LymphedemaV1, PubMed, Curation, bibRecord, 002575

Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline.

Identifieur interne : 002575 ( PubMed/Curation ); précédent : 002574; suivant : 002576

Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline.

Auteurs : Alexander Yaw Debrah [Ghana] ; Sabine Mand ; Yeboah Marfo-Debrekyei ; Linda Batsa ; Anna Albers ; Sabine Specht ; Ute Klarmann ; Kenneth Pfarr ; Ohene Adjei ; Achim Hoerauf

Source :

Journal of parasitology research [ 2090-0031 ] ; 2011.

RBID : pubmed:21687646

Abstract

Infection with the filarial nematode Wuchereria bancrofti can lead to lymphedema, hydrocele, and elephantiasis. Since adult worms cause pathology in lymphatic filariasis (LF), it is imperative to discover macrofilaricidal drugs for the treatment of the infection. Endosymbiotic Wolbachia in filariae have emerged as a new target for antibiotics which can lead to macrofilaricidal effects. In Ghana, a pilot study was carried out with 39 LF-infected men; 12 were treated with 200 mg doxycycline/day for 4 weeks, 16 were treated with a combination of 200 mg doxycycline/day + 10 mg/kg/day rifampicin for 2 weeks, and 11 patients received placebo. Patients were monitored for Wolbachia and microfilaria loads, antigenaemia, and filarial dance sign (FDS). Both 4-week doxycycline and the 2-week combination treatment reduced Wolbachia load significantly. At 18 months posttreatment, four-week doxycycline resulted in 100% adult worm loss, and the 2-week combination treatment resulted in a 50% adult worm loss. In conclusion, this pilot study with a combination of 2-week doxycycline and rifampicin demonstrates moderate macrofilaricidal activity against W. bancrofti.

DOI: 10.1155/2011/201617
PubMed: 21687646

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002575

Links to Exploration step

pubmed:21687646

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline.</title>
<author><name sortKey="Debrah, Alexander Yaw" sort="Debrah, Alexander Yaw" uniqKey="Debrah A" first="Alexander Yaw" last="Debrah">Alexander Yaw Debrah</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Allied Health Sciences, Kwame Nkrumah University of Science and Technology, UPO, PMB, Kumasi, Ghana.</nlm:affiliation>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Faculty of Allied Health Sciences, Kwame Nkrumah University of Science and Technology, UPO, PMB, Kumasi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mand, Sabine" sort="Mand, Sabine" uniqKey="Mand S" first="Sabine" last="Mand">Sabine Mand</name>
</author>
<author><name sortKey="Marfo Debrekyei, Yeboah" sort="Marfo Debrekyei, Yeboah" uniqKey="Marfo Debrekyei Y" first="Yeboah" last="Marfo-Debrekyei">Yeboah Marfo-Debrekyei</name>
</author>
<author><name sortKey="Batsa, Linda" sort="Batsa, Linda" uniqKey="Batsa L" first="Linda" last="Batsa">Linda Batsa</name>
</author>
<author><name sortKey="Albers, Anna" sort="Albers, Anna" uniqKey="Albers A" first="Anna" last="Albers">Anna Albers</name>
</author>
<author><name sortKey="Specht, Sabine" sort="Specht, Sabine" uniqKey="Specht S" first="Sabine" last="Specht">Sabine Specht</name>
</author>
<author><name sortKey="Klarmann, Ute" sort="Klarmann, Ute" uniqKey="Klarmann U" first="Ute" last="Klarmann">Ute Klarmann</name>
</author>
<author><name sortKey="Pfarr, Kenneth" sort="Pfarr, Kenneth" uniqKey="Pfarr K" first="Kenneth" last="Pfarr">Kenneth Pfarr</name>
</author>
<author><name sortKey="Adjei, Ohene" sort="Adjei, Ohene" uniqKey="Adjei O" first="Ohene" last="Adjei">Ohene Adjei</name>
</author>
<author><name sortKey="Hoerauf, Achim" sort="Hoerauf, Achim" uniqKey="Hoerauf A" first="Achim" last="Hoerauf">Achim Hoerauf</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2011">2011</date>
<idno type="RBID">pubmed:21687646</idno>
<idno type="pmid">21687646</idno>
<idno type="doi">10.1155/2011/201617</idno>
<idno type="wicri:Area/PubMed/Corpus">002575</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002575</idno>
<idno type="wicri:Area/PubMed/Curation">002575</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002575</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline.</title>
<author><name sortKey="Debrah, Alexander Yaw" sort="Debrah, Alexander Yaw" uniqKey="Debrah A" first="Alexander Yaw" last="Debrah">Alexander Yaw Debrah</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Allied Health Sciences, Kwame Nkrumah University of Science and Technology, UPO, PMB, Kumasi, Ghana.</nlm:affiliation>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Faculty of Allied Health Sciences, Kwame Nkrumah University of Science and Technology, UPO, PMB, Kumasi</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mand, Sabine" sort="Mand, Sabine" uniqKey="Mand S" first="Sabine" last="Mand">Sabine Mand</name>
</author>
<author><name sortKey="Marfo Debrekyei, Yeboah" sort="Marfo Debrekyei, Yeboah" uniqKey="Marfo Debrekyei Y" first="Yeboah" last="Marfo-Debrekyei">Yeboah Marfo-Debrekyei</name>
</author>
<author><name sortKey="Batsa, Linda" sort="Batsa, Linda" uniqKey="Batsa L" first="Linda" last="Batsa">Linda Batsa</name>
</author>
<author><name sortKey="Albers, Anna" sort="Albers, Anna" uniqKey="Albers A" first="Anna" last="Albers">Anna Albers</name>
</author>
<author><name sortKey="Specht, Sabine" sort="Specht, Sabine" uniqKey="Specht S" first="Sabine" last="Specht">Sabine Specht</name>
</author>
<author><name sortKey="Klarmann, Ute" sort="Klarmann, Ute" uniqKey="Klarmann U" first="Ute" last="Klarmann">Ute Klarmann</name>
</author>
<author><name sortKey="Pfarr, Kenneth" sort="Pfarr, Kenneth" uniqKey="Pfarr K" first="Kenneth" last="Pfarr">Kenneth Pfarr</name>
</author>
<author><name sortKey="Adjei, Ohene" sort="Adjei, Ohene" uniqKey="Adjei O" first="Ohene" last="Adjei">Ohene Adjei</name>
</author>
<author><name sortKey="Hoerauf, Achim" sort="Hoerauf, Achim" uniqKey="Hoerauf A" first="Achim" last="Hoerauf">Achim Hoerauf</name>
</author>
</analytic>
<series><title level="j">Journal of parasitology research</title>
<idno type="eISSN">2090-0031</idno>
<imprint><date when="2011" type="published">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Infection with the filarial nematode Wuchereria bancrofti can lead to lymphedema, hydrocele, and elephantiasis. Since adult worms cause pathology in lymphatic filariasis (LF), it is imperative to discover macrofilaricidal drugs for the treatment of the infection. Endosymbiotic Wolbachia in filariae have emerged as a new target for antibiotics which can lead to macrofilaricidal effects. In Ghana, a pilot study was carried out with 39 LF-infected men; 12 were treated with 200 mg doxycycline/day for 4 weeks, 16 were treated with a combination of 200 mg doxycycline/day + 10 mg/kg/day rifampicin for 2 weeks, and 11 patients received placebo. Patients were monitored for Wolbachia and microfilaria loads, antigenaemia, and filarial dance sign (FDS). Both 4-week doxycycline and the 2-week combination treatment reduced Wolbachia load significantly. At 18 months posttreatment, four-week doxycycline resulted in 100% adult worm loss, and the 2-week combination treatment resulted in a 50% adult worm loss. In conclusion, this pilot study with a combination of 2-week doxycycline and rifampicin demonstrates moderate macrofilaricidal activity against W. bancrofti.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">21687646</PMID>
<DateCreated><Year>2011</Year>
<Month>06</Month>
<Day>20</Day>
</DateCreated>
<DateCompleted><Year>2011</Year>
<Month>07</Month>
<Day>14</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>02</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2090-0031</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>2011</Volume>
<PubDate><Year>2011</Year>
</PubDate>
</JournalIssue>
<Title>Journal of parasitology research</Title>
<ISOAbbreviation>J Parasitol Res</ISOAbbreviation>
</Journal>
<ArticleTitle>Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline.</ArticleTitle>
<Pagination><MedlinePgn>201617</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1155/2011/201617</ELocationID>
<Abstract><AbstractText>Infection with the filarial nematode Wuchereria bancrofti can lead to lymphedema, hydrocele, and elephantiasis. Since adult worms cause pathology in lymphatic filariasis (LF), it is imperative to discover macrofilaricidal drugs for the treatment of the infection. Endosymbiotic Wolbachia in filariae have emerged as a new target for antibiotics which can lead to macrofilaricidal effects. In Ghana, a pilot study was carried out with 39 LF-infected men; 12 were treated with 200 mg doxycycline/day for 4 weeks, 16 were treated with a combination of 200 mg doxycycline/day + 10 mg/kg/day rifampicin for 2 weeks, and 11 patients received placebo. Patients were monitored for Wolbachia and microfilaria loads, antigenaemia, and filarial dance sign (FDS). Both 4-week doxycycline and the 2-week combination treatment reduced Wolbachia load significantly. At 18 months posttreatment, four-week doxycycline resulted in 100% adult worm loss, and the 2-week combination treatment resulted in a 50% adult worm loss. In conclusion, this pilot study with a combination of 2-week doxycycline and rifampicin demonstrates moderate macrofilaricidal activity against W. bancrofti.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Debrah</LastName>
<ForeName>Alexander Yaw</ForeName>
<Initials>AY</Initials>
<AffiliationInfo><Affiliation>Faculty of Allied Health Sciences, Kwame Nkrumah University of Science and Technology, UPO, PMB, Kumasi, Ghana.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mand</LastName>
<ForeName>Sabine</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Marfo-Debrekyei</LastName>
<ForeName>Yeboah</ForeName>
<Initials>Y</Initials>
</Author>
<Author ValidYN="Y"><LastName>Batsa</LastName>
<ForeName>Linda</ForeName>
<Initials>L</Initials>
</Author>
<Author ValidYN="Y"><LastName>Albers</LastName>
<ForeName>Anna</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Specht</LastName>
<ForeName>Sabine</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Klarmann</LastName>
<ForeName>Ute</ForeName>
<Initials>U</Initials>
</Author>
<Author ValidYN="Y"><LastName>Pfarr</LastName>
<ForeName>Kenneth</ForeName>
<Initials>K</Initials>
</Author>
<Author ValidYN="Y"><LastName>Adjei</LastName>
<ForeName>Ohene</ForeName>
<Initials>O</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hoerauf</LastName>
<ForeName>Achim</ForeName>
<Initials>A</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2011</Year>
<Month>05</Month>
<Day>22</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Parasitol Res</MedlineTA>
<NlmUniqueID>101526294</NlmUniqueID>
<ISSNLinking>2090-0023</ISSNLinking>
</MedlineJournalInfo>
<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Curr Opin Infect Dis. 2008 Dec;21(6):673-81</RefSource>
<PMID Version="1">18978537</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Expert Opin Pharmacother. 2005 Feb;6(2):179-200</RefSource>
<PMID Version="1">15757416</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Infect Dis. 2006 Apr 15;42(8):1081-9</RefSource>
<PMID Version="1">16575724</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Ann Trop Med Parasitol. 2000 Dec;94(8):801-16</RefSource>
<PMID Version="1">11214099</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Trop Med Hyg. 2008 Jun;78(6):854-5</RefSource>
<PMID Version="1">18541758</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cochrane Database Syst Rev. 2005 Oct 19;(4):CD003753</RefSource>
<PMID Version="1">16235339</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Parasitol. 2002 Jun;88(3):605-11</RefSource>
<PMID Version="1">12099435</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet. 2001 May 5;357(9266):1415-6</RefSource>
<PMID Version="1">11356444</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Trop Med Hyg. 2009 Oct;81(4):702-11</RefSource>
<PMID Version="1">19815891</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Trop Med Hyg. 2009 Jun;80(6):956-63</RefSource>
<PMID Version="1">19478258</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet. 2000 Apr 8;355(9211):1242-3</RefSource>
<PMID Version="1">10770311</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Wkly Epidemiol Rec. 2007 Jun 1;82(22/23):197-202</RefSource>
<PMID Version="1">17542091</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet. 2005 Jun 18-24;365(9477):2116-21</RefSource>
<PMID Version="1">15964448</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Expert Rev Anti Infect Ther. 2006 Apr;4(2):211-22</RefSource>
<PMID Version="1">16597203</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Trans R Soc Trop Med Hyg. 1997 Jan-Feb;91(1):78-81</RefSource>
<PMID Version="1">9093637</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Parasitol Res. 2009 Jan;104(2):437-47</RefSource>
<PMID Version="1">18850111</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Trans R Soc Trop Med Hyg. 2006 Dec;100(12):1118-25</RefSource>
<PMID Version="1">16860830</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Parasitol Res. 2008 Nov;103(6):1303-9</RefSource>
<PMID Version="1">18679718</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Filaria J. 2003 Feb 27;2(1):3</RefSource>
<PMID Version="1">12636874</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Wkly Epidemiol Rec. 2007 Oct 19;82(42):361-80</RefSource>
<PMID Version="1">17948605</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Bull World Health Organ. 1997;75(6):491-503</RefSource>
<PMID Version="1">9509621</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Med Microbiol Immunol. 2003 Nov;192(4):211-6</RefSource>
<PMID Version="1">12684759</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Wkly Epidemiol Rec. 2010 Sep 17;85(38):365-72</RefSource>
<PMID Version="1">20853547</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Trop Med Int Health. 2007 Dec;12(12):1433-41</RefSource>
<PMID Version="1">18076549</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Trop Med Hyg. 2004 Oct;71(4):471-7</RefSource>
<PMID Version="1">15516645</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Trans R Soc Trop Med Hyg. 2004 Apr;98(4):205-17</RefSource>
<PMID Version="1">15049459</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Trop Med Int Health. 2003 May;8(5):392-401</RefSource>
<PMID Version="1">12753632</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Filaria J. 2006 Feb 05;5:1</RefSource>
<PMID Version="1">16457735</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet. 2010 Oct 2;376(9747):1175-85</RefSource>
<PMID Version="1">20739055</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mem Inst Oswaldo Cruz. 1996 Jan-Feb;91(1):95-6</RefSource>
<PMID Version="1">8734956</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS Pathog. 2006 Sep;2(9):e92</RefSource>
<PMID Version="1">17044733</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Trans R Soc Trop Med Hyg. 1999 Mar-Apr;93(2):189-94</RefSource>
<PMID Version="1">10450448</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<OtherID Source="NLM">PMC3112504</OtherID>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2010</Year>
<Month>12</Month>
<Day>06</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2011</Year>
<Month>03</Month>
<Day>02</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2011</Year>
<Month>6</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2011</Year>
<Month>6</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2011</Year>
<Month>6</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>1</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">21687646</ArticleId>
<ArticleId IdType="doi">10.1155/2011/201617</ArticleId>
<ArticleId IdType="pmc">PMC3112504</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/PubMed/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002575 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 002575 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    PubMed
   |étape=   Curation
   |type=    RBID
   |clé=     pubmed:21687646
   |texte=   Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i   -Sk "pubmed:21687646" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le lymphœdème

Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline.

Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline.

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki