Proposed panel of diagnostic criteria, including the use of ultrasound, to refine the concept of 'endemic normals' in lymphatic filariasis.
Identifieur interne : 004B96 ( PubMed/Curation ); précédent : 004B95; suivant : 004B97Proposed panel of diagnostic criteria, including the use of ultrasound, to refine the concept of 'endemic normals' in lymphatic filariasis.
Auteurs : G. Dreyer [Brésil] ; A. Santos ; J. Noroes ; D. AddissSource :
- Tropical medicine & international health : TM & IH [ 1360-2276 ] ; 1999.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Animaux, Diéthylcarbamazine (usage thérapeutique), Filaricides (usage thérapeutique), Filariose lymphatique (diagnostic), Filariose lymphatique (imagerie diagnostique), Filariose lymphatique (traitement médicamenteux), Humains, Mâle, Scrotum (imagerie diagnostique), Scrotum (parasitologie), Sensibilité et spécificité, Wuchereria bancrofti (isolement et purification), Échographie.
- MESH :
- diagnostic : Filariose lymphatique.
- imagerie diagnostique : Filariose lymphatique, Scrotum.
- isolement et purification : Wuchereria bancrofti.
- parasitologie : Scrotum.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Diéthylcarbamazine, Filaricides.
- Adulte, Adulte d'âge moyen, Animaux, Humains, Mâle, Sensibilité et spécificité, Échographie.
English descriptors
- KwdEn :
- Adult, Animals, Diethylcarbamazine (therapeutic use), Elephantiasis, Filarial (diagnosis), Elephantiasis, Filarial (diagnostic imaging), Elephantiasis, Filarial (drug therapy), Filaricides (therapeutic use), Humans, Male, Middle Aged, Scrotum (diagnostic imaging), Scrotum (parasitology), Sensitivity and Specificity, Ultrasonography, Wuchereria bancrofti (isolation & purification).
- MESH :
- chemical , therapeutic use : Diethylcarbamazine, Filaricides.
- diagnosis : Elephantiasis, Filarial.
- diagnostic imaging : Elephantiasis, Filarial, Scrotum.
- drug therapy : Elephantiasis, Filarial.
- isolation & purification : Wuchereria bancrofti.
- parasitology : Scrotum.
- Adult, Animals, Humans, Male, Middle Aged, Sensitivity and Specificity, Ultrasonography.
Abstract
Although living adult Wuchereria bancrofti worms can be detected by ultrasound examination of the scrotal area in approximately 80% of men infected with this filarial parasite, the location of the adult worms in the remaining 20% remains unclear. To determine this, 32 individuals who had W. bancrofti microfilaraemia but no adult worms detectable on ultrasound were treated with diethylcarbarmazine (DEC), either with a single 6 mg/kg dose (n = 13) or with a 12-day course of 6 mg/kg per day (n = 19). They were then monitored with serial physical and ultrasound examinations. Thirteen (41%) subjects developed small, single scrotal nodules 12 h to 7 days after treatment; this rate was unaffected by the dose of DEC. No nodules were detected outside the scrotal area. All 5 men with lymphangiectasia suspected on ultrasound before treatment developed scrotal nodules, compared to 8 (29.6%) of 27 men without ultrasonographic evidence (P = 0.006). Thus, using both ultrasound and 'provocative' treatment with DEC, adult W. bancrofti can be detected in the scrotal area of an estimated 88% of infected men. Because no single diagnostic test for W. bancrofti infection is completely sensitive, a panel of tests, including ultrasound, is proposed to identify with greater accuracy 'endemic normals' for immunological and epidemiological studies.
PubMed: 10499081
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Dreyer</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Parasitologia, Centro de Pesquisas Aggeu Magalhaes-FIOCRUZ, Universidade Federal de Pernambuco, Recife, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Departamento de Parasitologia, Centro de Pesquisas Aggeu Magalhaes-FIOCRUZ, Universidade Federal de Pernambuco, Recife</wicri:regionArea></affiliation></author><author><name sortKey="Santos, A" sort="Santos, A" uniqKey="Santos A" first="A" last="Santos">A. Santos</name></author><author><name sortKey="Noroes, J" sort="Noroes, J" uniqKey="Noroes J" first="J" last="Noroes">J. Noroes</name></author><author><name sortKey="Addiss, D" sort="Addiss, D" uniqKey="Addiss D" first="D" last="Addiss">D. Addiss</name></author></analytic><series><title level="j">Tropical medicine & international health : TM & IH</title><idno type="ISSN">1360-2276</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Animals</term><term>Diethylcarbamazine (therapeutic use)</term><term>Elephantiasis, Filarial (diagnosis)</term><term>Elephantiasis, Filarial (diagnostic imaging)</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Filaricides (therapeutic use)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Scrotum (diagnostic imaging)</term><term>Scrotum (parasitology)</term><term>Sensitivity and Specificity</term><term>Ultrasonography</term><term>Wuchereria bancrofti (isolation & purification)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Diéthylcarbamazine (usage thérapeutique)</term><term>Filaricides (usage thérapeutique)</term><term>Filariose lymphatique (diagnostic)</term><term>Filariose lymphatique (imagerie diagnostique)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Humains</term><term>Mâle</term><term>Scrotum (imagerie diagnostique)</term><term>Scrotum (parasitologie)</term><term>Sensibilité et spécificité</term><term>Wuchereria bancrofti (isolement et purification)</term><term>Échographie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Diethylcarbamazine</term><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Scrotum</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Filariose lymphatique</term><term>Scrotum</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Scrotum</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Scrotum</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Diéthylcarbamazine</term><term>Filaricides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Animals</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Sensitivity and Specificity</term><term>Ultrasonography</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Humains</term><term>Mâle</term><term>Sensibilité et spécificité</term><term>Échographie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although living adult Wuchereria bancrofti worms can be detected by ultrasound examination of the scrotal area in approximately 80% of men infected with this filarial parasite, the location of the adult worms in the remaining 20% remains unclear. To determine this, 32 individuals who had W. bancrofti microfilaraemia but no adult worms detectable on ultrasound were treated with diethylcarbarmazine (DEC), either with a single 6 mg/kg dose (n = 13) or with a 12-day course of 6 mg/kg per day (n = 19). They were then monitored with serial physical and ultrasound examinations. Thirteen (41%) subjects developed small, single scrotal nodules 12 h to 7 days after treatment; this rate was unaffected by the dose of DEC. No nodules were detected outside the scrotal area. All 5 men with lymphangiectasia suspected on ultrasound before treatment developed scrotal nodules, compared to 8 (29.6%) of 27 men without ultrasonographic evidence (P = 0.006). Thus, using both ultrasound and 'provocative' treatment with DEC, adult W. bancrofti can be detected in the scrotal area of an estimated 88% of infected men. Because no single diagnostic test for W. bancrofti infection is completely sensitive, a panel of tests, including ultrasound, is proposed to identify with greater accuracy 'endemic normals' for immunological and epidemiological studies.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">10499081</PMID><DateCreated><Year>1999</Year><Month>10</Month><Day>12</Day></DateCreated><DateCompleted><Year>1999</Year><Month>10</Month><Day>12</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1360-2276</ISSN><JournalIssue CitedMedium="Print"><Volume>4</Volume><Issue>8</Issue><PubDate><Year>1999</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Tropical medicine & international health : TM & IH</Title><ISOAbbreviation>Trop. Med. Int. Health</ISOAbbreviation></Journal><ArticleTitle>Proposed panel of diagnostic criteria, including the use of ultrasound, to refine the concept of 'endemic normals' in lymphatic filariasis.</ArticleTitle><Pagination><MedlinePgn>575-9</MedlinePgn></Pagination><Abstract><AbstractText>Although living adult Wuchereria bancrofti worms can be detected by ultrasound examination of the scrotal area in approximately 80% of men infected with this filarial parasite, the location of the adult worms in the remaining 20% remains unclear. To determine this, 32 individuals who had W. bancrofti microfilaraemia but no adult worms detectable on ultrasound were treated with diethylcarbarmazine (DEC), either with a single 6 mg/kg dose (n = 13) or with a 12-day course of 6 mg/kg per day (n = 19). They were then monitored with serial physical and ultrasound examinations. Thirteen (41%) subjects developed small, single scrotal nodules 12 h to 7 days after treatment; this rate was unaffected by the dose of DEC. No nodules were detected outside the scrotal area. All 5 men with lymphangiectasia suspected on ultrasound before treatment developed scrotal nodules, compared to 8 (29.6%) of 27 men without ultrasonographic evidence (P = 0.006). Thus, using both ultrasound and 'provocative' treatment with DEC, adult W. bancrofti can be detected in the scrotal area of an estimated 88% of infected men. Because no single diagnostic test for W. bancrofti infection is completely sensitive, a panel of tests, including ultrasound, is proposed to identify with greater accuracy 'endemic normals' for immunological and epidemiological studies.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dreyer</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Departamento de Parasitologia, Centro de Pesquisas Aggeu Magalhaes-FIOCRUZ, Universidade Federal de Pernambuco, Recife, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Santos</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Noroes</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Addiss</LastName><ForeName>D</ForeName><Initials>D</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Trop Med Int Health</MedlineTA><NlmUniqueID>9610576</NlmUniqueID><ISSNLinking>1360-2276</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005369">Filaricides</NameOfSubstance></Chemical><Chemical><RegistryNumber>V867Q8X3ZD</RegistryNumber><NameOfSubstance UI="D004049">Diethylcarbamazine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004049" MajorTopicYN="N">Diethylcarbamazine</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005369" MajorTopicYN="N">Filaricides</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012611" MajorTopicYN="N">Scrotum</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012680" MajorTopicYN="N">Sensitivity and Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014463" MajorTopicYN="N">Ultrasonography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014958" MajorTopicYN="N">Wuchereria bancrofti</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1999</Year><Month>9</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1999</Year><Month>9</Month><Day>28</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1999</Year><Month>9</Month><Day>28</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">10499081</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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