A review of the microcirculation in skin in patients with chronic venous insufficiency: the problem and the evidence available for therapeutic options.
Identifieur interne : 003896 ( PubMed/Curation ); précédent : 003895; suivant : 003897A review of the microcirculation in skin in patients with chronic venous insufficiency: the problem and the evidence available for therapeutic options.
Auteurs : Uwe Wollina [Allemagne] ; Mohamed Badawy Abdel-Naser ; Raj ManiSource :
- The international journal of lower extremity wounds [ 1534-7346 ] ; 2006.
Descripteurs français
- KwdFr :
- MESH :
- physiologie : Microcirculation.
- physiopathologie : Insuffisance veineuse.
- usage thérapeutique : Préparations à base de plantes.
- Bas de contention, Humains, Insuffisance veineuse, Maladie chronique, Peau, Phytothérapie, Pronostic.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Plant Preparations.
- blood supply : Skin.
- methods : Phytotherapy.
- physiology : Microcirculation.
- physiopathology : Venous Insufficiency.
- therapy : Venous Insufficiency.
- Chronic Disease, Humans, Prognosis, Stockings, Compression.
Abstract
Impairment of the cutaneous microcirculation is a major predisposing factor in inflammation and ulceration in patients with chronic venous insufficiency (CVI). Increase of capillary filtration rate predisposes to the formation of edema. Local lymphedema is a complication of CVI, often underdiagnosed. This review is focused on CVI but excludes the complication of ulceration. Treatment of microcirculatory dysfunction can be done by pharmacologic intervention or compression therapy or using a combination of both. This review is focused on drugs that have been evaluated by randomized prospective controlled trials. The following compounds are discussed: horse chestnut seed extracts, flavonoids, red vine leaves extracts, total triterpenic fraction of Centella asiatica (L), prociadins, calcium dobesilate, and pentoxifylline. The microcirculatory effects of compression therapy using bandages or stockings are also reviewed. The major microcirculatory effects that have been shown are the reduction of capillary filtration rate and improvements in levels of transcutaneous partial pressures of oxygen and carbon dioxide (TcPO(2) and TcPCO(2)). Available data suggest that a combination of pharmacologic and compression therapy may have some additive effects.
DOI: 10.1177/1534734606291870
PubMed: 16928673
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pubmed:16928673Le document en format XML
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<author><name sortKey="Wollina, Uwe" sort="Wollina, Uwe" uniqKey="Wollina U" first="Uwe" last="Wollina">Uwe Wollina</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Hospital Dresden-Friedrichstadt, Academic Teaching Hospital of the Technical University of Dresden, Germany. wollina-uw@khdf.de.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Dermatology, Hospital Dresden-Friedrichstadt, Academic Teaching Hospital of the Technical University of Dresden</wicri:regionArea>
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<author><name sortKey="Abdel Naser, Mohamed Badawy" sort="Abdel Naser, Mohamed Badawy" uniqKey="Abdel Naser M" first="Mohamed Badawy" last="Abdel-Naser">Mohamed Badawy Abdel-Naser</name>
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<author><name sortKey="Wollina, Uwe" sort="Wollina, Uwe" uniqKey="Wollina U" first="Uwe" last="Wollina">Uwe Wollina</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chronic Disease</term>
<term>Humans</term>
<term>Microcirculation (physiology)</term>
<term>Phytotherapy (methods)</term>
<term>Plant Preparations (therapeutic use)</term>
<term>Prognosis</term>
<term>Skin (blood supply)</term>
<term>Stockings, Compression</term>
<term>Venous Insufficiency (physiopathology)</term>
<term>Venous Insufficiency (therapy)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Bas de contention</term>
<term>Humains</term>
<term>Insuffisance veineuse ()</term>
<term>Insuffisance veineuse (physiopathologie)</term>
<term>Maladie chronique</term>
<term>Microcirculation (physiologie)</term>
<term>Peau ()</term>
<term>Phytothérapie ()</term>
<term>Pronostic</term>
<term>Préparations à base de plantes (usage thérapeutique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Plant Preparations</term>
</keywords>
<keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Skin</term>
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<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Phytotherapy</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Microcirculation</term>
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<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Insuffisance veineuse</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Venous Insufficiency</term>
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<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Venous Insufficiency</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Préparations à base de plantes</term>
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<term>Humans</term>
<term>Prognosis</term>
<term>Stockings, Compression</term>
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<term>Humains</term>
<term>Insuffisance veineuse</term>
<term>Maladie chronique</term>
<term>Peau</term>
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<front><div type="abstract" xml:lang="en">Impairment of the cutaneous microcirculation is a major predisposing factor in inflammation and ulceration in patients with chronic venous insufficiency (CVI). Increase of capillary filtration rate predisposes to the formation of edema. Local lymphedema is a complication of CVI, often underdiagnosed. This review is focused on CVI but excludes the complication of ulceration. Treatment of microcirculatory dysfunction can be done by pharmacologic intervention or compression therapy or using a combination of both. This review is focused on drugs that have been evaluated by randomized prospective controlled trials. The following compounds are discussed: horse chestnut seed extracts, flavonoids, red vine leaves extracts, total triterpenic fraction of Centella asiatica (L), prociadins, calcium dobesilate, and pentoxifylline. The microcirculatory effects of compression therapy using bandages or stockings are also reviewed. The major microcirculatory effects that have been shown are the reduction of capillary filtration rate and improvements in levels of transcutaneous partial pressures of oxygen and carbon dioxide (TcPO(2) and TcPCO(2)). Available data suggest that a combination of pharmacologic and compression therapy may have some additive effects.</div>
</front>
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<Title>The international journal of lower extremity wounds</Title>
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<Abstract><AbstractText>Impairment of the cutaneous microcirculation is a major predisposing factor in inflammation and ulceration in patients with chronic venous insufficiency (CVI). Increase of capillary filtration rate predisposes to the formation of edema. Local lymphedema is a complication of CVI, often underdiagnosed. This review is focused on CVI but excludes the complication of ulceration. Treatment of microcirculatory dysfunction can be done by pharmacologic intervention or compression therapy or using a combination of both. This review is focused on drugs that have been evaluated by randomized prospective controlled trials. The following compounds are discussed: horse chestnut seed extracts, flavonoids, red vine leaves extracts, total triterpenic fraction of Centella asiatica (L), prociadins, calcium dobesilate, and pentoxifylline. The microcirculatory effects of compression therapy using bandages or stockings are also reviewed. The major microcirculatory effects that have been shown are the reduction of capillary filtration rate and improvements in levels of transcutaneous partial pressures of oxygen and carbon dioxide (TcPO(2) and TcPCO(2)). Available data suggest that a combination of pharmacologic and compression therapy may have some additive effects.</AbstractText>
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