Protective immunity in human lymphatic filariasis: problems and prospects.
Identifieur interne : 004354 ( PubMed/Curation ); précédent : 004353; suivant : 004355Protective immunity in human lymphatic filariasis: problems and prospects.
Auteurs : Balachandran Ravindran [Inde] ; Ashok K. Satapathy ; Prakash K. Sahoo ; Madhu Chhanda MohantySource :
- Medical microbiology and immunology [ 0300-8584 ] ; 2003.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Filariose lymphatique, Larve.
- épidémiologie : Filariose lymphatique.
- Animaux, Humains, Maladies endémiques, Modèles animaux de maladie humaine.
English descriptors
- KwdEn :
- MESH :
- epidemiology : Elephantiasis, Filarial.
- immunology : Elephantiasis, Filarial, Larva.
- Animals, Disease Models, Animal, Endemic Diseases, Humans.
Abstract
Human filariasis caused by lymphatic dwelling nematodes, affecting 120 million persons worldwide, is a major public health problem. Efforts towards development of vaccines for such large tissue-dwelling nematodes depends significantly on identification and demonstration of protective immunity in the exposed population. Immunological studies conducted in human filariasis so far are essentially attempts to establish a correlation of the immune response phenotypes with presence or absence of filarial infections/disease in the host, and the cause-effect relationship between the observed immune responses in the host and protective immunity continues to be conjectural. This short review attempts to clarify the functional definition of protective immunity, problems associated with identification of putatively immune subjects in endemic areas, role of antibodies reactive to surface of microfilariae and larvae stages of filarial parasites and importance of undertaking immunological investigations on a longitudinal basis in different cohorts of subjects presenting with one or the features of infection and/or disease for more accurate delineation of protective immunity in human filariasis.
DOI: 10.1007/s00430-002-0157-7
PubMed: 12592562
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :004354
Links to Exploration step
pubmed:12592562Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Protective immunity in human lymphatic filariasis: problems and prospects.</title><author><name sortKey="Ravindran, Balachandran" sort="Ravindran, Balachandran" uniqKey="Ravindran B" first="Balachandran" last="Ravindran">Balachandran Ravindran</name><affiliation wicri:level="1"><nlm:affiliation>Division of Immunology, Regional Medical Research Centre (Indian Council of Medical Research), Bhubaneswar 7510123, India. balaravi@sancharnet.in</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Division of Immunology, Regional Medical Research Centre (Indian Council of Medical Research), Bhubaneswar 7510123</wicri:regionArea></affiliation></author><author><name sortKey="Satapathy, Ashok K" sort="Satapathy, Ashok K" uniqKey="Satapathy A" first="Ashok K" last="Satapathy">Ashok K. Satapathy</name></author><author><name sortKey="Sahoo, Prakash K" sort="Sahoo, Prakash K" uniqKey="Sahoo P" first="Prakash K" last="Sahoo">Prakash K. Sahoo</name></author><author><name sortKey="Mohanty, Madhu Chhanda" sort="Mohanty, Madhu Chhanda" uniqKey="Mohanty M" first="Madhu Chhanda" last="Mohanty">Madhu Chhanda Mohanty</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:12592562</idno><idno type="pmid">12592562</idno><idno type="doi">10.1007/s00430-002-0157-7</idno><idno type="wicri:Area/PubMed/Corpus">004354</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">004354</idno><idno type="wicri:Area/PubMed/Curation">004354</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">004354</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Protective immunity in human lymphatic filariasis: problems and prospects.</title><author><name sortKey="Ravindran, Balachandran" sort="Ravindran, Balachandran" uniqKey="Ravindran B" first="Balachandran" last="Ravindran">Balachandran Ravindran</name><affiliation wicri:level="1"><nlm:affiliation>Division of Immunology, Regional Medical Research Centre (Indian Council of Medical Research), Bhubaneswar 7510123, India. balaravi@sancharnet.in</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Division of Immunology, Regional Medical Research Centre (Indian Council of Medical Research), Bhubaneswar 7510123</wicri:regionArea></affiliation></author><author><name sortKey="Satapathy, Ashok K" sort="Satapathy, Ashok K" uniqKey="Satapathy A" first="Ashok K" last="Satapathy">Ashok K. Satapathy</name></author><author><name sortKey="Sahoo, Prakash K" sort="Sahoo, Prakash K" uniqKey="Sahoo P" first="Prakash K" last="Sahoo">Prakash K. Sahoo</name></author><author><name sortKey="Mohanty, Madhu Chhanda" sort="Mohanty, Madhu Chhanda" uniqKey="Mohanty M" first="Madhu Chhanda" last="Mohanty">Madhu Chhanda Mohanty</name></author></analytic><series><title level="j">Medical microbiology and immunology</title><idno type="ISSN">0300-8584</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Elephantiasis, Filarial (epidemiology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Endemic Diseases</term><term>Humans</term><term>Larva (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Filariose lymphatique (immunologie)</term><term>Filariose lymphatique (épidémiologie)</term><term>Humains</term><term>Larve (immunologie)</term><term>Maladies endémiques</term><term>Modèles animaux de maladie humaine</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Larve</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Larva</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Endemic Diseases</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Maladies endémiques</term><term>Modèles animaux de maladie humaine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Human filariasis caused by lymphatic dwelling nematodes, affecting 120 million persons worldwide, is a major public health problem. Efforts towards development of vaccines for such large tissue-dwelling nematodes depends significantly on identification and demonstration of protective immunity in the exposed population. Immunological studies conducted in human filariasis so far are essentially attempts to establish a correlation of the immune response phenotypes with presence or absence of filarial infections/disease in the host, and the cause-effect relationship between the observed immune responses in the host and protective immunity continues to be conjectural. This short review attempts to clarify the functional definition of protective immunity, problems associated with identification of putatively immune subjects in endemic areas, role of antibodies reactive to surface of microfilariae and larvae stages of filarial parasites and importance of undertaking immunological investigations on a longitudinal basis in different cohorts of subjects presenting with one or the features of infection and/or disease for more accurate delineation of protective immunity in human filariasis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12592562</PMID><DateCreated><Year>2003</Year><Month>02</Month><Day>19</Day></DateCreated><DateCompleted><Year>2003</Year><Month>05</Month><Day>15</Day></DateCompleted><DateRevised><Year>2007</Year><Month>02</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0300-8584</ISSN><JournalIssue CitedMedium="Print"><Volume>192</Volume><Issue>1</Issue><PubDate><Year>2003</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Medical microbiology and immunology</Title><ISOAbbreviation>Med. Microbiol. Immunol.</ISOAbbreviation></Journal><ArticleTitle>Protective immunity in human lymphatic filariasis: problems and prospects.</ArticleTitle><Pagination><MedlinePgn>41-6</MedlinePgn></Pagination><Abstract><AbstractText>Human filariasis caused by lymphatic dwelling nematodes, affecting 120 million persons worldwide, is a major public health problem. Efforts towards development of vaccines for such large tissue-dwelling nematodes depends significantly on identification and demonstration of protective immunity in the exposed population. Immunological studies conducted in human filariasis so far are essentially attempts to establish a correlation of the immune response phenotypes with presence or absence of filarial infections/disease in the host, and the cause-effect relationship between the observed immune responses in the host and protective immunity continues to be conjectural. This short review attempts to clarify the functional definition of protective immunity, problems associated with identification of putatively immune subjects in endemic areas, role of antibodies reactive to surface of microfilariae and larvae stages of filarial parasites and importance of undertaking immunological investigations on a longitudinal basis in different cohorts of subjects presenting with one or the features of infection and/or disease for more accurate delineation of protective immunity in human filariasis.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ravindran</LastName><ForeName>Balachandran</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Division of Immunology, Regional Medical Research Centre (Indian Council of Medical Research), Bhubaneswar 7510123, India. balaravi@sancharnet.in</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Satapathy</LastName><ForeName>Ashok K</ForeName><Initials>AK</Initials></Author><Author ValidYN="Y"><LastName>Sahoo</LastName><ForeName>Prakash K</ForeName><Initials>PK</Initials></Author><Author ValidYN="Y"><LastName>Mohanty</LastName><ForeName>Madhu Chhanda</ForeName><Initials>MC</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2002</Year><Month>10</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Med Microbiol Immunol</MedlineTA><NlmUniqueID>0314524</NlmUniqueID><ISSNLinking>0300-8584</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019353" MajorTopicYN="Y">Endemic Diseases</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007814" MajorTopicYN="N">Larva</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2002</Year><Month>06</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2003</Year><Month>2</Month><Day>20</Day><Hour>4</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2003</Year><Month>5</Month><Day>16</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2003</Year><Month>2</Month><Day>20</Day><Hour>4</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12592562</ArticleId><ArticleId IdType="doi">10.1007/s00430-002-0157-7</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004354 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 004354 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:12592562
|texte= Protective immunity in human lymphatic filariasis: problems and prospects.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:12592562" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |