Proposed panel of diagnostic criteria, including the use of ultrasound, to refine the concept of 'endemic normals' in lymphatic filariasis.
Identifieur interne : 004B96 ( PubMed/Curation ); précédent : 004B95; suivant : 004B97Proposed panel of diagnostic criteria, including the use of ultrasound, to refine the concept of 'endemic normals' in lymphatic filariasis.
Auteurs : G. Dreyer [Brésil] ; A. Santos ; J. Noroes ; D. AddissSource :
- Tropical medicine & international health : TM & IH [ 1360-2276 ] ; 1999.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Animaux, Diéthylcarbamazine (usage thérapeutique), Filaricides (usage thérapeutique), Filariose lymphatique (diagnostic), Filariose lymphatique (imagerie diagnostique), Filariose lymphatique (traitement médicamenteux), Humains, Mâle, Scrotum (imagerie diagnostique), Scrotum (parasitologie), Sensibilité et spécificité, Wuchereria bancrofti (isolement et purification), Échographie.
- MESH :
- diagnostic : Filariose lymphatique.
- imagerie diagnostique : Filariose lymphatique, Scrotum.
- isolement et purification : Wuchereria bancrofti.
- parasitologie : Scrotum.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Diéthylcarbamazine, Filaricides.
- Adulte, Adulte d'âge moyen, Animaux, Humains, Mâle, Sensibilité et spécificité, Échographie.
English descriptors
- KwdEn :
- Adult, Animals, Diethylcarbamazine (therapeutic use), Elephantiasis, Filarial (diagnosis), Elephantiasis, Filarial (diagnostic imaging), Elephantiasis, Filarial (drug therapy), Filaricides (therapeutic use), Humans, Male, Middle Aged, Scrotum (diagnostic imaging), Scrotum (parasitology), Sensitivity and Specificity, Ultrasonography, Wuchereria bancrofti (isolation & purification).
- MESH :
- chemical , therapeutic use : Diethylcarbamazine, Filaricides.
- diagnosis : Elephantiasis, Filarial.
- diagnostic imaging : Elephantiasis, Filarial, Scrotum.
- drug therapy : Elephantiasis, Filarial.
- isolation & purification : Wuchereria bancrofti.
- parasitology : Scrotum.
- Adult, Animals, Humans, Male, Middle Aged, Sensitivity and Specificity, Ultrasonography.
Abstract
Although living adult Wuchereria bancrofti worms can be detected by ultrasound examination of the scrotal area in approximately 80% of men infected with this filarial parasite, the location of the adult worms in the remaining 20% remains unclear. To determine this, 32 individuals who had W. bancrofti microfilaraemia but no adult worms detectable on ultrasound were treated with diethylcarbarmazine (DEC), either with a single 6 mg/kg dose (n = 13) or with a 12-day course of 6 mg/kg per day (n = 19). They were then monitored with serial physical and ultrasound examinations. Thirteen (41%) subjects developed small, single scrotal nodules 12 h to 7 days after treatment; this rate was unaffected by the dose of DEC. No nodules were detected outside the scrotal area. All 5 men with lymphangiectasia suspected on ultrasound before treatment developed scrotal nodules, compared to 8 (29.6%) of 27 men without ultrasonographic evidence (P = 0.006). Thus, using both ultrasound and 'provocative' treatment with DEC, adult W. bancrofti can be detected in the scrotal area of an estimated 88% of infected men. Because no single diagnostic test for W. bancrofti infection is completely sensitive, a panel of tests, including ultrasound, is proposed to identify with greater accuracy 'endemic normals' for immunological and epidemiological studies.
PubMed: 10499081
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pubmed:10499081Le document en format XML
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<front><div type="abstract" xml:lang="en">Although living adult Wuchereria bancrofti worms can be detected by ultrasound examination of the scrotal area in approximately 80% of men infected with this filarial parasite, the location of the adult worms in the remaining 20% remains unclear. To determine this, 32 individuals who had W. bancrofti microfilaraemia but no adult worms detectable on ultrasound were treated with diethylcarbarmazine (DEC), either with a single 6 mg/kg dose (n = 13) or with a 12-day course of 6 mg/kg per day (n = 19). They were then monitored with serial physical and ultrasound examinations. Thirteen (41%) subjects developed small, single scrotal nodules 12 h to 7 days after treatment; this rate was unaffected by the dose of DEC. No nodules were detected outside the scrotal area. All 5 men with lymphangiectasia suspected on ultrasound before treatment developed scrotal nodules, compared to 8 (29.6%) of 27 men without ultrasonographic evidence (P = 0.006). Thus, using both ultrasound and 'provocative' treatment with DEC, adult W. bancrofti can be detected in the scrotal area of an estimated 88% of infected men. Because no single diagnostic test for W. bancrofti infection is completely sensitive, a panel of tests, including ultrasound, is proposed to identify with greater accuracy 'endemic normals' for immunological and epidemiological studies.</div>
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<Abstract><AbstractText>Although living adult Wuchereria bancrofti worms can be detected by ultrasound examination of the scrotal area in approximately 80% of men infected with this filarial parasite, the location of the adult worms in the remaining 20% remains unclear. To determine this, 32 individuals who had W. bancrofti microfilaraemia but no adult worms detectable on ultrasound were treated with diethylcarbarmazine (DEC), either with a single 6 mg/kg dose (n = 13) or with a 12-day course of 6 mg/kg per day (n = 19). They were then monitored with serial physical and ultrasound examinations. Thirteen (41%) subjects developed small, single scrotal nodules 12 h to 7 days after treatment; this rate was unaffected by the dose of DEC. No nodules were detected outside the scrotal area. All 5 men with lymphangiectasia suspected on ultrasound before treatment developed scrotal nodules, compared to 8 (29.6%) of 27 men without ultrasonographic evidence (P = 0.006). Thus, using both ultrasound and 'provocative' treatment with DEC, adult W. bancrofti can be detected in the scrotal area of an estimated 88% of infected men. Because no single diagnostic test for W. bancrofti infection is completely sensitive, a panel of tests, including ultrasound, is proposed to identify with greater accuracy 'endemic normals' for immunological and epidemiological studies.</AbstractText>
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