Non-specific immune suppression by CD8+ T cells in Brugia pahangi-infected rats.
Identifieur interne : 005C79 ( PubMed/Curation ); précédent : 005C78; suivant : 005C80Non-specific immune suppression by CD8+ T cells in Brugia pahangi-infected rats.
Auteurs : M. Owhashi [Japon] ; Y. Horii ; T. Ikeda ; S. Tsukidate ; K. Fujita ; Y. NawaSource :
- International journal for parasitology [ 0020-7519 ] ; 1990.
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- MESH :
English descriptors
- KwdEn :
- MESH :
Abstract
Non-specific suppression of the immune response was investigated in Brugia pahangi-infected Lewis rats. The proliferative response of peripheral blood lymphocytes or splenic non-adherent cells to mitogens was significantly reduced by B. pahangi infection. The degree of hyporesponsiveness of splenic non-adherent cells to mitogens was comparable between microfilaremic and non-microfilaremic animals. The suppressed proliferative response of splenic non-adherent cells was restored by blocking with anti-CD8 monoclonal antibody. After separation of T cells into CD4+ and CD8+ subpopulations, only CD8+ T cells from B. pahangi-infected rats suppressed the proliferative response of normal spleen cells to concanavalin A. CD8+ T cells from normal rats had no suppressive effect. On the other hand, the proliferative response of CD4+ T cells to concanavalin A was comparable between normal and infected rats. These results suggest that CD8+ T cells participate in the non-specific suppression of immune response in experimental filariasis.
PubMed: 2148931
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<author><name sortKey="Owhashi, M" sort="Owhashi, M" uniqKey="Owhashi M" first="M" last="Owhashi">M. Owhashi</name>
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<author><name sortKey="Ikeda, T" sort="Ikeda, T" uniqKey="Ikeda T" first="T" last="Ikeda">T. Ikeda</name>
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<author><name sortKey="Tsukidate, S" sort="Tsukidate, S" uniqKey="Tsukidate S" first="S" last="Tsukidate">S. Tsukidate</name>
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<author><name sortKey="Fujita, K" sort="Fujita, K" uniqKey="Fujita K" first="K" last="Fujita">K. Fujita</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Non-specific immune suppression by CD8+ T cells in Brugia pahangi-infected rats.</title>
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<author><name sortKey="Tsukidate, S" sort="Tsukidate, S" uniqKey="Tsukidate S" first="S" last="Tsukidate">S. Tsukidate</name>
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<author><name sortKey="Fujita, K" sort="Fujita, K" uniqKey="Fujita K" first="K" last="Fujita">K. Fujita</name>
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<term>Brugia (immunology)</term>
<term>Elephantiasis, Filarial (immunology)</term>
<term>Immune Tolerance</term>
<term>Lymphocyte Activation</term>
<term>Male</term>
<term>Rats</term>
<term>Rats, Inbred Lew</term>
<term>T-Lymphocytes, Regulatory (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes</term>
<term>Animaux</term>
<term>Brugia (immunologie)</term>
<term>Filariose lymphatique (immunologie)</term>
<term>Lymphocytes T régulateurs (immunologie)</term>
<term>Mâle</term>
<term>Rats</term>
<term>Rats de lignée LEW</term>
<term>Tolérance immunitaire</term>
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<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Brugia</term>
<term>Filariose lymphatique</term>
<term>Lymphocytes T régulateurs</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia</term>
<term>Elephantiasis, Filarial</term>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Immune Tolerance</term>
<term>Lymphocyte Activation</term>
<term>Male</term>
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<term>Rats, Inbred Lew</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term>
<term>Animaux</term>
<term>Mâle</term>
<term>Rats</term>
<term>Rats de lignée LEW</term>
<term>Tolérance immunitaire</term>
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<front><div type="abstract" xml:lang="en">Non-specific suppression of the immune response was investigated in Brugia pahangi-infected Lewis rats. The proliferative response of peripheral blood lymphocytes or splenic non-adherent cells to mitogens was significantly reduced by B. pahangi infection. The degree of hyporesponsiveness of splenic non-adherent cells to mitogens was comparable between microfilaremic and non-microfilaremic animals. The suppressed proliferative response of splenic non-adherent cells was restored by blocking with anti-CD8 monoclonal antibody. After separation of T cells into CD4+ and CD8+ subpopulations, only CD8+ T cells from B. pahangi-infected rats suppressed the proliferative response of normal spleen cells to concanavalin A. CD8+ T cells from normal rats had no suppressive effect. On the other hand, the proliferative response of CD4+ T cells to concanavalin A was comparable between normal and infected rats. These results suggest that CD8+ T cells participate in the non-specific suppression of immune response in experimental filariasis.</div>
</front>
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<Title>International journal for parasitology</Title>
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<ArticleTitle>Non-specific immune suppression by CD8+ T cells in Brugia pahangi-infected rats.</ArticleTitle>
<Pagination><MedlinePgn>951-6</MedlinePgn>
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<Abstract><AbstractText>Non-specific suppression of the immune response was investigated in Brugia pahangi-infected Lewis rats. The proliferative response of peripheral blood lymphocytes or splenic non-adherent cells to mitogens was significantly reduced by B. pahangi infection. The degree of hyporesponsiveness of splenic non-adherent cells to mitogens was comparable between microfilaremic and non-microfilaremic animals. The suppressed proliferative response of splenic non-adherent cells was restored by blocking with anti-CD8 monoclonal antibody. After separation of T cells into CD4+ and CD8+ subpopulations, only CD8+ T cells from B. pahangi-infected rats suppressed the proliferative response of normal spleen cells to concanavalin A. CD8+ T cells from normal rats had no suppressive effect. On the other hand, the proliferative response of CD4+ T cells to concanavalin A was comparable between normal and infected rats. These results suggest that CD8+ T cells participate in the non-specific suppression of immune response in experimental filariasis.</AbstractText>
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<MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName>
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<MeshHeading><DescriptorName UI="D007108" MajorTopicYN="N">Immune Tolerance</DescriptorName>
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