Longitudinal humoral immune responses of Indian leaf monkey (Presbytis entellus) to Brugia malayi infection.
Identifieur interne : 004C20 ( PubMed/Curation ); précédent : 004C19; suivant : 004C21Longitudinal humoral immune responses of Indian leaf monkey (Presbytis entellus) to Brugia malayi infection.
Auteurs : P K Murthy [Inde] ; K. Tyagi ; R P Ghosh ; P S Murthy ; R K ChatterjeeSource :
- Parasitology [ 0031-1820 ] ; 1999.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antihelminthe (sang), Antigènes d'helminthe (immunologie), Brugia malayi (immunologie), Cercopithecidae (parasitologie), Complexe antigène-anticorps (sang), Filariose lymphatique (immunologie), Filariose lymphatique (médecine vétérinaire), Filarioses (immunologie), Filarioses (médecine vétérinaire), Hydrocèle, Maladies des singes (immunologie), Mâle, Oedème, Porteur sain, Spécificité des anticorps, Test ELISA.
- MESH :
- immunologie : Antigènes d'helminthe, Brugia malayi, Filariose lymphatique, Filarioses, Maladies des singes.
- médecine vétérinaire : Filariose lymphatique, Filarioses.
- parasitologie : Cercopithecidae.
- sang : Anticorps antihelminthe, Complexe antigène-anticorps.
- Animaux, Hydrocèle, Mâle, Oedème, Porteur sain, Spécificité des anticorps, Test ELISA.
English descriptors
- KwdEn :
- Animals, Antibodies, Helminth (blood), Antibody Specificity, Antigen-Antibody Complex (blood), Antigens, Helminth (immunology), Brugia malayi (immunology), Carrier State, Cercopithecidae (parasitology), Edema, Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (veterinary), Enzyme-Linked Immunosorbent Assay, Filariasis (immunology), Filariasis (veterinary), Male, Monkey Diseases (immunology), Testicular Hydrocele.
- MESH :
- chemical , blood : Antibodies, Helminth, Antigen-Antibody Complex.
- chemical , immunology : Antigens, Helminth.
- immunology : Brugia malayi, Elephantiasis, Filarial, Filariasis, Monkey Diseases.
- parasitology : Cercopithecidae.
- veterinary : Elephantiasis, Filarial, Filariasis.
- Animals, Antibody Specificity, Carrier State, Edema, Enzyme-Linked Immunosorbent Assay, Male, Testicular Hydrocele.
Abstract
Humoral immune responses of the Indian leaf monkey (Presbytis entellus) experimentally infected with Brugia malayi and exhibiting disease manifestations were studied. Microfilaraemia, filaria-specific IgG and circulating immune complexes (CICs) were determined in the monkeys at different time-points after inoculation of B. malayi 3rd-stage larvae. Sera were analysed for recognition pattern of adult parasite antigen molecules by immunoblotting. More than 60% of the infected monkeys developed episodic or persistent limb oedema with or without fever and with low or no microfilaraemia. While both CIC and filaria specific IgG levels were comparable in animals showing no disease symptoms (asymptomatics) and some animals showing symptoms (symptomatics), IgG levels peaked during pre-patent stage in symptomatics and during latent stage in asymptomatic animals. However, some of the symptomatic animals showed a low level of filaria-specific IgG as compared to asymptomatic and other symptomatic animals. The immunoblot analysis showed non-reactivity of 17 and 55 kDa antigens with sera of symptomatic animals. The results thus suggest that humoral immune responses as measured in the present study do not precede the development of the manifestations. However, 2 non-reactive antigen molecules identified by symptomatic sera need further study to establish their possible involvement, if any, in the development of acute disease manifestations in this model.
PubMed: 10446704
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Tyagi</name></author><author><name sortKey="Ghosh, R P" sort="Ghosh, R P" uniqKey="Ghosh R" first="R P" last="Ghosh">R P Ghosh</name></author><author><name sortKey="Murthy, P S" sort="Murthy, P S" uniqKey="Murthy P" first="P S" last="Murthy">P S Murthy</name></author><author><name sortKey="Chatterjee, R K" sort="Chatterjee, R K" uniqKey="Chatterjee R" first="R K" last="Chatterjee">R K Chatterjee</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1999">1999</date><idno type="RBID">pubmed:10446704</idno><idno type="pmid">10446704</idno><idno type="wicri:Area/PubMed/Corpus">004C20</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">004C20</idno><idno type="wicri:Area/PubMed/Curation">004C20</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">004C20</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Longitudinal humoral immune responses of Indian leaf monkey (Presbytis entellus) to Brugia malayi infection.</title><author><name sortKey="Murthy, P K" sort="Murthy, P K" uniqKey="Murthy P" first="P K" last="Murthy">P K Murthy</name><affiliation wicri:level="1"><nlm:affiliation>Division of Parasitology, Central Drug Research Institute, Lucknow, India. root@cscdri.ren.nic.in</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Division of Parasitology, Central Drug Research Institute, Lucknow</wicri:regionArea></affiliation></author><author><name sortKey="Tyagi, K" sort="Tyagi, K" uniqKey="Tyagi K" first="K" last="Tyagi">K. 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Microfilaraemia, filaria-specific IgG and circulating immune complexes (CICs) were determined in the monkeys at different time-points after inoculation of B. malayi 3rd-stage larvae. Sera were analysed for recognition pattern of adult parasite antigen molecules by immunoblotting. More than 60% of the infected monkeys developed episodic or persistent limb oedema with or without fever and with low or no microfilaraemia. While both CIC and filaria specific IgG levels were comparable in animals showing no disease symptoms (asymptomatics) and some animals showing symptoms (symptomatics), IgG levels peaked during pre-patent stage in symptomatics and during latent stage in asymptomatic animals. However, some of the symptomatic animals showed a low level of filaria-specific IgG as compared to asymptomatic and other symptomatic animals. The immunoblot analysis showed non-reactivity of 17 and 55 kDa antigens with sera of symptomatic animals. The results thus suggest that humoral immune responses as measured in the present study do not precede the development of the manifestations. However, 2 non-reactive antigen molecules identified by symptomatic sera need further study to establish their possible involvement, if any, in the development of acute disease manifestations in this model.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">10446704</PMID><DateCreated><Year>1999</Year><Month>09</Month><Day>29</Day></DateCreated><DateCompleted><Year>1999</Year><Month>09</Month><Day>29</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0031-1820</ISSN><JournalIssue CitedMedium="Print"><Volume>119 ( Pt 1)</Volume><PubDate><Year>1999</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Parasitology</Title><ISOAbbreviation>Parasitology</ISOAbbreviation></Journal><ArticleTitle>Longitudinal humoral immune responses of Indian leaf monkey (Presbytis entellus) to Brugia malayi infection.</ArticleTitle><Pagination><MedlinePgn>53-60</MedlinePgn></Pagination><Abstract><AbstractText>Humoral immune responses of the Indian leaf monkey (Presbytis entellus) experimentally infected with Brugia malayi and exhibiting disease manifestations were studied. Microfilaraemia, filaria-specific IgG and circulating immune complexes (CICs) were determined in the monkeys at different time-points after inoculation of B. malayi 3rd-stage larvae. Sera were analysed for recognition pattern of adult parasite antigen molecules by immunoblotting. More than 60% of the infected monkeys developed episodic or persistent limb oedema with or without fever and with low or no microfilaraemia. While both CIC and filaria specific IgG levels were comparable in animals showing no disease symptoms (asymptomatics) and some animals showing symptoms (symptomatics), IgG levels peaked during pre-patent stage in symptomatics and during latent stage in asymptomatic animals. However, some of the symptomatic animals showed a low level of filaria-specific IgG as compared to asymptomatic and other symptomatic animals. The immunoblot analysis showed non-reactivity of 17 and 55 kDa antigens with sera of symptomatic animals. The results thus suggest that humoral immune responses as measured in the present study do not precede the development of the manifestations. However, 2 non-reactive antigen molecules identified by symptomatic sera need further study to establish their possible involvement, if any, in the development of acute disease manifestations in this model.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Murthy</LastName><ForeName>P K</ForeName><Initials>PK</Initials><AffiliationInfo><Affiliation>Division of Parasitology, Central Drug Research Institute, Lucknow, India. root@cscdri.ren.nic.in</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tyagi</LastName><ForeName>K</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Ghosh</LastName><ForeName>R P</ForeName><Initials>RP</Initials></Author><Author ValidYN="Y"><LastName>Murthy</LastName><ForeName>P S</ForeName><Initials>PS</Initials></Author><Author ValidYN="Y"><LastName>Chatterjee</LastName><ForeName>R K</ForeName><Initials>RK</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Parasitology</MedlineTA><NlmUniqueID>0401121</NlmUniqueID><ISSNLinking>0031-1820</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000909">Antibodies, Helminth</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000936">Antigen-Antibody Complex</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000947">Antigens, Helminth</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000909" MajorTopicYN="N">Antibodies, Helminth</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000918" MajorTopicYN="N">Antibody Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000936" MajorTopicYN="N">Antigen-Antibody Complex</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000947" MajorTopicYN="N">Antigens, Helminth</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017178" MajorTopicYN="N">Brugia malayi</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002353" MajorTopicYN="N">Carrier State</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002520" MajorTopicYN="N">Cercopithecidae</DescriptorName><QualifierName UI="Q000469" MajorTopicYN="Y">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004487" MajorTopicYN="N">Edema</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000662" MajorTopicYN="N">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004797" MajorTopicYN="N">Enzyme-Linked Immunosorbent Assay</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005368" MajorTopicYN="N">Filariasis</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008992" MajorTopicYN="N">Monkey Diseases</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006848" MajorTopicYN="N">Testicular Hydrocele</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1999</Year><Month>8</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1999</Year><Month>8</Month><Day>14</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1999</Year><Month>8</Month><Day>14</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">10446704</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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