Prophylactic chemoradiation of inguinofemoral lymph nodes in patients with locally extensive vulvar cancer.
Identifieur interne : 004F68 ( PubMed/Curation ); précédent : 004F67; suivant : 004F69Prophylactic chemoradiation of inguinofemoral lymph nodes in patients with locally extensive vulvar cancer.
Auteurs : G S Leiserowitz [États-Unis] ; A H Russell ; W K Kinney ; L H Smith ; M H Taylor ; S A ScudderSource :
- Gynecologic oncology [ 0090-8258 ] ; 1997.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Aine, Carcinome épidermoïde (), Carcinome épidermoïde (radiothérapie), Carcinome épidermoïde (secondaire), Femelle, Humains, Métastase lymphatique (), Radiothérapie adjuvante, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Traitement médicamenteux adjuvant, Tumeurs de la vulve (anatomopathologie), Tumeurs de la vulve (radiothérapie).
- MESH :
- anatomopathologie : Tumeurs de la vulve.
- radiothérapie : Carcinome épidermoïde, Tumeurs de la vulve.
- secondaire : Carcinome épidermoïde.
- Adolescent, Adulte, Adulte d'âge moyen, Aine, Carcinome épidermoïde, Femelle, Humains, Métastase lymphatique, Radiothérapie adjuvante, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Traitement médicamenteux adjuvant.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell (prevention & control), Carcinoma, Squamous Cell (radiotherapy), Carcinoma, Squamous Cell (secondary), Chemotherapy, Adjuvant, Female, Groin, Humans, Lymphatic Metastasis (prevention & control), Middle Aged, Radiotherapy, Adjuvant, Treatment Outcome, Vulvar Neoplasms (pathology), Vulvar Neoplasms (radiotherapy).
- MESH :
- pathology : Vulvar Neoplasms.
- prevention & control : Carcinoma, Squamous Cell, Lymphatic Metastasis.
- radiotherapy : Carcinoma, Squamous Cell, Vulvar Neoplasms.
- secondary : Carcinoma, Squamous Cell.
- Adolescent, Adult, Aged, Aged, 80 and over, Chemotherapy, Adjuvant, Female, Groin, Humans, Middle Aged, Radiotherapy, Adjuvant, Treatment Outcome.
Abstract
Primary surgical resection of locally advanced squamous cancer of the vulva may compromise the integrity of important midline structures such as the anus, clitoris, urethra, and vagina. Chemoradiation (synchronous radiation and cytotoxic chemotherapy) has been used as alternative initial treatment which may serve as definitive management for some patients, or may reduce the scope and functional sequelae of subsequent surgery in others. Inguinofemoral node dissection is associated with substantial risk of both acute and late morbidity, prompting consideration of elective inclusion of groin nodes within the irradiated volume and deletion of subsequent groin surgery. Concern that disease relapse in the groins is potentially fatal suggested the prudence of formal outcome assessment of our recent experience with prophylactic treatment of clinically uninvolved groin nodes in the context of concurrent chemoradiation for locally advanced primary vulvar cancer.
DOI: 10.1006/gyno.1997.4804
PubMed: 9299268
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uniqKey="Smith L" first="L H" last="Smith">L H Smith</name></author><author><name sortKey="Taylor, M H" sort="Taylor, M H" uniqKey="Taylor M" first="M H" last="Taylor">M H Taylor</name></author><author><name sortKey="Scudder, S A" sort="Scudder, S A" uniqKey="Scudder S" first="S A" last="Scudder">S A Scudder</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1997">1997</date><idno type="RBID">pubmed:9299268</idno><idno type="pmid">9299268</idno><idno type="doi">10.1006/gyno.1997.4804</idno><idno type="wicri:Area/PubMed/Corpus">004F68</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">004F68</idno><idno type="wicri:Area/PubMed/Curation">004F68</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">004F68</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Prophylactic chemoradiation of inguinofemoral lymph nodes in patients with locally extensive vulvar cancer.</title><author><name sortKey="Leiserowitz, G S" sort="Leiserowitz, G S" uniqKey="Leiserowitz G" first="G S" last="Leiserowitz">G S Leiserowitz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Gynecology, University of California, Sacramento, California 95816, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of California, Sacramento, California 95816</wicri:regionArea></affiliation></author><author><name sortKey="Russell, A H" sort="Russell, A H" uniqKey="Russell A" first="A H" last="Russell">A H Russell</name></author><author><name sortKey="Kinney, W K" sort="Kinney, W K" uniqKey="Kinney W" first="W K" last="Kinney">W K Kinney</name></author><author><name sortKey="Smith, L H" sort="Smith, L H" uniqKey="Smith L" first="L H" last="Smith">L H Smith</name></author><author><name sortKey="Taylor, M H" sort="Taylor, M H" uniqKey="Taylor M" first="M H" last="Taylor">M H Taylor</name></author><author><name sortKey="Scudder, S A" sort="Scudder, S A" uniqKey="Scudder S" first="S A" last="Scudder">S A Scudder</name></author></analytic><series><title level="j">Gynecologic oncology</title><idno type="ISSN">0090-8258</idno><imprint><date when="1997" type="published">1997</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Carcinoma, Squamous Cell (prevention & control)</term><term>Carcinoma, Squamous Cell (radiotherapy)</term><term>Carcinoma, Squamous Cell (secondary)</term><term>Chemotherapy, Adjuvant</term><term>Female</term><term>Groin</term><term>Humans</term><term>Lymphatic Metastasis (prevention & control)</term><term>Middle Aged</term><term>Radiotherapy, Adjuvant</term><term>Treatment Outcome</term><term>Vulvar Neoplasms (pathology)</term><term>Vulvar Neoplasms (radiotherapy)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Aine</term><term>Carcinome épidermoïde ()</term><term>Carcinome épidermoïde (radiothérapie)</term><term>Carcinome épidermoïde (secondaire)</term><term>Femelle</term><term>Humains</term><term>Métastase lymphatique ()</term><term>Radiothérapie adjuvante</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Traitement médicamenteux adjuvant</term><term>Tumeurs de la vulve (anatomopathologie)</term><term>Tumeurs de la vulve (radiothérapie)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs de la vulve</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Vulvar Neoplasms</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Lymphatic Metastasis</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Vulvar Neoplasms</term></keywords><keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Carcinome épidermoïde</term><term>Tumeurs de la vulve</term></keywords><keywords scheme="MESH" qualifier="secondaire" xml:lang="fr"><term>Carcinome épidermoïde</term></keywords><keywords scheme="MESH" qualifier="secondary" xml:lang="en"><term>Carcinoma, Squamous Cell</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Chemotherapy, Adjuvant</term><term>Female</term><term>Groin</term><term>Humans</term><term>Middle Aged</term><term>Radiotherapy, Adjuvant</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Aine</term><term>Carcinome épidermoïde</term><term>Femelle</term><term>Humains</term><term>Métastase lymphatique</term><term>Radiothérapie adjuvante</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Traitement médicamenteux adjuvant</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Primary surgical resection of locally advanced squamous cancer of the vulva may compromise the integrity of important midline structures such as the anus, clitoris, urethra, and vagina. Chemoradiation (synchronous radiation and cytotoxic chemotherapy) has been used as alternative initial treatment which may serve as definitive management for some patients, or may reduce the scope and functional sequelae of subsequent surgery in others. Inguinofemoral node dissection is associated with substantial risk of both acute and late morbidity, prompting consideration of elective inclusion of groin nodes within the irradiated volume and deletion of subsequent groin surgery. Concern that disease relapse in the groins is potentially fatal suggested the prudence of formal outcome assessment of our recent experience with prophylactic treatment of clinically uninvolved groin nodes in the context of concurrent chemoradiation for locally advanced primary vulvar cancer.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9299268</PMID><DateCreated><Year>1997</Year><Month>10</Month><Day>02</Day></DateCreated><DateCompleted><Year>1997</Year><Month>10</Month><Day>02</Day></DateCompleted><DateRevised><Year>2004</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0090-8258</ISSN><JournalIssue CitedMedium="Print"><Volume>66</Volume><Issue>3</Issue><PubDate><Year>1997</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Gynecologic oncology</Title><ISOAbbreviation>Gynecol. Oncol.</ISOAbbreviation></Journal><ArticleTitle>Prophylactic chemoradiation of inguinofemoral lymph nodes in patients with locally extensive vulvar cancer.</ArticleTitle><Pagination><MedlinePgn>509-14</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Primary surgical resection of locally advanced squamous cancer of the vulva may compromise the integrity of important midline structures such as the anus, clitoris, urethra, and vagina. Chemoradiation (synchronous radiation and cytotoxic chemotherapy) has been used as alternative initial treatment which may serve as definitive management for some patients, or may reduce the scope and functional sequelae of subsequent surgery in others. Inguinofemoral node dissection is associated with substantial risk of both acute and late morbidity, prompting consideration of elective inclusion of groin nodes within the irradiated volume and deletion of subsequent groin surgery. Concern that disease relapse in the groins is potentially fatal suggested the prudence of formal outcome assessment of our recent experience with prophylactic treatment of clinically uninvolved groin nodes in the context of concurrent chemoradiation for locally advanced primary vulvar cancer.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A review was conducted of 23 previously untreated patients with locally advanced squamous cancer of the vulva (2 T2, 20 T3, 1 T4) and clinically uninvolved groin nodes (1969 FIGO stages 14 N0, 4 N1, and 5 N2 with negative node biopsies) who were treated since 1987 with chemoradiation administered to a volume electively including bilateral inguinofemoral nodes. These patients did not undergo subsequent groin surgery.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">With follow-up from 6 to 98 months (mean, 45.3 months; median, 42 months), no patient has failed in the prophylactically irradiated inguinofemoral nodes. No patient has developed lymphedema, vascular insufficiency, or neurological injury in a lower extremity, and no patient has experienced aseptic necrosis of a femur.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Elective irradiation of the groin nodes in the context of initial chemoradiation for locally advanced vulvar cancer is an effective therapy associated with acceptable acute toxicity and minimal late sequelae. It constitutes a sensible alternative to groin dissection in this patient population.</AbstractText><CopyrightInformation>Copyright 1997 Academic Press.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Leiserowitz</LastName><ForeName>G S</ForeName><Initials>GS</Initials><AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, University of California, Sacramento, California 95816, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Russell</LastName><ForeName>A H</ForeName><Initials>AH</Initials></Author><Author ValidYN="Y"><LastName>Kinney</LastName><ForeName>W K</ForeName><Initials>WK</Initials></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>L H</ForeName><Initials>LH</Initials></Author><Author ValidYN="Y"><LastName>Taylor</LastName><ForeName>M H</ForeName><Initials>MH</Initials></Author><Author ValidYN="Y"><LastName>Scudder</LastName><ForeName>S A</ForeName><Initials>SA</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Gynecol Oncol</MedlineTA><NlmUniqueID>0365304</NlmUniqueID><ISSNLinking>0090-8258</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002294" MajorTopicYN="N">Carcinoma, Squamous Cell</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName><QualifierName UI="Q000532" MajorTopicYN="Y">radiotherapy</QualifierName><QualifierName UI="Q000556" MajorTopicYN="N">secondary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017024" MajorTopicYN="N">Chemotherapy, Adjuvant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006119" MajorTopicYN="N">Groin</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008207" MajorTopicYN="N">Lymphatic Metastasis</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018714" MajorTopicYN="N">Radiotherapy, Adjuvant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014846" MajorTopicYN="N">Vulvar Neoplasms</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000532" MajorTopicYN="Y">radiotherapy</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1997</Year><Month>9</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1997</Year><Month>9</Month><Day>23</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1997</Year><Month>9</Month><Day>23</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9299268</ArticleId><ArticleId IdType="pii">S0090-8258(97)94804-6</ArticleId><ArticleId IdType="doi">10.1006/gyno.1997.4804</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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