (SCCS) has recommended the ban or restricted use of a number of preservatives due to safety concerns.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Antimicrob Agents Chemother</journal-id><journal-id journal-id-type="iso-abbrev">Antimicrob Agents Chemother</journal-id><journal-id journal-id-type="hwp">aac</journal-id><journal-id journal-id-type="pmc">aac</journal-id><journal-id journal-id-type="publisher-id">AAC</journal-id><journal-title-group><journal-title>Antimicrobial Agents and Chemotherapy</journal-title></journal-title-group><issn pub-type="ppub">0066-4804</issn><issn pub-type="epub">1098-6596</issn><publisher><publisher-name>American Society for Microbiology</publisher-name><publisher-loc>1752 N St., N.W., Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">33468481</article-id><article-id pub-id-type="pmc">8097443</article-id><article-id pub-id-type="publisher-id">02711-20</article-id><article-id pub-id-type="doi">10.1128/AAC.02711-20</article-id><article-categories><subj-group subj-group-type="heading"><subject>Mechanisms of Action: Physiological Effects</subject></subj-group></article-categories><title-group><article-title>Ethylzingerone, a Novel Compound with Antifungal Activity</article-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Rossignol</surname><given-names>Tristan</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="author-notes" rid="fn1">*</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><contrib-id contrib-id-type="orcid" authenticated="false">https://orcid.org/0000-0001-9238-2218</contrib-id><name><surname>Znaidi</surname><given-names>Sadri</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author" equal-contrib="no"><name><surname>Chauvel</surname><given-names>Murielle</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author" equal-contrib="no"><name><surname>Wesgate</surname><given-names>Rebecca</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author" equal-contrib="no"><name><surname>Decourty</surname><given-names>Laurence</given-names></name><xref ref-type="aff" rid="aff4"><sup>d</sup></xref></contrib><contrib contrib-type="author" equal-contrib="no"><name><surname>Menard-Szczebara</surname><given-names>Florence</given-names></name><xref ref-type="aff" rid="aff5"><sup>e</sup></xref></contrib><contrib contrib-type="author" corresp="yes" equal-contrib="no"><name><surname>Cupferman</surname><given-names>Sylvie</given-names></name><xref ref-type="aff" rid="aff5"><sup>e</sup></xref></contrib><contrib contrib-type="author" equal-contrib="no"><name><surname>Dalko-Sciba</surname><given-names>Maria</given-names></name><xref ref-type="aff" rid="aff5"><sup>e</sup></xref></contrib><contrib contrib-type="author" equal-contrib="no"><name><surname>Barnes</surname><given-names>Rosemary</given-names></name><xref ref-type="aff" rid="aff6"><sup>f</sup></xref></contrib><contrib contrib-type="author" equal-contrib="no"><contrib-id contrib-id-type="orcid" authenticated="false">https://orcid.org/0000-0002-8617-9288</contrib-id><name><surname>Maillard</surname><given-names>Jean-Yves</given-names></name><xref ref-type="aff" rid="aff6"><sup>f</sup></xref></contrib><contrib contrib-type="author" equal-contrib="no"><name><surname>Saveanu</surname><given-names>Cosmin</given-names></name><xref ref-type="aff" rid="aff4"><sup>d</sup></xref></contrib><contrib contrib-type="author" corresp="yes" equal-contrib="no"><contrib-id contrib-id-type="orcid" authenticated="false">https://orcid.org/0000-0002-6235-3886</contrib-id><name><surname>d’Enfert</surname><given-names>Christophe</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><aff id="aff1"><label>a</label><addr-line>Unité Biologie et Pathogénicité Fongiques, USC2019 INRA, Institut Pasteur, Paris, France</addr-line></aff><aff id="aff2"><label>b</label><addr-line>Laboratoire de Microbiologie Moléculaire, Vaccinologie et Développement Biotechnologique, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis-Belvédère, Tunisia</addr-line></aff><aff id="aff3"><label>c</label><addr-line>Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, United Kingdom</addr-line></aff><aff id="aff4"><label>d</label><addr-line>Unité Génétique des Interactions Macromoléculaires, UMR3525 CNRS, Institut Pasteur, Paris, France</addr-line></aff><aff id="aff5"><label>e</label><addr-line>L’Oréal Research and Innovation, Aulnay sous Bois, France</addr-line></aff><aff id="aff6"><label>f</label><addr-line>University Hospital of Wales, Cardiff University, Cardiff, United Kingdom</addr-line></aff></contrib-group><author-notes><corresp id="cor1">Address correspondence to Sylvie Cupferman, <email>sylvie.cupferman@rd.loreal.com</email>, or Christophe d’Enfert, <email>christophe.denfert@pasteur.fr</email>.</corresp><fn id="fn1" fn-type="present-address"><label>*</label><p>Present address: Tristan Rossignol, Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France.</p></fn><fn fn-type="equal"><p>Tristan Rossignol and Sadri Znaidi contributed equally to this work. Author order was determined alphabetically.</p></fn><fn fn-type="other"><p><bold>Citation</bold> Rossignol T, Znaidi S, Chauvel M, Wesgate R, Decourty L, Menard-Szczebara F, Cupferman S, Dalko-Sciba M, Barnes R, Maillard J-Y, Saveanu C, d’Enfert C. 2021. Ethylzingerone, a novel compound with antifungal activity. Antimicrob Agents Chemother 65:e02711-20. <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1128/AAC.02711-20">https://doi.org/10.1128/AAC.02711-20</ext-link>.</p></fn></author-notes><pub-date pub-type="epreprint"><day>19</day><month>1</month><year>2021</year></pub-date><pub-date pub-type="epub"><day>18</day><month>3</month><year>2021</year></pub-date><pub-date pub-type="collection"><month>4</month><year>2021</year></pub-date><volume>65</volume><issue>4</issue><elocation-id>e02711-20</elocation-id><history><date date-type="received"><day>4</day><month>1</month><year>2021</year></date><date date-type="accepted"><day>4</day><month>1</month><year>2021</year></date></history><permissions><copyright-statement>Copyright © 2021 American Society for Microbiology.</copyright-statement><copyright-year>2021</copyright-year><copyright-holder>American Society for Microbiology</copyright-holder><license><ali:license_ref>https://doi.org/10.1128/ASMCopyrightv1</ali:license_ref><license-p><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1128/ASMCopyrightv1">All Rights Reserved</ext-link>.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="AAC.02711-20.pdf"></self-uri><abstract abstract-type="precis"><p>Preservatives increase the shelf life of cosmetic products by preventing growth of contaminating microbes, including bacteria and fungi. In recent years, the Scientific Committee on Consumer Safety (SCCS) has recommended the ban or restricted use of a number of preservatives due to safety concerns.</p></abstract><abstract><title>ABSTRACT</title><p>Preservatives increase the shelf life of cosmetic products by preventing growth of contaminating microbes, including bacteria and fungi. In recent years, the Scientific Committee on Consumer Safety (SCCS) has recommended the ban or restricted use of a number of preservatives due to safety concerns. Here, we characterize the antifungal activity of ethylzingerone (hydroxyethoxyphenyl butanone [HEPB]), an SCCS-approved new preservative for use in rinse-off, oral care, and leave-on cosmetic products. We show that HEPB significantly inhibits growth of <named-content content-type="genus-species">Candida albicans</named-content>, <named-content content-type="genus-species">Candida glabrata</named-content>, and <named-content content-type="genus-species">Saccharomyces cerevisiae</named-content>, acting fungicidally against <named-content content-type="genus-species">C. albicans</named-content>. Using transcript profiling experiments, we found that the <named-content content-type="genus-species">C. albicans</named-content> transcriptome responded to HEPB exposure by increasing the expression of genes involved in amino acid biosynthesis while activating pathways involved in chemical detoxification/oxidative stress response. Comparative analyses revealed that <named-content content-type="genus-species">C. albicans</named-content> phenotypic and transcriptomic responses to HEPB treatment were distinguishable from those of two widely used preservatives, triclosan and methylparaben. Chemogenomic analyses, using a barcoded <named-content content-type="genus-species">S. cerevisiae</named-content> nonessential mutant library, revealed that HEPB antifungal activity strongly interfered with the biosynthesis of aromatic amino acids. The <italic>trp1</italic>Δ mutants in <named-content content-type="genus-species">S. cerevisiae</named-content> and <named-content content-type="genus-species">C. albicans</named-content> were particularly sensitive to HEPB treatment, a phenotype rescued by exogenous addition of tryptophan to the growth medium, providing a direct link between HEPB mode of action and tryptophan availability. Collectively, our study sheds light on the antifungal activity of HEPB, a new molecule with safe properties for use as a preservative in the cosmetic industry, and exemplifies the powerful use of functional genomics to illuminate the mode of action of antimicrobial agents.</p></abstract><kwd-group><title>KEYWORDS</title><kwd>cosmetics</kwd><kwd>ethylzingerone</kwd><kwd>hydroxyethoxyphenyl butanone</kwd><kwd>HEPB</kwd><kwd>antifungal</kwd><kwd>mechanism of action</kwd><kwd><italic>Candida albicans</italic></kwd></kwd-group><funding-group><award-group id="award1"><funding-source><institution-wrap><institution>L'Oréal</institution></institution-wrap></funding-source><principal-award-recipient><name><surname>Saveanu</surname><given-names>Cosmin</given-names></name></principal-award-recipient><principal-award-recipient><name><surname>Maillard</surname><given-names>Jean-Yves</given-names></name></principal-award-recipient><principal-award-recipient><name><surname>d’Enfert</surname><given-names>Christophe</given-names></name></principal-award-recipient></award-group><award-group id="award2"><funding-source><institution-wrap><institution>Institut Pasteur International Network</institution></institution-wrap></funding-source><principal-award-recipient><name><surname>Znaidi</surname><given-names>Sadri</given-names></name></principal-award-recipient></award-group><award-group id="award3"><funding-source><institution-wrap><institution>Agence Nationale de la Recherche (ANR)</institution><institution-id>https://doi.org/10.13039/501100001665</institution-id></institution-wrap></funding-source><award-id>ANR-10-LABX-62-IBEID</award-id><principal-award-recipient><name><surname>d’Enfert</surname><given-names>Christophe</given-names></name></principal-award-recipient></award-group><award-group id="award4"><funding-source><institution-wrap><institution>Agence Nationale de la Recherche (ANR)</institution><institution-id>https://doi.org/10.13039/501100001665</institution-id></institution-wrap></funding-source><award-id>ANR-08-JCJC-0019-01/GENO-GIM</award-id><principal-award-recipient><name><surname>Saveanu</surname><given-names>Cosmin</given-names></name></principal-award-recipient></award-group></funding-group><counts><fig-count count="7"></fig-count><table-count count="2"></table-count><equation-count count="0"></equation-count><ref-count count="62"></ref-count><page-count count="17"></page-count><word-count count="10816"></word-count></counts><custom-meta-group><custom-meta><meta-name>cover-date</meta-name><meta-value>April 2021</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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