Adjuvant small field pelvic radiation for patients with high risk, stage IB lymph node negative cervix carcinoma after radical hysterectomy and pelvic lymph node dissection. A pilot study.
Identifieur interne : 004B77 ( PubMed/Curation ); précédent : 004B76; suivant : 004B78Adjuvant small field pelvic radiation for patients with high risk, stage IB lymph node negative cervix carcinoma after radical hysterectomy and pelvic lymph node dissection. A pilot study.
Auteurs : F J Kridelka [Belgique] ; D O Berg ; M. Neuman ; L S Edwards ; G. Robertson ; P T Grant ; N F HackerSource :
- Cancer [ 0008-543X ] ; 1999.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Facteurs de risque, Femelle, Humains, Hystérectomie (), Lymphadénectomie, Métastase lymphatique, Pelvis, Projets pilotes, Radiothérapie adjuvante, Sujet âgé, Sujet âgé de 80 ans ou plus, Tumeurs du col de l'utérus (anatomopathologie), Tumeurs du col de l'utérus (radiothérapie).
- MESH :
- anatomopathologie : Tumeurs du col de l'utérus.
- radiothérapie : Tumeurs du col de l'utérus.
- Adulte, Adulte d'âge moyen, Facteurs de risque, Femelle, Humains, Hystérectomie, Lymphadénectomie, Métastase lymphatique, Pelvis, Projets pilotes, Radiothérapie adjuvante, Sujet âgé, Sujet âgé de 80 ans ou plus.
English descriptors
- KwdEn :
- MESH :
- methods : Hysterectomy.
- pathology : Uterine Cervical Neoplasms.
- radiotherapy : Uterine Cervical Neoplasms.
- Adult, Aged, Aged, 80 and over, Female, Humans, Lymph Node Excision, Lymphatic Metastasis, Middle Aged, Pelvis, Pilot Projects, Radiotherapy, Adjuvant, Risk Factors.
Abstract
After radical hysterectomy and pelvic lymph node dissection, an identifiable subgroup of patients with International Federation of Gynecology and Obstetrics Stage IB lymph node negative cervix carcinoma remains at high risk of pelvic recurrence. This study attempted to determine whether postoperative small field of pelvic radiation can improve the disease free survival (DFS) of this high risk group of patients without producing significant morbidity.
PubMed: 10570432
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Adjuvant small field pelvic radiation for patients with high risk, stage IB lymph node negative cervix carcinoma after radical hysterectomy and pelvic lymph node dissection. A pilot study.</title><author><name sortKey="Kridelka, F J" sort="Kridelka, F J" uniqKey="Kridelka F" first="F J" last="Kridelka">F J Kridelka</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gynecology, CHU Liège, Liège, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Gynecology, CHU Liège, Liège</wicri:regionArea></affiliation></author><author><name sortKey="Berg, D O" sort="Berg, D O" uniqKey="Berg D" first="D O" last="Berg">D O Berg</name></author><author><name sortKey="Neuman, M" sort="Neuman, M" uniqKey="Neuman M" first="M" last="Neuman">M. Neuman</name></author><author><name sortKey="Edwards, L S" sort="Edwards, L S" uniqKey="Edwards L" first="L S" last="Edwards">L S Edwards</name></author><author><name sortKey="Robertson, G" sort="Robertson, G" uniqKey="Robertson G" first="G" last="Robertson">G. Robertson</name></author><author><name sortKey="Grant, P T" sort="Grant, P T" uniqKey="Grant P" first="P T" last="Grant">P T Grant</name></author><author><name sortKey="Hacker, N F" sort="Hacker, N F" uniqKey="Hacker N" first="N F" last="Hacker">N F Hacker</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1999">1999</date><idno type="RBID">pubmed:10570432</idno><idno type="pmid">10570432</idno><idno type="wicri:Area/PubMed/Corpus">004B77</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">004B77</idno><idno type="wicri:Area/PubMed/Curation">004B77</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">004B77</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Adjuvant small field pelvic radiation for patients with high risk, stage IB lymph node negative cervix carcinoma after radical hysterectomy and pelvic lymph node dissection. A pilot study.</title><author><name sortKey="Kridelka, F J" sort="Kridelka, F J" uniqKey="Kridelka F" first="F J" last="Kridelka">F J Kridelka</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gynecology, CHU Liège, Liège, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Gynecology, CHU Liège, Liège</wicri:regionArea></affiliation></author><author><name sortKey="Berg, D O" sort="Berg, D O" uniqKey="Berg D" first="D O" last="Berg">D O Berg</name></author><author><name sortKey="Neuman, M" sort="Neuman, M" uniqKey="Neuman M" first="M" last="Neuman">M. Neuman</name></author><author><name sortKey="Edwards, L S" sort="Edwards, L S" uniqKey="Edwards L" first="L S" last="Edwards">L S Edwards</name></author><author><name sortKey="Robertson, G" sort="Robertson, G" uniqKey="Robertson G" first="G" last="Robertson">G. Robertson</name></author><author><name sortKey="Grant, P T" sort="Grant, P T" uniqKey="Grant P" first="P T" last="Grant">P T Grant</name></author><author><name sortKey="Hacker, N F" sort="Hacker, N F" uniqKey="Hacker N" first="N F" last="Hacker">N F Hacker</name></author></analytic><series><title level="j">Cancer</title><idno type="ISSN">0008-543X</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Hysterectomy (methods)</term><term>Lymph Node Excision</term><term>Lymphatic Metastasis</term><term>Middle Aged</term><term>Pelvis</term><term>Pilot Projects</term><term>Radiotherapy, Adjuvant</term><term>Risk Factors</term><term>Uterine Cervical Neoplasms (pathology)</term><term>Uterine Cervical Neoplasms (radiotherapy)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Hystérectomie ()</term><term>Lymphadénectomie</term><term>Métastase lymphatique</term><term>Pelvis</term><term>Projets pilotes</term><term>Radiothérapie adjuvante</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tumeurs du col de l'utérus (anatomopathologie)</term><term>Tumeurs du col de l'utérus (radiothérapie)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs du col de l'utérus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Hysterectomy</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Tumeurs du col de l'utérus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Lymph Node Excision</term><term>Lymphatic Metastasis</term><term>Middle Aged</term><term>Pelvis</term><term>Pilot Projects</term><term>Radiotherapy, Adjuvant</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Hystérectomie</term><term>Lymphadénectomie</term><term>Métastase lymphatique</term><term>Pelvis</term><term>Projets pilotes</term><term>Radiothérapie adjuvante</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">After radical hysterectomy and pelvic lymph node dissection, an identifiable subgroup of patients with International Federation of Gynecology and Obstetrics Stage IB lymph node negative cervix carcinoma remains at high risk of pelvic recurrence. This study attempted to determine whether postoperative small field of pelvic radiation can improve the disease free survival (DFS) of this high risk group of patients without producing significant morbidity.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">10570432</PMID><DateCreated><Year>2000</Year><Month>01</Month><Day>04</Day></DateCreated><DateCompleted><Year>2000</Year><Month>01</Month><Day>04</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0008-543X</ISSN><JournalIssue CitedMedium="Print"><Volume>86</Volume><Issue>10</Issue><PubDate><Year>1999</Year><Month>Nov</Month><Day>15</Day></PubDate></JournalIssue><Title>Cancer</Title><ISOAbbreviation>Cancer</ISOAbbreviation></Journal><ArticleTitle>Adjuvant small field pelvic radiation for patients with high risk, stage IB lymph node negative cervix carcinoma after radical hysterectomy and pelvic lymph node dissection. A pilot study.</ArticleTitle><Pagination><MedlinePgn>2059-65</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">After radical hysterectomy and pelvic lymph node dissection, an identifiable subgroup of patients with International Federation of Gynecology and Obstetrics Stage IB lymph node negative cervix carcinoma remains at high risk of pelvic recurrence. This study attempted to determine whether postoperative small field of pelvic radiation can improve the disease free survival (DFS) of this high risk group of patients without producing significant morbidity.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Between 1991 and 1995, after radical surgery, 25 patients with Stage IB lymph node negative cervix carcinoma were considered to be at high risk of pelvic recurrence on the basis of tumor dimension, depth of stromal invasion, and the presence of lymph-vascular space invasion. All had a score >/= 120 as determined by the Gynecologic Oncology Group (GOG) study. These patients received 50.4 gray of adjuvant radiation to a small central pelvic field and were followed prospectively. A Kaplan-Meier 5-year DFS curve was generated. A log rank analysis produced an estimated log rank P value (est P value) by comparing the 5-year DFS of the patients in the current study with the 5-year DFS of the corresponding high risk group of the GOG study (observation only). The morbidity of small field pelvic radiation was recorded.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Among the 25 patients who received small field pelvic radiation, the mean GOG score was 166 (range, 120-263) and the mean follow-up was 32 months (range, 12-64 months). There was 1 recurrence (4%) recorded at 16 months. The log rank analysis demonstrated a significant improvement in the 5-year DFS for the group who received adjuvant small field pelvic radiation (est P value = 0.005) when compared with the DFS of the high risk GOG patients who were observed postoperatively. Four cases of minor morbidity were recorded: lymphedema (three cases) and mild rectal incontinence (one case). No major morbidity was reported.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">With low morbidity, adjuvant small field pelvic radiation appears to improve significantly the 5-year DFS of patients with high risk, lymph node negative Stage IB cervical carcinoma. However, this pilot study requires verification.</AbstractText><CopyrightInformation>Copyright 1999 American Cancer Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kridelka</LastName><ForeName>F J</ForeName><Initials>FJ</Initials><AffiliationInfo><Affiliation>Department of Gynecology, CHU Liège, Liège, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berg</LastName><ForeName>D O</ForeName><Initials>DO</Initials></Author><Author ValidYN="Y"><LastName>Neuman</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Edwards</LastName><ForeName>L S</ForeName><Initials>LS</Initials></Author><Author ValidYN="Y"><LastName>Robertson</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Grant</LastName><ForeName>P T</ForeName><Initials>PT</Initials></Author><Author ValidYN="Y"><LastName>Hacker</LastName><ForeName>N F</ForeName><Initials>NF</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cancer</MedlineTA><NlmUniqueID>0374236</NlmUniqueID><ISSNLinking>0008-543X</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007044" MajorTopicYN="N">Hysterectomy</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008197" MajorTopicYN="N">Lymph Node Excision</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008207" MajorTopicYN="N">Lymphatic Metastasis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010388" MajorTopicYN="N">Pelvis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010865" MajorTopicYN="N">Pilot Projects</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018714" MajorTopicYN="N">Radiotherapy, Adjuvant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002583" MajorTopicYN="N">Uterine Cervical Neoplasms</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000532" MajorTopicYN="Y">radiotherapy</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1999</Year><Month>11</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1999</Year><Month>11</Month><Day>26</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1999</Year><Month>11</Month><Day>26</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">10570432</ArticleId><ArticleId IdType="pii">10.1002/(SICI)1097-0142(19991115)86:10<2059::AID-CNCR25>3.0.CO;2-X</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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