Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors.
Identifieur interne : 003D56 ( PubMed/Curation ); précédent : 003D55; suivant : 003D57Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors.
Auteurs : Vivien Schacht [États-Unis] ; Soheil S. Dadras ; Louise A. Johnson ; David G. Jackson ; Young-Kwon Hong ; Michael DetmarSource :
- The American journal of pathology [ 0002-9440 ] ; 2005.
Descripteurs français
- KwdFr :
- Animaux, Anticorps monoclonaux (), Carcinome épidermoïde (métabolisme), Cellules de la granulosa (métabolisme), Cellules dendritiques (métabolisme), Femelle, Glycoprotéines (biosynthèse), Glycoprotéines membranaires (biosynthèse), Humains, Lignée cellulaire, Lignée cellulaire tumorale, Microscopie de fluorescence, Mucines (métabolisme), Ovaire (métabolisme), Petit ARN interférent (métabolisme), Protéines de fusion recombinantes (), Rats, Régulation positive, Souris, Système lymphatique (embryologie), Technique de Western, Test ELISA, Transfection, Tumeur de la granulosa (métabolisme), Tumeurs embryonnaires et germinales (métabolisme), Épithélium (métabolisme), Évolution de la maladie.
- MESH :
- biosynthèse : Glycoprotéines, Glycoprotéines membranaires.
- embryologie : Système lymphatique.
- métabolisme : Carcinome épidermoïde, Cellules de la granulosa, Cellules dendritiques, Mucines, Ovaire, Petit ARN interférent, Tumeur de la granulosa, Tumeurs embryonnaires et germinales, Épithélium.
- Animaux, Anticorps monoclonaux, Femelle, Humains, Lignée cellulaire, Lignée cellulaire tumorale, Microscopie de fluorescence, Protéines de fusion recombinantes, Rats, Régulation positive, Souris, Technique de Western, Test ELISA, Transfection, Évolution de la maladie.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal (chemistry), Blotting, Western, Carcinoma, Squamous Cell (metabolism), Cell Line, Cell Line, Tumor, Dendritic Cells (metabolism), Disease Progression, Enzyme-Linked Immunosorbent Assay, Epithelium (metabolism), Female, Glycoproteins (biosynthesis), Granulosa Cell Tumor (metabolism), Granulosa Cells (metabolism), Humans, Lymphatic System (embryology), Membrane Glycoproteins (biosynthesis), Mice, Microscopy, Fluorescence, Mucins (metabolism), Neoplasms, Germ Cell and Embryonal (metabolism), Ovary (metabolism), RNA, Small Interfering (metabolism), Rats, Recombinant Fusion Proteins (chemistry), Transfection, Up-Regulation.
- MESH :
- chemical , biosynthesis : Glycoproteins, Membrane Glycoproteins.
- chemical , chemistry : Antibodies, Monoclonal, Recombinant Fusion Proteins.
- embryology : Lymphatic System.
- metabolism : Carcinoma, Squamous Cell, Dendritic Cells, Epithelium, Granulosa Cell Tumor, Granulosa Cells, Mucins, Neoplasms, Germ Cell and Embryonal, Ovary, RNA, Small Interfering.
- Animals, Blotting, Western, Cell Line, Cell Line, Tumor, Disease Progression, Enzyme-Linked Immunosorbent Assay, Female, Humans, Mice, Microscopy, Fluorescence, Rats, Transfection, Up-Regulation.
Abstract
The mucin-type glycoprotein podoplanin is specifically expressed by lymphatic but not blood vascular endothelial cells in culture and in tumor-associated lymphangiogenesis, and podoplanin deficiency results in congenital lymphedema and impaired lymphatic vascular patterning. However, research into the biological importance of podoplanin has been hampered by the lack of a generally available antibody against the human protein, and its expression in normal tissues and in human malignancies has remained unclear. We generated a human podoplanin-Fc fusion protein and found that the commercially available mouse monoclonal antibody D2-40 specifically recognized human podoplanin, as assessed by enzyme-linked immunosorbent assay and Western blot analyses. We found that, in addition to lymphatic endothelium, podoplanin was also expressed by peritoneal mesothelial cells, osteocytes, glandular myoepithelial cells, ependymal cells, and by stromal reticular cells and follicular dendritic cells of lymphoid organs. These findings were confirmed in normal mouse tissues with anti-podoplanin antibody 8.1.1. Podoplanin was also strongly expressed by granulosa cells in normal ovarian follicles, and by ovarian dysgerminomas and granulosa cell tumors. Although podoplanin was primarily absent from normal human epidermis, its expression was strongly induced in 22 of 28 squamous cell carcinomas studied. These findings suggest a potential role of podoplanin in tumor progression, and they also identify the first commercially available antibody for the specific staining of a defined lymphatic marker in archival human tissue sections, thereby enabling more widespread studies of tumor lymphangiogenesis in human cancers.
DOI: 10.1016/S0002-9440(10)62311-5
PubMed: 15743802
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :003D56
Links to Exploration step
pubmed:15743802Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors.</title>
<author><name sortKey="Schacht, Vivien" sort="Schacht, Vivien" uniqKey="Schacht V" first="Vivien" last="Schacht">Vivien Schacht</name>
<affiliation wicri:level="1"><nlm:affiliation>Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dadras, Soheil S" sort="Dadras, Soheil S" uniqKey="Dadras S" first="Soheil S" last="Dadras">Soheil S. Dadras</name>
</author>
<author><name sortKey="Johnson, Louise A" sort="Johnson, Louise A" uniqKey="Johnson L" first="Louise A" last="Johnson">Louise A. Johnson</name>
</author>
<author><name sortKey="Jackson, David G" sort="Jackson, David G" uniqKey="Jackson D" first="David G" last="Jackson">David G. Jackson</name>
</author>
<author><name sortKey="Hong, Young Kwon" sort="Hong, Young Kwon" uniqKey="Hong Y" first="Young-Kwon" last="Hong">Young-Kwon Hong</name>
</author>
<author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2005">2005</date>
<idno type="RBID">pubmed:15743802</idno>
<idno type="pmid">15743802</idno>
<idno type="doi">10.1016/S0002-9440(10)62311-5</idno>
<idno type="wicri:Area/PubMed/Corpus">003D56</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003D56</idno>
<idno type="wicri:Area/PubMed/Curation">003D56</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003D56</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors.</title>
<author><name sortKey="Schacht, Vivien" sort="Schacht, Vivien" uniqKey="Schacht V" first="Vivien" last="Schacht">Vivien Schacht</name>
<affiliation wicri:level="1"><nlm:affiliation>Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dadras, Soheil S" sort="Dadras, Soheil S" uniqKey="Dadras S" first="Soheil S" last="Dadras">Soheil S. Dadras</name>
</author>
<author><name sortKey="Johnson, Louise A" sort="Johnson, Louise A" uniqKey="Johnson L" first="Louise A" last="Johnson">Louise A. Johnson</name>
</author>
<author><name sortKey="Jackson, David G" sort="Jackson, David G" uniqKey="Jackson D" first="David G" last="Jackson">David G. Jackson</name>
</author>
<author><name sortKey="Hong, Young Kwon" sort="Hong, Young Kwon" uniqKey="Hong Y" first="Young-Kwon" last="Hong">Young-Kwon Hong</name>
</author>
<author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name>
</author>
</analytic>
<series><title level="j">The American journal of pathology</title>
<idno type="ISSN">0002-9440</idno>
<imprint><date when="2005" type="published">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antibodies, Monoclonal (chemistry)</term>
<term>Blotting, Western</term>
<term>Carcinoma, Squamous Cell (metabolism)</term>
<term>Cell Line</term>
<term>Cell Line, Tumor</term>
<term>Dendritic Cells (metabolism)</term>
<term>Disease Progression</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Epithelium (metabolism)</term>
<term>Female</term>
<term>Glycoproteins (biosynthesis)</term>
<term>Granulosa Cell Tumor (metabolism)</term>
<term>Granulosa Cells (metabolism)</term>
<term>Humans</term>
<term>Lymphatic System (embryology)</term>
<term>Membrane Glycoproteins (biosynthesis)</term>
<term>Mice</term>
<term>Microscopy, Fluorescence</term>
<term>Mucins (metabolism)</term>
<term>Neoplasms, Germ Cell and Embryonal (metabolism)</term>
<term>Ovary (metabolism)</term>
<term>RNA, Small Interfering (metabolism)</term>
<term>Rats</term>
<term>Recombinant Fusion Proteins (chemistry)</term>
<term>Transfection</term>
<term>Up-Regulation</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Anticorps monoclonaux ()</term>
<term>Carcinome épidermoïde (métabolisme)</term>
<term>Cellules de la granulosa (métabolisme)</term>
<term>Cellules dendritiques (métabolisme)</term>
<term>Femelle</term>
<term>Glycoprotéines (biosynthèse)</term>
<term>Glycoprotéines membranaires (biosynthèse)</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
<term>Lignée cellulaire tumorale</term>
<term>Microscopie de fluorescence</term>
<term>Mucines (métabolisme)</term>
<term>Ovaire (métabolisme)</term>
<term>Petit ARN interférent (métabolisme)</term>
<term>Protéines de fusion recombinantes ()</term>
<term>Rats</term>
<term>Régulation positive</term>
<term>Souris</term>
<term>Système lymphatique (embryologie)</term>
<term>Technique de Western</term>
<term>Test ELISA</term>
<term>Transfection</term>
<term>Tumeur de la granulosa (métabolisme)</term>
<term>Tumeurs embryonnaires et germinales (métabolisme)</term>
<term>Épithélium (métabolisme)</term>
<term>Évolution de la maladie</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Glycoproteins</term>
<term>Membrane Glycoproteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antibodies, Monoclonal</term>
<term>Recombinant Fusion Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Glycoprotéines</term>
<term>Glycoprotéines membranaires</term>
</keywords>
<keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Système lymphatique</term>
</keywords>
<keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Lymphatic System</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Carcinoma, Squamous Cell</term>
<term>Dendritic Cells</term>
<term>Epithelium</term>
<term>Granulosa Cell Tumor</term>
<term>Granulosa Cells</term>
<term>Mucins</term>
<term>Neoplasms, Germ Cell and Embryonal</term>
<term>Ovary</term>
<term>RNA, Small Interfering</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Carcinome épidermoïde</term>
<term>Cellules de la granulosa</term>
<term>Cellules dendritiques</term>
<term>Mucines</term>
<term>Ovaire</term>
<term>Petit ARN interférent</term>
<term>Tumeur de la granulosa</term>
<term>Tumeurs embryonnaires et germinales</term>
<term>Épithélium</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Blotting, Western</term>
<term>Cell Line</term>
<term>Cell Line, Tumor</term>
<term>Disease Progression</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Female</term>
<term>Humans</term>
<term>Mice</term>
<term>Microscopy, Fluorescence</term>
<term>Rats</term>
<term>Transfection</term>
<term>Up-Regulation</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Anticorps monoclonaux</term>
<term>Femelle</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
<term>Lignée cellulaire tumorale</term>
<term>Microscopie de fluorescence</term>
<term>Protéines de fusion recombinantes</term>
<term>Rats</term>
<term>Régulation positive</term>
<term>Souris</term>
<term>Technique de Western</term>
<term>Test ELISA</term>
<term>Transfection</term>
<term>Évolution de la maladie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The mucin-type glycoprotein podoplanin is specifically expressed by lymphatic but not blood vascular endothelial cells in culture and in tumor-associated lymphangiogenesis, and podoplanin deficiency results in congenital lymphedema and impaired lymphatic vascular patterning. However, research into the biological importance of podoplanin has been hampered by the lack of a generally available antibody against the human protein, and its expression in normal tissues and in human malignancies has remained unclear. We generated a human podoplanin-Fc fusion protein and found that the commercially available mouse monoclonal antibody D2-40 specifically recognized human podoplanin, as assessed by enzyme-linked immunosorbent assay and Western blot analyses. We found that, in addition to lymphatic endothelium, podoplanin was also expressed by peritoneal mesothelial cells, osteocytes, glandular myoepithelial cells, ependymal cells, and by stromal reticular cells and follicular dendritic cells of lymphoid organs. These findings were confirmed in normal mouse tissues with anti-podoplanin antibody 8.1.1. Podoplanin was also strongly expressed by granulosa cells in normal ovarian follicles, and by ovarian dysgerminomas and granulosa cell tumors. Although podoplanin was primarily absent from normal human epidermis, its expression was strongly induced in 22 of 28 squamous cell carcinomas studied. These findings suggest a potential role of podoplanin in tumor progression, and they also identify the first commercially available antibody for the specific staining of a defined lymphatic marker in archival human tissue sections, thereby enabling more widespread studies of tumor lymphangiogenesis in human cancers.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15743802</PMID>
<DateCreated><Year>2005</Year>
<Month>03</Month>
<Day>03</Day>
</DateCreated>
<DateCompleted><Year>2005</Year>
<Month>04</Month>
<Day>08</Day>
</DateCompleted>
<DateRevised><Year>2016</Year>
<Month>10</Month>
<Day>19</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0002-9440</ISSN>
<JournalIssue CitedMedium="Print"><Volume>166</Volume>
<Issue>3</Issue>
<PubDate><Year>2005</Year>
<Month>Mar</Month>
</PubDate>
</JournalIssue>
<Title>The American journal of pathology</Title>
<ISOAbbreviation>Am. J. Pathol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors.</ArticleTitle>
<Pagination><MedlinePgn>913-21</MedlinePgn>
</Pagination>
<Abstract><AbstractText>The mucin-type glycoprotein podoplanin is specifically expressed by lymphatic but not blood vascular endothelial cells in culture and in tumor-associated lymphangiogenesis, and podoplanin deficiency results in congenital lymphedema and impaired lymphatic vascular patterning. However, research into the biological importance of podoplanin has been hampered by the lack of a generally available antibody against the human protein, and its expression in normal tissues and in human malignancies has remained unclear. We generated a human podoplanin-Fc fusion protein and found that the commercially available mouse monoclonal antibody D2-40 specifically recognized human podoplanin, as assessed by enzyme-linked immunosorbent assay and Western blot analyses. We found that, in addition to lymphatic endothelium, podoplanin was also expressed by peritoneal mesothelial cells, osteocytes, glandular myoepithelial cells, ependymal cells, and by stromal reticular cells and follicular dendritic cells of lymphoid organs. These findings were confirmed in normal mouse tissues with anti-podoplanin antibody 8.1.1. Podoplanin was also strongly expressed by granulosa cells in normal ovarian follicles, and by ovarian dysgerminomas and granulosa cell tumors. Although podoplanin was primarily absent from normal human epidermis, its expression was strongly induced in 22 of 28 squamous cell carcinomas studied. These findings suggest a potential role of podoplanin in tumor progression, and they also identify the first commercially available antibody for the specific staining of a defined lymphatic marker in archival human tissue sections, thereby enabling more widespread studies of tumor lymphangiogenesis in human cancers.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schacht</LastName>
<ForeName>Vivien</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dadras</LastName>
<ForeName>Soheil S</ForeName>
<Initials>SS</Initials>
</Author>
<Author ValidYN="Y"><LastName>Johnson</LastName>
<ForeName>Louise A</ForeName>
<Initials>LA</Initials>
</Author>
<Author ValidYN="Y"><LastName>Jackson</LastName>
<ForeName>David G</ForeName>
<Initials>DG</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hong</LastName>
<ForeName>Young-Kwon</ForeName>
<Initials>YK</Initials>
</Author>
<Author ValidYN="Y"><LastName>Detmar</LastName>
<ForeName>Michael</ForeName>
<Initials>M</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>CA86410</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>5T32CA09216</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 CA069184</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P01 CA092644</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>CA92644</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>T32 CA009216</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>CA69184</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 CA086410</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
<PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Am J Pathol</MedlineTA>
<NlmUniqueID>0370502</NlmUniqueID>
<ISSNLinking>0002-9440</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000911">Antibodies, Monoclonal</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D006023">Glycoproteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C490441">Gp38 protein, mouse</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C092025">Gp38 protein, rat</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D008562">Membrane Glycoproteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D009077">Mucins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C117468">PDPN protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D034741">RNA, Small Interfering</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011993">Recombinant Fusion Proteins</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Verh Dtsch Ges Pathol. 1999;83:270-5</RefSource>
<PMID Version="1">10714221</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biochem J. 1997 Aug 15;326 ( Pt 1):99-108</RefSource>
<PMID Version="1">9337856</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Br J Cancer. 1999 May;80(3-4):569-78</RefSource>
<PMID Version="1">10408868</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biochim Biophys Acta. 1998 Dec 8;1429(1):208-16</RefSource>
<PMID Version="1">9920397</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biochem J. 1999 Jul 15;341 ( Pt 2):277-84</RefSource>
<PMID Version="1">10393083</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell. 1999 Sep 17;98(6):769-78</RefSource>
<PMID Version="1">10499794</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2000 Oct 5;343(14):1020-34</RefSource>
<PMID Version="1">11018170</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>EMBO J. 2001 Feb 15;20(4):672-82</RefSource>
<PMID Version="1">11179212</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2001 Feb;7(2):186-91</RefSource>
<PMID Version="1">11175849</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2001 Feb;7(2):192-8</RefSource>
<PMID Version="1">11175850</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cancer Res. 2001 Mar 1;61(5):1786-90</RefSource>
<PMID Version="1">11280723</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2001 Jun 1;276(22):19420-30</RefSource>
<PMID Version="1">11278811</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Microsc Res Tech. 2001 Oct 15;55(2):122-45</RefSource>
<PMID Version="1">11596157</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cancer Res. 2001 Nov 15;61(22):8079-84</RefSource>
<PMID Version="1">11719431</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>EMBO J. 2002 Apr 2;21(7):1505-13</RefSource>
<PMID Version="1">11927535</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>FASEB J. 2002 Jul;16(9):922-34</RefSource>
<PMID Version="1">12087053</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lab Invest. 2002 Sep;82(9):1255-7</RefSource>
<PMID Version="1">12218087</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Dev Dyn. 2002 Nov;225(3):351-7</RefSource>
<PMID Version="1">12412020</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Cancer Res. 2003 Jan;9(1):250-6</RefSource>
<PMID Version="1">12538477</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Pathol. 2003 Feb;162(2):575-86</RefSource>
<PMID Version="1">12547715</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cancer Res. 2003 Apr 15;63(8):1920-6</RefSource>
<PMID Version="1">12702584</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Pathol. 2003 Jun;162(6):1951-60</RefSource>
<PMID Version="1">12759251</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>EMBO J. 2003 Jul 15;22(14):3546-56</RefSource>
<PMID Version="1">12853470</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Immunol. 2004 Jan;5(1):74-80</RefSource>
<PMID Version="1">14634646</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biochim Biophys Acta. 1988 Jun 30;970(2):146-56</RefSource>
<PMID Version="1">3382696</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell Growth Differ. 1990 Nov;1(11):511-8</RefSource>
<PMID Version="1">2088477</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 1992 Nov 1;176(5):1477-82</RefSource>
<PMID Version="1">1402691</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Dev Biol. 1995 Jan;167(1):294-306</RefSource>
<PMID Version="1">7851650</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Respir Cell Mol Biol. 1996 Jun;14(6):577-85</RefSource>
<PMID Version="1">8652186</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Bone. 1996 Feb;18(2):125-32</RefSource>
<PMID Version="1">8833206</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 1997 Mar 7;272(10):6621-8</RefSource>
<PMID Version="1">9045692</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mol Carcinog. 1997 Sep;20(1):10-8</RefSource>
<PMID Version="1">9328432</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Pathol. 1997 Oct;151(4):1141-52</RefSource>
<PMID Version="1">9327748</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Cell Biol. 1999 Feb 22;144(4):789-801</RefSource>
<PMID Version="1">10037799</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000911" MajorTopicYN="N">Antibodies, Monoclonal</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015153" MajorTopicYN="N">Blotting, Western</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002294" MajorTopicYN="N">Carcinoma, Squamous Cell</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003713" MajorTopicYN="N">Dendritic Cells</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018450" MajorTopicYN="N">Disease Progression</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004797" MajorTopicYN="N">Enzyme-Linked Immunosorbent Assay</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004848" MajorTopicYN="N">Epithelium</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006023" MajorTopicYN="N">Glycoproteins</DescriptorName>
<QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006106" MajorTopicYN="N">Granulosa Cell Tumor</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006107" MajorTopicYN="N">Granulosa Cells</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008208" MajorTopicYN="N">Lymphatic System</DescriptorName>
<QualifierName UI="Q000196" MajorTopicYN="N">embryology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008562" MajorTopicYN="N">Membrane Glycoproteins</DescriptorName>
<QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008856" MajorTopicYN="N">Microscopy, Fluorescence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009077" MajorTopicYN="N">Mucins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009373" MajorTopicYN="N">Neoplasms, Germ Cell and Embryonal</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010053" MajorTopicYN="N">Ovary</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D034741" MajorTopicYN="N">RNA, Small Interfering</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011993" MajorTopicYN="N">Recombinant Fusion Proteins</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014162" MajorTopicYN="N">Transfection</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015854" MajorTopicYN="Y">Up-Regulation</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<OtherID Source="NLM">PMC1602360</OtherID>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year>
<Month>3</Month>
<Day>4</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2005</Year>
<Month>4</Month>
<Day>9</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2005</Year>
<Month>3</Month>
<Day>4</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">15743802</ArticleId>
<ArticleId IdType="pii">S0002-9440(10)62311-5</ArticleId>
<ArticleId IdType="pmc">PMC1602360</ArticleId>
<ArticleId IdType="doi">10.1016/S0002-9440(10)62311-5</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003D56 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 003D56 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= PubMed |étape= Curation |type= RBID |clé= pubmed:15743802 |texte= Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:15743802" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
![]() | This area was generated with Dilib version V0.6.31. | ![]() |