The effect of coumarin on protein and PVP clearance from rat legs with various high protein oedemas.
Identifieur interne : 007311 ( PubMed/Curation ); précédent : 007310; suivant : 007312The effect of coumarin on protein and PVP clearance from rat legs with various high protein oedemas.
Auteurs : N B Piller ; J R Casley-SmithSource :
- British journal of experimental pathology [ 0007-1021 ] ; 1975.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Protéines.
- pharmacologie : Coumarines.
- traitement médicamenteux : Brûlures, Lymphoedème, Oedème.
- usage thérapeutique : Coumarines.
- Animaux, Membre pelvien, Povidone, Rats, Taille d'organe.
English descriptors
- KwdEn :
- MESH :
Abstract
Coumarin (a benzo-pyrone) has been shown to bring about the rapid removal of protein from normal or burnt tissues and from those with lymphoedema, with or without burning. This was particularly evident when the removal of protein was compared with that of a non-metabolizable control-PVP. The mode of action would seem to be by stimulation of proteolysis. The fragments of protein could then rapidly leave the tissues because of their small size, their high diffusion coefficients and a concentration gradient which was directed from the tissues to the blood. In this way excessive amounts of protein would be removed, thus releasing the oedema fluid. The removal of non-metabolizable PVP was reduced with normal and burnt legs, possibly of stimulated phagocytosis. In the presence of lymphoedema there was a more rapid removal of PVP with coumarin; this was possibly a consequence of the great reduction of intercapillary distances resulting from the removal of oedema fluid.
PubMed: 1212425
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This was particularly evident when the removal of protein was compared with that of a non-metabolizable control-PVP. The mode of action would seem to be by stimulation of proteolysis. The fragments of protein could then rapidly leave the tissues because of their small size, their high diffusion coefficients and a concentration gradient which was directed from the tissues to the blood. In this way excessive amounts of protein would be removed, thus releasing the oedema fluid. The removal of non-metabolizable PVP was reduced with normal and burnt legs, possibly of stimulated phagocytosis. In the presence of lymphoedema there was a more rapid removal of PVP with coumarin; this was possibly a consequence of the great reduction of intercapillary distances resulting from the removal of oedema fluid.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">1212425</PMID><DateCreated><Year>1976</Year><Month>04</Month><Day>30</Day></DateCreated><DateCompleted><Year>1976</Year><Month>04</Month><Day>30</Day></DateCompleted><DateRevised><Year>2012</Year><Month>05</Month><Day>07</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0007-1021</ISSN><JournalIssue CitedMedium="Print"><Volume>56</Volume><Issue>5</Issue><PubDate><Year>1975</Year><Month>Oct</Month></PubDate></JournalIssue><Title>British journal of experimental pathology</Title><ISOAbbreviation>Br J Exp Pathol</ISOAbbreviation></Journal><ArticleTitle>The effect of coumarin on protein and PVP clearance from rat legs with various high protein oedemas.</ArticleTitle><Pagination><MedlinePgn>439-43</MedlinePgn></Pagination><Abstract><AbstractText>Coumarin (a benzo-pyrone) has been shown to bring about the rapid removal of protein from normal or burnt tissues and from those with lymphoedema, with or without burning. This was particularly evident when the removal of protein was compared with that of a non-metabolizable control-PVP. The mode of action would seem to be by stimulation of proteolysis. The fragments of protein could then rapidly leave the tissues because of their small size, their high diffusion coefficients and a concentration gradient which was directed from the tissues to the blood. In this way excessive amounts of protein would be removed, thus releasing the oedema fluid. The removal of non-metabolizable PVP was reduced with normal and burnt legs, possibly of stimulated phagocytosis. In the presence of lymphoedema there was a more rapid removal of PVP with coumarin; this was possibly a consequence of the great reduction of intercapillary distances resulting from the removal of oedema fluid.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Piller</LastName><ForeName>N B</ForeName><Initials>NB</Initials></Author><Author ValidYN="Y"><LastName>Casley-Smith</LastName><ForeName>J R</ForeName><Initials>JR</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Br J Exp Pathol</MedlineTA><NlmUniqueID>0372543</NlmUniqueID><ISSNLinking>0007-1021</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003374">Coumarins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011506">Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>9003-39-8</RegistryNumber><NameOfSubstance UI="D011205">Povidone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Angiologica. 1972;9(2):92-8</RefSource><PMID Version="1">4564850</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Reticuloendothel Soc. 1973 Mar;13(3):210-20</RefSource><PMID Version="1">4736160</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Pathol. 1962 Sep;41:365-71</RefSource><PMID Version="1">14449255</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochem Pharmacol. 1967 Jun;16(6):1099-111</RefSource><PMID Version="1">6040391</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 1967 Nov 1;126(5):941-58</RefSource><PMID Version="1">6062005</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arzneimittelforschung. 1971 Oct;21(10):1468-82</RefSource><PMID Version="1">4945248</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002056" MajorTopicYN="N">Burns</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003374" MajorTopicYN="N">Coumarins</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004487" MajorTopicYN="N">Edema</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006614" MajorTopicYN="N">Hindlimb</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009929" MajorTopicYN="N">Organ Size</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011205" MajorTopicYN="Y">Povidone</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011506" MajorTopicYN="N">Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC2072776</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1975</Year><Month>10</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1975</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1975</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">1212425</ArticleId><ArticleId IdType="pmc">PMC2072776</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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