Histopathology of Brugia malayi-infected nude mice after immune-reconstitution.
Identifieur interne : 005B75 ( PubMed/Curation ); précédent : 005B74; suivant : 005B76Histopathology of Brugia malayi-infected nude mice after immune-reconstitution.
Auteurs : A C Vickery [États-Unis] ; K H Albertine ; J K Nayar ; B H KwaSource :
- Acta tropica [ 0001-706X ] ; 1991.
Descripteurs français
- KwdFr :
- Animaux, Brugia, Cellules géantes de Langhans (anatomopathologie), Fibrose, Filariose lymphatique (), Filariose lymphatique (anatomopathologie), Filariose lymphatique (immunologie), Granulome (anatomopathologie), Immunothérapie adoptive, Lymphocytes (anatomopathologie), Macrophages (anatomopathologie), Microscopie électronique, Modèles animaux de maladie humaine, Mâle, Souris, Souris nude, Système lymphatique (anatomopathologie), Système lymphatique (ultrastructure).
- MESH :
- anatomopathologie : Cellules géantes de Langhans, Filariose lymphatique, Granulome, Lymphocytes, Macrophages, Système lymphatique.
- immunologie : Filariose lymphatique.
- Animaux, Brugia, Fibrose, Filariose lymphatique, Immunothérapie adoptive, Microscopie électronique, Modèles animaux de maladie humaine, Mâle, Souris, Souris nude, Système lymphatique.
English descriptors
- KwdEn :
- Animals, Brugia, Disease Models, Animal, Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (pathology), Elephantiasis, Filarial (therapy), Fibrosis, Giant Cells, Langhans (pathology), Granuloma (pathology), Immunotherapy, Adoptive, Lymphatic System (pathology), Lymphatic System (ultrastructure), Lymphocytes (pathology), Macrophages (pathology), Male, Mice, Mice, Nude, Microscopy, Electron.
- MESH :
- immunology : Elephantiasis, Filarial.
- pathology : Elephantiasis, Filarial, Giant Cells, Langhans, Granuloma, Lymphatic System, Lymphocytes, Macrophages.
- therapy : Elephantiasis, Filarial.
- ultrastructure : Lymphatic System.
- Animals, Brugia, Disease Models, Animal, Fibrosis, Immunotherapy, Adoptive, Male, Mice, Mice, Nude, Microscopy, Electron.
Abstract
Long term (greater than 200 day) Brugia malayi-infected nude mice with grossly dilated lymphatics were reconstituted with 10(8) primed spleen cells from heterozygous donors. Histological and ultrastructural examination at 7, 14, 21 and 28 days post-reconstitution revealed progressive fibrosis, obliterative lymph thrombus formation, interstitial infiltrates and extensive perilymphangitis. Formation of lymph thrombi/granulomas was associated with killing of adult worms and microfilariae, and the predominant cell types involved were large granular macrophages. Langhan's giant cells and eosinophils. Thus, the ability to initiate the formation of obstructive lesions in the dilated lymphatics of chronically parasitized nude mice by immunological reconstitution, suggests that several complex mechanisms might operate in stages to cause filarial elephantiasis.
PubMed: 1678575
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Kwa</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1991">1991</date><idno type="RBID">pubmed:1678575</idno><idno type="pmid">1678575</idno><idno type="wicri:Area/PubMed/Corpus">005B75</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005B75</idno><idno type="wicri:Area/PubMed/Curation">005B75</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">005B75</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Histopathology of Brugia malayi-infected nude mice after immune-reconstitution.</title><author><name sortKey="Vickery, A C" sort="Vickery, A C" uniqKey="Vickery A" first="A C" last="Vickery">A C Vickery</name><affiliation wicri:level="4"><nlm:affiliation>College of Public Health, University of South Florida, Tampa 33612.</nlm:affiliation><orgName type="university">Université de Floride du 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Filarial (therapy)</term><term>Fibrosis</term><term>Giant Cells, Langhans (pathology)</term><term>Granuloma (pathology)</term><term>Immunotherapy, Adoptive</term><term>Lymphatic System (pathology)</term><term>Lymphatic System (ultrastructure)</term><term>Lymphocytes (pathology)</term><term>Macrophages (pathology)</term><term>Male</term><term>Mice</term><term>Mice, Nude</term><term>Microscopy, Electron</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Brugia</term><term>Cellules géantes de Langhans (anatomopathologie)</term><term>Fibrose</term><term>Filariose lymphatique ()</term><term>Filariose lymphatique (anatomopathologie)</term><term>Filariose lymphatique (immunologie)</term><term>Granulome (anatomopathologie)</term><term>Immunothérapie adoptive</term><term>Lymphocytes (anatomopathologie)</term><term>Macrophages (anatomopathologie)</term><term>Microscopie électronique</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Souris</term><term>Souris nude</term><term>Système lymphatique (anatomopathologie)</term><term>Système lymphatique (ultrastructure)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cellules géantes de Langhans</term><term>Filariose lymphatique</term><term>Granulome</term><term>Lymphocytes</term><term>Macrophages</term><term>Système lymphatique</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Giant Cells, Langhans</term><term>Granuloma</term><term>Lymphatic System</term><term>Lymphocytes</term><term>Macrophages</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Lymphatic System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Brugia</term><term>Disease Models, Animal</term><term>Fibrosis</term><term>Immunotherapy, Adoptive</term><term>Male</term><term>Mice</term><term>Mice, Nude</term><term>Microscopy, Electron</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Brugia</term><term>Fibrose</term><term>Filariose lymphatique</term><term>Immunothérapie adoptive</term><term>Microscopie électronique</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Souris</term><term>Souris nude</term><term>Système lymphatique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Long term (greater than 200 day) Brugia malayi-infected nude mice with grossly dilated lymphatics were reconstituted with 10(8) primed spleen cells from heterozygous donors. Histological and ultrastructural examination at 7, 14, 21 and 28 days post-reconstitution revealed progressive fibrosis, obliterative lymph thrombus formation, interstitial infiltrates and extensive perilymphangitis. Formation of lymph thrombi/granulomas was associated with killing of adult worms and microfilariae, and the predominant cell types involved were large granular macrophages. Langhan's giant cells and eosinophils. Thus, the ability to initiate the formation of obstructive lesions in the dilated lymphatics of chronically parasitized nude mice by immunological reconstitution, suggests that several complex mechanisms might operate in stages to cause filarial elephantiasis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">1678575</PMID><DateCreated><Year>1991</Year><Month>09</Month><Day>17</Day></DateCreated><DateCompleted><Year>1991</Year><Month>09</Month><Day>17</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0001-706X</ISSN><JournalIssue CitedMedium="Print"><Volume>49</Volume><Issue>1</Issue><PubDate><Year>1991</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Acta tropica</Title><ISOAbbreviation>Acta Trop.</ISOAbbreviation></Journal><ArticleTitle>Histopathology of Brugia malayi-infected nude mice after immune-reconstitution.</ArticleTitle><Pagination><MedlinePgn>45-55</MedlinePgn></Pagination><Abstract><AbstractText>Long term (greater than 200 day) Brugia malayi-infected nude mice with grossly dilated lymphatics were reconstituted with 10(8) primed spleen cells from heterozygous donors. Histological and ultrastructural examination at 7, 14, 21 and 28 days post-reconstitution revealed progressive fibrosis, obliterative lymph thrombus formation, interstitial infiltrates and extensive perilymphangitis. Formation of lymph thrombi/granulomas was associated with killing of adult worms and microfilariae, and the predominant cell types involved were large granular macrophages. Langhan's giant cells and eosinophils. Thus, the ability to initiate the formation of obstructive lesions in the dilated lymphatics of chronically parasitized nude mice by immunological reconstitution, suggests that several complex mechanisms might operate in stages to cause filarial elephantiasis.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vickery</LastName><ForeName>A C</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>College of Public Health, University of South Florida, Tampa 33612.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Albertine</LastName><ForeName>K H</ForeName><Initials>KH</Initials></Author><Author ValidYN="Y"><LastName>Nayar</LastName><ForeName>J K</ForeName><Initials>JK</Initials></Author><Author ValidYN="Y"><LastName>Kwa</LastName><ForeName>B H</ForeName><Initials>BH</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Acta Trop</MedlineTA><NlmUniqueID>0370374</NlmUniqueID><ISSNLinking>0001-706X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002009" MajorTopicYN="Y">Brugia</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005355" MajorTopicYN="N">Fibrosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015744" MajorTopicYN="N">Giant Cells, Langhans</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006099" MajorTopicYN="N">Granuloma</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016219" MajorTopicYN="Y">Immunotherapy, Adoptive</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008208" MajorTopicYN="N">Lymphatic System</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008214" MajorTopicYN="N">Lymphocytes</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008264" MajorTopicYN="N">Macrophages</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008819" MajorTopicYN="N">Mice, Nude</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008854" MajorTopicYN="N">Microscopy, Electron</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1991</Year><Month>4</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1991</Year><Month>4</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1991</Year><Month>4</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">1678575</ArticleId><ArticleId IdType="pii">0001-706X(91)90029-J</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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