Primary structure of and immunoglobulin E response to the repeat subunit of gp15/400 from human lymphatic filarial parasites.
Identifieur interne : 005706 ( PubMed/Curation ); précédent : 005705; suivant : 005707Primary structure of and immunoglobulin E response to the repeat subunit of gp15/400 from human lymphatic filarial parasites.
Auteurs : W A Paxton [Royaume-Uni] ; M. Yazdanbakhsh ; A. Kurniawan ; F. Partono ; R M Maizels ; M E SelkirkSource :
- Infection and immunity [ 0019-9567 ] ; 1993.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Animaux, Anticorps antihelminthe (biosynthèse), Antigènes d'helminthe (), Antigènes d'helminthe (immunologie), Brugia malayi (immunologie), Clonage moléculaire, Données de séquences moléculaires, Filariose lymphatique (immunologie), Filariose lymphatique (parasitologie), Glycoprotéines membranaires (), Glycoprotéines membranaires (immunologie), Humains, Immunoglobuline E (biosynthèse), Mâle, Protéines d'helminthes (), Protéines d'helminthes (immunologie), Réaction de polymérisation en chaîne, Sujet âgé, Séquence d'acides aminés, Séquence nucléotidique, Wuchereria bancrofti (immunologie).
- MESH :
- biosynthèse : Anticorps antihelminthe, Immunoglobuline E.
- immunologie : Antigènes d'helminthe, Brugia malayi, Filariose lymphatique, Glycoprotéines membranaires, Protéines d'helminthes, Wuchereria bancrofti.
- parasitologie : Filariose lymphatique.
- Adulte, Adulte d'âge moyen, Animaux, Antigènes d'helminthe, Clonage moléculaire, Données de séquences moléculaires, Glycoprotéines membranaires, Humains, Mâle, Protéines d'helminthes, Réaction de polymérisation en chaîne, Sujet âgé, Séquence d'acides aminés, Séquence nucléotidique.
English descriptors
- KwdEn :
- Adult, Aged, Amino Acid Sequence, Animals, Antibodies, Helminth (biosynthesis), Antigens, Helminth (chemistry), Antigens, Helminth (immunology), Base Sequence, Brugia malayi (immunology), Cloning, Molecular, Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Helminth Proteins (chemistry), Helminth Proteins (immunology), Humans, Immunoglobulin E (biosynthesis), Male, Membrane Glycoproteins (chemistry), Membrane Glycoproteins (immunology), Middle Aged, Molecular Sequence Data, Polymerase Chain Reaction, Wuchereria bancrofti (immunology).
- MESH :
- chemical , biosynthesis : Antibodies, Helminth, Immunoglobulin E.
- chemical , chemistry : Antigens, Helminth, Helminth Proteins, Membrane Glycoproteins.
- chemical , immunology : Antigens, Helminth, Helminth Proteins, Membrane Glycoproteins.
- immunology : Brugia malayi, Elephantiasis, Filarial, Wuchereria bancrofti.
- parasitology : Elephantiasis, Filarial.
- Adult, Aged, Amino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, Humans, Male, Middle Aged, Molecular Sequence Data, Polymerase Chain Reaction.
Abstract
We have isolated and sequenced clones encoding the repeated subunit of the surface-associated glycoprotein gp15/400 from the two nematode species predominantly responsible for lymphatic filariasis in humans: Brugia malayi and Wuchereria bancrofti. The amino acid sequence of the 15-kDa subunit, derived from the nucleotide sequence of the gene fragment from B. malayi, is identical to that previously reported for B. pahangi, whereas the derived W. bancrofti protein sequence differs in only 7 of 132 residues. The identity of the protein in the two Brugia species allowed us to use a recombinant from B. pahangi to examine the serological response of adult Indonesian subjects infected with B. malayi. The polymerase chain reaction-amplified subunit was expressed in Escherichia coli via the pDS56/RBS11 plasmid and purified by nickel-chelating chromatography. A significant proportion of individuals produced antigen-specific immunoglobulin E (IgE). This was most pronounced in the individuals with elephantiasis, with 14 of 15 showing elevated titers and a mean of 3.2 ng of specific IgE ml-1. Only 2 of 15 microfilaremic individuals possessed elevated titers of specific IgE, with a mean of 0.045 ng ml-1 for the group as a whole. Asymptomatic amicrofilaremic residents showed approximately equal numbers of responders (defined as having a value in the radioimmunoassay greater than two standard deviations above controls) and nonresponders, with a group mean of 1.2 ng of antigen-specific IgE ml-1.
PubMed: 8514385
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The amino acid sequence of the 15-kDa subunit, derived from the nucleotide sequence of the gene fragment from B. malayi, is identical to that previously reported for B. pahangi, whereas the derived W. bancrofti protein sequence differs in only 7 of 132 residues. The identity of the protein in the two Brugia species allowed us to use a recombinant from B. pahangi to examine the serological response of adult Indonesian subjects infected with B. malayi. The polymerase chain reaction-amplified subunit was expressed in Escherichia coli via the pDS56/RBS11 plasmid and purified by nickel-chelating chromatography. A significant proportion of individuals produced antigen-specific immunoglobulin E (IgE). This was most pronounced in the individuals with elephantiasis, with 14 of 15 showing elevated titers and a mean of 3.2 ng of specific IgE ml-1. Only 2 of 15 microfilaremic individuals possessed elevated titers of specific IgE, with a mean of 0.045 ng ml-1 for the group as a whole. Asymptomatic amicrofilaremic residents showed approximately equal numbers of responders (defined as having a value in the radioimmunoassay greater than two standard deviations above controls) and nonresponders, with a group mean of 1.2 ng of antigen-specific IgE ml-1.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">8514385</PMID><DateCreated><Year>1993</Year><Month>07</Month><Day>22</Day></DateCreated><DateCompleted><Year>1993</Year><Month>07</Month><Day>22</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0019-9567</ISSN><JournalIssue CitedMedium="Print"><Volume>61</Volume><Issue>7</Issue><PubDate><Year>1993</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Infection and immunity</Title><ISOAbbreviation>Infect. Immun.</ISOAbbreviation></Journal><ArticleTitle>Primary structure of and immunoglobulin E response to the repeat subunit of gp15/400 from human lymphatic filarial parasites.</ArticleTitle><Pagination><MedlinePgn>2827-33</MedlinePgn></Pagination><Abstract><AbstractText>We have isolated and sequenced clones encoding the repeated subunit of the surface-associated glycoprotein gp15/400 from the two nematode species predominantly responsible for lymphatic filariasis in humans: Brugia malayi and Wuchereria bancrofti. The amino acid sequence of the 15-kDa subunit, derived from the nucleotide sequence of the gene fragment from B. malayi, is identical to that previously reported for B. pahangi, whereas the derived W. bancrofti protein sequence differs in only 7 of 132 residues. The identity of the protein in the two Brugia species allowed us to use a recombinant from B. pahangi to examine the serological response of adult Indonesian subjects infected with B. malayi. The polymerase chain reaction-amplified subunit was expressed in Escherichia coli via the pDS56/RBS11 plasmid and purified by nickel-chelating chromatography. A significant proportion of individuals produced antigen-specific immunoglobulin E (IgE). This was most pronounced in the individuals with elephantiasis, with 14 of 15 showing elevated titers and a mean of 3.2 ng of specific IgE ml-1. Only 2 of 15 microfilaremic individuals possessed elevated titers of specific IgE, with a mean of 0.045 ng ml-1 for the group as a whole. Asymptomatic amicrofilaremic residents showed approximately equal numbers of responders (defined as having a value in the radioimmunoassay greater than two standard deviations above controls) and nonresponders, with a group mean of 1.2 ng of antigen-specific IgE ml-1.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Paxton</LastName><ForeName>W A</ForeName><Initials>WA</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, Wellcome Centre for Parasitic Infections, Imperial College of Science, Technology and Medicine, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yazdanbakhsh</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Kurniawan</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Partono</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Maizels</LastName><ForeName>R M</ForeName><Initials>RM</Initials></Author><Author ValidYN="Y"><LastName>Selkirk</LastName><ForeName>M E</ForeName><Initials>ME</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Infect Immun</MedlineTA><NlmUniqueID>0246127</NlmUniqueID><ISSNLinking>0019-9567</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000909">Antibodies, Helminth</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000947">Antigens, Helminth</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015801">Helminth Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008562">Membrane Glycoproteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C094735">gp15-400 protein, Brugia pahangi</NameOfSubstance></Chemical><Chemical><RegistryNumber>37341-29-0</RegistryNumber><NameOfSubstance UI="D007073">Immunoglobulin E</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Am Rev Respir Dis. 1990 Nov;142(5):1088-92</RefSource><PMID Version="1">2173455</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parasitology. 1987 Jun;94 ( Pt 3):485-96</RefSource><PMID Version="1">3614990</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 1979 Jun 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