Prevalence of human papillomavirus detection in ovarian cancer: a meta-analysis.
Identifieur interne : 000822 ( Main/Exploration ); précédent : 000821; suivant : 000823Prevalence of human papillomavirus detection in ovarian cancer: a meta-analysis.
Auteurs : Soumia Cherif [Allemagne, Maroc] ; Abdessamad Amine [Maroc] ; Sarah Thies [Allemagne] ; Eliane T. Taube [Allemagne] ; Elena Ioana Braicu [Allemagne] ; Jalid Sehouli [Allemagne] ; Andreas M. Kaufmann [Allemagne]Source :
- European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [ 1435-4373 ] ; 2021.
Abstract
We conducted a meta-analysis of published data to update and estimate the prevalence of HPV in ovarian cancer. A comprehensive literature search was performed according to the PRISMA guidelines. Eligible articles published from 1989 until 2020 by searching Web of Sciences, Pubmed, Embase, and the Cochrane Library Central databases were gathered. A pooled estimation of HPV prevalence with a 95% confidence interval (CI) was calculated based on a random effect model. Quantitative assessment of heterogeneity was explored using Cochrane test and I2. Additionally, publication bias, sensitivity, meta-regression, and subgroup analyses were also performed. Twenty-nine studies involving 2280 patients with ovarian cancer were included. The statistical heterogeneity was high (I2 = 88%, P<0.0001). The pooled prevalence of HPV in ovarian cancer cases was 15.9% (95% CI, 11-22). In subgroup analyses, the highest prevalence of HPV was reported by studies from Asia (30.9%; 95% CI, 20-44) and Eastern Europe (29.3%; 95% CI, 4.4-78). Furthermore, the most frequently detected HPV genotype was HPV16 (54%; 95% CI, 27.9-55), followed by HPV18 (23.2%; 95% CI, 18.8-28.2). Our meta-analysis suggests a great difference in the prevalence of HPV detected in ovarian cancer by different studies, which is not seen in strongly HPV-associated cancers such as cervical cancer. However, the prevalence varied markedly by geographic region. Considering the substantial heterogeneity found, more studies with control groups and precise assays measuring HPV mRNA expression are needed to further evaluate the link and causative aetiology between HPV and ovarian cancer.
DOI: 10.1007/s10096-021-04282-7
PubMed: 34086102
Affiliations:
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Kaufmann</name><affiliation wicri:level="3"><nlm:affiliation>Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Gynecology, Augustenburger Platz 1, 13353, Berlin, Germany. andreas.kaufmann@charite.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Gynecology, Augustenburger Platz 1, 13353, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author></analytic><series><title level="j">European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology</title><idno type="eISSN">1435-4373</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We conducted a meta-analysis of published data to update and estimate the prevalence of HPV in ovarian cancer. A comprehensive literature search was performed according to the PRISMA guidelines. Eligible articles published from 1989 until 2020 by searching Web of Sciences, Pubmed, Embase, and the Cochrane Library Central databases were gathered. A pooled estimation of HPV prevalence with a 95% confidence interval (CI) was calculated based on a random effect model. Quantitative assessment of heterogeneity was explored using Cochrane test and I<sup>2</sup>. Additionally, publication bias, sensitivity, meta-regression, and subgroup analyses were also performed. Twenty-nine studies involving 2280 patients with ovarian cancer were included. The statistical heterogeneity was high (I<sup>2</sup> = 88%, P<0.0001). The pooled prevalence of HPV in ovarian cancer cases was 15.9% (95% CI, 11-22). In subgroup analyses, the highest prevalence of HPV was reported by studies from Asia (30.9%; 95% CI, 20-44) and Eastern Europe (29.3%; 95% CI, 4.4-78). Furthermore, the most frequently detected HPV genotype was HPV16 (54%; 95% CI, 27.9-55), followed by HPV18 (23.2%; 95% CI, 18.8-28.2). Our meta-analysis suggests a great difference in the prevalence of HPV detected in ovarian cancer by different studies, which is not seen in strongly HPV-associated cancers such as cervical cancer. However, the prevalence varied markedly by geographic region. Considering the substantial heterogeneity found, more studies with control groups and precise assays measuring HPV mRNA expression are needed to further evaluate the link and causative aetiology between HPV and ovarian cancer.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Maroc</li></country><region><li>Berlin</li></region><settlement><li>Berlin</li></settlement></list><tree><country name="Allemagne"><region name="Berlin"><name sortKey="Cherif, Soumia" sort="Cherif, Soumia" uniqKey="Cherif S" first="Soumia" last="Cherif">Soumia Cherif</name></region><name sortKey="Braicu, Elena Ioana" sort="Braicu, Elena Ioana" uniqKey="Braicu E" first="Elena Ioana" last="Braicu">Elena Ioana Braicu</name><name sortKey="Kaufmann, Andreas M" sort="Kaufmann, Andreas M" uniqKey="Kaufmann A" first="Andreas M" last="Kaufmann">Andreas M. Kaufmann</name><name sortKey="Sehouli, Jalid" sort="Sehouli, Jalid" uniqKey="Sehouli J" first="Jalid" last="Sehouli">Jalid Sehouli</name><name sortKey="Taube, Eliane T" sort="Taube, Eliane T" uniqKey="Taube E" first="Eliane T" last="Taube">Eliane T. Taube</name><name sortKey="Thies, Sarah" sort="Thies, Sarah" uniqKey="Thies S" first="Sarah" last="Thies">Sarah Thies</name></country><country name="Maroc"><noRegion><name sortKey="Cherif, Soumia" sort="Cherif, Soumia" uniqKey="Cherif S" first="Soumia" last="Cherif">Soumia Cherif</name></noRegion><name sortKey="Amine, Abdessamad" sort="Amine, Abdessamad" uniqKey="Amine A" first="Abdessamad" last="Amine">Abdessamad Amine</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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