Development of the lymphatic vascular system: a mystery unravels.
Identifieur interne : 003E94 ( PubMed/Curation ); précédent : 003E93; suivant : 003E95Development of the lymphatic vascular system: a mystery unravels.
Auteurs : Young-Kwon Hong [États-Unis] ; Jay W. Shin ; Michael DetmarSource :
- Developmental dynamics : an official publication of the American Association of Anatomists [ 1058-8388 ] ; 2004.
Descripteurs français
- KwdFr :
- Animaux, Développement embryonnaire, Facteur de croissance endothéliale vasculaire de type A (génétique), Facteur de croissance endothéliale vasculaire de type A (métabolisme), Facteurs de croissance endothéliale (génétique), Homéostasie, Humains, Lymphangiogenèse (génétique), Lymphoedème (génétique), Marqueurs biologiques, Modèles biologiques, Peau (métabolisme), Phylogénie, Récepteurs aux facteurs de croissance endothéliale vasculaire (génétique), Récepteurs aux facteurs de croissance endothéliale vasculaire (métabolisme), Système lymphatique (embryologie), Système lymphatique (métabolisme), Vaisseaux lymphatiques (embryologie), Vaisseaux lymphatiques (métabolisme).
- MESH :
- embryologie : Système lymphatique, Vaisseaux lymphatiques.
- génétique : Facteur de croissance endothéliale vasculaire de type A, Facteurs de croissance endothéliale, Lymphangiogenèse, Lymphoedème, Récepteurs aux facteurs de croissance endothéliale vasculaire.
- métabolisme : Facteur de croissance endothéliale vasculaire de type A, Peau, Récepteurs aux facteurs de croissance endothéliale vasculaire, Système lymphatique, Vaisseaux lymphatiques.
- Animaux, Développement embryonnaire, Homéostasie, Humains, Marqueurs biologiques, Modèles biologiques, Phylogénie.
English descriptors
- KwdEn :
- Animals, Biomarkers, Embryonic Development, Endothelial Growth Factors (genetics), Homeostasis, Humans, Lymphangiogenesis (genetics), Lymphatic System (embryology), Lymphatic System (metabolism), Lymphatic Vessels (embryology), Lymphatic Vessels (metabolism), Lymphedema (genetics), Models, Biological, Phylogeny, Receptors, Vascular Endothelial Growth Factor (genetics), Receptors, Vascular Endothelial Growth Factor (metabolism), Skin (metabolism), Vascular Endothelial Growth Factor A (genetics), Vascular Endothelial Growth Factor A (metabolism).
- MESH :
- chemical , genetics : Endothelial Growth Factors, Receptors, Vascular Endothelial Growth Factor, Vascular Endothelial Growth Factor A.
- chemical , metabolism : Receptors, Vascular Endothelial Growth Factor, Vascular Endothelial Growth Factor A.
- chemical : Biomarkers.
- embryology : Lymphatic System, Lymphatic Vessels.
- genetics : Lymphangiogenesis, Lymphedema.
- metabolism : Lymphatic System, Lymphatic Vessels, Skin.
- Animals, Embryonic Development, Homeostasis, Humans, Models, Biological, Phylogeny.
Abstract
The blood vascular and the lymphatic system play complementary roles in tissue perfusion and fluid reabsorption. Despite its critical role in mediating tissue fluid homeostasis, intestinal lipid absorption, and the immune response, the lymphatic system has not received as much attention as the blood vascular system, largely due to a lack of lymphatic-specific markers and to the dearth of knowledge about the molecular regulation of lymphatic development and function. A series of recent landmark studies now significantly has advanced our understanding of the lymphatic system. Based upon the discovery and characterization of lymphatic-specific growth factors, receptors, and transcriptional regulators, the mystery of lymphatic vascular system development begins to be unraveled. The successful isolation and cultivation of blood vascular and lymphatic endothelial cells has enabled comparative molecular and cellular analyses of these two genetically and developmentally closely related cell lineages. Moreover, studies of several genetic mouse models have set the framework for a new molecular model of embryonic lymphatic vascular development and have identified molecular pathways whose mutational inactivation leads to human diseases associated with lymphedema. Although these rapid advances already have led to development of the first lymphatic-targeted molecular therapies, there still remain many unanswered questions regarding almost every aspect of lymphatic vascular biology, making the lymphatic system a highly exciting and rewarding field of study.
DOI: 10.1002/dvdy.20179
PubMed: 15376314
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :003E94
Links to Exploration step
pubmed:15376314Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Development of the lymphatic vascular system: a mystery unravels.</title><author><name sortKey="Hong, Young Kwon" sort="Hong, Young Kwon" uniqKey="Hong Y" first="Young-Kwon" last="Hong">Young-Kwon Hong</name><affiliation wicri:level="1"><nlm:affiliation>Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA. young.hong@cbrc2.mgh.harvard.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129</wicri:regionArea></affiliation></author><author><name sortKey="Shin, Jay W" sort="Shin, Jay W" uniqKey="Shin J" first="Jay W" last="Shin">Jay W. Shin</name></author><author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15376314</idno><idno type="pmid">15376314</idno><idno type="doi">10.1002/dvdy.20179</idno><idno type="wicri:Area/PubMed/Corpus">003E94</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003E94</idno><idno type="wicri:Area/PubMed/Curation">003E94</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003E94</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Development of the lymphatic vascular system: a mystery unravels.</title><author><name sortKey="Hong, Young Kwon" sort="Hong, Young Kwon" uniqKey="Hong Y" first="Young-Kwon" last="Hong">Young-Kwon Hong</name><affiliation wicri:level="1"><nlm:affiliation>Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA. young.hong@cbrc2.mgh.harvard.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129</wicri:regionArea></affiliation></author><author><name sortKey="Shin, Jay W" sort="Shin, Jay W" uniqKey="Shin J" first="Jay W" last="Shin">Jay W. Shin</name></author><author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name></author></analytic><series><title level="j">Developmental dynamics : an official publication of the American Association of Anatomists</title><idno type="ISSN">1058-8388</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Biomarkers</term><term>Embryonic Development</term><term>Endothelial Growth Factors (genetics)</term><term>Homeostasis</term><term>Humans</term><term>Lymphangiogenesis (genetics)</term><term>Lymphatic System (embryology)</term><term>Lymphatic System (metabolism)</term><term>Lymphatic Vessels (embryology)</term><term>Lymphatic Vessels (metabolism)</term><term>Lymphedema (genetics)</term><term>Models, Biological</term><term>Phylogeny</term><term>Receptors, Vascular Endothelial Growth Factor (genetics)</term><term>Receptors, Vascular Endothelial Growth Factor (metabolism)</term><term>Skin (metabolism)</term><term>Vascular Endothelial Growth Factor A (genetics)</term><term>Vascular Endothelial Growth Factor A (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Développement embryonnaire</term><term>Facteur de croissance endothéliale vasculaire de type A (génétique)</term><term>Facteur de croissance endothéliale vasculaire de type A (métabolisme)</term><term>Facteurs de croissance endothéliale (génétique)</term><term>Homéostasie</term><term>Humains</term><term>Lymphangiogenèse (génétique)</term><term>Lymphoedème (génétique)</term><term>Marqueurs biologiques</term><term>Modèles biologiques</term><term>Peau (métabolisme)</term><term>Phylogénie</term><term>Récepteurs aux facteurs de croissance endothéliale vasculaire (génétique)</term><term>Récepteurs aux facteurs de croissance endothéliale vasculaire (métabolisme)</term><term>Système lymphatique (embryologie)</term><term>Système lymphatique (métabolisme)</term><term>Vaisseaux lymphatiques (embryologie)</term><term>Vaisseaux lymphatiques (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Endothelial Growth Factors</term><term>Receptors, Vascular Endothelial Growth Factor</term><term>Vascular Endothelial Growth Factor A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptors, Vascular Endothelial Growth Factor</term><term>Vascular Endothelial Growth Factor A</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Biomarkers</term></keywords><keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Système lymphatique</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Lymphatic System</term><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Lymphangiogenesis</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type A</term><term>Facteurs de croissance endothéliale</term><term>Lymphangiogenèse</term><term>Lymphoedème</term><term>Récepteurs aux facteurs de croissance endothéliale vasculaire</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lymphatic System</term><term>Lymphatic Vessels</term><term>Skin</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type A</term><term>Peau</term><term>Récepteurs aux facteurs de croissance endothéliale vasculaire</term><term>Système lymphatique</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Embryonic Development</term><term>Homeostasis</term><term>Humans</term><term>Models, Biological</term><term>Phylogeny</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Développement embryonnaire</term><term>Homéostasie</term><term>Humains</term><term>Marqueurs biologiques</term><term>Modèles biologiques</term><term>Phylogénie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The blood vascular and the lymphatic system play complementary roles in tissue perfusion and fluid reabsorption. Despite its critical role in mediating tissue fluid homeostasis, intestinal lipid absorption, and the immune response, the lymphatic system has not received as much attention as the blood vascular system, largely due to a lack of lymphatic-specific markers and to the dearth of knowledge about the molecular regulation of lymphatic development and function. A series of recent landmark studies now significantly has advanced our understanding of the lymphatic system. Based upon the discovery and characterization of lymphatic-specific growth factors, receptors, and transcriptional regulators, the mystery of lymphatic vascular system development begins to be unraveled. The successful isolation and cultivation of blood vascular and lymphatic endothelial cells has enabled comparative molecular and cellular analyses of these two genetically and developmentally closely related cell lineages. Moreover, studies of several genetic mouse models have set the framework for a new molecular model of embryonic lymphatic vascular development and have identified molecular pathways whose mutational inactivation leads to human diseases associated with lymphedema. Although these rapid advances already have led to development of the first lymphatic-targeted molecular therapies, there still remain many unanswered questions regarding almost every aspect of lymphatic vascular biology, making the lymphatic system a highly exciting and rewarding field of study.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15376314</PMID><DateCreated><Year>2004</Year><Month>10</Month><Day>11</Day></DateCreated><DateCompleted><Year>2005</Year><Month>03</Month><Day>24</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1058-8388</ISSN><JournalIssue CitedMedium="Print"><Volume>231</Volume><Issue>3</Issue><PubDate><Year>2004</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Developmental dynamics : an official publication of the American Association of Anatomists</Title><ISOAbbreviation>Dev. Dyn.</ISOAbbreviation></Journal><ArticleTitle>Development of the lymphatic vascular system: a mystery unravels.</ArticleTitle><Pagination><MedlinePgn>462-73</MedlinePgn></Pagination><Abstract><AbstractText>The blood vascular and the lymphatic system play complementary roles in tissue perfusion and fluid reabsorption. Despite its critical role in mediating tissue fluid homeostasis, intestinal lipid absorption, and the immune response, the lymphatic system has not received as much attention as the blood vascular system, largely due to a lack of lymphatic-specific markers and to the dearth of knowledge about the molecular regulation of lymphatic development and function. A series of recent landmark studies now significantly has advanced our understanding of the lymphatic system. Based upon the discovery and characterization of lymphatic-specific growth factors, receptors, and transcriptional regulators, the mystery of lymphatic vascular system development begins to be unraveled. The successful isolation and cultivation of blood vascular and lymphatic endothelial cells has enabled comparative molecular and cellular analyses of these two genetically and developmentally closely related cell lineages. Moreover, studies of several genetic mouse models have set the framework for a new molecular model of embryonic lymphatic vascular development and have identified molecular pathways whose mutational inactivation leads to human diseases associated with lymphedema. Although these rapid advances already have led to development of the first lymphatic-targeted molecular therapies, there still remain many unanswered questions regarding almost every aspect of lymphatic vascular biology, making the lymphatic system a highly exciting and rewarding field of study.</AbstractText><CopyrightInformation>(c) 2004 Wiley-Liss, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hong</LastName><ForeName>Young-Kwon</ForeName><Initials>YK</Initials><AffiliationInfo><Affiliation>Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA. young.hong@cbrc2.mgh.harvard.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shin</LastName><ForeName>Jay W</ForeName><Initials>JW</Initials></Author><Author ValidYN="Y"><LastName>Detmar</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>CA 69184</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA 86410</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA 91861</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Dev Dyn</MedlineTA><NlmUniqueID>9201927</NlmUniqueID><ISSNLinking>1058-8388</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016228">Endothelial Growth Factors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D042461">Vascular Endothelial Growth Factor A</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.10.1</RegistryNumber><NameOfSubstance UI="D040262">Receptors, Vascular Endothelial Growth Factor</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D047108" MajorTopicYN="N">Embryonic Development</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016228" MajorTopicYN="N">Endothelial Growth Factors</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006706" MajorTopicYN="N">Homeostasis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D042583" MajorTopicYN="N">Lymphangiogenesis</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008208" MajorTopicYN="N">Lymphatic System</DescriptorName><QualifierName UI="Q000196" MajorTopicYN="Y">embryology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D042601" MajorTopicYN="N">Lymphatic Vessels</DescriptorName><QualifierName UI="Q000196" MajorTopicYN="N">embryology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008954" MajorTopicYN="N">Models, Biological</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D040262" MajorTopicYN="N">Receptors, Vascular Endothelial Growth Factor</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012867" MajorTopicYN="N">Skin</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D042461" MajorTopicYN="N">Vascular Endothelial Growth Factor A</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList><NumberOfReferences>108</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>9</Month><Day>18</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>3</Month><Day>25</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>9</Month><Day>18</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15376314</ArticleId><ArticleId IdType="doi">10.1002/dvdy.20179</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003E94 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 003E94 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:15376314
|texte= Development of the lymphatic vascular system: a mystery unravels.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:15376314" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |