Double-blind placebo-controlled randomised trial of vitamin E and pentoxifylline in patients with chronic arm lymphoedema and fibrosis after surgery and radiotherapy for breast cancer.
Identifieur interne : 003E56 ( PubMed/Curation ); précédent : 003E55; suivant : 003E57Double-blind placebo-controlled randomised trial of vitamin E and pentoxifylline in patients with chronic arm lymphoedema and fibrosis after surgery and radiotherapy for breast cancer.
Auteurs : Lone Gothard [Royaume-Uni] ; Paul Cornes ; Judith Earl ; Emma Hall ; Julie Maclaren ; Peter Mortimer ; John Peacock ; Clare Peckitt ; Mary Woods ; John YarnoldSource :
- Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [ 0167-8140 ] ; 2004.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Association de médicaments, Association thérapeutique, Dosimétrie en radiothérapie, Femelle, Fibrose (anatomopathologie), Fibrose (traitement médicamenteux), Fibrose (étiologie), Humains, Intervalles de confiance, Lymphoedème (traitement médicamenteux), Lymphoedème (étiologie), Maladie chronique, Mastectomie (), Mastectomie (effets indésirables), Méthode en double aveugle, Pentoxifylline (usage thérapeutique), Probabilité, Qualité de vie, Radiothérapie adjuvante (), Radiothérapie adjuvante (effets indésirables), Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Tumeurs du sein (), Tumeurs du sein (anatomopathologie), Valeurs de référence, Vitamine E (usage thérapeutique), Études de suivi, Évaluation des risques.
- MESH :
- anatomopathologie : Fibrose, Tumeurs du sein.
- effets indésirables : Mastectomie, Radiothérapie adjuvante.
- traitement médicamenteux : Fibrose, Lymphoedème.
- usage thérapeutique : Pentoxifylline, Vitamine E.
- étiologie : Fibrose, Lymphoedème.
- Adulte, Adulte d'âge moyen, Association de médicaments, Association thérapeutique, Dosimétrie en radiothérapie, Femelle, Humains, Intervalles de confiance, Maladie chronique, Mastectomie, Méthode en double aveugle, Probabilité, Qualité de vie, Radiothérapie adjuvante, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Tumeurs du sein, Valeurs de référence, Études de suivi, Évaluation des risques.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Breast Neoplasms (pathology), Breast Neoplasms (therapy), Chronic Disease, Combined Modality Therapy, Confidence Intervals, Double-Blind Method, Drug Therapy, Combination, Female, Fibrosis (drug therapy), Fibrosis (etiology), Fibrosis (pathology), Follow-Up Studies, Humans, Lymphedema (drug therapy), Lymphedema (etiology), Mastectomy (adverse effects), Mastectomy (methods), Middle Aged, Pentoxifylline (therapeutic use), Probability, Quality of Life, Radiotherapy Dosage, Radiotherapy, Adjuvant (adverse effects), Radiotherapy, Adjuvant (methods), Reference Values, Risk Assessment, Treatment Outcome, Vitamin E (therapeutic use).
- MESH :
- chemical , therapeutic use : Pentoxifylline, Vitamin E.
- adverse effects : Mastectomy, Radiotherapy, Adjuvant.
- drug therapy : Fibrosis, Lymphedema.
- etiology : Fibrosis, Lymphedema.
- methods : Mastectomy, Radiotherapy, Adjuvant.
- pathology : Breast Neoplasms, Fibrosis.
- therapy : Breast Neoplasms.
- Adult, Aged, Aged, 80 and over, Chronic Disease, Combined Modality Therapy, Confidence Intervals, Double-Blind Method, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Middle Aged, Probability, Quality of Life, Radiotherapy Dosage, Reference Values, Risk Assessment, Treatment Outcome.
Abstract
Treatment-induced arm lymphoedema is a common and distressing complication of curative surgery and radiotherapy for early breast cancer. A number of studies testing alpha-tocopherol (vitamin E) and pentoxifylline suggest evidence of clinical regression of superficial radiation-induced fibrosis but there is only very limited evidence from randomised trials. Arm lymphoedema after lymphatic radiotherapy and surgery has been used in the present study as a clinical system for testing these drugs in a double-blind placebo-controlled randomised phase II trial.
DOI: 10.1016/j.radonc.2004.09.013
PubMed: 15542159
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :003E56
Links to Exploration step
pubmed:15542159Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Double-blind placebo-controlled randomised trial of vitamin E and pentoxifylline in patients with chronic arm lymphoedema and fibrosis after surgery and radiotherapy for breast cancer.</title><author><name sortKey="Gothard, Lone" sort="Gothard, Lone" uniqKey="Gothard L" first="Lone" last="Gothard">Lone Gothard</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiotherapy, Royal Marsden Hospital, Sutton, Surrey, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Radiotherapy, Royal Marsden Hospital, Sutton, Surrey</wicri:regionArea></affiliation></author><author><name sortKey="Cornes, Paul" sort="Cornes, Paul" uniqKey="Cornes P" first="Paul" last="Cornes">Paul Cornes</name></author><author><name sortKey="Earl, Judith" sort="Earl, Judith" uniqKey="Earl J" first="Judith" last="Earl">Judith Earl</name></author><author><name sortKey="Hall, Emma" sort="Hall, Emma" uniqKey="Hall E" first="Emma" last="Hall">Emma Hall</name></author><author><name sortKey="Maclaren, Julie" sort="Maclaren, Julie" uniqKey="Maclaren J" first="Julie" last="Maclaren">Julie Maclaren</name></author><author><name sortKey="Mortimer, Peter" sort="Mortimer, Peter" uniqKey="Mortimer P" first="Peter" last="Mortimer">Peter Mortimer</name></author><author><name sortKey="Peacock, John" sort="Peacock, John" uniqKey="Peacock J" first="John" last="Peacock">John Peacock</name></author><author><name sortKey="Peckitt, Clare" sort="Peckitt, Clare" uniqKey="Peckitt C" first="Clare" last="Peckitt">Clare Peckitt</name></author><author><name sortKey="Woods, Mary" sort="Woods, Mary" uniqKey="Woods M" first="Mary" last="Woods">Mary Woods</name></author><author><name sortKey="Yarnold, John" sort="Yarnold, John" uniqKey="Yarnold J" first="John" last="Yarnold">John Yarnold</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15542159</idno><idno type="pmid">15542159</idno><idno type="doi">10.1016/j.radonc.2004.09.013</idno><idno type="wicri:Area/PubMed/Corpus">003E56</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003E56</idno><idno type="wicri:Area/PubMed/Curation">003E56</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003E56</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Double-blind placebo-controlled randomised trial of vitamin E and pentoxifylline in patients with chronic arm lymphoedema and fibrosis after surgery and radiotherapy for breast cancer.</title><author><name sortKey="Gothard, Lone" sort="Gothard, Lone" uniqKey="Gothard L" first="Lone" last="Gothard">Lone Gothard</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiotherapy, Royal Marsden Hospital, Sutton, Surrey, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Radiotherapy, Royal Marsden Hospital, Sutton, Surrey</wicri:regionArea></affiliation></author><author><name sortKey="Cornes, Paul" sort="Cornes, Paul" uniqKey="Cornes P" first="Paul" last="Cornes">Paul Cornes</name></author><author><name sortKey="Earl, Judith" sort="Earl, Judith" uniqKey="Earl J" first="Judith" last="Earl">Judith Earl</name></author><author><name sortKey="Hall, Emma" sort="Hall, Emma" uniqKey="Hall E" first="Emma" last="Hall">Emma Hall</name></author><author><name sortKey="Maclaren, Julie" sort="Maclaren, Julie" uniqKey="Maclaren J" first="Julie" last="Maclaren">Julie Maclaren</name></author><author><name sortKey="Mortimer, Peter" sort="Mortimer, Peter" uniqKey="Mortimer P" first="Peter" last="Mortimer">Peter Mortimer</name></author><author><name sortKey="Peacock, John" sort="Peacock, John" uniqKey="Peacock J" first="John" last="Peacock">John Peacock</name></author><author><name sortKey="Peckitt, Clare" sort="Peckitt, Clare" uniqKey="Peckitt C" first="Clare" last="Peckitt">Clare Peckitt</name></author><author><name sortKey="Woods, Mary" sort="Woods, Mary" uniqKey="Woods M" first="Mary" last="Woods">Mary Woods</name></author><author><name sortKey="Yarnold, John" sort="Yarnold, John" uniqKey="Yarnold J" first="John" last="Yarnold">John Yarnold</name></author></analytic><series><title level="j">Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology</title><idno type="ISSN">0167-8140</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Breast Neoplasms (pathology)</term><term>Breast Neoplasms (therapy)</term><term>Chronic Disease</term><term>Combined Modality Therapy</term><term>Confidence Intervals</term><term>Double-Blind Method</term><term>Drug Therapy, Combination</term><term>Female</term><term>Fibrosis (drug therapy)</term><term>Fibrosis (etiology)</term><term>Fibrosis (pathology)</term><term>Follow-Up Studies</term><term>Humans</term><term>Lymphedema (drug therapy)</term><term>Lymphedema (etiology)</term><term>Mastectomy (adverse effects)</term><term>Mastectomy (methods)</term><term>Middle Aged</term><term>Pentoxifylline (therapeutic use)</term><term>Probability</term><term>Quality of Life</term><term>Radiotherapy Dosage</term><term>Radiotherapy, Adjuvant (adverse effects)</term><term>Radiotherapy, Adjuvant (methods)</term><term>Reference Values</term><term>Risk Assessment</term><term>Treatment Outcome</term><term>Vitamin E (therapeutic use)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association de médicaments</term><term>Association thérapeutique</term><term>Dosimétrie en radiothérapie</term><term>Femelle</term><term>Fibrose (anatomopathologie)</term><term>Fibrose (traitement médicamenteux)</term><term>Fibrose (étiologie)</term><term>Humains</term><term>Intervalles de confiance</term><term>Lymphoedème (traitement médicamenteux)</term><term>Lymphoedème (étiologie)</term><term>Maladie chronique</term><term>Mastectomie ()</term><term>Mastectomie (effets indésirables)</term><term>Méthode en double aveugle</term><term>Pentoxifylline (usage thérapeutique)</term><term>Probabilité</term><term>Qualité de vie</term><term>Radiothérapie adjuvante ()</term><term>Radiothérapie adjuvante (effets indésirables)</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tumeurs du sein ()</term><term>Tumeurs du sein (anatomopathologie)</term><term>Valeurs de référence</term><term>Vitamine E (usage thérapeutique)</term><term>Études de suivi</term><term>Évaluation des risques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Pentoxifylline</term><term>Vitamin E</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Mastectomy</term><term>Radiotherapy, Adjuvant</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Fibrose</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Fibrosis</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Mastectomie</term><term>Radiothérapie adjuvante</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Fibrosis</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Mastectomy</term><term>Radiotherapy, Adjuvant</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term><term>Fibrosis</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Fibrose</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Pentoxifylline</term><term>Vitamine E</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Fibrose</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Chronic Disease</term><term>Combined Modality Therapy</term><term>Confidence Intervals</term><term>Double-Blind Method</term><term>Drug Therapy, Combination</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Middle Aged</term><term>Probability</term><term>Quality of Life</term><term>Radiotherapy Dosage</term><term>Reference Values</term><term>Risk Assessment</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association de médicaments</term><term>Association thérapeutique</term><term>Dosimétrie en radiothérapie</term><term>Femelle</term><term>Humains</term><term>Intervalles de confiance</term><term>Maladie chronique</term><term>Mastectomie</term><term>Méthode en double aveugle</term><term>Probabilité</term><term>Qualité de vie</term><term>Radiothérapie adjuvante</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tumeurs du sein</term><term>Valeurs de référence</term><term>Études de suivi</term><term>Évaluation des risques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Treatment-induced arm lymphoedema is a common and distressing complication of curative surgery and radiotherapy for early breast cancer. A number of studies testing alpha-tocopherol (vitamin E) and pentoxifylline suggest evidence of clinical regression of superficial radiation-induced fibrosis but there is only very limited evidence from randomised trials. Arm lymphoedema after lymphatic radiotherapy and surgery has been used in the present study as a clinical system for testing these drugs in a double-blind placebo-controlled randomised phase II trial.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15542159</PMID><DateCreated><Year>2004</Year><Month>11</Month><Day>15</Day></DateCreated><DateCompleted><Year>2005</Year><Month>03</Month><Day>22</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0167-8140</ISSN><JournalIssue CitedMedium="Print"><Volume>73</Volume><Issue>2</Issue><PubDate><Year>2004</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology</Title><ISOAbbreviation>Radiother Oncol</ISOAbbreviation></Journal><ArticleTitle>Double-blind placebo-controlled randomised trial of vitamin E and pentoxifylline in patients with chronic arm lymphoedema and fibrosis after surgery and radiotherapy for breast cancer.</ArticleTitle><Pagination><MedlinePgn>133-9</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND AND PURPOSE" NlmCategory="OBJECTIVE">Treatment-induced arm lymphoedema is a common and distressing complication of curative surgery and radiotherapy for early breast cancer. A number of studies testing alpha-tocopherol (vitamin E) and pentoxifylline suggest evidence of clinical regression of superficial radiation-induced fibrosis but there is only very limited evidence from randomised trials. Arm lymphoedema after lymphatic radiotherapy and surgery has been used in the present study as a clinical system for testing these drugs in a double-blind placebo-controlled randomised phase II trial.</AbstractText><AbstractText Label="PATIENTS AND METHODS" NlmCategory="METHODS">Sixty-eight eligible research volunteers with a minimum 20% increase in arm volume at a median 15.5 years (range 2-41) after axillary/supraclavicular radiotherapy (plus axillary surgery in 51/68 (75%) cases) were randomised to active drugs or placebo. All volunteers were given dl-alpha tocopheryl acetate 500 mg twice a day orally plus pentoxifylline 400 mg twice a day orally, or corresponding placebos, for 6 months. The primary endpoint was volume of the ipsilateral limb measured opto-electronically using a perometer and expressed as a percentage of the contralateral limb volume.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">At 12 months post-randomisation, there was no significant difference between treatment and control groups in terms of arm volume. Absolute change in arm volume at 12 months was 2.5% (95% CI -0.40 to 5.3) in the treatment group compared to 1.2% (95% CI -2.8 to 5.1) in the placebo group. The difference in mean volume change between randomisation groups at 12 months was not statistically significant (P = 0.6), -1.3% (95% CI -6.1 to 3.5), nor was there a significant difference in response at 6 months (P = 0.7), where mean change in arm volume from baseline in the treatment and placebo groups was -2.3% (95% CI -7.9 to 3.4) and -1.1% (95% CI -3.9 to 1.7), respectively. There were no significant differences between randomised groups in terms of secondary endpoints, including tissue induration (fibrosis) in the irradiated breast or chest wall, pectoral fold or supraclavicular fossa, change in photographic breast/chest wall appearance or patient self-assessment of function and Quality of Life at either 6 or 12 months.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The study fails to demonstrate efficacy of dl-alpha tocopheryl acetate plus pentoxifylline in patients with arm lymphoedema following axillary surgery and lymphatic radiotherapy, nor does it suggest any benefits of these drugs in radiation-induced induration (fibrosis) in the breast, chest wall, pectoral fold, axilla or supraclavicular fossa.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gothard</LastName><ForeName>Lone</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Radiotherapy, Royal Marsden Hospital, Sutton, Surrey, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cornes</LastName><ForeName>Paul</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Earl</LastName><ForeName>Judith</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Hall</LastName><ForeName>Emma</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>MacLaren</LastName><ForeName>Julie</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Mortimer</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Peacock</LastName><ForeName>John</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Peckitt</LastName><ForeName>Clare</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Woods</LastName><ForeName>Mary</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Yarnold</LastName><ForeName>John</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Ireland</Country><MedlineTA>Radiother Oncol</MedlineTA><NlmUniqueID>8407192</NlmUniqueID><ISSNLinking>0167-8140</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>1406-18-4</RegistryNumber><NameOfSubstance UI="D014810">Vitamin E</NameOfSubstance></Chemical><Chemical><RegistryNumber>SD6QCT3TSU</RegistryNumber><NameOfSubstance UI="D010431">Pentoxifylline</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001943" MajorTopicYN="N">Breast Neoplasms</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002908" MajorTopicYN="N">Chronic Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003131" MajorTopicYN="N">Combined Modality Therapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016001" MajorTopicYN="N">Confidence Intervals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004359" MajorTopicYN="N">Drug Therapy, Combination</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005355" MajorTopicYN="N">Fibrosis</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008408" MajorTopicYN="N">Mastectomy</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010431" MajorTopicYN="N">Pentoxifylline</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011336" MajorTopicYN="N">Probability</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011788" MajorTopicYN="N">Quality of Life</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011879" MajorTopicYN="N">Radiotherapy Dosage</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018714" MajorTopicYN="N">Radiotherapy, Adjuvant</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012016" MajorTopicYN="N">Reference Values</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018570" MajorTopicYN="N">Risk Assessment</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014810" MajorTopicYN="N">Vitamin E</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2004</Year><Month>01</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2004</Year><Month>09</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2004</Year><Month>09</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>11</Month><Day>16</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>3</Month><Day>23</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>11</Month><Day>16</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15542159</ArticleId><ArticleId IdType="pii">S0167-8140(04)00456-6</ArticleId><ArticleId IdType="doi">10.1016/j.radonc.2004.09.013</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003E56 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 003E56 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:15542159
|texte= Double-blind placebo-controlled randomised trial of vitamin E and pentoxifylline in patients with chronic arm lymphoedema and fibrosis after surgery and radiotherapy for breast cancer.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:15542159" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |