Histopathology of Brugia malayi-infected nude mice after immune-reconstitution.
Identifieur interne : 005B75 ( PubMed/Curation ); précédent : 005B74; suivant : 005B76Histopathology of Brugia malayi-infected nude mice after immune-reconstitution.
Auteurs : A C Vickery [États-Unis] ; K H Albertine ; J K Nayar ; B H KwaSource :
- Acta tropica [ 0001-706X ] ; 1991.
Descripteurs français
- KwdFr :
- Animaux, Brugia, Cellules géantes de Langhans (anatomopathologie), Fibrose, Filariose lymphatique (), Filariose lymphatique (anatomopathologie), Filariose lymphatique (immunologie), Granulome (anatomopathologie), Immunothérapie adoptive, Lymphocytes (anatomopathologie), Macrophages (anatomopathologie), Microscopie électronique, Modèles animaux de maladie humaine, Mâle, Souris, Souris nude, Système lymphatique (anatomopathologie), Système lymphatique (ultrastructure).
- MESH :
- anatomopathologie : Cellules géantes de Langhans, Filariose lymphatique, Granulome, Lymphocytes, Macrophages, Système lymphatique.
- immunologie : Filariose lymphatique.
- Animaux, Brugia, Fibrose, Filariose lymphatique, Immunothérapie adoptive, Microscopie électronique, Modèles animaux de maladie humaine, Mâle, Souris, Souris nude, Système lymphatique.
English descriptors
- KwdEn :
- Animals, Brugia, Disease Models, Animal, Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (pathology), Elephantiasis, Filarial (therapy), Fibrosis, Giant Cells, Langhans (pathology), Granuloma (pathology), Immunotherapy, Adoptive, Lymphatic System (pathology), Lymphatic System (ultrastructure), Lymphocytes (pathology), Macrophages (pathology), Male, Mice, Mice, Nude, Microscopy, Electron.
- MESH :
- immunology : Elephantiasis, Filarial.
- pathology : Elephantiasis, Filarial, Giant Cells, Langhans, Granuloma, Lymphatic System, Lymphocytes, Macrophages.
- therapy : Elephantiasis, Filarial.
- ultrastructure : Lymphatic System.
- Animals, Brugia, Disease Models, Animal, Fibrosis, Immunotherapy, Adoptive, Male, Mice, Mice, Nude, Microscopy, Electron.
Abstract
Long term (greater than 200 day) Brugia malayi-infected nude mice with grossly dilated lymphatics were reconstituted with 10(8) primed spleen cells from heterozygous donors. Histological and ultrastructural examination at 7, 14, 21 and 28 days post-reconstitution revealed progressive fibrosis, obliterative lymph thrombus formation, interstitial infiltrates and extensive perilymphangitis. Formation of lymph thrombi/granulomas was associated with killing of adult worms and microfilariae, and the predominant cell types involved were large granular macrophages. Langhan's giant cells and eosinophils. Thus, the ability to initiate the formation of obstructive lesions in the dilated lymphatics of chronically parasitized nude mice by immunological reconstitution, suggests that several complex mechanisms might operate in stages to cause filarial elephantiasis.
PubMed: 1678575
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<author><name sortKey="Vickery, A C" sort="Vickery, A C" uniqKey="Vickery A" first="A C" last="Vickery">A C Vickery</name>
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<author><name sortKey="Albertine, K H" sort="Albertine, K H" uniqKey="Albertine K" first="K H" last="Albertine">K H Albertine</name>
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<author><name sortKey="Nayar, J K" sort="Nayar, J K" uniqKey="Nayar J" first="J K" last="Nayar">J K Nayar</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Brugia</term>
<term>Disease Models, Animal</term>
<term>Elephantiasis, Filarial (immunology)</term>
<term>Elephantiasis, Filarial (pathology)</term>
<term>Elephantiasis, Filarial (therapy)</term>
<term>Fibrosis</term>
<term>Giant Cells, Langhans (pathology)</term>
<term>Granuloma (pathology)</term>
<term>Immunotherapy, Adoptive</term>
<term>Lymphatic System (pathology)</term>
<term>Lymphatic System (ultrastructure)</term>
<term>Lymphocytes (pathology)</term>
<term>Macrophages (pathology)</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Nude</term>
<term>Microscopy, Electron</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Brugia</term>
<term>Cellules géantes de Langhans (anatomopathologie)</term>
<term>Fibrose</term>
<term>Filariose lymphatique ()</term>
<term>Filariose lymphatique (anatomopathologie)</term>
<term>Filariose lymphatique (immunologie)</term>
<term>Granulome (anatomopathologie)</term>
<term>Immunothérapie adoptive</term>
<term>Lymphocytes (anatomopathologie)</term>
<term>Macrophages (anatomopathologie)</term>
<term>Microscopie électronique</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mâle</term>
<term>Souris</term>
<term>Souris nude</term>
<term>Système lymphatique (anatomopathologie)</term>
<term>Système lymphatique (ultrastructure)</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cellules géantes de Langhans</term>
<term>Filariose lymphatique</term>
<term>Granulome</term>
<term>Lymphocytes</term>
<term>Macrophages</term>
<term>Système lymphatique</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Filariose lymphatique</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Elephantiasis, Filarial</term>
<term>Giant Cells, Langhans</term>
<term>Granuloma</term>
<term>Lymphatic System</term>
<term>Lymphocytes</term>
<term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Lymphatic System</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Brugia</term>
<term>Disease Models, Animal</term>
<term>Fibrosis</term>
<term>Immunotherapy, Adoptive</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Nude</term>
<term>Microscopy, Electron</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Brugia</term>
<term>Fibrose</term>
<term>Filariose lymphatique</term>
<term>Immunothérapie adoptive</term>
<term>Microscopie électronique</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mâle</term>
<term>Souris</term>
<term>Souris nude</term>
<term>Système lymphatique</term>
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<front><div type="abstract" xml:lang="en">Long term (greater than 200 day) Brugia malayi-infected nude mice with grossly dilated lymphatics were reconstituted with 10(8) primed spleen cells from heterozygous donors. Histological and ultrastructural examination at 7, 14, 21 and 28 days post-reconstitution revealed progressive fibrosis, obliterative lymph thrombus formation, interstitial infiltrates and extensive perilymphangitis. Formation of lymph thrombi/granulomas was associated with killing of adult worms and microfilariae, and the predominant cell types involved were large granular macrophages. Langhan's giant cells and eosinophils. Thus, the ability to initiate the formation of obstructive lesions in the dilated lymphatics of chronically parasitized nude mice by immunological reconstitution, suggests that several complex mechanisms might operate in stages to cause filarial elephantiasis.</div>
</front>
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<Abstract><AbstractText>Long term (greater than 200 day) Brugia malayi-infected nude mice with grossly dilated lymphatics were reconstituted with 10(8) primed spleen cells from heterozygous donors. Histological and ultrastructural examination at 7, 14, 21 and 28 days post-reconstitution revealed progressive fibrosis, obliterative lymph thrombus formation, interstitial infiltrates and extensive perilymphangitis. Formation of lymph thrombi/granulomas was associated with killing of adult worms and microfilariae, and the predominant cell types involved were large granular macrophages. Langhan's giant cells and eosinophils. Thus, the ability to initiate the formation of obstructive lesions in the dilated lymphatics of chronically parasitized nude mice by immunological reconstitution, suggests that several complex mechanisms might operate in stages to cause filarial elephantiasis.</AbstractText>
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