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HLA and filariasis in Sri Lankans and Indians.

Identifieur interne : 006921 ( PubMed/Curation ); précédent : 006920; suivant : 006922

HLA and filariasis in Sri Lankans and Indians.

Auteurs : S H Chan ; S. Dissanayake ; J W Mak ; M M Ismail ; G B Wee ; N. Srinivasan ; B H Soo ; V. Zaman

Source :

RBID : pubmed:6523169

Descripteurs français

English descriptors

Abstract

Similar HLA association was found in patients with elephantiasis in Sri Lankans and Southern Indians. HLA-B15 was observed in 13/44 (30%) Sri Lankan patients with elephantiasis compared to 1/27 (4%) Sri Lankan controls (p = .0058; RR = 10.9) and in 5/8 (28%) Southern Indian elephantiasis compared to 10/101 (10%) Southern Indian controls (p = 0.04; RR = 3.5). In combining the data, the significance of the difference of the frequency of B15 between patients with elephantiasis and controls was even more marked (p = 0.00045; corrected p = 0.012; RR = 4.4).

PubMed: 6523169

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pubmed:6523169

Le document en format XML

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<title xml:lang="en">HLA and filariasis in Sri Lankans and Indians.</title>
<author>
<name sortKey="Chan, S H" sort="Chan, S H" uniqKey="Chan S" first="S H" last="Chan">S H Chan</name>
</author>
<author>
<name sortKey="Dissanayake, S" sort="Dissanayake, S" uniqKey="Dissanayake S" first="S" last="Dissanayake">S. Dissanayake</name>
</author>
<author>
<name sortKey="Mak, J W" sort="Mak, J W" uniqKey="Mak J" first="J W" last="Mak">J W Mak</name>
</author>
<author>
<name sortKey="Ismail, M M" sort="Ismail, M M" uniqKey="Ismail M" first="M M" last="Ismail">M M Ismail</name>
</author>
<author>
<name sortKey="Wee, G B" sort="Wee, G B" uniqKey="Wee G" first="G B" last="Wee">G B Wee</name>
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<author>
<name sortKey="Srinivasan, N" sort="Srinivasan, N" uniqKey="Srinivasan N" first="N" last="Srinivasan">N. Srinivasan</name>
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<name sortKey="Soo, B H" sort="Soo, B H" uniqKey="Soo B" first="B H" last="Soo">B H Soo</name>
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<name sortKey="Zaman, V" sort="Zaman, V" uniqKey="Zaman V" first="V" last="Zaman">V. Zaman</name>
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<term>Asian Continental Ancestry Group</term>
<term>Disease Susceptibility</term>
<term>Elephantiasis (genetics)</term>
<term>Elephantiasis (immunology)</term>
<term>Female</term>
<term>Filariasis (genetics)</term>
<term>Filariasis (immunology)</term>
<term>HLA Antigens (genetics)</term>
<term>Humans</term>
<term>Lymphedema (genetics)</term>
<term>Malaysia</term>
<term>Male</term>
<term>Singapore</term>
<term>Sri Lanka</term>
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<term>Antigènes HLA (génétique)</term>
<term>Femelle</term>
<term>Filarioses (génétique)</term>
<term>Filarioses (immunologie)</term>
<term>Humains</term>
<term>Lymphoedème (génétique)</term>
<term>Malaisie</term>
<term>Mâle</term>
<term>Population d'origine asiatique</term>
<term>Singapour</term>
<term>Sri Lanka</term>
<term>Susceptibilité à une maladie</term>
<term>Éléphantiasis (génétique)</term>
<term>Éléphantiasis (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en">
<term>HLA Antigens</term>
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<term>Malaysia</term>
<term>Singapore</term>
<term>Sri Lanka</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en">
<term>Elephantiasis</term>
<term>Filariasis</term>
<term>Lymphedema</term>
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<keywords scheme="MESH" qualifier="génétique" xml:lang="fr">
<term>Antigènes HLA</term>
<term>Filarioses</term>
<term>Lymphoedème</term>
<term>Éléphantiasis</term>
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<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr">
<term>Filarioses</term>
<term>Éléphantiasis</term>
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<term>Elephantiasis</term>
<term>Filariasis</term>
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<keywords scheme="MESH" xml:lang="fr">
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<term>Humains</term>
<term>Malaisie</term>
<term>Mâle</term>
<term>Population d'origine asiatique</term>
<term>Singapour</term>
<term>Sri Lanka</term>
<term>Susceptibilité à une maladie</term>
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<front>
<div type="abstract" xml:lang="en">Similar HLA association was found in patients with elephantiasis in Sri Lankans and Southern Indians. HLA-B15 was observed in 13/44 (30%) Sri Lankan patients with elephantiasis compared to 1/27 (4%) Sri Lankan controls (p = .0058; RR = 10.9) and in 5/8 (28%) Southern Indian elephantiasis compared to 10/101 (10%) Southern Indian controls (p = 0.04; RR = 3.5). In combining the data, the significance of the difference of the frequency of B15 between patients with elephantiasis and controls was even more marked (p = 0.00045; corrected p = 0.012; RR = 4.4).</div>
</front>
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<Title>The Southeast Asian journal of tropical medicine and public health</Title>
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<ArticleTitle>HLA and filariasis in Sri Lankans and Indians.</ArticleTitle>
<Pagination>
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<Abstract>
<AbstractText>Similar HLA association was found in patients with elephantiasis in Sri Lankans and Southern Indians. HLA-B15 was observed in 13/44 (30%) Sri Lankan patients with elephantiasis compared to 1/27 (4%) Sri Lankan controls (p = .0058; RR = 10.9) and in 5/8 (28%) Southern Indian elephantiasis compared to 10/101 (10%) Southern Indian controls (p = 0.04; RR = 3.5). In combining the data, the significance of the difference of the frequency of B15 between patients with elephantiasis and controls was even more marked (p = 0.00045; corrected p = 0.012; RR = 4.4).</AbstractText>
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