Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors.
Identifieur interne : 003D56 ( PubMed/Curation ); précédent : 003D55; suivant : 003D57Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors.
Auteurs : Vivien Schacht [États-Unis] ; Soheil S. Dadras ; Louise A. Johnson ; David G. Jackson ; Young-Kwon Hong ; Michael DetmarSource :
- The American journal of pathology [ 0002-9440 ] ; 2005.
Descripteurs français
- KwdFr :
- Animaux, Anticorps monoclonaux (), Carcinome épidermoïde (métabolisme), Cellules de la granulosa (métabolisme), Cellules dendritiques (métabolisme), Femelle, Glycoprotéines (biosynthèse), Glycoprotéines membranaires (biosynthèse), Humains, Lignée cellulaire, Lignée cellulaire tumorale, Microscopie de fluorescence, Mucines (métabolisme), Ovaire (métabolisme), Petit ARN interférent (métabolisme), Protéines de fusion recombinantes (), Rats, Régulation positive, Souris, Système lymphatique (embryologie), Technique de Western, Test ELISA, Transfection, Tumeur de la granulosa (métabolisme), Tumeurs embryonnaires et germinales (métabolisme), Épithélium (métabolisme), Évolution de la maladie.
- MESH :
- biosynthèse : Glycoprotéines, Glycoprotéines membranaires.
- embryologie : Système lymphatique.
- métabolisme : Carcinome épidermoïde, Cellules de la granulosa, Cellules dendritiques, Mucines, Ovaire, Petit ARN interférent, Tumeur de la granulosa, Tumeurs embryonnaires et germinales, Épithélium.
- Animaux, Anticorps monoclonaux, Femelle, Humains, Lignée cellulaire, Lignée cellulaire tumorale, Microscopie de fluorescence, Protéines de fusion recombinantes, Rats, Régulation positive, Souris, Technique de Western, Test ELISA, Transfection, Évolution de la maladie.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal (chemistry), Blotting, Western, Carcinoma, Squamous Cell (metabolism), Cell Line, Cell Line, Tumor, Dendritic Cells (metabolism), Disease Progression, Enzyme-Linked Immunosorbent Assay, Epithelium (metabolism), Female, Glycoproteins (biosynthesis), Granulosa Cell Tumor (metabolism), Granulosa Cells (metabolism), Humans, Lymphatic System (embryology), Membrane Glycoproteins (biosynthesis), Mice, Microscopy, Fluorescence, Mucins (metabolism), Neoplasms, Germ Cell and Embryonal (metabolism), Ovary (metabolism), RNA, Small Interfering (metabolism), Rats, Recombinant Fusion Proteins (chemistry), Transfection, Up-Regulation.
- MESH :
- chemical , biosynthesis : Glycoproteins, Membrane Glycoproteins.
- chemical , chemistry : Antibodies, Monoclonal, Recombinant Fusion Proteins.
- embryology : Lymphatic System.
- metabolism : Carcinoma, Squamous Cell, Dendritic Cells, Epithelium, Granulosa Cell Tumor, Granulosa Cells, Mucins, Neoplasms, Germ Cell and Embryonal, Ovary, RNA, Small Interfering.
- Animals, Blotting, Western, Cell Line, Cell Line, Tumor, Disease Progression, Enzyme-Linked Immunosorbent Assay, Female, Humans, Mice, Microscopy, Fluorescence, Rats, Transfection, Up-Regulation.
Abstract
The mucin-type glycoprotein podoplanin is specifically expressed by lymphatic but not blood vascular endothelial cells in culture and in tumor-associated lymphangiogenesis, and podoplanin deficiency results in congenital lymphedema and impaired lymphatic vascular patterning. However, research into the biological importance of podoplanin has been hampered by the lack of a generally available antibody against the human protein, and its expression in normal tissues and in human malignancies has remained unclear. We generated a human podoplanin-Fc fusion protein and found that the commercially available mouse monoclonal antibody D2-40 specifically recognized human podoplanin, as assessed by enzyme-linked immunosorbent assay and Western blot analyses. We found that, in addition to lymphatic endothelium, podoplanin was also expressed by peritoneal mesothelial cells, osteocytes, glandular myoepithelial cells, ependymal cells, and by stromal reticular cells and follicular dendritic cells of lymphoid organs. These findings were confirmed in normal mouse tissues with anti-podoplanin antibody 8.1.1. Podoplanin was also strongly expressed by granulosa cells in normal ovarian follicles, and by ovarian dysgerminomas and granulosa cell tumors. Although podoplanin was primarily absent from normal human epidermis, its expression was strongly induced in 22 of 28 squamous cell carcinomas studied. These findings suggest a potential role of podoplanin in tumor progression, and they also identify the first commercially available antibody for the specific staining of a defined lymphatic marker in archival human tissue sections, thereby enabling more widespread studies of tumor lymphangiogenesis in human cancers.
DOI: 10.1016/S0002-9440(10)62311-5
PubMed: 15743802
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xml:lang="en">The mucin-type glycoprotein podoplanin is specifically expressed by lymphatic but not blood vascular endothelial cells in culture and in tumor-associated lymphangiogenesis, and podoplanin deficiency results in congenital lymphedema and impaired lymphatic vascular patterning. However, research into the biological importance of podoplanin has been hampered by the lack of a generally available antibody against the human protein, and its expression in normal tissues and in human malignancies has remained unclear. We generated a human podoplanin-Fc fusion protein and found that the commercially available mouse monoclonal antibody D2-40 specifically recognized human podoplanin, as assessed by enzyme-linked immunosorbent assay and Western blot analyses. We found that, in addition to lymphatic endothelium, podoplanin was also expressed by peritoneal mesothelial cells, osteocytes, glandular myoepithelial cells, ependymal cells, and by stromal reticular cells and follicular dendritic cells of lymphoid organs. These findings were confirmed in normal mouse tissues with anti-podoplanin antibody 8.1.1. Podoplanin was also strongly expressed by granulosa cells in normal ovarian follicles, and by ovarian dysgerminomas and granulosa cell tumors. Although podoplanin was primarily absent from normal human epidermis, its expression was strongly induced in 22 of 28 squamous cell carcinomas studied. These findings suggest a potential role of podoplanin in tumor progression, and they also identify the first commercially available antibody for the specific staining of a defined lymphatic marker in archival human tissue sections, thereby enabling more widespread studies of tumor lymphangiogenesis in human cancers.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15743802</PMID><DateCreated><Year>2005</Year><Month>03</Month><Day>03</Day></DateCreated><DateCompleted><Year>2005</Year><Month>04</Month><Day>08</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0002-9440</ISSN><JournalIssue CitedMedium="Print"><Volume>166</Volume><Issue>3</Issue><PubDate><Year>2005</Year><Month>Mar</Month></PubDate></JournalIssue><Title>The American journal of pathology</Title><ISOAbbreviation>Am. J. Pathol.</ISOAbbreviation></Journal><ArticleTitle>Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors.</ArticleTitle><Pagination><MedlinePgn>913-21</MedlinePgn></Pagination><Abstract><AbstractText>The mucin-type glycoprotein podoplanin is specifically expressed by lymphatic but not blood vascular endothelial cells in culture and in tumor-associated lymphangiogenesis, and podoplanin deficiency results in congenital lymphedema and impaired lymphatic vascular patterning. However, research into the biological importance of podoplanin has been hampered by the lack of a generally available antibody against the human protein, and its expression in normal tissues and in human malignancies has remained unclear. We generated a human podoplanin-Fc fusion protein and found that the commercially available mouse monoclonal antibody D2-40 specifically recognized human podoplanin, as assessed by enzyme-linked immunosorbent assay and Western blot analyses. We found that, in addition to lymphatic endothelium, podoplanin was also expressed by peritoneal mesothelial cells, osteocytes, glandular myoepithelial cells, ependymal cells, and by stromal reticular cells and follicular dendritic cells of lymphoid organs. These findings were confirmed in normal mouse tissues with anti-podoplanin antibody 8.1.1. Podoplanin was also strongly expressed by granulosa cells in normal ovarian follicles, and by ovarian dysgerminomas and granulosa cell tumors. Although podoplanin was primarily absent from normal human epidermis, its expression was strongly induced in 22 of 28 squamous cell carcinomas studied. These findings suggest a potential role of podoplanin in tumor progression, and they also identify the first commercially available antibody for the specific staining of a defined lymphatic marker in archival human tissue sections, thereby enabling more widespread studies of tumor lymphangiogenesis in human cancers.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schacht</LastName><ForeName>Vivien</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dadras</LastName><ForeName>Soheil S</ForeName><Initials>SS</Initials></Author><Author ValidYN="Y"><LastName>Johnson</LastName><ForeName>Louise A</ForeName><Initials>LA</Initials></Author><Author ValidYN="Y"><LastName>Jackson</LastName><ForeName>David G</ForeName><Initials>DG</Initials></Author><Author ValidYN="Y"><LastName>Hong</LastName><ForeName>Young-Kwon</ForeName><Initials>YK</Initials></Author><Author ValidYN="Y"><LastName>Detmar</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>CA86410</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>5T32CA09216</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA069184</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P01 CA092644</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA92644</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T32 CA009216</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA69184</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA086410</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Pathol</MedlineTA><NlmUniqueID>0370502</NlmUniqueID><ISSNLinking>0002-9440</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000911">Antibodies, Monoclonal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006023">Glycoproteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C490441">Gp38 protein, mouse</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C092025">Gp38 protein, rat</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008562">Membrane Glycoproteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009077">Mucins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C117468">PDPN protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D034741">RNA, Small Interfering</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011993">Recombinant Fusion Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Verh Dtsch Ges Pathol. 1999;83:270-5</RefSource><PMID Version="1">10714221</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochem J. 1997 Aug 15;326 ( Pt 1):99-108</RefSource><PMID Version="1">9337856</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Cancer. 1999 May;80(3-4):569-78</RefSource><PMID Version="1">10408868</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochim Biophys Acta. 1998 Dec 8;1429(1):208-16</RefSource><PMID Version="1">9920397</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochem J. 1999 Jul 15;341 ( Pt 2):277-84</RefSource><PMID Version="1">10393083</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 1999 Sep 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Version="1">9328432</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Pathol. 1997 Oct;151(4):1141-52</RefSource><PMID Version="1">9327748</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Cell Biol. 1999 Feb 22;144(4):789-801</RefSource><PMID Version="1">10037799</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000911" MajorTopicYN="N">Antibodies, Monoclonal</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015153" MajorTopicYN="N">Blotting, Western</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002294" MajorTopicYN="N">Carcinoma, Squamous Cell</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName 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