Molecular regulation of microlymphatic formation and function: role of nitric oxide.
Identifieur interne : 003C05 ( PubMed/Curation ); précédent : 003C04; suivant : 003C06Molecular regulation of microlymphatic formation and function: role of nitric oxide.
Auteurs : Jeroen Hagendoorn [États-Unis] ; Timothy P. Padera ; Dai Fukumura ; Rakesh K. JainSource :
- Trends in cardiovascular medicine [ 1050-1738 ] ; 2005.
Descripteurs français
- KwdFr :
- MESH :
- croissance et développement : Système lymphatique.
- métabolisme : Monoxyde d'azote, Système lymphatique.
- physiologie : Lymphangiogenèse.
- Animaux, Humains.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Nitric Oxide.
- growth & development : Lymphatic System.
- metabolism : Lymphatic System.
- physiology : Lymphangiogenesis.
- Animals, Humans.
Abstract
Inhibition of lymphangiogenesis prevents lymphatic cancer metastasis, whereas induction of lymphangiogenesis alleviates lymphedema in experimental animal models. The number of known molecular players that govern the formation and function of the microlymphatic system is growing. Here, we review the role of nitric oxide within the regulation of lymphatic formation and function and point out key unanswered questions for its translation into clinical therapy.
DOI: 10.1016/j.tcm.2005.06.003
PubMed: 16165013
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