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Non-specific immune suppression by CD8+ T cells in Brugia pahangi-infected rats.

Identifieur interne : 005C79 ( PubMed/Curation ); précédent : 005C78; suivant : 005C80

Non-specific immune suppression by CD8+ T cells in Brugia pahangi-infected rats.

Auteurs : M. Owhashi [Japon] ; Y. Horii ; T. Ikeda ; S. Tsukidate ; K. Fujita ; Y. Nawa

Source :

International journal for parasitology [ 0020-7519 ] ; 1990.

RBID : pubmed:2148931

Descripteurs français

KwdFr :
- Activation des lymphocytes, Animaux, Brugia (immunologie), Filariose lymphatique (immunologie), Lymphocytes T régulateurs (immunologie), Mâle, Rats, Rats de lignée LEW, Tolérance immunitaire.
MESH :
- immunologie : Brugia, Filariose lymphatique, Lymphocytes T régulateurs.
- Activation des lymphocytes, Animaux, Mâle, Rats, Rats de lignée LEW, Tolérance immunitaire.

English descriptors

KwdEn :
- Animals, Brugia (immunology), Elephantiasis, Filarial (immunology), Immune Tolerance, Lymphocyte Activation, Male, Rats, Rats, Inbred Lew, T-Lymphocytes, Regulatory (immunology).
MESH :
- immunology : Brugia, Elephantiasis, Filarial, T-Lymphocytes, Regulatory.
- Animals, Immune Tolerance, Lymphocyte Activation, Male, Rats, Rats, Inbred Lew.

Abstract

Non-specific suppression of the immune response was investigated in Brugia pahangi-infected Lewis rats. The proliferative response of peripheral blood lymphocytes or splenic non-adherent cells to mitogens was significantly reduced by B. pahangi infection. The degree of hyporesponsiveness of splenic non-adherent cells to mitogens was comparable between microfilaremic and non-microfilaremic animals. The suppressed proliferative response of splenic non-adherent cells was restored by blocking with anti-CD8 monoclonal antibody. After separation of T cells into CD4+ and CD8+ subpopulations, only CD8+ T cells from B. pahangi-infected rats suppressed the proliferative response of normal spleen cells to concanavalin A. CD8+ T cells from normal rats had no suppressive effect. On the other hand, the proliferative response of CD4+ T cells to concanavalin A was comparable between normal and infected rats. These results suggest that CD8+ T cells participate in the non-specific suppression of immune response in experimental filariasis.

PubMed: 2148931

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Le document en format XML

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<author><name sortKey="Owhashi, M" sort="Owhashi, M" uniqKey="Owhashi M" first="M" last="Owhashi">M. Owhashi</name>
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<wicri:regionArea>Department of Parasitology, Miyazaki Medical College</wicri:regionArea>
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<author><name sortKey="Horii, Y" sort="Horii, Y" uniqKey="Horii Y" first="Y" last="Horii">Y. Horii</name>
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<author><name sortKey="Ikeda, T" sort="Ikeda, T" uniqKey="Ikeda T" first="T" last="Ikeda">T. Ikeda</name>
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<author><name sortKey="Tsukidate, S" sort="Tsukidate, S" uniqKey="Tsukidate S" first="S" last="Tsukidate">S. Tsukidate</name>
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<author><name sortKey="Fujita, K" sort="Fujita, K" uniqKey="Fujita K" first="K" last="Fujita">K. Fujita</name>
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<author><name sortKey="Nawa, Y" sort="Nawa, Y" uniqKey="Nawa Y" first="Y" last="Nawa">Y. Nawa</name>
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<author><name sortKey="Tsukidate, S" sort="Tsukidate, S" uniqKey="Tsukidate S" first="S" last="Tsukidate">S. Tsukidate</name>
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<author><name sortKey="Fujita, K" sort="Fujita, K" uniqKey="Fujita K" first="K" last="Fujita">K. Fujita</name>
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<term>Elephantiasis, Filarial (immunology)</term>
<term>Immune Tolerance</term>
<term>Lymphocyte Activation</term>
<term>Male</term>
<term>Rats</term>
<term>Rats, Inbred Lew</term>
<term>T-Lymphocytes, Regulatory (immunology)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes</term>
<term>Animaux</term>
<term>Brugia (immunologie)</term>
<term>Filariose lymphatique (immunologie)</term>
<term>Lymphocytes T régulateurs (immunologie)</term>
<term>Mâle</term>
<term>Rats</term>
<term>Rats de lignée LEW</term>
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<term>T-Lymphocytes, Regulatory</term>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Immune Tolerance</term>
<term>Lymphocyte Activation</term>
<term>Male</term>
<term>Rats</term>
<term>Rats, Inbred Lew</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term>
<term>Animaux</term>
<term>Mâle</term>
<term>Rats</term>
<term>Rats de lignée LEW</term>
<term>Tolérance immunitaire</term>
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<front><div type="abstract" xml:lang="en">Non-specific suppression of the immune response was investigated in Brugia pahangi-infected Lewis rats. The proliferative response of peripheral blood lymphocytes or splenic non-adherent cells to mitogens was significantly reduced by B. pahangi infection. The degree of hyporesponsiveness of splenic non-adherent cells to mitogens was comparable between microfilaremic and non-microfilaremic animals. The suppressed proliferative response of splenic non-adherent cells was restored by blocking with anti-CD8 monoclonal antibody. After separation of T cells into CD4+ and CD8+ subpopulations, only CD8+ T cells from B. pahangi-infected rats suppressed the proliferative response of normal spleen cells to concanavalin A. CD8+ T cells from normal rats had no suppressive effect. On the other hand, the proliferative response of CD4+ T cells to concanavalin A was comparable between normal and infected rats. These results suggest that CD8+ T cells participate in the non-specific suppression of immune response in experimental filariasis.</div>
</front>
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<Title>International journal for parasitology</Title>
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<Abstract><AbstractText>Non-specific suppression of the immune response was investigated in Brugia pahangi-infected Lewis rats. The proliferative response of peripheral blood lymphocytes or splenic non-adherent cells to mitogens was significantly reduced by B. pahangi infection. The degree of hyporesponsiveness of splenic non-adherent cells to mitogens was comparable between microfilaremic and non-microfilaremic animals. The suppressed proliferative response of splenic non-adherent cells was restored by blocking with anti-CD8 monoclonal antibody. After separation of T cells into CD4+ and CD8+ subpopulations, only CD8+ T cells from B. pahangi-infected rats suppressed the proliferative response of normal spleen cells to concanavalin A. CD8+ T cells from normal rats had no suppressive effect. On the other hand, the proliferative response of CD4+ T cells to concanavalin A was comparable between normal and infected rats. These results suggest that CD8+ T cells participate in the non-specific suppression of immune response in experimental filariasis.</AbstractText>
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Non-specific immune suppression by CD8+ T cells in Brugia pahangi-infected rats.

Non-specific immune suppression by CD8+ T cells in Brugia pahangi-infected rats.

Source :

Descripteurs français

English descriptors

Abstract

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Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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Pour générer des pages wiki