Antibodies to phosphocholine-bearing antigens in lymphatic filariasis and changes following treatment with diethylcarbamazine.
Identifieur interne : 006069 ( PubMed/Curation ); précédent : 006068; suivant : 006070Antibodies to phosphocholine-bearing antigens in lymphatic filariasis and changes following treatment with diethylcarbamazine.
Auteurs : R B Lal [États-Unis] ; E A OttesenSource :
- Clinical and experimental immunology [ 0009-9104 ] ; 1989.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Anticorps (analyse), Antigènes (immunologie), Choline (analogues et dérivés), Diéthylcarbamazine (usage thérapeutique), Femelle, Filariose lymphatique (immunologie), Filariose lymphatique (traitement médicamenteux), Filarioses (immunologie), Humains, Immunoglobuline G (immunologie), Immunoglobuline M (immunologie), Microfilaria (immunologie), Mâle, Phosphoryl-choline (immunologie), Sang (parasitologie), Sujet âgé, Wuchereria bancrofti (immunologie).
- MESH :
- analogues et dérivés : Choline.
- analyse : Anticorps.
- immunologie : Antigènes, Filariose lymphatique, Filarioses, Immunoglobuline G, Immunoglobuline M, Microfilaria, Phosphoryl-choline, Wuchereria bancrofti.
- parasitologie : Sang.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Diéthylcarbamazine.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Femelle, Humains, Mâle, Sujet âgé.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Animals, Antibodies (analysis), Antigens (immunology), Blood (parasitology), Choline (analogs & derivatives), Diethylcarbamazine (therapeutic use), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (immunology), Female, Filariasis (immunology), Humans, Immunoglobulin G (immunology), Immunoglobulin M (immunology), Male, Microfilariae (immunology), Middle Aged, Phosphorylcholine (immunology), Wuchereria bancrofti (immunology).
- MESH :
- chemical , analogs & derivatives : Choline.
- chemical , analysis : Antibodies.
- chemical , immunology : Antigens, Immunoglobulin G, Immunoglobulin M, Phosphorylcholine.
- drug therapy : Elephantiasis, Filarial.
- immunology : Elephantiasis, Filarial, Filariasis, Microfilariae, Wuchereria bancrofti.
- parasitology : Blood.
- chemical , therapeutic use : Diethylcarbamazine.
- Adolescent, Adult, Aged, Animals, Female, Humans, Male, Middle Aged.
Abstract
Sera from a total of 78 patients infected with Wuchereria bancrofti or appropriate controls were assayed for anti-phosphocholine antibodies in an enzyme-linked immunosorbent-assay (ELISA), using phosphocholine as an antigen. Anti-PC antibodies (both IgM and IgG) were observed in patients with all clinical forms of filariasis but, unexpectedly, were not significantly different from those of normal controls. Among the filariasis patients, however, individuals with patent microfilaraemia had significantly lower IgM-anti-PC titres (P less than 0.05) than did those of the other clinical groups. Competitive studies showed that 'naturally occurring' anti-PC antibodies interfere with PC antigen detection. Transient increases in the levels of circulating PC antigen were found by 3 days after treatment of microfilaraemic individuals with the filaricidal drug diethylcarbamazine. The subsequent decreases in antigen levels were generally associated with increased IgM- and IgG-anti-PC antibody levels. Such changes likely affect not only the ability to monitor the parasitological status of such individuals, but also the patient's subsequent immune interactions with filarial parasites.
PubMed: 2649285
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National Institute of Allergy and Infectious Diseases, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Ottesen, E A" sort="Ottesen, E A" uniqKey="Ottesen E" first="E A" last="Ottesen">E A Ottesen</name></author></analytic><series><title level="j">Clinical and experimental immunology</title><idno type="ISSN">0009-9104</idno><imprint><date when="1989" type="published">1989</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Animals</term><term>Antibodies (analysis)</term><term>Antigens (immunology)</term><term>Blood (parasitology)</term><term>Choline (analogs & derivatives)</term><term>Diethylcarbamazine (therapeutic use)</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Elephantiasis, Filarial (immunology)</term><term>Female</term><term>Filariasis (immunology)</term><term>Humans</term><term>Immunoglobulin G 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(immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Choline</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens</term><term>Immunoglobulin G</term><term>Immunoglobulin M</term><term>Phosphorylcholine</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Choline</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes</term><term>Filariose lymphatique</term><term>Filarioses</term><term>Immunoglobuline G</term><term>Immunoglobuline M</term><term>Microfilaria</term><term>Phosphoryl-choline</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Filariasis</term><term>Microfilariae</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Sang</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Blood</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Diethylcarbamazine</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Diéthylcarbamazine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Animals</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Sera from a total of 78 patients infected with Wuchereria bancrofti or appropriate controls were assayed for anti-phosphocholine antibodies in an enzyme-linked immunosorbent-assay (ELISA), using phosphocholine as an antigen. Anti-PC antibodies (both IgM and IgG) were observed in patients with all clinical forms of filariasis but, unexpectedly, were not significantly different from those of normal controls. Among the filariasis patients, however, individuals with patent microfilaraemia had significantly lower IgM-anti-PC titres (P less than 0.05) than did those of the other clinical groups. Competitive studies showed that 'naturally occurring' anti-PC antibodies interfere with PC antigen detection. Transient increases in the levels of circulating PC antigen were found by 3 days after treatment of microfilaraemic individuals with the filaricidal drug diethylcarbamazine. The subsequent decreases in antigen levels were generally associated with increased IgM- and IgG-anti-PC antibody levels. Such changes likely affect not only the ability to monitor the parasitological status of such individuals, but also the patient's subsequent immune interactions with filarial parasites.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">2649285</PMID><DateCreated><Year>1989</Year><Month>05</Month><Day>22</Day></DateCreated><DateCompleted><Year>1989</Year><Month>05</Month><Day>22</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>23</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0009-9104</ISSN><JournalIssue CitedMedium="Print"><Volume>75</Volume><Issue>1</Issue><PubDate><Year>1989</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Clinical and experimental immunology</Title><ISOAbbreviation>Clin. Exp. Immunol.</ISOAbbreviation></Journal><ArticleTitle>Antibodies to phosphocholine-bearing antigens in lymphatic filariasis and changes following treatment with diethylcarbamazine.</ArticleTitle><Pagination><MedlinePgn>52-7</MedlinePgn></Pagination><Abstract><AbstractText>Sera from a total of 78 patients infected with Wuchereria bancrofti or appropriate controls were assayed for anti-phosphocholine antibodies in an enzyme-linked immunosorbent-assay (ELISA), using phosphocholine as an antigen. Anti-PC antibodies (both IgM and IgG) were observed in patients with all clinical forms of filariasis but, unexpectedly, were not significantly different from those of normal controls. Among the filariasis patients, however, individuals with patent microfilaraemia had significantly lower IgM-anti-PC titres (P less than 0.05) than did those of the other clinical groups. Competitive studies showed that 'naturally occurring' anti-PC antibodies interfere with PC antigen detection. Transient increases in the levels of circulating PC antigen were found by 3 days after treatment of microfilaraemic individuals with the filaricidal drug diethylcarbamazine. The subsequent decreases in antigen levels were generally associated with increased IgM- and IgG-anti-PC antibody levels. Such changes likely affect not only the ability to monitor the parasitological status of such individuals, but also the patient's subsequent immune interactions with filarial parasites.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lal</LastName><ForeName>R B</ForeName><Initials>RB</Initials><AffiliationInfo><Affiliation>Laboratory of Parasitic Disease, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ottesen</LastName><ForeName>E A</ForeName><Initials>EA</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Clin Exp Immunol</MedlineTA><NlmUniqueID>0057202</NlmUniqueID><ISSNLinking>0009-9104</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000906">Antibodies</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000941">Antigens</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007075">Immunoglobulin M</NameOfSubstance></Chemical><Chemical><RegistryNumber>107-73-3</RegistryNumber><NameOfSubstance UI="D010767">Phosphorylcholine</NameOfSubstance></Chemical><Chemical><RegistryNumber>N91BDP6H0X</RegistryNumber><NameOfSubstance UI="D002794">Choline</NameOfSubstance></Chemical><Chemical><RegistryNumber>V867Q8X3ZD</RegistryNumber><NameOfSubstance UI="D004049">Diethylcarbamazine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Int Arch Allergy Appl Immunol. 1976;52(1-4):64-78</RefSource><PMID Version="1">1087923</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Immunology. 1977 Sep;33(3):413-21</RefSource><PMID Version="1">332621</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parasitology. 1979 Dec;79(3):303-16</RefSource><PMID Version="1">575562</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Immunol (Paris). 1979 Nov-Dec;130(6):879-88</RefSource><PMID Version="1">398680</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Parasitol. 1981 Oct;67(5):728-30</RefSource><PMID Version="1">7299586</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Trop. 1981 Sep;38(3):227-34</RefSource><PMID 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Version="1">2436131</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 1987 May 15;138(10):3454-60</RefSource><PMID Version="1">2437195</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 1987 Jun;155(6):1307-14</RefSource><PMID Version="1">3572041</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 1987 Aug;156(2):350-5</RefSource><PMID Version="1">3298458</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parasitology. 1987 Jun;94 ( Pt 3):543-53</RefSource><PMID Version="1">2441342</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Trop Med Hyg. 1988 Jan;38(1):133-41</RefSource><PMID Version="1">2449088</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000906" MajorTopicYN="N">Antibodies</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000941" MajorTopicYN="N">Antigens</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001769" MajorTopicYN="N">Blood</DescriptorName><QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002794" MajorTopicYN="N">Choline</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004049" MajorTopicYN="N">Diethylcarbamazine</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005368" MajorTopicYN="N">Filariasis</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007075" MajorTopicYN="N">Immunoglobulin M</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008842" MajorTopicYN="N">Microfilariae</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010767" MajorTopicYN="N">Phosphorylcholine</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014958" MajorTopicYN="N">Wuchereria bancrofti</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC1541878</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate 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