Rapid diagnostic tests : Pros, cons and potential use in the COVID-19 management in Tunisia.
Identifieur interne : 000771 ( Main/Exploration ); précédent : 000770; suivant : 000772Rapid diagnostic tests : Pros, cons and potential use in the COVID-19 management in Tunisia.
Auteurs : Mouna Jameleddine Chtioui ; Hela Grati ; Nabil Harzallah ; Marie Christine Odabachian Jebali ; Abdelhalim Trabelsi ; Mélika Ben Ahmed ; Lamia Thabet ; Salma Mhalla ; Mohamed Ben Moussa ; Taieb Messaoud ; Habiba Ben Romdhane ; Adnene Toumi ; Chokri HamoudaSource :
- La Tunisie medicale [ 0041-4131 ]
Descripteurs français
- KwdFr :
- MESH :
- Wicri :
- geographic : Tunisie.
English descriptors
- KwdEn :
- MESH :
- geographic : Tunisia.
- diagnosis : COVID-19.
- methods : COVID-19 Testing.
- Humans, Time Factors.
Abstract
OBJECTIVES
Diagnosis of SARS-CoV-2 infection is a major public health issue. In a context of limited diagnostic capacity with the reference technique (real-time RT-PCR), many manufacturers have developed rapid diagnostic tests (RDTs). Although very promising in theory, these tests have raised many questions. This article is a rapid review that synthesizes data regarding different types of available RDTs, their performance, their limits and their potential indications in Tunisia as proposed by a multidisciplinary group of experts.
METHODS
A literature review was carried out on the websites of international organizations, governmental bodies and on INAHTA database, completed by a search of relevant scientific articles up to 1 June 2020. The synthesis of the data was submitted to a panel of experts to propose recommendations for the Tunisian context.
RESULTS
RDTs based on the detection of antigens and antibodies have sensitivity and specificity related issues. Few validation reports are published in the scientific literature. Pending more evidence on their performance and validity, several international organizations recommend their use only for research purposes. TDRs based on antibody detection are not appropriate for the early diagnosis of COVID-19. However, validated and specific tests could provide complementary diagnostic information to reference tests.
CONCLUSION
Pending further evidence, the panel recommends the use of RDTs mainly for research purposes at the community level.
PubMed: 33480019
Affiliations:
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Le document en format XML
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last="Trabelsi">Abdelhalim Trabelsi</name></author><author><name sortKey="Ben Ahmed, Melika" sort="Ben Ahmed, Melika" uniqKey="Ben Ahmed M" first="Mélika" last="Ben Ahmed">Mélika Ben Ahmed</name></author><author><name sortKey="Thabet, Lamia" sort="Thabet, Lamia" uniqKey="Thabet L" first="Lamia" last="Thabet">Lamia Thabet</name></author><author><name sortKey="Mhalla, Salma" sort="Mhalla, Salma" uniqKey="Mhalla S" first="Salma" last="Mhalla">Salma Mhalla</name></author><author><name sortKey="Ben Moussa, Mohamed" sort="Ben Moussa, Mohamed" uniqKey="Ben Moussa M" first="Mohamed" last="Ben Moussa">Mohamed Ben Moussa</name></author><author><name sortKey="Messaoud, Taieb" sort="Messaoud, Taieb" uniqKey="Messaoud T" first="Taieb" last="Messaoud">Taieb Messaoud</name></author><author><name sortKey="Ben Romdhane, Habiba" sort="Ben Romdhane, Habiba" uniqKey="Ben Romdhane H" first="Habiba" last="Ben Romdhane">Habiba Ben Romdhane</name></author><author><name sortKey="Toumi, Adnene" sort="Toumi, 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In a context of limited diagnostic capacity with the reference technique (real-time RT-PCR), many manufacturers have developed rapid diagnostic tests (RDTs). Although very promising in theory, these tests have raised many questions. This article is a rapid review that synthesizes data regarding different types of available RDTs, their performance, their limits and their potential indications in Tunisia as proposed by a multidisciplinary group of experts.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>A literature review was carried out on the websites of international organizations, governmental bodies and on INAHTA database, completed by a search of relevant scientific articles up to 1 June 2020. The synthesis of the data was submitted to a panel of experts to propose recommendations for the Tunisian context.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>RDTs based on the detection of antigens and antibodies have sensitivity and specificity related issues. Few validation reports are published in the scientific literature. Pending more evidence on their performance and validity, several international organizations recommend their use only for research purposes. TDRs based on antibody detection are not appropriate for the early diagnosis of COVID-19. However, validated and specific tests could provide complementary diagnostic information to reference tests.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Pending further evidence, the panel recommends the use of RDTs mainly for research purposes at the community level.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Ben Ahmed, Melika" sort="Ben Ahmed, Melika" uniqKey="Ben Ahmed M" first="Mélika" last="Ben Ahmed">Mélika Ben Ahmed</name><name sortKey="Ben Moussa, Mohamed" sort="Ben Moussa, Mohamed" uniqKey="Ben Moussa M" first="Mohamed" last="Ben Moussa">Mohamed Ben Moussa</name><name sortKey="Ben Romdhane, Habiba" sort="Ben Romdhane, Habiba" uniqKey="Ben Romdhane H" first="Habiba" last="Ben Romdhane">Habiba Ben Romdhane</name><name sortKey="Grati, Hela" sort="Grati, Hela" uniqKey="Grati H" first="Hela" last="Grati">Hela Grati</name><name sortKey="Hamouda, Chokri" sort="Hamouda, Chokri" uniqKey="Hamouda C" first="Chokri" last="Hamouda">Chokri Hamouda</name><name sortKey="Harzallah, Nabil" sort="Harzallah, Nabil" uniqKey="Harzallah N" first="Nabil" last="Harzallah">Nabil Harzallah</name><name sortKey="Jameleddine Chtioui, Mouna" sort="Jameleddine Chtioui, Mouna" uniqKey="Jameleddine Chtioui M" first="Mouna" last="Jameleddine Chtioui">Mouna Jameleddine Chtioui</name><name sortKey="Messaoud, Taieb" sort="Messaoud, Taieb" uniqKey="Messaoud T" first="Taieb" last="Messaoud">Taieb Messaoud</name><name sortKey="Mhalla, Salma" sort="Mhalla, Salma" uniqKey="Mhalla S" first="Salma" last="Mhalla">Salma Mhalla</name><name sortKey="Odabachian Jebali, Marie Christine" sort="Odabachian Jebali, Marie Christine" uniqKey="Odabachian Jebali M" first="Marie Christine" last="Odabachian Jebali">Marie Christine Odabachian Jebali</name><name sortKey="Thabet, Lamia" sort="Thabet, Lamia" uniqKey="Thabet L" first="Lamia" last="Thabet">Lamia Thabet</name><name sortKey="Toumi, Adnene" sort="Toumi, Adnene" uniqKey="Toumi A" first="Adnene" last="Toumi">Adnene Toumi</name><name sortKey="Trabelsi, Abdelhalim" sort="Trabelsi, Abdelhalim" uniqKey="Trabelsi A" first="Abdelhalim" last="Trabelsi">Abdelhalim Trabelsi</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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