The transcription factor Prox1 is a marker for lymphatic endothelial cells in normal and diseased human tissues.
Identifieur interne : 004556 ( PubMed/Curation ); précédent : 004555; suivant : 004557The transcription factor Prox1 is a marker for lymphatic endothelial cells in normal and diseased human tissues.
Auteurs : Jörg Wilting [Allemagne] ; Maria Papoutsi ; Bodo Christ ; Kypros H. Nicolaides ; Constantin S. Von Kaisenberg ; Jörg Borges ; G Björn Stark ; Kari Alitalo ; Stanislav I. Tomarev ; Charlotte Niemeyer ; Jochen RösslerSource :
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology [ 1530-6860 ] ; 2002.
Descripteurs français
- KwdFr :
- Antigènes CD31 (analyse), Antigènes CD34 (analyse), Endothélium lymphatique (), Endothélium lymphatique (métabolisme), Enfant d'âge préscolaire, Facteurs de transcription (analyse), Facteurs de transcription (métabolisme), Humains, Hémangiome (), Lymphangiome (), Lymphoedème (métabolisme), Maladies lymphatiques (métabolisme), Marqueurs biologiques (analyse), Marqueurs biologiques tumoraux (analyse), Nourrisson, Nouveau-né, Protéines suppresseurs de tumeurs, Protéines à homéodomaine (analyse), Protéines à homéodomaine (métabolisme), Récepteur facteur croissance (métabolisme), Récepteur-3 au facteur croissance endothéliale vasculaire, Récepteurs à activité tyrosine kinase (métabolisme), Spécificité d'organe.
- MESH :
- analyse : Antigènes CD31, Antigènes CD34, Facteurs de transcription, Marqueurs biologiques, Marqueurs biologiques tumoraux, Protéines à homéodomaine.
- métabolisme : Endothélium lymphatique, Facteurs de transcription, Lymphoedème, Maladies lymphatiques, Protéines à homéodomaine, Récepteur facteur croissance, Récepteurs à activité tyrosine kinase.
- Endothélium lymphatique, Enfant d'âge préscolaire, Humains, Hémangiome, Lymphangiome, Nourrisson, Nouveau-né, Protéines suppresseurs de tumeurs, Récepteur-3 au facteur croissance endothéliale vasculaire, Spécificité d'organe.
English descriptors
- KwdEn :
- Antigens, CD31 (analysis), Antigens, CD34 (analysis), Biomarkers (analysis), Biomarkers, Tumor (analysis), Child, Preschool, Endothelium, Lymphatic (chemistry), Endothelium, Lymphatic (metabolism), Hemangioma (chemistry), Homeodomain Proteins (analysis), Homeodomain Proteins (metabolism), Humans, Infant, Infant, Newborn, Lymphangioma (chemistry), Lymphatic Diseases (metabolism), Lymphedema (metabolism), Organ Specificity, Receptor Protein-Tyrosine Kinases (metabolism), Receptors, Growth Factor (metabolism), Transcription Factors (analysis), Transcription Factors (metabolism), Tumor Suppressor Proteins, Vascular Endothelial Growth Factor Receptor-3.
- MESH :
- chemical , analysis : Antigens, CD31, Antigens, CD34, Biomarkers, Biomarkers, Tumor, Homeodomain Proteins, Transcription Factors.
- chemistry : Endothelium, Lymphatic, Hemangioma, Lymphangioma.
- metabolism : Endothelium, Lymphatic, Homeodomain Proteins, Lymphatic Diseases, Lymphedema, Receptor Protein-Tyrosine Kinases, Receptors, Growth Factor, Transcription Factors.
- Child, Preschool, Humans, Infant, Infant, Newborn, Organ Specificity, Tumor Suppressor Proteins, Vascular Endothelial Growth Factor Receptor-3.
Abstract
Detection of lymphatic endothelal cells (LECs) has been problematic because of the lack of specific markers. The homeobox transcription factor Prox1 is expressed in LECs of murine and avian embryos. We have studied expression of Prox1 in human tissues with immunofluorescence. In 19-wk-old human fetuses, Prox1 and vascular endothelial growth factor receptor-3 (VEGFR-3) are coexpressed in LECs of lymphatic trunks and lymphatic capillaries. Prox1 is located in the nucleus, and its expression is mutually exclusive with that of the blood vascular marker PAL-E. Prox1 is a constitutive marker of LECs and is found in tissues of healthy adults and lymphedema patients. Blood vascular endothelial cells (BECs) of hemangiomas express CD31 and CD34, but not Prox1. A subset of these cells is positive for VEGFR-3. Lymphatics in the periphery of hemangiomas express Prox1 and CD31, but not CD34. In lymphangiomas, LECs express Prox1, CD31, and VEGFR-3, but rarely CD34. In the stroma, spindle-shaped CD34-positive cells are present. We show that Prox1 is a reliable marker for LECs in normal and pathologic human tissues, coexpressed with VEGFR-3 and CD31. VEGFR-3 and CD34 are less reliable markers for LECs and BECs, respectively, because exceptions from their normal expression patterns are found in pathologic tissues.
DOI: 10.1096/fj.01-1010fje
PubMed: 12060670
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Von Kaisenberg</name></author><author><name sortKey="Borges, Jorg" sort="Borges, Jorg" uniqKey="Borges J" first="Jörg" last="Borges">Jörg Borges</name></author><author><name sortKey="Stark, G Bjorn" sort="Stark, G Bjorn" uniqKey="Stark G" first="G Björn" last="Stark">G Björn Stark</name></author><author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name></author><author><name sortKey="Tomarev, Stanislav I" sort="Tomarev, Stanislav I" uniqKey="Tomarev S" first="Stanislav I" last="Tomarev">Stanislav I. Tomarev</name></author><author><name sortKey="Niemeyer, Charlotte" sort="Niemeyer, Charlotte" uniqKey="Niemeyer C" first="Charlotte" last="Niemeyer">Charlotte Niemeyer</name></author><author><name sortKey="Rossler, Jochen" sort="Rossler, Jochen" uniqKey="Rossler J" first="Jochen" last="Rössler">Jochen Rössler</name></author></analytic><series><title level="j">FASEB journal : official publication of the Federation of American Societies for Experimental Biology</title><idno type="eISSN">1530-6860</idno><imprint><date when="2002" type="published">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antigens, CD31 (analysis)</term><term>Antigens, CD34 (analysis)</term><term>Biomarkers (analysis)</term><term>Biomarkers, Tumor (analysis)</term><term>Child, Preschool</term><term>Endothelium, Lymphatic (chemistry)</term><term>Endothelium, Lymphatic (metabolism)</term><term>Hemangioma (chemistry)</term><term>Homeodomain Proteins (analysis)</term><term>Homeodomain Proteins (metabolism)</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Lymphangioma (chemistry)</term><term>Lymphatic Diseases (metabolism)</term><term>Lymphedema (metabolism)</term><term>Organ Specificity</term><term>Receptor Protein-Tyrosine Kinases (metabolism)</term><term>Receptors, Growth Factor (metabolism)</term><term>Transcription Factors (analysis)</term><term>Transcription Factors (metabolism)</term><term>Tumor Suppressor Proteins</term><term>Vascular Endothelial Growth Factor Receptor-3</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antigènes CD31 (analyse)</term><term>Antigènes CD34 (analyse)</term><term>Endothélium lymphatique ()</term><term>Endothélium lymphatique (métabolisme)</term><term>Enfant d'âge préscolaire</term><term>Facteurs de transcription (analyse)</term><term>Facteurs de transcription (métabolisme)</term><term>Humains</term><term>Hémangiome ()</term><term>Lymphangiome ()</term><term>Lymphoedème (métabolisme)</term><term>Maladies lymphatiques (métabolisme)</term><term>Marqueurs biologiques (analyse)</term><term>Marqueurs biologiques tumoraux (analyse)</term><term>Nourrisson</term><term>Nouveau-né</term><term>Protéines suppresseurs de tumeurs</term><term>Protéines à homéodomaine (analyse)</term><term>Protéines à homéodomaine (métabolisme)</term><term>Récepteur facteur croissance (métabolisme)</term><term>Récepteur-3 au facteur croissance endothéliale vasculaire</term><term>Récepteurs à activité tyrosine kinase (métabolisme)</term><term>Spécificité d'organe</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antigens, CD31</term><term>Antigens, CD34</term><term>Biomarkers</term><term>Biomarkers, Tumor</term><term>Homeodomain Proteins</term><term>Transcription Factors</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Antigènes CD31</term><term>Antigènes CD34</term><term>Facteurs de transcription</term><term>Marqueurs biologiques</term><term>Marqueurs biologiques tumoraux</term><term>Protéines à homéodomaine</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Endothelium, Lymphatic</term><term>Hemangioma</term><term>Lymphangioma</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Endothelium, Lymphatic</term><term>Homeodomain Proteins</term><term>Lymphatic Diseases</term><term>Lymphedema</term><term>Receptor Protein-Tyrosine Kinases</term><term>Receptors, Growth Factor</term><term>Transcription Factors</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Endothélium lymphatique</term><term>Facteurs de transcription</term><term>Lymphoedème</term><term>Maladies lymphatiques</term><term>Protéines à homéodomaine</term><term>Récepteur facteur croissance</term><term>Récepteurs à activité tyrosine kinase</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child, Preschool</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Organ Specificity</term><term>Tumor Suppressor Proteins</term><term>Vascular Endothelial Growth Factor Receptor-3</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Endothélium lymphatique</term><term>Enfant d'âge préscolaire</term><term>Humains</term><term>Hémangiome</term><term>Lymphangiome</term><term>Nourrisson</term><term>Nouveau-né</term><term>Protéines suppresseurs de tumeurs</term><term>Récepteur-3 au facteur croissance endothéliale vasculaire</term><term>Spécificité d'organe</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Detection of lymphatic endothelal cells (LECs) has been problematic because of the lack of specific markers. The homeobox transcription factor Prox1 is expressed in LECs of murine and avian embryos. We have studied expression of Prox1 in human tissues with immunofluorescence. In 19-wk-old human fetuses, Prox1 and vascular endothelial growth factor receptor-3 (VEGFR-3) are coexpressed in LECs of lymphatic trunks and lymphatic capillaries. Prox1 is located in the nucleus, and its expression is mutually exclusive with that of the blood vascular marker PAL-E. Prox1 is a constitutive marker of LECs and is found in tissues of healthy adults and lymphedema patients. Blood vascular endothelial cells (BECs) of hemangiomas express CD31 and CD34, but not Prox1. A subset of these cells is positive for VEGFR-3. Lymphatics in the periphery of hemangiomas express Prox1 and CD31, but not CD34. In lymphangiomas, LECs express Prox1, CD31, and VEGFR-3, but rarely CD34. In the stroma, spindle-shaped CD34-positive cells are present. We show that Prox1 is a reliable marker for LECs in normal and pathologic human tissues, coexpressed with VEGFR-3 and CD31. VEGFR-3 and CD34 are less reliable markers for LECs and BECs, respectively, because exceptions from their normal expression patterns are found in pathologic tissues.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12060670</PMID><DateCreated><Year>2002</Year><Month>08</Month><Day>02</Day></DateCreated><DateCompleted><Year>2002</Year><Month>09</Month><Day>03</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1530-6860</ISSN><JournalIssue CitedMedium="Internet"><Volume>16</Volume><Issue>10</Issue><PubDate><Year>2002</Year><Month>Aug</Month></PubDate></JournalIssue><Title>FASEB journal : official publication of the Federation of American Societies for Experimental Biology</Title><ISOAbbreviation>FASEB J.</ISOAbbreviation></Journal><ArticleTitle>The transcription factor Prox1 is a marker for lymphatic endothelial cells in normal and diseased human tissues.</ArticleTitle><Pagination><MedlinePgn>1271-3</MedlinePgn></Pagination><Abstract><AbstractText>Detection of lymphatic endothelal cells (LECs) has been problematic because of the lack of specific markers. The homeobox transcription factor Prox1 is expressed in LECs of murine and avian embryos. We have studied expression of Prox1 in human tissues with immunofluorescence. In 19-wk-old human fetuses, Prox1 and vascular endothelial growth factor receptor-3 (VEGFR-3) are coexpressed in LECs of lymphatic trunks and lymphatic capillaries. Prox1 is located in the nucleus, and its expression is mutually exclusive with that of the blood vascular marker PAL-E. Prox1 is a constitutive marker of LECs and is found in tissues of healthy adults and lymphedema patients. Blood vascular endothelial cells (BECs) of hemangiomas express CD31 and CD34, but not Prox1. A subset of these cells is positive for VEGFR-3. Lymphatics in the periphery of hemangiomas express Prox1 and CD31, but not CD34. In lymphangiomas, LECs express Prox1, CD31, and VEGFR-3, but rarely CD34. In the stroma, spindle-shaped CD34-positive cells are present. We show that Prox1 is a reliable marker for LECs in normal and pathologic human tissues, coexpressed with VEGFR-3 and CD31. VEGFR-3 and CD34 are less reliable markers for LECs and BECs, respectively, because exceptions from their normal expression patterns are found in pathologic tissues.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wilting</LastName><ForeName>Jörg</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Anatomisches Institut, Albert-Ludwigs-Universität Freiburg, 79104 Freiburg, Germany. Joerg.Wilting@anat.uni-freiburg.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Papoutsi</LastName><ForeName>Maria</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Christ</LastName><ForeName>Bodo</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Nicolaides</LastName><ForeName>Kypros H</ForeName><Initials>KH</Initials></Author><Author ValidYN="Y"><LastName>von Kaisenberg</LastName><ForeName>Constantin S</ForeName><Initials>CS</Initials></Author><Author ValidYN="Y"><LastName>Borges</LastName><ForeName>Jörg</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Stark</LastName><ForeName>G Björn</ForeName><Initials>GB</Initials></Author><Author ValidYN="Y"><LastName>Alitalo</LastName><ForeName>Kari</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Tomarev</LastName><ForeName>Stanislav I</ForeName><Initials>SI</Initials></Author><Author ValidYN="Y"><LastName>Niemeyer</LastName><ForeName>Charlotte</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Rössler</LastName><ForeName>Jochen</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2002</Year><Month>06</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>FASEB J</MedlineTA><NlmUniqueID>8804484</NlmUniqueID><ISSNLinking>0892-6638</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019408">Antigens, CD31</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018952">Antigens, CD34</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014408">Biomarkers, Tumor</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018398">Homeodomain Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017978">Receptors, Growth Factor</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014157">Transcription Factors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D025521">Tumor Suppressor Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C102225">prospero-related homeobox 1 protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.10.1</RegistryNumber><NameOfSubstance UI="D020794">Receptor Protein-Tyrosine Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.10.1</RegistryNumber><NameOfSubstance UI="D040321">Vascular Endothelial Growth Factor Receptor-3</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D019408" MajorTopicYN="N">Antigens, CD31</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018952" MajorTopicYN="N">Antigens, CD34</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014408" MajorTopicYN="N">Biomarkers, Tumor</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004729" MajorTopicYN="N">Endothelium, Lymphatic</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006391" MajorTopicYN="N">Hemangioma</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018398" MajorTopicYN="N">Homeodomain Proteins</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008202" MajorTopicYN="N">Lymphangioma</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008206" MajorTopicYN="N">Lymphatic Diseases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009928" MajorTopicYN="N">Organ Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020794" MajorTopicYN="N">Receptor Protein-Tyrosine Kinases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017978" MajorTopicYN="N">Receptors, Growth Factor</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014157" MajorTopicYN="N">Transcription Factors</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D025521" MajorTopicYN="N">Tumor Suppressor Proteins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D040321" MajorTopicYN="N">Vascular Endothelial Growth Factor Receptor-3</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2002</Year><Month>6</Month><Day>13</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2002</Year><Month>9</Month><Day>11</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate 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