Anti-filarial IgG4 in men and women living in Brugia malayi-endemic areas.
Identifieur interne : 004C87 ( PubMed/Curation ); précédent : 004C86; suivant : 004C88Anti-filarial IgG4 in men and women living in Brugia malayi-endemic areas.
Auteurs : M. Haarbrink [Pays-Bas] ; A J Terhell ; K. Abadi ; M. Asri ; F. De Medeiros ; M. YazdanbakhshSource :
- Tropical medicine & international health : TM & IH [ 1360-2276 ] ; 1999.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Anticorps antihelminthe (sang), Antigènes d'helminthe, Brugia malayi (croissance et développement), Brugia malayi (immunologie), Enfant, Femelle, Filariose lymphatique (immunologie), Filariose lymphatique (parasitologie), Filariose lymphatique (épidémiologie), Filarioses (immunologie), Filarioses (épidémiologie), Humains, Immunoglobuline G (sang), Indonésie (épidémiologie), Maladies endémiques, Microfilaria (immunologie), Mâle, Prévalence, Répartition par sexe, Répartition par âge, Sujet âgé.
- MESH :
- croissance et développement : Brugia malayi.
- immunologie : Brugia malayi, Filariose lymphatique, Filarioses, Microfilaria.
- parasitologie : Filariose lymphatique.
- sang : Anticorps antihelminthe, Immunoglobuline G.
- épidémiologie : Filariose lymphatique, Filarioses, Indonésie.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Antigènes d'helminthe, Enfant, Femelle, Humains, Maladies endémiques, Mâle, Prévalence, Répartition par sexe, Répartition par âge, Sujet âgé.
English descriptors
- KwdEn :
- Adolescent, Adult, Age Distribution, Aged, Animals, Antibodies, Helminth (blood), Antigens, Helminth, Brugia malayi (growth & development), Brugia malayi (immunology), Child, Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Endemic Diseases, Female, Filariasis (epidemiology), Filariasis (immunology), Humans, Immunoglobulin G (blood), Indonesia (epidemiology), Male, Microfilariae (immunology), Middle Aged, Prevalence, Sex Distribution.
- MESH :
- chemical , blood : Antibodies, Helminth, Immunoglobulin G.
- epidemiology : Elephantiasis, Filarial, Filariasis, Indonesia.
- growth & development : Brugia malayi.
- immunology : Brugia malayi, Elephantiasis, Filarial, Filariasis, Microfilariae.
- parasitology : Elephantiasis, Filarial.
- Adolescent, Adult, Age Distribution, Aged, Animals, Antigens, Helminth, Child, Endemic Diseases, Female, Humans, Male, Middle Aged, Prevalence, Sex Distribution.
Abstract
To assess whether antifilarial IgG4 can be used to study various epidemiological facets of filarial infections, we studied this isotype in 238 individuals resident in areas endemic for brugian filariasis, focusing on the differences between men and women. In the study area, the prevalence of microfilariae was 6.7% and the prevalence of antifilarial IgG4 was 49.2%. All microfilariae carriers were positive for antifilarial IgG4, whereas a proportion of the endemic normals (94/208) and clephantiasis patients (7/14) had IgG4 antibodies to filarial antigens. Data were analysed as a function of gender in distinct clinical groups and stratified for age. The prevalence of microfilariae was higher in males in all age groups, as reflected in significantly higher antifilarial IgG4 antibody levels compared to females. The prevalence of IgG4 increased to reach a plateau at the age of 30 years in both males and females. These results indicate that antifilarial IgG4 antibodies can reflect the differences in the extent of infection in males and females as measured by microfilarial counts, and that this parameter can be used for epidemiological assessments of filarial infection.
PubMed: 10206262
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Haarbrink</name><affiliation wicri:level="1"><nlm:affiliation>Department of Parasitology, Leiden University Medical Centre, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Parasitology, Leiden University Medical Centre</wicri:regionArea></affiliation></author><author><name sortKey="Terhell, A J" sort="Terhell, A J" uniqKey="Terhell A" first="A J" last="Terhell">A J Terhell</name></author><author><name sortKey="Abadi, K" sort="Abadi, K" uniqKey="Abadi K" first="K" last="Abadi">K. Abadi</name></author><author><name sortKey="Asri, M" sort="Asri, M" uniqKey="Asri M" first="M" last="Asri">M. Asri</name></author><author><name sortKey="De Medeiros, F" sort="De Medeiros, F" uniqKey="De Medeiros F" first="F" last="De Medeiros">F. De Medeiros</name></author><author><name sortKey="Yazdanbakhsh, M" sort="Yazdanbakhsh, M" uniqKey="Yazdanbakhsh M" first="M" last="Yazdanbakhsh">M. Yazdanbakhsh</name></author></analytic><series><title level="j">Tropical medicine & international health : TM & IH</title><idno type="ISSN">1360-2276</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Distribution</term><term>Aged</term><term>Animals</term><term>Antibodies, Helminth (blood)</term><term>Antigens, Helminth</term><term>Brugia malayi (growth & development)</term><term>Brugia malayi (immunology)</term><term>Child</term><term>Elephantiasis, Filarial (epidemiology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Endemic Diseases</term><term>Female</term><term>Filariasis (epidemiology)</term><term>Filariasis (immunology)</term><term>Humans</term><term>Immunoglobulin G (blood)</term><term>Indonesia (epidemiology)</term><term>Male</term><term>Microfilariae (immunology)</term><term>Middle Aged</term><term>Prevalence</term><term>Sex Distribution</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Anticorps antihelminthe (sang)</term><term>Antigènes d'helminthe</term><term>Brugia malayi (croissance et développement)</term><term>Brugia malayi (immunologie)</term><term>Enfant</term><term>Femelle</term><term>Filariose lymphatique (immunologie)</term><term>Filariose lymphatique (parasitologie)</term><term>Filariose lymphatique (épidémiologie)</term><term>Filarioses (immunologie)</term><term>Filarioses (épidémiologie)</term><term>Humains</term><term>Immunoglobuline G (sang)</term><term>Indonésie (épidémiologie)</term><term>Maladies endémiques</term><term>Microfilaria (immunologie)</term><term>Mâle</term><term>Prévalence</term><term>Répartition par sexe</term><term>Répartition par âge</term><term>Sujet âgé</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Helminth</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Brugia malayi</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Filariasis</term><term>Indonesia</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Brugia malayi</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Brugia malayi</term><term>Filariose lymphatique</term><term>Filarioses</term><term>Microfilaria</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia malayi</term><term>Elephantiasis, Filarial</term><term>Filariasis</term><term>Microfilariae</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Filarioses</term><term>Indonésie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Distribution</term><term>Aged</term><term>Animals</term><term>Antigens, Helminth</term><term>Child</term><term>Endemic Diseases</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prevalence</term><term>Sex Distribution</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Antigènes d'helminthe</term><term>Enfant</term><term>Femelle</term><term>Humains</term><term>Maladies endémiques</term><term>Mâle</term><term>Prévalence</term><term>Répartition par sexe</term><term>Répartition par âge</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To assess whether antifilarial IgG4 can be used to study various epidemiological facets of filarial infections, we studied this isotype in 238 individuals resident in areas endemic for brugian filariasis, focusing on the differences between men and women. In the study area, the prevalence of microfilariae was 6.7% and the prevalence of antifilarial IgG4 was 49.2%. All microfilariae carriers were positive for antifilarial IgG4, whereas a proportion of the endemic normals (94/208) and clephantiasis patients (7/14) had IgG4 antibodies to filarial antigens. Data were analysed as a function of gender in distinct clinical groups and stratified for age. The prevalence of microfilariae was higher in males in all age groups, as reflected in significantly higher antifilarial IgG4 antibody levels compared to females. The prevalence of IgG4 increased to reach a plateau at the age of 30 years in both males and females. These results indicate that antifilarial IgG4 antibodies can reflect the differences in the extent of infection in males and females as measured by microfilarial counts, and that this parameter can be used for epidemiological assessments of filarial infection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">10206262</PMID><DateCreated><Year>1999</Year><Month>04</Month><Day>23</Day></DateCreated><DateCompleted><Year>1999</Year><Month>04</Month><Day>23</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1360-2276</ISSN><JournalIssue CitedMedium="Print"><Volume>4</Volume><Issue>2</Issue><PubDate><Year>1999</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Tropical medicine & international health : TM & IH</Title><ISOAbbreviation>Trop. Med. Int. Health</ISOAbbreviation></Journal><ArticleTitle>Anti-filarial IgG4 in men and women living in Brugia malayi-endemic areas.</ArticleTitle><Pagination><MedlinePgn>93-7</MedlinePgn></Pagination><Abstract><AbstractText>To assess whether antifilarial IgG4 can be used to study various epidemiological facets of filarial infections, we studied this isotype in 238 individuals resident in areas endemic for brugian filariasis, focusing on the differences between men and women. In the study area, the prevalence of microfilariae was 6.7% and the prevalence of antifilarial IgG4 was 49.2%. All microfilariae carriers were positive for antifilarial IgG4, whereas a proportion of the endemic normals (94/208) and clephantiasis patients (7/14) had IgG4 antibodies to filarial antigens. Data were analysed as a function of gender in distinct clinical groups and stratified for age. The prevalence of microfilariae was higher in males in all age groups, as reflected in significantly higher antifilarial IgG4 antibody levels compared to females. The prevalence of IgG4 increased to reach a plateau at the age of 30 years in both males and females. These results indicate that antifilarial IgG4 antibodies can reflect the differences in the extent of infection in males and females as measured by microfilarial counts, and that this parameter can be used for epidemiological assessments of filarial infection.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Haarbrink</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Parasitology, Leiden University Medical Centre, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Terhell</LastName><ForeName>A J</ForeName><Initials>AJ</Initials></Author><Author ValidYN="Y"><LastName>Abadi</LastName><ForeName>K</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Asri</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>de Medeiros</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Yazdanbakhsh</LastName><ForeName>M</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Trop Med Int Health</MedlineTA><NlmUniqueID>9610576</NlmUniqueID><ISSNLinking>1360-2276</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000909">Antibodies, Helminth</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000947">Antigens, Helminth</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017677" MajorTopicYN="N">Age Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000909" MajorTopicYN="N">Antibodies, Helminth</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000947" MajorTopicYN="N">Antigens, Helminth</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017178" MajorTopicYN="N">Brugia malayi</DescriptorName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019353" MajorTopicYN="Y">Endemic Diseases</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005368" MajorTopicYN="N">Filariasis</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007214" MajorTopicYN="N">Indonesia</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008842" MajorTopicYN="N">Microfilariae</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017678" MajorTopicYN="N">Sex Distribution</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1999</Year><Month>4</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1999</Year><Month>4</Month><Day>17</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1999</Year><Month>4</Month><Day>17</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">10206262</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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