Adjuvant radiotherapy following radical hysterectomy for patients with stage IB and IIA cervical cancer.
Identifieur interne : 005D50 ( PubMed/Curation ); précédent : 005D49; suivant : 005D51Adjuvant radiotherapy following radical hysterectomy for patients with stage IB and IIA cervical cancer.
Auteurs : A P Soisson [États-Unis] ; J T Soper ; D L Clarke-Pearson ; A. Berchuck ; G. Montana ; W T CreasmanSource :
- Gynecologic oncology [ 0090-8258 ] ; 1990.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Analyse de survie, Association thérapeutique, Femelle, Humains, Hystérectomie (), Lymphoedème (étiologie), Lésions radio-induites, Métastase lymphatique, Noeuds lymphatiques (anatomopathologie), Récidive tumorale locale, Sujet âgé, Tumeurs du col de l'utérus (), Tumeurs du col de l'utérus (mortalité), Tumeurs du col de l'utérus (radiothérapie).
- MESH :
- anatomopathologie : Noeuds lymphatiques.
- mortalité : Tumeurs du col de l'utérus.
- radiothérapie : Tumeurs du col de l'utérus.
- étiologie : Lymphoedème.
- Adolescent, Adulte, Adulte d'âge moyen, Analyse de survie, Association thérapeutique, Femelle, Humains, Hystérectomie, Lésions radio-induites, Métastase lymphatique, Récidive tumorale locale, Sujet âgé, Tumeurs du col de l'utérus.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Combined Modality Therapy, Female, Humans, Hysterectomy (methods), Lymph Nodes (pathology), Lymphatic Metastasis, Lymphedema (etiology), Middle Aged, Neoplasm Recurrence, Local, Radiation Injuries, Survival Analysis, Uterine Cervical Neoplasms (mortality), Uterine Cervical Neoplasms (radiotherapy), Uterine Cervical Neoplasms (surgery).
- MESH :
- etiology : Lymphedema.
- methods : Hysterectomy.
- mortality : Uterine Cervical Neoplasms.
- pathology : Lymph Nodes.
- radiotherapy : Uterine Cervical Neoplasms.
- surgery : Uterine Cervical Neoplasms.
- Adolescent, Adult, Aged, Combined Modality Therapy, Female, Humans, Lymphatic Metastasis, Middle Aged, Neoplasm Recurrence, Local, Radiation Injuries, Survival Analysis.
Abstract
From 1971 through 1984, 320 women underwent radical hysterectomy as primary therapy of stage IB and IIA cervical cancer. Two hundred forty-eight patients (78%) were treated with surgery alone and 72 patients (22%) received adjuvant postoperative external-beam radiotherapy. Presence of lymph node metastasis, large lesion (greater than 4 cm in diameter), histologic grade, race (noncaucasian), and age (greater than 40 years) were significant poor prognostic factors for the entire group of patients. Patients treated with surgery alone had a better disease-free survival than those who received combination therapy (P less than 0.001). However, patients receiving adjuvant radiation therapy had a higher incidence of lymphatic metastases, tumor involvement of the surgical margin, and large cervical lesions. Adjuvant pelvic radiation therapy did not improve the survival of patients with unilateral nodal metastases or those who had a large cervical lesion with free surgical margins and the absence of nodal involvement. Radiation therapy appears to reduce the incidence of pelvic recurrences. Unfortunately, 84% of patients who developed recurrent tumor after combination therapy had a component of distant failure. The incidence of severe gastrointestinal or genitourinary tract complications was not different in the two treatment groups. However, the incidence of lymphedema was increased in patients who received adjuvant radiation therapy. Although adjuvant radiation therapy appears to be tolerated without a significant increase in serious complications, the extent to which it may improve local control rates and survival in high-risk patients appears to be limited. In view of the high incidence of distant metastases in high-risk patients, consideration should be given to adjuvant systemic chemotherapy in addition to radiation therapy.
PubMed: 2351324
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :005D50
Links to Exploration step
pubmed:2351324Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Adjuvant radiotherapy following radical hysterectomy for patients with stage IB and IIA cervical cancer.</title><author><name sortKey="Soisson, A P" sort="Soisson, A P" uniqKey="Soisson A" first="A P" last="Soisson">A P Soisson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina 27710.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Obstetrics and Gynecology, Duke University Medical Center, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Soper, J T" sort="Soper, J T" uniqKey="Soper J" first="J T" last="Soper">J T Soper</name></author><author><name sortKey="Clarke Pearson, D L" sort="Clarke Pearson, D L" uniqKey="Clarke Pearson D" first="D L" last="Clarke-Pearson">D L Clarke-Pearson</name></author><author><name sortKey="Berchuck, A" sort="Berchuck, A" uniqKey="Berchuck A" first="A" last="Berchuck">A. Berchuck</name></author><author><name sortKey="Montana, G" sort="Montana, G" uniqKey="Montana G" first="G" last="Montana">G. Montana</name></author><author><name sortKey="Creasman, W T" sort="Creasman, W T" uniqKey="Creasman W" first="W T" last="Creasman">W T Creasman</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1990">1990</date><idno type="RBID">pubmed:2351324</idno><idno type="pmid">2351324</idno><idno type="wicri:Area/PubMed/Corpus">005D50</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005D50</idno><idno type="wicri:Area/PubMed/Curation">005D50</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">005D50</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Adjuvant radiotherapy following radical hysterectomy for patients with stage IB and IIA cervical cancer.</title><author><name sortKey="Soisson, A P" sort="Soisson, A P" uniqKey="Soisson A" first="A P" last="Soisson">A P Soisson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina 27710.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Obstetrics and Gynecology, Duke University Medical Center, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Soper, J T" sort="Soper, J T" uniqKey="Soper J" first="J T" last="Soper">J T Soper</name></author><author><name sortKey="Clarke Pearson, D L" sort="Clarke Pearson, D L" uniqKey="Clarke Pearson D" first="D L" last="Clarke-Pearson">D L Clarke-Pearson</name></author><author><name sortKey="Berchuck, A" sort="Berchuck, A" uniqKey="Berchuck A" first="A" last="Berchuck">A. Berchuck</name></author><author><name sortKey="Montana, G" sort="Montana, G" uniqKey="Montana G" first="G" last="Montana">G. Montana</name></author><author><name sortKey="Creasman, W T" sort="Creasman, W T" uniqKey="Creasman W" first="W T" last="Creasman">W T Creasman</name></author></analytic><series><title level="j">Gynecologic oncology</title><idno type="ISSN">0090-8258</idno><imprint><date when="1990" type="published">1990</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Combined Modality Therapy</term><term>Female</term><term>Humans</term><term>Hysterectomy (methods)</term><term>Lymph Nodes (pathology)</term><term>Lymphatic Metastasis</term><term>Lymphedema (etiology)</term><term>Middle Aged</term><term>Neoplasm Recurrence, Local</term><term>Radiation Injuries</term><term>Survival Analysis</term><term>Uterine Cervical Neoplasms (mortality)</term><term>Uterine Cervical Neoplasms (radiotherapy)</term><term>Uterine Cervical Neoplasms (surgery)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de survie</term><term>Association thérapeutique</term><term>Femelle</term><term>Humains</term><term>Hystérectomie ()</term><term>Lymphoedème (étiologie)</term><term>Lésions radio-induites</term><term>Métastase lymphatique</term><term>Noeuds lymphatiques (anatomopathologie)</term><term>Récidive tumorale locale</term><term>Sujet âgé</term><term>Tumeurs du col de l'utérus ()</term><term>Tumeurs du col de l'utérus (mortalité)</term><term>Tumeurs du col de l'utérus (radiothérapie)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Noeuds lymphatiques</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Hysterectomy</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Tumeurs du col de l'utérus</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymph Nodes</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Tumeurs du col de l'utérus</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Combined Modality Therapy</term><term>Female</term><term>Humans</term><term>Lymphatic Metastasis</term><term>Middle Aged</term><term>Neoplasm Recurrence, Local</term><term>Radiation Injuries</term><term>Survival Analysis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de survie</term><term>Association thérapeutique</term><term>Femelle</term><term>Humains</term><term>Hystérectomie</term><term>Lésions radio-induites</term><term>Métastase lymphatique</term><term>Récidive tumorale locale</term><term>Sujet âgé</term><term>Tumeurs du col de l'utérus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">From 1971 through 1984, 320 women underwent radical hysterectomy as primary therapy of stage IB and IIA cervical cancer. Two hundred forty-eight patients (78%) were treated with surgery alone and 72 patients (22%) received adjuvant postoperative external-beam radiotherapy. Presence of lymph node metastasis, large lesion (greater than 4 cm in diameter), histologic grade, race (noncaucasian), and age (greater than 40 years) were significant poor prognostic factors for the entire group of patients. Patients treated with surgery alone had a better disease-free survival than those who received combination therapy (P less than 0.001). However, patients receiving adjuvant radiation therapy had a higher incidence of lymphatic metastases, tumor involvement of the surgical margin, and large cervical lesions. Adjuvant pelvic radiation therapy did not improve the survival of patients with unilateral nodal metastases or those who had a large cervical lesion with free surgical margins and the absence of nodal involvement. Radiation therapy appears to reduce the incidence of pelvic recurrences. Unfortunately, 84% of patients who developed recurrent tumor after combination therapy had a component of distant failure. The incidence of severe gastrointestinal or genitourinary tract complications was not different in the two treatment groups. However, the incidence of lymphedema was increased in patients who received adjuvant radiation therapy. Although adjuvant radiation therapy appears to be tolerated without a significant increase in serious complications, the extent to which it may improve local control rates and survival in high-risk patients appears to be limited. In view of the high incidence of distant metastases in high-risk patients, consideration should be given to adjuvant systemic chemotherapy in addition to radiation therapy.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">2351324</PMID><DateCreated><Year>1990</Year><Month>07</Month><Day>13</Day></DateCreated><DateCompleted><Year>1990</Year><Month>07</Month><Day>13</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0090-8258</ISSN><JournalIssue CitedMedium="Print"><Volume>37</Volume><Issue>3</Issue><PubDate><Year>1990</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Gynecologic oncology</Title><ISOAbbreviation>Gynecol. Oncol.</ISOAbbreviation></Journal><ArticleTitle>Adjuvant radiotherapy following radical hysterectomy for patients with stage IB and IIA cervical cancer.</ArticleTitle><Pagination><MedlinePgn>390-5</MedlinePgn></Pagination><Abstract><AbstractText>From 1971 through 1984, 320 women underwent radical hysterectomy as primary therapy of stage IB and IIA cervical cancer. Two hundred forty-eight patients (78%) were treated with surgery alone and 72 patients (22%) received adjuvant postoperative external-beam radiotherapy. Presence of lymph node metastasis, large lesion (greater than 4 cm in diameter), histologic grade, race (noncaucasian), and age (greater than 40 years) were significant poor prognostic factors for the entire group of patients. Patients treated with surgery alone had a better disease-free survival than those who received combination therapy (P less than 0.001). However, patients receiving adjuvant radiation therapy had a higher incidence of lymphatic metastases, tumor involvement of the surgical margin, and large cervical lesions. Adjuvant pelvic radiation therapy did not improve the survival of patients with unilateral nodal metastases or those who had a large cervical lesion with free surgical margins and the absence of nodal involvement. Radiation therapy appears to reduce the incidence of pelvic recurrences. Unfortunately, 84% of patients who developed recurrent tumor after combination therapy had a component of distant failure. The incidence of severe gastrointestinal or genitourinary tract complications was not different in the two treatment groups. However, the incidence of lymphedema was increased in patients who received adjuvant radiation therapy. Although adjuvant radiation therapy appears to be tolerated without a significant increase in serious complications, the extent to which it may improve local control rates and survival in high-risk patients appears to be limited. In view of the high incidence of distant metastases in high-risk patients, consideration should be given to adjuvant systemic chemotherapy in addition to radiation therapy.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Soisson</LastName><ForeName>A P</ForeName><Initials>AP</Initials><AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina 27710.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soper</LastName><ForeName>J T</ForeName><Initials>JT</Initials></Author><Author ValidYN="Y"><LastName>Clarke-Pearson</LastName><ForeName>D L</ForeName><Initials>DL</Initials></Author><Author ValidYN="Y"><LastName>Berchuck</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Montana</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Creasman</LastName><ForeName>W T</ForeName><Initials>WT</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Gynecol Oncol</MedlineTA><NlmUniqueID>0365304</NlmUniqueID><ISSNLinking>0090-8258</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003131" MajorTopicYN="N">Combined Modality Therapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007044" MajorTopicYN="N">Hysterectomy</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008198" MajorTopicYN="N">Lymph Nodes</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008207" MajorTopicYN="N">Lymphatic Metastasis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009364" MajorTopicYN="N">Neoplasm Recurrence, Local</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011832" MajorTopicYN="N">Radiation Injuries</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016019" MajorTopicYN="N">Survival Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002583" MajorTopicYN="N">Uterine Cervical Neoplasms</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000532" MajorTopicYN="Y">radiotherapy</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1990</Year><Month>6</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1990</Year><Month>6</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1990</Year><Month>6</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">2351324</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005D50 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 005D50 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:2351324
|texte= Adjuvant radiotherapy following radical hysterectomy for patients with stage IB and IIA cervical cancer.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:2351324" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |