Statin therapy in athletes and patients performing regular intense exercise - Position paper from the International Lipid Expert Panel (ILEP).
Identifieur interne : 000653 ( Main/Merge ); précédent : 000652; suivant : 000654Statin therapy in athletes and patients performing regular intense exercise - Position paper from the International Lipid Expert Panel (ILEP).
Auteurs : Niki Katsiki [Grèce] ; Dimitri P. Mikhailidis [Royaume-Uni] ; Gani Bajraktari [Suède] ; Andre R. Miserez [Suisse] ; Arrigo F G. Cicero [Italie] ; Eric Bruckert [France] ; Maria-Corina Serban [Roumanie] ; Erkin Mirrakhimov [Kirghizistan] ; Fahad Alnouri [Arabie saoudite] ; Željko Reiner [Croatie] ; György Paragh [Hongrie] ; Amirhossein Sahebkar [Iran] ; Maciej Banach [Pologne]Source :
- Pharmacological research [ 1096-1186 ] ; 2020.
Descripteurs français
- KwdFr :
- Athlètes (MeSH), Consensus (MeSH), Dyslipidémies (traitement médicamenteux), Exercice physique (MeSH), Humains (MeSH), Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase (effets indésirables), Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase (usage thérapeutique), Maladies musculaires (induit chimiquement).
- MESH :
- effets indésirables : Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase.
- induit chimiquement : Maladies musculaires.
- traitement médicamenteux : Dyslipidémies.
- usage thérapeutique : Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase.
- Athlètes, Consensus, Exercice physique, Humains.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Hydroxymethylglutaryl-CoA Reductase Inhibitors.
- chemically induced : Muscular Diseases.
- drug therapy : Dyslipidemias.
- chemical , therapeutic use : Hydroxymethylglutaryl-CoA Reductase Inhibitors.
- Athletes, Consensus, Exercise, Humans.
Abstract
Acute and chronic physical exercises may enhance the development of statin-related myopathy. In this context, the recent (2019) guidelines of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) for the management of dyslipidemias recommend that, although individuals with dyslipidemia should be advised to engage in regular moderate physical exercise (for at least 30 min daily), physicians should be alerted with regard to myopathy and creatine kinase (CK) elevation in statin-treated sport athletes. However it is worth emphasizing that abovementioned guidelines, previous and recent ESC/EAS consensus papers on adverse effects of statin therapy as well as other previous attempts on this issue, including the ones from the International Lipid Expert Panel (ILEP), give only general recommendations on how to manage patients requiring statin therapy on regular exercises. Therefore, these guidelines in the form of the Position Paper are the first such an attempt to summary existing, often scarce knowledge, and to present this important issue in the form of step-by-step practical recommendations. It is critically important as we might observe more and more individuals on regular exercises/athletes requiring statin therapy due to their cardiovascular risk.
DOI: 10.1016/j.phrs.2020.104719
PubMed: 32087236
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Electronic address: maciejbanach77@gmail.com.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Lodz, Poland; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland; Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora</wicri:regionArea><wicri:noRegion>Zielona Gora</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32087236</idno><idno type="pmid">32087236</idno><idno type="doi">10.1016/j.phrs.2020.104719</idno><idno type="wicri:Area/PubMed/Corpus">000167</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000167</idno><idno type="wicri:Area/PubMed/Curation">000166</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000166</idno><idno type="wicri:Area/PubMed/Checkpoint">000089</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000089</idno><idno type="wicri:Area/Main/Merge">000653</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Statin therapy in athletes and patients performing regular intense exercise - Position paper from the International Lipid Expert Panel (ILEP).</title><author><name sortKey="Katsiki, Niki" sort="Katsiki, Niki" uniqKey="Katsiki N" first="Niki" last="Katsiki">Niki Katsiki</name><affiliation wicri:level="1"><nlm:affiliation>First Department of Internal Medicine, Division of Endocrinology and Metabolism, Diabetes Center, Medical School, AHEPA University Hospital, Thessaloniki, Greece. Electronic address: nikikatsiki@hotmail.com.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>First Department of Internal Medicine, Division of Endocrinology and Metabolism, Diabetes Center, Medical School, AHEPA University Hospital, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Mikhailidis, Dimitri P" sort="Mikhailidis, Dimitri P" uniqKey="Mikhailidis D" first="Dimitri P" last="Mikhailidis">Dimitri P. Mikhailidis</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Biochemistry, Royal Free Campus, University College London Medical School, University College London (UCL), London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Biochemistry, Royal Free Campus, University College London Medical School, University College London (UCL), London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Bajraktari, Gani" sort="Bajraktari, Gani" uniqKey="Bajraktari G" first="Gani" last="Bajraktari">Gani Bajraktari</name><affiliation wicri:level="1"><nlm:affiliation>Clinic of Cardiology, University Clinical Centre of Kosovo, Prishtina, Kosovo, Serbia; Medical Faculty, University of Prishtina, Prishtina, Kosovo, Serbia; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Clinic of Cardiology, University Clinical Centre of Kosovo, Prishtina, Kosovo, Serbia; Medical Faculty, University of Prishtina, Prishtina, Kosovo, Serbia; Department of Public Health and Clinical Medicine, Umeå University, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Miserez, Andre R" sort="Miserez, Andre R" uniqKey="Miserez A" first="Andre R" last="Miserez">Andre R. Miserez</name><affiliation wicri:level="1"><nlm:affiliation>Diagene Research Institute, Reinach, Switzerland; University of Basel, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Diagene Research Institute, Reinach, Switzerland; University of Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Cicero, Arrigo F G" sort="Cicero, Arrigo F G" uniqKey="Cicero A" first="Arrigo F G" last="Cicero">Arrigo F G. Cicero</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine and Surgery Sciences, University of Bologna, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medicine and Surgery Sciences, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Bruckert, Eric" sort="Bruckert, Eric" uniqKey="Bruckert E" first="Eric" last="Bruckert">Eric Bruckert</name><affiliation wicri:level="3"><nlm:affiliation>Pitié-Salpêtrière Hospital and Sorbonne University, Cardio Metabolic Institute, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pitié-Salpêtrière Hospital and Sorbonne University, Cardio Metabolic Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Serban, Maria Corina" sort="Serban, Maria Corina" uniqKey="Serban M" first="Maria-Corina" last="Serban">Maria-Corina Serban</name><affiliation wicri:level="1"><nlm:affiliation>Department of Functional Sciences, Discipline of Pathophysiology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.</nlm:affiliation><country xml:lang="fr">Roumanie</country><wicri:regionArea>Department of Functional Sciences, Discipline of Pathophysiology, "Victor Babes" University of Medicine and Pharmacy, Timisoara</wicri:regionArea><wicri:noRegion>Timisoara</wicri:noRegion></affiliation></author><author><name sortKey="Mirrakhimov, Erkin" sort="Mirrakhimov, Erkin" uniqKey="Mirrakhimov E" first="Erkin" last="Mirrakhimov">Erkin Mirrakhimov</name><affiliation wicri:level="1"><nlm:affiliation>Kyrgyz State Medical Academy, Named after Akhunbaev I.K., Bishkek, Kyrgyzstan.</nlm:affiliation><country xml:lang="fr">Kirghizistan</country><wicri:regionArea>Kyrgyz State Medical Academy, Named after Akhunbaev I.K., Bishkek</wicri:regionArea><wicri:noRegion>Bishkek</wicri:noRegion></affiliation></author><author><name sortKey="Alnouri, Fahad" sort="Alnouri, Fahad" uniqKey="Alnouri F" first="Fahad" last="Alnouri">Fahad Alnouri</name><affiliation wicri:level="1"><nlm:affiliation>Cardiovascular Prevention Unit, Adult Cardiology Department, Prince Sultan Cardiac Centre Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Cardiovascular Prevention Unit, Adult Cardiology Department, Prince Sultan Cardiac Centre Riyadh</wicri:regionArea><wicri:noRegion>Prince Sultan Cardiac Centre Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Reiner, Zeljko" sort="Reiner, Zeljko" uniqKey="Reiner Z" first="Željko" last="Reiner">Željko Reiner</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Diseases University Hospital Center Zagreb School of Medicine, Zagreb University, Zagreb, Croatia.</nlm:affiliation><country xml:lang="fr">Croatie</country><wicri:regionArea>Department of Internal Diseases University Hospital Center Zagreb School of Medicine, Zagreb University, Zagreb</wicri:regionArea><wicri:noRegion>Zagreb</wicri:noRegion></affiliation></author><author><name sortKey="Paragh, Gyorgy" sort="Paragh, Gyorgy" uniqKey="Paragh G" first="György" last="Paragh">György Paragh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen</wicri:regionArea><wicri:noRegion>Debrecen</wicri:noRegion></affiliation></author><author><name sortKey="Sahebkar, Amirhossein" sort="Sahebkar, Amirhossein" uniqKey="Sahebkar A" first="Amirhossein" last="Sahebkar">Amirhossein Sahebkar</name><affiliation wicri:level="1"><nlm:affiliation>Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea><wicri:noRegion>Mashhad</wicri:noRegion></affiliation></author><author><name sortKey="Banach, Maciej" sort="Banach, Maciej" uniqKey="Banach M" first="Maciej" last="Banach">Maciej Banach</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Lodz, Poland; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland; Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland. Electronic address: maciejbanach77@gmail.com.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Lodz, Poland; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland; Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora</wicri:regionArea><wicri:noRegion>Zielona Gora</wicri:noRegion></affiliation></author></analytic><series><title level="j">Pharmacological research</title><idno type="eISSN">1096-1186</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Athletes (MeSH)</term><term>Consensus (MeSH)</term><term>Dyslipidemias (drug therapy)</term><term>Exercise (MeSH)</term><term>Humans (MeSH)</term><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors (adverse effects)</term><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use)</term><term>Muscular Diseases (chemically induced)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Athlètes (MeSH)</term><term>Consensus (MeSH)</term><term>Dyslipidémies (traitement médicamenteux)</term><term>Exercice physique (MeSH)</term><term>Humains (MeSH)</term><term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase (effets indésirables)</term><term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase (usage thérapeutique)</term><term>Maladies musculaires (induit chimiquement)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Muscular Diseases</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dyslipidemias</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase</term></keywords><keywords scheme="MESH" qualifier="induit chimiquement" xml:lang="fr"><term>Maladies musculaires</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Dyslipidémies</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Athletes</term><term>Consensus</term><term>Exercise</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Athlètes</term><term>Consensus</term><term>Exercice physique</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Acute and chronic physical exercises may enhance the development of statin-related myopathy. In this context, the recent (2019) guidelines of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) for the management of dyslipidemias recommend that, although individuals with dyslipidemia should be advised to engage in regular moderate physical exercise (for at least 30 min daily), physicians should be alerted with regard to myopathy and creatine kinase (CK) elevation in statin-treated sport athletes. However it is worth emphasizing that abovementioned guidelines, previous and recent ESC/EAS consensus papers on adverse effects of statin therapy as well as other previous attempts on this issue, including the ones from the International Lipid Expert Panel (ILEP), give only general recommendations on how to manage patients requiring statin therapy on regular exercises. Therefore, these guidelines in the form of the Position Paper are the first such an attempt to summary existing, often scarce knowledge, and to present this important issue in the form of step-by-step practical recommendations. It is critically important as we might observe more and more individuals on regular exercises/athletes requiring statin therapy due to their cardiovascular risk.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32087236</PMID><DateCompleted><Year>2021</Year><Month>03</Month><Day>29</Day></DateCompleted><DateRevised><Year>2021</Year><Month>03</Month><Day>29</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1096-1186</ISSN><JournalIssue CitedMedium="Internet"><Volume>155</Volume><PubDate><Year>2020</Year><Month>05</Month></PubDate></JournalIssue><Title>Pharmacological research</Title><ISOAbbreviation>Pharmacol Res</ISOAbbreviation></Journal><ArticleTitle>Statin therapy in athletes and patients performing regular intense exercise - Position paper from the International Lipid Expert Panel (ILEP).</ArticleTitle><Pagination><MedlinePgn>104719</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1043-6618(20)30581-8</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.phrs.2020.104719</ELocationID><Abstract><AbstractText>Acute and chronic physical exercises may enhance the development of statin-related myopathy. In this context, the recent (2019) guidelines of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) for the management of dyslipidemias recommend that, although individuals with dyslipidemia should be advised to engage in regular moderate physical exercise (for at least 30 min daily), physicians should be alerted with regard to myopathy and creatine kinase (CK) elevation in statin-treated sport athletes. However it is worth emphasizing that abovementioned guidelines, previous and recent ESC/EAS consensus papers on adverse effects of statin therapy as well as other previous attempts on this issue, including the ones from the International Lipid Expert Panel (ILEP), give only general recommendations on how to manage patients requiring statin therapy on regular exercises. Therefore, these guidelines in the form of the Position Paper are the first such an attempt to summary existing, often scarce knowledge, and to present this important issue in the form of step-by-step practical recommendations. It is critically important as we might observe more and more individuals on regular exercises/athletes requiring statin therapy due to their cardiovascular risk.</AbstractText><CopyrightInformation>Copyright © 2020. Published by Elsevier Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Katsiki</LastName><ForeName>Niki</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>First Department of Internal Medicine, Division of Endocrinology and Metabolism, Diabetes Center, Medical School, AHEPA University Hospital, Thessaloniki, Greece. Electronic address: nikikatsiki@hotmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mikhailidis</LastName><ForeName>Dimitri P</ForeName><Initials>DP</Initials><AffiliationInfo><Affiliation>Department of Clinical Biochemistry, Royal Free Campus, University College London Medical School, University College London (UCL), London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bajraktari</LastName><ForeName>Gani</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Clinic of Cardiology, University Clinical Centre of Kosovo, Prishtina, Kosovo, Serbia; Medical Faculty, University of Prishtina, Prishtina, Kosovo, Serbia; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miserez</LastName><ForeName>Andre R</ForeName><Initials>AR</Initials><AffiliationInfo><Affiliation>Diagene Research Institute, Reinach, Switzerland; University of Basel, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cicero</LastName><ForeName>Arrigo F G</ForeName><Initials>AFG</Initials><AffiliationInfo><Affiliation>Department of Medicine and Surgery Sciences, University of Bologna, Bologna, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bruckert</LastName><ForeName>Eric</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Pitié-Salpêtrière Hospital and Sorbonne University, Cardio Metabolic Institute, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Serban</LastName><ForeName>Maria-Corina</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Department of Functional Sciences, Discipline of Pathophysiology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mirrakhimov</LastName><ForeName>Erkin</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Kyrgyz State Medical Academy, Named after Akhunbaev I.K., Bishkek, Kyrgyzstan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alnouri</LastName><ForeName>Fahad</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Cardiovascular Prevention Unit, Adult Cardiology Department, Prince Sultan Cardiac Centre Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reiner</LastName><ForeName>Željko</ForeName><Initials>Ž</Initials><AffiliationInfo><Affiliation>Department of Internal Diseases University Hospital Center Zagreb School of Medicine, Zagreb University, Zagreb, Croatia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Paragh</LastName><ForeName>György</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sahebkar</LastName><ForeName>Amirhossein</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Banach</LastName><ForeName>Maciej</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Lodz, Poland; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland; Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland. Electronic address: maciejbanach77@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>International Lipid Expert Panel (ILEP)</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>02</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Pharmacol Res</MedlineTA><NlmUniqueID>8907422</NlmUniqueID><ISSNLinking>1043-6618</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019161">Hydroxymethylglutaryl-CoA Reductase Inhibitors</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D056352" MajorTopicYN="Y">Athletes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D032921" MajorTopicYN="N">Consensus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D050171" MajorTopicYN="N">Dyslipidemias</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015444" MajorTopicYN="Y">Exercise</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019161" MajorTopicYN="N">Hydroxymethylglutaryl-CoA Reductase Inhibitors</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009135" MajorTopicYN="N">Muscular Diseases</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Athleths</Keyword><Keyword MajorTopicYN="Y">Exercises</Keyword><Keyword MajorTopicYN="Y">Management</Keyword><Keyword MajorTopicYN="Y">Mylagia</Keyword><Keyword MajorTopicYN="Y">Statin intolerance</Keyword></KeywordList><CoiStatement>Declaration of Competing Interest NK has given talks, attended conferences and participated in trials sponsored by Amgen, Astra Zeneca, Bausch Health, Boehringer Ingelheim, Elpen, MSD, Mylan, Novo Nordisk, Sanofi and Servier; GB has given talks and attended conferences sponsored by KRKA, Trepharm, Bosnalijek, Akaloid and Novartis; AC has received honoraria as scientific consultant from Meda-Mylan, Menarini International and Sharper; EB - consulting/presentation: Amgen, Genfit, MSD, Sanofi-Regeneron, Aegerion, Chiesi, Rottapharm, Lilly, Ionis pharmaceuticals, Servier, Mylan and Akcea; FA has given talks, attended conferences and participated in trials sponsored by Amgen, AMRYT Pharma and Sanofi; MB - speakers bureau: Abbott/Mylan, Abbott Vascular, Actavis, Akcea, Amgen, Biofarm, KRKA, MSD, Polpharma, Sanofi-Aventis, Servier and Valeant; consultant to Abbott Vascular, Akcea, Amgen, Daichii Sankyo, Freia Pharmaceuticals, Esperion, Lilly, MSD, Polfarmex, Resverlogix, Sanofi-Aventis; Grants from Sanofi and Valeant; All other authors have nothing to declare. #International Lipid Expert Panel (ILEP) Experts (alphabetically): Fahad Alnouri (Cardiovascular Prevention Unit, Adult Cardiology Department. Prince Sultan Cardiac Centre Riyadh, Saudi Arabia), Fahma Amar (Unit of Diabetes &Metabolism, Alexandria University, Alexandria, Egypt), Atanas G. Atanasov (Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, Jastrzebiec, Poland; Department of Pharmacognosy, University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Digital Health and Patient Safety, Medical University of Vienna, Vienna, Austria; Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria), Gani Bajraktari (Institute of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden; Clinic of Cardiology, University Clinical Centre of Kosovo, Prishtina, Kosovo; Medical Faculty, University of Prishtina, Prishtina, Kosovo), Maciej Banach (Department of Hypertension, Medical University of Lodz, Poland; Polish Mother’s Memorial Hospital Research Institute (PMMHRI), Lodz, Poland, Cardiovascular Research Centre, University of Zielona-Gora, Zielona-Gora, Poland), Marcin A. Bartlomiejczyk (Department of Hypertension, Medical University of Lodz, Poland; Polish Mother’s Memorial Hospital Research Institute (PMMHRI), Lodz, Poland), Bojko Bjelakovic (Clinic of Pediatrics, Clinical Center, Nis, Faculty of Medicine, University of Nis, Serbia), Eric Bruckert (Pitié-Salpetrière Hospital and Sorbonne University, Cardio metabolic Institute, Paris, France), Agata Bielecka-Dabrowa (Polish Mother’s Memorial Hospital Research Institute (PMMHRI), Lodz, Poland), Alberto Cafferata (Facultad de Medicina, Instituto Universitario de Ciencias de la Salud, Fundación H.A. Barceló, Argentina), Richard Ceska (Third Department of Medicine - Department of Endocrinology and Metabolism of the First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic), Arrigo F.G. Cicero (Atherosclerosis and Hypertension Research Group, Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy), Xavier Collet (Institute of Metabolic and Cardiovascular Diseases, Inserm, Toulouse, France), Olivier Descamps (Department of Internal Medicine, Centres Hospitaliers Jolimont, Haine Saint-Paul, Belgium; Department of Cardiology, Cliniques Universitaires Saint-Luc, Bruxells, Belgium), Nair Devaki (Department of Clinical Biochemistry, the Royal Free London NHS Foundation Trust, Pond Street, London, UK), Dragan Djuric (Institute of Medical Physiology "Richard Burian" Faculty of Medicine, University of Belgrade, Belgrade, Serbia), Ronen Durst (Cardiology Department, Hadassah Hebrew University Medical Center, Ein Kerem, Jerusalem, Israel), Marat V. Ezhov (National Cardiology Research Center, Moscow, Russia), Zlatko Fras (Preventive Cardiology Unit, Department of Vascular Medicine, Division of Medicine, University Medical Centre Ljubljana, Slovenia; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia), Dan Gaita (Institutul de Boli Cardiovasculare, Universitatea de Medicina si Farmacie Victor Babes din Timisoara, Romania), Stephan von Haehling (Department of Cardiology and Pneumology, Heart Center Göttingen, University of Göttingen Medical Center, Georg-August-University, Göttingen, Germany), Adrian V. Hernandez (Health Outcomes, Policy, and Evidence Synthesis (HOPES) Group, University of Connecticut/Hartford Hospital Evidence-Based Practice Center, Hartford, CT, USA; Vicerrectorado de Investigación, Universidad San Ignacio de Loyola (USIL), Lima, Peru), Steven R. Jones (the Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA), Jacek Jozwiak (Department of Family Medicine and Public Health Faculty of Medicine University of Opole, Opole, Poland), Nona Kakauridze (Department of Internal Medicine, Faculty of Medicine, Tbilisi State Medical University, Tbilisi, Georgia), Niki Katsiki (Second Department of Propaedeutic Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece), Amit Khera (Division of Cardiology, UT Southwestern, Dallas, TX, USA), Karam Kostner (Mater Hospital, University of Queensland, St Lucia, QLD, Australia), Raimondas Kubilius (Department of Rehabilitation, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania), Gustavs Latkovskis (Institute of Cardiology and Regenerative Medicine, Faculty of Medicine, University of Latvia, Riga, Latvia; Pauls Stradins Clinical University Hospital, Riga, Latvia), G.B. John Mancini (Department of Medicine, Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada), A. David Marais (Chemical Pathology Division of the Department of Pathology, University of Cape Town Health Science Faculty, Cape Town, South Africa), Seth S. Martin (Ciccarone Center for Prevention of Heart Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA), Julio Acosta Martinez (Medico Cardiologo de la Policlinica Metropolitana, Carcass, Venezuela), Mohsen Mazidi (Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Hospital, Strand, London, UK), Dimitri P. Mikhailidis (Department of Clinical Biochemistry, Royal Free Campus, University College London Medical School, University College London (UCL), London, UK), Erkin Mirrakhimov (Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan), Andre R. Miserez (diagene Research Institute, Reinach, Switzerland; President of Swiss Society of Familial Forms of Hypercholesterolemia (SSFH), Breitenbach, Switzerland; University of Basel, Basel, Switzerland), Olena Mitchenko (Dyslipidaemia Department, Institute of Cardiology AMS of Ukraine, Ukraine; Ukrainian Atherosclerosis Society), Patrick Moriarty (Division of Clinical Pharmacology, Division of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA), Seyed Mohammad Nabavi (Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran), Demosthenes B. Panagiotakos (School of Health Science and Education, Department of Nutrition and Dietetics, Harokopio University of Athens, Athens, Greece), György Paragh (University of Debrecen Faculty of Medicine, Department of Internal Medicine, Debrecen, Hungary), Daniel Pella (1 st Department of Internal Medicine, Faculty of Medicine, Pavol Jozef Safarik University, Košice, Slovakia), Peter E. Penson (School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK), Zaneta Petrulioniene (Vilnius University Faculty of Medicine, Vilnius, Lithuania; Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania), Matteo Pirro (Department of Medicine, University of Perugia, Perugia, Italy), Arman Postadzhiyan (Bulgarian Society of Cardiology, Medical University of Sofia, Sofia, Bulgaria), Raman Puri (I P Apollo Hospital, New Delhi, India), Ashraf Reda (Menoufia University, President of EAVA), Željko Reiner (University Hospital Center Zagreb, Department of Internal Medicine, School of Medicine, University of Zagreb, Zagreb, Croatia), Jemaa Riadh (Laboratory of Biochemistry, Faculty of Medicine of Tunis, Rabta Hospital, University of Tunis El Manar, Tunis, Tunisia), Dimitri Richter (Cardiac Department, Euroclinic, Athens, Greece), Manfredi Rizzo (Biomedical Department of Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy), Massimiliano Ruscica (Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy), Amirhossein Sahebkar (Biotechnology Research Center, Pharmaceutical Technology Institute, Neurogenic Inflammation Research Center, and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran), Naveed Sattar (Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK), Maria-Corina Serban (Department of Functional Sciences, Discipline of Pathophysiology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania), Abdulla M.A Shehab (Medical Education Department, United Arab Emirates University, Al Ain, United Arab Emirates), Aleksandr B. Shek (Department of Ischemic Heart Disease and Atherosclerosis, Republican Specialised Center of Cardiology, Tashkent, Uzbekistan), Cesare R. Sirtori (Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano Centro Dislipidemie, Grande Ospedale Metropolitano, Niguarda Ca'Granda President, Fondazione Carlo Sirtori), Claudia Stefanutti (Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy), Tomasz Tomasik (Department of Family Medicine, Chair of Internal Medicine and Gerontology, Jagiellonian University Medical College, Krakow, Poland), Peter P. Toth (The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA), Margus Viigimaa (Tallinn University of Technology, North Estonia Medical Centre, Tallinn, Estonia), Dragos Vinereanu (Cardiology Department, University and Emergency Hospital, Bucharest, Romania, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania), Branislav Vohnout (Institute of Nutrition, Faculty of Nursing and Health Professional Studies and Coordination Centre for Familial Hyperlipoproteinemias, Slovak Medical University in Bratislava, Bratislava, Slovakia; Institute of Epidemiology, School of Medicine, Comenius University, Bratislava, Slovakia), Michal Vrablik (1 st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic), Nathan D. Wong (Department of Medicine, School of Medicine University of California, Irvine, CA, USA; Heart Disease Prevention Program, Division of Cardiology, University of California, Irvine, California, USA), Hung-I Yeh (Department of Medicine, Mackay Medical College, Taipei, Taiwan; Cardiovascular Division, Department of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan), Jiang Zhisheng (Institute of Cardiovascular Disease, University of South China, Hengyang, Hunan, China), Andreas Zirlik (University Heart Centre Freiburg University, Department of Cardiology and Angiology I, Faculty of Medicine, University of Freiburg, Freiburg, Germany). With the official endorsement of: Association of Cardiologists of the Republic of Uzbekistan, Baltic Society of Atherosclerosis, Chinese Atherosclerosis Society, College of Family Physicians in Poland, Croatian Atherosclerosis Society, Czech Society for Atherosclerosis, Egyptian Association for Endocrinology, Diabetes and Atherosclerosis (EAEDA), French Atherosclerosis Society, Hellenic Atherosclerosis Society, Hellenic Lipidology Society, Hungarian Atherosclerosis Society, International Natural Product Sciences Taskforce (INPST), Israeli Society for Treatment and Prevention of Atherosclerosis, Italian Nutraceuticals Society (SINut), Italian Society for Cardiovascular Prevention (SIPREC), Kosovo Society of Cardiology, Kyrgyz Atherosclerosis Society, Latvian Society of Cardiology, Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group, Lithuanian Heart Association, Mighty Medic, Polish Lipid Association (PoLA), Romanian National Forum for Prevention, Romanian Society of Cardiology, Russian National Atherosclerosis Society, Saudi Group for Cardiovascular Prevention and Rehabilitation of the Saudi Heart Association, Serbian Association for Arteriosclerosis, Thrombosis and Vascular Biology Research (SAATVBR), Slovak Association of Atherosclerosis, Slovenian Society of Cardiology, Society of Endocrine and Metabolic Disease of South Africa, Society on Sarcopenia, Cachexia and Wasting Disorders, South African Heart Association, Swiss Society for Familial forms of Hypercholesterolemia (SSFH), Tunisian Association of Study and Research on Atherosclerosis, Ukrainian Atherosclerosis Society, Very Large Database of Lipids (VLDL).</CoiStatement><InvestigatorList><Investigator ValidYN="Y"><LastName>Alnouri</LastName><ForeName>Fahad</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Amar</LastName><ForeName>Fahma</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Atanasov</LastName><ForeName>Atanas G</ForeName><Initials>AG</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bajraktari</LastName><ForeName>Gani</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Banach</LastName><ForeName>Maciej</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bartlomiejczyk</LastName><ForeName>Marcin A</ForeName><Initials>MA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bjelakovic</LastName><ForeName>Bojko</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bruckert</LastName><ForeName>Eric</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bielecka-Dabrowa</LastName><ForeName>Agata</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cafferata</LastName><ForeName>Alberto</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ceska</LastName><ForeName>Richard</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cicero</LastName><ForeName>Arrigo F G</ForeName><Initials>AFG</Initials></Investigator><Investigator ValidYN="Y"><LastName>Collet</LastName><ForeName>Xavier</ForeName><Initials>X</Initials></Investigator><Investigator ValidYN="Y"><LastName>Descamps</LastName><ForeName>Olivier</ForeName><Initials>O</Initials></Investigator><Investigator ValidYN="Y"><LastName>Devaki</LastName><ForeName>Nair</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Djuric</LastName><ForeName>Dragan</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Durst</LastName><ForeName>Ronen</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ezhov</LastName><ForeName>Marat V</ForeName><Initials>MV</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fras</LastName><ForeName>Zlatko</ForeName><Initials>Z</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gaita</LastName><ForeName>Dan</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>von Haehling</LastName><ForeName>Stephan</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hernandez</LastName><ForeName>Adrian V</ForeName><Initials>AV</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jones</LastName><ForeName>Steven R</ForeName><Initials>SR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jozwiak</LastName><ForeName>Jacek</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kakauridze</LastName><ForeName>Nona</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Katsiki</LastName><ForeName>Niki</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Khera</LastName><ForeName>Amit</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kostner</LastName><ForeName>Karam</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kubilius</LastName><ForeName>Raimondas</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Latkovskis</LastName><ForeName>Gustavs</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mancini</LastName><ForeName>G B John</ForeName><Initials>GBJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Marais</LastName><ForeName>A David</ForeName><Initials>AD</Initials></Investigator><Investigator ValidYN="Y"><LastName>Martin</LastName><ForeName>Seth S</ForeName><Initials>SS</Initials></Investigator><Investigator ValidYN="Y"><LastName>Martinez</LastName><ForeName>Julio Acosta</ForeName><Initials>JA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mazidi</LastName><ForeName>Mohsen</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mikhailidis</LastName><ForeName>Dimitri P</ForeName><Initials>DP</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mirrakhimov</LastName><ForeName>Erkin</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Miserez</LastName><ForeName>Andre R</ForeName><Initials>AR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mitchenko</LastName><ForeName>Olena</ForeName><Initials>O</Initials></Investigator><Investigator ValidYN="Y"><LastName>Moriarty</LastName><ForeName>Patrick</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nabavi</LastName><ForeName>Seyed Mohammad</ForeName><Initials>SM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Panagiotakos</LastName><ForeName>Demosthenes B</ForeName><Initials>DB</Initials></Investigator><Investigator ValidYN="Y"><LastName>Paragh</LastName><ForeName>György</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pella</LastName><ForeName>Daniel</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Penson</LastName><ForeName>Peter E</ForeName><Initials>PE</Initials></Investigator><Investigator ValidYN="Y"><LastName>Petrulioniene</LastName><ForeName>Zaneta</ForeName><Initials>Z</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pirro</LastName><ForeName>Matteo</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Postadzhiyan</LastName><ForeName>Arman</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Puri</LastName><ForeName>Raman</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Reda</LastName><ForeName>Ashraf</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Reiner</LastName><ForeName>Željko</ForeName><Initials>Ž</Initials></Investigator><Investigator ValidYN="Y"><LastName>Riadh</LastName><ForeName>Jemaa</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Richter</LastName><ForeName>Dimitri</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rizzo</LastName><ForeName>Manfredi</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ruscica</LastName><ForeName>Massimiliano</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sahebkar</LastName><ForeName>Amirhossein</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sattar</LastName><ForeName>Naveed</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Serban</LastName><ForeName>Maria-Corina</ForeName><Initials>MC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Shehab</LastName><ForeName>Abdulla M A</ForeName><Initials>AMA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Shek</LastName><ForeName>Aleksandr B</ForeName><Initials>AB</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sirtori</LastName><ForeName>Cesare R</ForeName><Initials>CR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Stefanutti</LastName><ForeName>Claudia</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tomasik</LastName><ForeName>Tomasz</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Toth</LastName><ForeName>Peter P</ForeName><Initials>PP</Initials></Investigator><Investigator ValidYN="Y"><LastName>Viigimaa</LastName><ForeName>Margus</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vinereanu</LastName><ForeName>Dragos</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vohnout</LastName><ForeName>Branislav</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vrablik</LastName><ForeName>Michal</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Wong</LastName><ForeName>Nathan D</ForeName><Initials>ND</Initials></Investigator><Investigator ValidYN="Y"><LastName>Yeh</LastName><ForeName>Hung-I</ForeName><Initials>HI</Initials></Investigator><Investigator ValidYN="Y"><LastName>Zhisheng</LastName><ForeName>Jiang</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Zirlik</LastName><ForeName>Andreas</ForeName><Initials>A</Initials></Investigator></InvestigatorList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>02</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>02</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>2</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>3</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>2</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32087236</ArticleId><ArticleId IdType="pii">S1043-6618(20)30581-8</ArticleId><ArticleId IdType="doi">10.1016/j.phrs.2020.104719</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Arabie saoudite</li><li>Croatie</li><li>France</li><li>Grèce</li><li>Hongrie</li><li>Iran</li><li>Italie</li><li>Kirghizistan</li><li>Pologne</li><li>Roumanie</li><li>Royaume-Uni</li><li>Suisse</li><li>Suède</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Île-de-France</li></region><settlement><li>Londres</li><li>Paris</li></settlement></list><tree><country name="Grèce"><noRegion><name sortKey="Katsiki, Niki" sort="Katsiki, Niki" uniqKey="Katsiki N" first="Niki" last="Katsiki">Niki Katsiki</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Mikhailidis, Dimitri P" sort="Mikhailidis, Dimitri P" uniqKey="Mikhailidis D" first="Dimitri P" last="Mikhailidis">Dimitri P. 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Cicero</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Bruckert, Eric" sort="Bruckert, Eric" uniqKey="Bruckert E" first="Eric" last="Bruckert">Eric Bruckert</name></region></country><country name="Roumanie"><noRegion><name sortKey="Serban, Maria Corina" sort="Serban, Maria Corina" uniqKey="Serban M" first="Maria-Corina" last="Serban">Maria-Corina Serban</name></noRegion></country><country name="Kirghizistan"><noRegion><name sortKey="Mirrakhimov, Erkin" sort="Mirrakhimov, Erkin" uniqKey="Mirrakhimov E" first="Erkin" last="Mirrakhimov">Erkin Mirrakhimov</name></noRegion></country><country name="Arabie saoudite"><noRegion><name sortKey="Alnouri, Fahad" sort="Alnouri, Fahad" uniqKey="Alnouri F" first="Fahad" last="Alnouri">Fahad Alnouri</name></noRegion></country><country name="Croatie"><noRegion><name sortKey="Reiner, Zeljko" sort="Reiner, Zeljko" uniqKey="Reiner Z" first="Željko" last="Reiner">Željko Reiner</name></noRegion></country><country name="Hongrie"><noRegion><name sortKey="Paragh, Gyorgy" sort="Paragh, Gyorgy" uniqKey="Paragh G" first="György" last="Paragh">György Paragh</name></noRegion></country><country name="Iran"><noRegion><name sortKey="Sahebkar, Amirhossein" sort="Sahebkar, Amirhossein" uniqKey="Sahebkar A" first="Amirhossein" last="Sahebkar">Amirhossein Sahebkar</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Banach, Maciej" sort="Banach, Maciej" uniqKey="Banach M" first="Maciej" last="Banach">Maciej Banach</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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