The role of transforming growth factor-beta1 and oxidative stress in podoconiosis pathogenesis.
Identifieur interne : 002B43 ( PubMed/Curation ); précédent : 002B42; suivant : 002B44The role of transforming growth factor-beta1 and oxidative stress in podoconiosis pathogenesis.
Auteurs : S. Addisu [Éthiopie] ; T H El-Metwally ; G. Davey ; Y. Worku ; M A TitheradgeSource :
- The British journal of dermatology [ 1365-2133 ] ; 2010.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Facteur de croissance transformant bêta-1 (physiologie), Facteur de croissance transformant bêta-1 (sang), Humains, Indice de gravité médicale, Jeune adulte, Malonaldéhyde (sang), Marqueurs biologiques (sang), Nitrites (sang), Peroxydes (sang), Stress oxydatif (physiologie), Sujet âgé, Superoxide dismutase (sang), Éléphantiasis (physiopathologie), Éléphantiasis (étiologie).
- MESH :
- physiologie : Facteur de croissance transformant bêta-1, Stress oxydatif.
- physiopathologie : Éléphantiasis.
- sang : Facteur de croissance transformant bêta-1, Malonaldéhyde, Marqueurs biologiques, Nitrites, Peroxydes, Superoxide dismutase.
- étiologie : Éléphantiasis.
- Adulte, Adulte d'âge moyen, Humains, Indice de gravité médicale, Jeune adulte, Sujet âgé.
English descriptors
- KwdEn :
- Adult, Aged, Biomarkers (blood), Elephantiasis (etiology), Elephantiasis (physiopathology), Humans, Malondialdehyde (blood), Middle Aged, Nitrites (blood), Oxidative Stress (physiology), Peroxides (blood), Severity of Illness Index, Superoxide Dismutase (blood), Transforming Growth Factor beta1 (blood), Transforming Growth Factor beta1 (physiology), Young Adult.
- MESH :
- chemical , blood : Biomarkers, Malondialdehyde, Nitrites, Peroxides, Superoxide Dismutase, Transforming Growth Factor beta1.
- etiology : Elephantiasis.
- physiology : Oxidative Stress, Transforming Growth Factor beta1.
- physiopathology : Elephantiasis.
- Adult, Aged, Humans, Middle Aged, Severity of Illness Index, Young Adult.
Abstract
Podoconiosis (endemic nonfilarial elephantiasis) occurs in susceptible individuals who go barefoot in regions of irritant volcanic soil. Silicate particles absorbed via the skin are thought to induce an inflammatory process and a consequent endolymphangitis of the lower leg lymphatics.
DOI: 10.1111/j.1365-2133.2010.09652.x
PubMed: 20199540
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Davey</name></author><author><name sortKey="Worku, Y" sort="Worku, Y" uniqKey="Worku Y" first="Y" last="Worku">Y. Worku</name></author><author><name sortKey="Titheradge, M A" sort="Titheradge, M A" uniqKey="Titheradge M" first="M A" last="Titheradge">M A Titheradge</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20199540</idno><idno type="pmid">20199540</idno><idno type="doi">10.1111/j.1365-2133.2010.09652.x</idno><idno type="wicri:Area/PubMed/Corpus">002B43</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002B43</idno><idno type="wicri:Area/PubMed/Curation">002B43</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002B43</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The role of transforming growth factor-beta1 and oxidative stress in podoconiosis pathogenesis.</title><author><name sortKey="Addisu, S" sort="Addisu, S" uniqKey="Addisu S" first="S" last="Addisu">S. Addisu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Faculty of Medicine, Addis Ababa University, PO Box 26905/1000, Addis Ababa, Ethiopia.</nlm:affiliation><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Department of Biochemistry, Faculty of Medicine, Addis Ababa University, PO Box 26905/1000, Addis Ababa</wicri:regionArea></affiliation></author><author><name sortKey="El Metwally, T H" sort="El Metwally, T H" uniqKey="El Metwally T" first="T H" last="El-Metwally">T H El-Metwally</name></author><author><name sortKey="Davey, G" sort="Davey, G" uniqKey="Davey G" first="G" last="Davey">G. Davey</name></author><author><name sortKey="Worku, Y" sort="Worku, Y" uniqKey="Worku Y" first="Y" last="Worku">Y. Worku</name></author><author><name sortKey="Titheradge, M A" sort="Titheradge, M A" uniqKey="Titheradge M" first="M A" last="Titheradge">M A Titheradge</name></author></analytic><series><title level="j">The British journal of dermatology</title><idno type="eISSN">1365-2133</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Biomarkers (blood)</term><term>Elephantiasis (etiology)</term><term>Elephantiasis (physiopathology)</term><term>Humans</term><term>Malondialdehyde (blood)</term><term>Middle Aged</term><term>Nitrites (blood)</term><term>Oxidative Stress (physiology)</term><term>Peroxides (blood)</term><term>Severity of Illness Index</term><term>Superoxide Dismutase (blood)</term><term>Transforming Growth Factor beta1 (blood)</term><term>Transforming Growth Factor beta1 (physiology)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteur de croissance transformant bêta-1 (physiologie)</term><term>Facteur de croissance transformant bêta-1 (sang)</term><term>Humains</term><term>Indice de gravité médicale</term><term>Jeune adulte</term><term>Malonaldéhyde (sang)</term><term>Marqueurs biologiques (sang)</term><term>Nitrites (sang)</term><term>Peroxydes (sang)</term><term>Stress oxydatif (physiologie)</term><term>Sujet âgé</term><term>Superoxide dismutase (sang)</term><term>Éléphantiasis (physiopathologie)</term><term>Éléphantiasis (étiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term><term>Malondialdehyde</term><term>Nitrites</term><term>Peroxides</term><term>Superoxide Dismutase</term><term>Transforming Growth Factor beta1</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Elephantiasis</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Facteur de croissance transformant bêta-1</term><term>Stress oxydatif</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Oxidative Stress</term><term>Transforming Growth Factor beta1</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Éléphantiasis</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Elephantiasis</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Facteur de croissance transformant bêta-1</term><term>Malonaldéhyde</term><term>Marqueurs biologiques</term><term>Nitrites</term><term>Peroxydes</term><term>Superoxide dismutase</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Éléphantiasis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Humans</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Humains</term><term>Indice de gravité médicale</term><term>Jeune adulte</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Podoconiosis (endemic nonfilarial elephantiasis) occurs in susceptible individuals who go barefoot in regions of irritant volcanic soil. Silicate particles absorbed via the skin are thought to induce an inflammatory process and a consequent endolymphangitis of the lower leg lymphatics.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20199540</PMID><DateCreated><Year>2010</Year><Month>04</Month><Day>28</Day></DateCreated><DateCompleted><Year>2010</Year><Month>06</Month><Day>28</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1365-2133</ISSN><JournalIssue CitedMedium="Internet"><Volume>162</Volume><Issue>5</Issue><PubDate><Year>2010</Year><Month>May</Month></PubDate></JournalIssue><Title>The British journal of dermatology</Title><ISOAbbreviation>Br. J. Dermatol.</ISOAbbreviation></Journal><ArticleTitle>The role of transforming growth factor-beta1 and oxidative stress in podoconiosis pathogenesis.</ArticleTitle><Pagination><MedlinePgn>998-1003</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/j.1365-2133.2010.09652.x</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Podoconiosis (endemic nonfilarial elephantiasis) occurs in susceptible individuals who go barefoot in regions of irritant volcanic soil. Silicate particles absorbed via the skin are thought to induce an inflammatory process and a consequent endolymphangitis of the lower leg lymphatics.</AbstractText><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To establish which oxidative stress biomarkers play a part in the inflammatory process, and to test whether transforming growth factor (TGF)-beta1 also has a pathogenetic role.</AbstractText><AbstractText Label="PATIENTS AND METHODS" NlmCategory="METHODS">We enrolled 50 patients with early clinical stage disease, 43 patients with advanced stage disease and 35 local healthy controls. Oxidative stress biomarkers included serum total peroxides (TP), total antioxidant capacity (TAC), total nitrate plus nitrite (TN), malondialdehyde (MDA) and total superoxide dismutase (SOD) activity. The oxidative stress index (OSI) was also determined. Serum total TGF-beta1 was assayed using sandwich enzyme-linked immunosorbent assay.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Compared with healthy controls, patients with early stage disease showed significantly higher mean levels of TP (P < 0.001), MDA (P < 0.05) and OSI (P < 0.01); and significantly lower mean concentrations of SOD (P < 0.001) and TGF-beta1 (P < 0.001). Mean levels of TGF-beta1 were even lower among patients with advanced stage disease (P < 0.001). Mean TAC levels were significantly lower among patients with advanced disease than either other group (P < 0.001).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This is the first study, to our knowledge, to attempt to elucidate the molecular pathogenetic events in podoconiosis. We conclude that TGF-beta1 may have a pathogenetic role, with oxidative stress playing a minor role in the early stages of disease.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Addisu</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, Faculty of Medicine, Addis Ababa University, PO Box 26905/1000, Addis Ababa, Ethiopia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>El-Metwally</LastName><ForeName>T H</ForeName><Initials>TH</Initials></Author><Author ValidYN="Y"><LastName>Davey</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Worku</LastName><ForeName>Y</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Titheradge</LastName><ForeName>M A</ForeName><Initials>MA</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal 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