An experimental model for the study of lymphedema and its response to therapeutic lymphangiogenesis.
Identifieur interne : 003794 ( PubMed/Curation ); précédent : 003793; suivant : 003795An experimental model for the study of lymphedema and its response to therapeutic lymphangiogenesis.
Auteurs : Lauren Cheung [États-Unis] ; Jennifer Han ; Andreas Beilhack ; Smita Joshi ; Paul Wilburn ; Aman Dua ; Andrew An ; Stanley G. RocksonSource :
- BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy [ 1173-8804 ] ; 2006.
Descripteurs français
- KwdFr :
- Animaux, Facteur de croissance endothéliale vasculaire de type A (pharmacologie), Femelle, Glycoprotéines (métabolisme), Immunohistochimie, Lymphangiogenèse (), Lymphoedème (), Lymphoedème (anatomopathologie), Lymphoedème (immunologie), Lymphoedème (métabolisme), Maladie aigüe, Modèles animaux de maladie humaine, Souris, Transport de protéines.
- MESH :
- anatomopathologie : Lymphoedème.
- immunologie : Lymphoedème.
- métabolisme : Glycoprotéines, Lymphoedème.
- pharmacologie : Facteur de croissance endothéliale vasculaire de type A.
- Animaux, Femelle, Immunohistochimie, Lymphangiogenèse, Lymphoedème, Maladie aigüe, Modèles animaux de maladie humaine, Souris, Transport de protéines.
English descriptors
- KwdEn :
- Acute Disease, Animals, Disease Models, Animal, Female, Glycoproteins (metabolism), Immunohistochemistry, Lymphangiogenesis (drug effects), Lymphedema (immunology), Lymphedema (metabolism), Lymphedema (pathology), Lymphedema (therapy), Mice, Protein Transport, Vascular Endothelial Growth Factor A (pharmacology).
- MESH :
- chemical , metabolism : Glycoproteins.
- drug effects : Lymphangiogenesis.
- immunology : Lymphedema.
- metabolism : Lymphedema.
- pathology : Lymphedema.
- chemical , pharmacology : Vascular Endothelial Growth Factor A.
- therapy : Lymphedema.
- Acute Disease, Animals, Disease Models, Animal, Female, Immunohistochemistry, Mice, Protein Transport.
Abstract
Evaluation of the efficacy of molecular treatment strategies for lymphatic vascular insufficiency requires a suitable preclinical animal model. Ideally, the model should closely replicate the untreated human disease in its pathogenesis and pathological expression.
PubMed: 17176124
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Rockson</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="RBID">pubmed:17176124</idno><idno type="pmid">17176124</idno><idno type="wicri:Area/PubMed/Corpus">003794</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003794</idno><idno type="wicri:Area/PubMed/Curation">003794</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003794</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">An experimental model for the study of lymphedema and its response to therapeutic lymphangiogenesis.</title><author><name sortKey="Cheung, Lauren" sort="Cheung, Lauren" uniqKey="Cheung L" first="Lauren" last="Cheung">Lauren Cheung</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cardiovascular Medicine, Stanford Center for Lymphatic and Venous Disorders, Stanford University School of Medicine, Falk Cardiovascular Research Center, Stanford, California 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cardiovascular Medicine, Stanford Center for Lymphatic and Venous Disorders, Stanford University School of Medicine, Falk Cardiovascular Research Center, Stanford, California 94305</wicri:regionArea></affiliation></author><author><name sortKey="Han, Jennifer" sort="Han, Jennifer" uniqKey="Han J" first="Jennifer" last="Han">Jennifer Han</name></author><author><name sortKey="Beilhack, Andreas" sort="Beilhack, Andreas" uniqKey="Beilhack A" first="Andreas" last="Beilhack">Andreas Beilhack</name></author><author><name sortKey="Joshi, Smita" sort="Joshi, Smita" uniqKey="Joshi S" first="Smita" last="Joshi">Smita Joshi</name></author><author><name sortKey="Wilburn, Paul" sort="Wilburn, Paul" uniqKey="Wilburn P" first="Paul" last="Wilburn">Paul Wilburn</name></author><author><name sortKey="Dua, Aman" sort="Dua, Aman" uniqKey="Dua A" first="Aman" last="Dua">Aman Dua</name></author><author><name sortKey="An, Andrew" sort="An, Andrew" uniqKey="An A" first="Andrew" last="An">Andrew An</name></author><author><name sortKey="Rockson, Stanley G" sort="Rockson, Stanley G" uniqKey="Rockson S" first="Stanley G" last="Rockson">Stanley G. Rockson</name></author></analytic><series><title level="j">BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy</title><idno type="ISSN">1173-8804</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Disease</term><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Glycoproteins (metabolism)</term><term>Immunohistochemistry</term><term>Lymphangiogenesis (drug effects)</term><term>Lymphedema (immunology)</term><term>Lymphedema (metabolism)</term><term>Lymphedema (pathology)</term><term>Lymphedema (therapy)</term><term>Mice</term><term>Protein Transport</term><term>Vascular Endothelial Growth Factor A (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Facteur de croissance endothéliale vasculaire de type A (pharmacologie)</term><term>Femelle</term><term>Glycoprotéines (métabolisme)</term><term>Immunohistochimie</term><term>Lymphangiogenèse ()</term><term>Lymphoedème ()</term><term>Lymphoedème (anatomopathologie)</term><term>Lymphoedème (immunologie)</term><term>Lymphoedème (métabolisme)</term><term>Maladie aigüe</term><term>Modèles animaux de maladie humaine</term><term>Souris</term><term>Transport de protéines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Glycoproteins</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Lymphangiogenesis</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Glycoprotéines</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Vascular Endothelial Growth Factor A</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acute Disease</term><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Immunohistochemistry</term><term>Mice</term><term>Protein Transport</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Immunohistochimie</term><term>Lymphangiogenèse</term><term>Lymphoedème</term><term>Maladie aigüe</term><term>Modèles animaux de maladie humaine</term><term>Souris</term><term>Transport de protéines</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Evaluation of the efficacy of molecular treatment strategies for lymphatic vascular insufficiency requires a suitable preclinical animal model. Ideally, the model should closely replicate the untreated human disease in its pathogenesis and pathological expression.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17176124</PMID><DateCreated><Year>2006</Year><Month>12</Month><Day>19</Day></DateCreated><DateCompleted><Year>2007</Year><Month>06</Month><Day>12</Day></DateCompleted><DateRevised><Year>2006</Year><Month>12</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1173-8804</ISSN><JournalIssue CitedMedium="Print"><Volume>20</Volume><Issue>6</Issue><PubDate><Year>2006</Year></PubDate></JournalIssue><Title>BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy</Title><ISOAbbreviation>BioDrugs</ISOAbbreviation></Journal><ArticleTitle>An experimental model for the study of lymphedema and its response to therapeutic lymphangiogenesis.</ArticleTitle><Pagination><MedlinePgn>363-70</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Evaluation of the efficacy of molecular treatment strategies for lymphatic vascular insufficiency requires a suitable preclinical animal model. Ideally, the model should closely replicate the untreated human disease in its pathogenesis and pathological expression.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">We have undertaken a study of the time course of the development and resolution of acquired, experimental lymphedema and of its responses to vascular endothelial growth factor (VEGF)-C lymphangiogenesis in the mouse tail model.</AbstractText><AbstractText Label="STUDY DESIGN" NlmCategory="METHODS">We provoked post-surgical lymphedema in the mouse tail model and assessed the effects of exogenously administered human recombinant VEGF-C. Quantitative assessment of immune traffic function was performed through sequential in vivo bioluminescent imaging.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In untreated lymphedema, tail edema was sustained until day 21. Exogenous administration of human recombinant VEGF-C produced a significant decrease in volume. Untreated lymphedema in the mouse tail model was characterized by the presence of dilated cutaneous lymphatics, marked acute inflammatory changes, and hypercellularity; VEGF-C produced a substantial reversion to the normal pattern, with notable regression in the size and number of cutaneous lymphatic vessels that express lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1). In vivo imaging confirmed the presence of an impairment of immune traffic in lymphedema that was ameliorated after VEGF-C administration.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The post-surgical murine tail model of lymphedema closely simulates attributes of human lymphedema and provides the requisite sensitivity to detect therapeutically induced functional and structural alterations. It can, therefore, be used as an investigative platform to assess mechanisms of disease and its responses to candidate therapies, such as therapeutic lymphangiogenesis.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cheung</LastName><ForeName>Lauren</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Division of Cardiovascular Medicine, Stanford Center for Lymphatic and Venous Disorders, Stanford University School of Medicine, Falk Cardiovascular Research Center, Stanford, California 94305, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Han</LastName><ForeName>Jennifer</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Beilhack</LastName><ForeName>Andreas</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Joshi</LastName><ForeName>Smita</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Wilburn</LastName><ForeName>Paul</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Dua</LastName><ForeName>Aman</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>An</LastName><ForeName>Andrew</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Rockson</LastName><ForeName>Stanley G</ForeName><Initials>SG</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>New Zealand</Country><MedlineTA>BioDrugs</MedlineTA><NlmUniqueID>9705305</NlmUniqueID><ISSNLinking>1173-8804</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006023">Glycoproteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D042461">Vascular Endothelial Growth Factor A</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C492273">Xlkd1 protein, mouse</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000208" MajorTopicYN="N">Acute Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="Y">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006023" MajorTopicYN="N">Glycoproteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D042583" MajorTopicYN="Y">Lymphangiogenesis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D021381" MajorTopicYN="N">Protein Transport</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D042461" MajorTopicYN="N">Vascular Endothelial Growth Factor A</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>12</Month><Day>21</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>6</Month><Day>15</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>12</Month><Day>21</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17176124</ArticleId><ArticleId IdType="pii">2067</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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