Combined-modality therapy for patients with regional nodal metastases from melanoma.
Identifieur interne : 003B94 ( PubMed/Curation ); précédent : 003B93; suivant : 003B95Combined-modality therapy for patients with regional nodal metastases from melanoma.
Auteurs : Matthew T. Ballo [États-Unis] ; Merrick I. Ross ; Janice N. Cormier ; Jeffrey N. Myers ; Jeffrey E. Lee ; Jeffrey E. Gershenwald ; Patrick Hwu ; Gunar K. ZagarsSource :
- International journal of radiation oncology, biology, physics [ 0360-3016 ] ; 2006.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Analyse de variance, Femelle, Humains, Lymphadénectomie (), Lymphadénectomie (effets indésirables), Mâle, Mélanome (), Mélanome (radiothérapie), Mélanome (secondaire), Métastase lymphatique, Radiothérapie adjuvante (), Radiothérapie adjuvante (effets indésirables), Sujet âgé, Sujet âgé de 80 ans ou plus, Survie sans rechute, Traitement médicamenteux adjuvant (), Tumeurs cutanées (), Tumeurs cutanées (anatomopathologie), Tumeurs cutanées (radiothérapie), Études rétrospectives.
- MESH :
- anatomopathologie : Tumeurs cutanées.
- effets indésirables : Lymphadénectomie, Radiothérapie adjuvante.
- radiothérapie : Mélanome, Tumeurs cutanées.
- secondaire : Mélanome.
- Adolescent, Adulte, Adulte d'âge moyen, Analyse de variance, Femelle, Humains, Lymphadénectomie, Mâle, Mélanome, Métastase lymphatique, Radiothérapie adjuvante, Sujet âgé, Sujet âgé de 80 ans ou plus, Survie sans rechute, Traitement médicamenteux adjuvant, Tumeurs cutanées, Études rétrospectives.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Analysis of Variance, Chemotherapy, Adjuvant (methods), Disease-Free Survival, Female, Humans, Lymph Node Excision (adverse effects), Lymph Node Excision (methods), Lymphatic Metastasis, Male, Melanoma (radiotherapy), Melanoma (secondary), Melanoma (surgery), Middle Aged, Radiotherapy, Adjuvant (adverse effects), Radiotherapy, Adjuvant (methods), Retrospective Studies, Skin Neoplasms (pathology), Skin Neoplasms (radiotherapy), Skin Neoplasms (surgery).
- MESH :
- adverse effects : Lymph Node Excision, Radiotherapy, Adjuvant.
- methods : Chemotherapy, Adjuvant, Lymph Node Excision, Radiotherapy, Adjuvant.
- pathology : Skin Neoplasms.
- radiotherapy : Melanoma, Skin Neoplasms.
- secondary : Melanoma.
- surgery : Melanoma, Skin Neoplasms.
- Adolescent, Adult, Aged, Aged, 80 and over, Analysis of Variance, Disease-Free Survival, Female, Humans, Lymphatic Metastasis, Male, Middle Aged, Retrospective Studies.
Abstract
To evaluate the outcome and patterns of failure for patients with nodal metastases from melanoma treated with combined-modality therapy.
DOI: 10.1016/j.ijrobp.2005.06.030
PubMed: 16182463
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Cormier</name></author><author><name sortKey="Myers, Jeffrey N" sort="Myers, Jeffrey N" uniqKey="Myers J" first="Jeffrey N" last="Myers">Jeffrey N. Myers</name></author><author><name sortKey="Lee, Jeffrey E" sort="Lee, Jeffrey E" uniqKey="Lee J" first="Jeffrey E" last="Lee">Jeffrey E. Lee</name></author><author><name sortKey="Gershenwald, Jeffrey E" sort="Gershenwald, Jeffrey E" uniqKey="Gershenwald J" first="Jeffrey E" last="Gershenwald">Jeffrey E. Gershenwald</name></author><author><name sortKey="Hwu, Patrick" sort="Hwu, Patrick" uniqKey="Hwu P" first="Patrick" last="Hwu">Patrick Hwu</name></author><author><name sortKey="Zagars, Gunar K" sort="Zagars, Gunar K" uniqKey="Zagars G" first="Gunar K" last="Zagars">Gunar K. 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Anderson Cancer Center, Houston, TX 77030, USA. mballo@mdanderson.org</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030</wicri:regionArea></affiliation></author><author><name sortKey="Ross, Merrick I" sort="Ross, Merrick I" uniqKey="Ross M" first="Merrick I" last="Ross">Merrick I. Ross</name></author><author><name sortKey="Cormier, Janice N" sort="Cormier, Janice N" uniqKey="Cormier J" first="Janice N" last="Cormier">Janice N. Cormier</name></author><author><name sortKey="Myers, Jeffrey N" sort="Myers, Jeffrey N" uniqKey="Myers J" first="Jeffrey N" last="Myers">Jeffrey N. Myers</name></author><author><name sortKey="Lee, Jeffrey E" sort="Lee, Jeffrey E" uniqKey="Lee J" first="Jeffrey E" last="Lee">Jeffrey E. Lee</name></author><author><name sortKey="Gershenwald, Jeffrey E" sort="Gershenwald, Jeffrey E" uniqKey="Gershenwald J" first="Jeffrey E" last="Gershenwald">Jeffrey E. Gershenwald</name></author><author><name sortKey="Hwu, Patrick" sort="Hwu, Patrick" uniqKey="Hwu P" first="Patrick" last="Hwu">Patrick Hwu</name></author><author><name sortKey="Zagars, Gunar K" sort="Zagars, Gunar K" uniqKey="Zagars G" first="Gunar K" last="Zagars">Gunar K. 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J. Radiat. Oncol. Biol. Phys.</ISOAbbreviation></Journal><ArticleTitle>Combined-modality therapy for patients with regional nodal metastases from melanoma.</ArticleTitle><Pagination><MedlinePgn>106-13</MedlinePgn></Pagination><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">To evaluate the outcome and patterns of failure for patients with nodal metastases from melanoma treated with combined-modality therapy.</AbstractText><AbstractText Label="METHODS AND MATERIALS" NlmCategory="METHODS">Between 1983 and 2003, 466 patients with nodal metastases from melanoma were managed with lymphadenectomy and radiation, with or without systemic therapy. Surgery was a therapeutic procedure for clinically apparent nodal disease in 434 patients (regionally advanced nodal disease). Adjuvant radiation was generally delivered with a hypofractionated regimen. Adjuvant systemic therapy was delivered to 154 patients.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">With a median follow-up of 4.2 years, 252 patients relapsed and 203 patients died of progressive disease. The actuarial 5-year disease-specific, disease-free, and distant metastasis-free survival rates were 49%, 42%, and 44%, respectively. By multivariate analysis, increasing number of involved lymph nodes and primary ulceration were associated with an inferior 5-year actuarial disease-specific and distant metastasis-free survival. Also, the number of involved lymph nodes was associated with the development of brain metastases, whereas thickness was associated with lung metastases, and primary ulceration was associated with liver metastases. The actuarial 5-year regional (in-basin) control rate for all patients was 89%, and on multivariate analysis there were no patient or disease characteristics associated with inferior regional control. The risk of lymphedema was highest for those patients with groin lymph node metastases.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Although regional nodal disease can be satisfactorily controlled with lymphadenectomy and radiation, the risk of distant metastases and melanoma death remains high. A management approach to these patients that accounts for the competing risks of distant metastases, regional failure, and long-term toxicity is needed.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ballo</LastName><ForeName>Matthew T</ForeName><Initials>MT</Initials><AffiliationInfo><Affiliation>Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA. mballo@mdanderson.org</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ross</LastName><ForeName>Merrick I</ForeName><Initials>MI</Initials></Author><Author ValidYN="Y"><LastName>Cormier</LastName><ForeName>Janice N</ForeName><Initials>JN</Initials></Author><Author ValidYN="Y"><LastName>Myers</LastName><ForeName>Jeffrey N</ForeName><Initials>JN</Initials></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Jeffrey E</ForeName><Initials>JE</Initials></Author><Author ValidYN="Y"><LastName>Gershenwald</LastName><ForeName>Jeffrey E</ForeName><Initials>JE</Initials></Author><Author ValidYN="Y"><LastName>Hwu</LastName><ForeName>Patrick</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Zagars</LastName><ForeName>Gunar K</ForeName><Initials>GK</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>CA 06294</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D023362">Evaluation Studies</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2005</Year><Month>09</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Int J Radiat Oncol Biol Phys</MedlineTA><NlmUniqueID>7603616</NlmUniqueID><ISSNLinking>0360-3016</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017024" MajorTopicYN="N">Chemotherapy, Adjuvant</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018572" MajorTopicYN="N">Disease-Free Survival</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008197" MajorTopicYN="N">Lymph Node Excision</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008207" MajorTopicYN="N">Lymphatic Metastasis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008545" MajorTopicYN="N">Melanoma</DescriptorName><QualifierName UI="Q000532" MajorTopicYN="Y">radiotherapy</QualifierName><QualifierName UI="Q000556" MajorTopicYN="N">secondary</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018714" MajorTopicYN="N">Radiotherapy, Adjuvant</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012878" MajorTopicYN="N">Skin Neoplasms</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000532" MajorTopicYN="Y">radiotherapy</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2005</Year><Month>03</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2005</Year><Month>06</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2005</Year><Month>06</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>9</Month><Day>27</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>3</Month><Day>24</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>9</Month><Day>27</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16182463</ArticleId><ArticleId IdType="pii">S0360-3016(05)01161-2</ArticleId><ArticleId IdType="doi">10.1016/j.ijrobp.2005.06.030</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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