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Puffy hand syndrome due to drug addiction: a case-control study of the pathogenesis.

Identifieur interne : 003907 ( PubMed/Curation ); précédent : 003906; suivant : 003908

Puffy hand syndrome due to drug addiction: a case-control study of the pathogenesis.

Auteurs : Valérie Andresz [France] ; Nicolas Marcantoni ; Florence Binder ; Michel Velten ; Martine Alt ; Jean-Christophe Weber ; Dominique Stephan

Source :

RBID : pubmed:16911735

Descripteurs français

English descriptors

Abstract

We studied the pathogenesis of puffy hand syndrome of intravenous drug use. We hypothesized that injections of high-dose sublingual buprenorphine, instead of the recommended sublingual administration, could play an important role in lymphatic obstruction and destruction.

DOI: 10.1111/j.1360-0443.2006.01521.x
PubMed: 16911735

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pubmed:16911735

Le document en format XML

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<title xml:lang="en">Puffy hand syndrome due to drug addiction: a case-control study of the pathogenesis.</title>
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<name sortKey="Andresz, Valerie" sort="Andresz, Valerie" uniqKey="Andresz V" first="Valérie" last="Andresz">Valérie Andresz</name>
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<nlm:affiliation>Hypertension Maladies vasculaires Pharmacologie clinique, Hôpitaux Universitaires de Strasbourg, 67091 Strasbourg cedex, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<name sortKey="Marcantoni, Nicolas" sort="Marcantoni, Nicolas" uniqKey="Marcantoni N" first="Nicolas" last="Marcantoni">Nicolas Marcantoni</name>
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<name sortKey="Binder, Florence" sort="Binder, Florence" uniqKey="Binder F" first="Florence" last="Binder">Florence Binder</name>
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<name sortKey="Velten, Michel" sort="Velten, Michel" uniqKey="Velten M" first="Michel" last="Velten">Michel Velten</name>
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<name sortKey="Alt, Martine" sort="Alt, Martine" uniqKey="Alt M" first="Martine" last="Alt">Martine Alt</name>
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<name sortKey="Weber, Jean Christophe" sort="Weber, Jean Christophe" uniqKey="Weber J" first="Jean-Christophe" last="Weber">Jean-Christophe Weber</name>
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<name sortKey="Stephan, Dominique" sort="Stephan, Dominique" uniqKey="Stephan D" first="Dominique" last="Stephan">Dominique Stephan</name>
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<term>Buprenorphine (administration & dosage)</term>
<term>Buprenorphine (adverse effects)</term>
<term>Case-Control Studies</term>
<term>Female</term>
<term>France</term>
<term>Hand</term>
<term>Humans</term>
<term>Lymphedema (chemically induced)</term>
<term>Male</term>
<term>Narcotic Antagonists (administration & dosage)</term>
<term>Narcotic Antagonists (adverse effects)</term>
<term>Risk Factors</term>
<term>Statistics, Nonparametric</term>
<term>Substance Abuse, Intravenous (complications)</term>
<term>Syndrome</term>
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<term>Antagonistes narcotiques (administration et posologie)</term>
<term>Antagonistes narcotiques (effets indésirables)</term>
<term>Buprénorphine (administration et posologie)</term>
<term>Buprénorphine (effets indésirables)</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>France</term>
<term>Humains</term>
<term>Lymphoedème ()</term>
<term>Main</term>
<term>Mâle</term>
<term>Statistique non paramétrique</term>
<term>Syndrome</term>
<term>Toxicomanie intraveineuse ()</term>
<term>Études cas-témoins</term>
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<term>Buprenorphine</term>
<term>Narcotic Antagonists</term>
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<term>Buprenorphine</term>
<term>Narcotic Antagonists</term>
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<term>France</term>
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<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr">
<term>Antagonistes narcotiques</term>
<term>Buprénorphine</term>
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<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en">
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en">
<term>Substance Abuse, Intravenous</term>
</keywords>
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<term>Antagonistes narcotiques</term>
<term>Buprénorphine</term>
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<term>Case-Control Studies</term>
<term>Female</term>
<term>Hand</term>
<term>Humans</term>
<term>Male</term>
<term>Risk Factors</term>
<term>Statistics, Nonparametric</term>
<term>Syndrome</term>
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<term>Toxicomanie intraveineuse</term>
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<front>
<div type="abstract" xml:lang="en">We studied the pathogenesis of puffy hand syndrome of intravenous drug use. We hypothesized that injections of high-dose sublingual buprenorphine, instead of the recommended sublingual administration, could play an important role in lymphatic obstruction and destruction.</div>
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<DateCreated>
<Year>2006</Year>
<Month>08</Month>
<Day>16</Day>
</DateCreated>
<DateCompleted>
<Year>2007</Year>
<Month>01</Month>
<Day>18</Day>
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<DateRevised>
<Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
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<ISSN IssnType="Print">0965-2140</ISSN>
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<Volume>101</Volume>
<Issue>9</Issue>
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<Title>Addiction (Abingdon, England)</Title>
<ISOAbbreviation>Addiction</ISOAbbreviation>
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<ArticleTitle>Puffy hand syndrome due to drug addiction: a case-control study of the pathogenesis.</ArticleTitle>
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<AbstractText Label="AIM" NlmCategory="OBJECTIVE">We studied the pathogenesis of puffy hand syndrome of intravenous drug use. We hypothesized that injections of high-dose sublingual buprenorphine, instead of the recommended sublingual administration, could play an important role in lymphatic obstruction and destruction.</AbstractText>
<AbstractText Label="DESIGN AND PARTICIPANTS" NlmCategory="METHODS">We set up a case-control study in substitution centres, recruiting intravenous drug addicts with and without puffy hands, respectively. The subjects were asked to answer anonymously a questionnaire of 40 items comprising social and demographic status, history of illicit drugs use, buprenorphine misuse and injection practices.</AbstractText>
<AbstractText Label="FINDINGS" NlmCategory="RESULTS">We included 33 cases and 33 controls, mean age of 34 years. They were past heroin users, mainly methadone-substituted. In multivariate analysis, sex (women) (OR = 8.9, P = 0.03), injections in the hands (OR = 5.9, P = 0.03), injections in the feet (OR = 6.5, P = 0.01) and the absence of tourniquet (OR = 7.0, p = 0.02) were significant risk factors for puffy hand syndrome. In 69.7% of the cases and 59.4% of the controls, respectively, there was a high-dose sublingual buprenorphine misuse, although it appeared not to be a significant risk factor for puffy hand syndrome.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Injection practices are likely to cause puffy hands syndrome, but buprenorphine misuse should not be considered as a significant risk factor. However, intravenous drug users must still be warned of local and systemic complications of intravenous drug misuse.</AbstractText>
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