Simultaneous administration of praziquantel, ivermectin and albendazole, in a community in rural northern Ghana endemic for schistosomiasis, onchocerciasis and lymphatic filariasis.
Identifieur interne : 002571 ( PubMed/Curation ); précédent : 002570; suivant : 002572Simultaneous administration of praziquantel, ivermectin and albendazole, in a community in rural northern Ghana endemic for schistosomiasis, onchocerciasis and lymphatic filariasis.
Auteurs : Francis Anto [Ghana] ; Victor Asoala ; Thomas Anyorigiya ; Abraham Oduro ; Martin Adjuik ; Patricia Akweongo ; Raymond Aborigo ; Langbong Bimi ; Joseph Amankwa ; Abraham HodgsonSource :
- Tropical medicine & international health : TM & IH [ 1365-3156 ] ; 2011.
Descripteurs français
- KwdFr :
- Adolescent, Albendazole (effets indésirables), Albendazole (usage thérapeutique), Association de médicaments, Enfant, Femelle, Filaricides (effets indésirables), Filaricides (usage thérapeutique), Filariose lymphatique (traitement médicamenteux), Filariose lymphatique (épidémiologie), Ghana, Humains, Ivermectine (effets indésirables), Ivermectine (usage thérapeutique), Maladies endémiques (), Mâle, Onchocercose (traitement médicamenteux), Onchocercose (épidémiologie), Population rurale, Praziquantel (administration et posologie), Praziquantel (usage thérapeutique), Schistosomiase (traitement médicamenteux), Schistosomiase (épidémiologie), Éducation pour la santé.
- MESH :
- administration et posologie : Praziquantel.
- effets indésirables : Albendazole, Filaricides, Ivermectine.
- traitement médicamenteux : Filariose lymphatique, Onchocercose, Schistosomiase.
- usage thérapeutique : Albendazole, Filaricides, Ivermectine, Praziquantel.
- épidémiologie : Filariose lymphatique, Onchocercose, Schistosomiase.
- Adolescent, Association de médicaments, Enfant, Femelle, Ghana, Humains, Maladies endémiques, Mâle, Population rurale, Éducation pour la santé.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- Adolescent, Albendazole (adverse effects), Albendazole (therapeutic use), Child, Drug Therapy, Combination, Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (epidemiology), Endemic Diseases (prevention & control), Female, Filaricides (adverse effects), Filaricides (therapeutic use), Ghana, Health Education, Humans, Ivermectin (adverse effects), Ivermectin (therapeutic use), Male, Onchocerciasis (drug therapy), Onchocerciasis (epidemiology), Praziquantel (administration & dosage), Praziquantel (therapeutic use), Rural Population, Schistosomiasis (drug therapy), Schistosomiasis (epidemiology).
- MESH :
- chemical , administration & dosage : Praziquantel.
- chemical , adverse effects : Albendazole, Filaricides, Ivermectin.
- chemical , therapeutic use : Albendazole, Filaricides, Ivermectin, Praziquantel.
- geographic : Ghana.
- drug therapy : Elephantiasis, Filarial, Onchocerciasis, Schistosomiasis.
- epidemiology : Elephantiasis, Filarial, Onchocerciasis, Schistosomiasis.
- prevention & control : Endemic Diseases.
- Adolescent, Child, Drug Therapy, Combination, Female, Health Education, Humans, Male, Rural Population.
Abstract
To compare (i) side effects associated with the simultaneous adminstration of praziquantel, albendazole and ivermectin with side affects associated with albendazole and ivermectin only and (ii) coverage by volunteers distributing three or two drugs.
DOI: 10.1111/j.1365-3156.2011.02814.x
PubMed: 21689221
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(traitement médicamenteux)</term><term>Filariose lymphatique (épidémiologie)</term><term>Ghana</term><term>Humains</term><term>Ivermectine (effets indésirables)</term><term>Ivermectine (usage thérapeutique)</term><term>Maladies endémiques ()</term><term>Mâle</term><term>Onchocercose (traitement médicamenteux)</term><term>Onchocercose (épidémiologie)</term><term>Population rurale</term><term>Praziquantel (administration et posologie)</term><term>Praziquantel (usage thérapeutique)</term><term>Schistosomiase (traitement médicamenteux)</term><term>Schistosomiase (épidémiologie)</term><term>Éducation pour la santé</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Praziquantel</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Albendazole</term><term>Filaricides</term><term>Ivermectin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" 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santé</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To compare (i) side effects associated with the simultaneous adminstration of praziquantel, albendazole and ivermectin with side affects associated with albendazole and ivermectin only and (ii) coverage by volunteers distributing three or two drugs.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21689221</PMID><DateCreated><Year>2011</Year><Month>08</Month><Day>08</Day></DateCreated><DateCompleted><Year>2012</Year><Month>01</Month><Day>12</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1365-3156</ISSN><JournalIssue CitedMedium="Internet"><Volume>16</Volume><Issue>9</Issue><PubDate><Year>2011</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Tropical medicine & international health : TM & IH</Title><ISOAbbreviation>Trop. Med. Int. Health</ISOAbbreviation></Journal><ArticleTitle>Simultaneous administration of praziquantel, ivermectin and albendazole, in a community in rural northern Ghana endemic for schistosomiasis, onchocerciasis and lymphatic filariasis.</ArticleTitle><Pagination><MedlinePgn>1112-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/j.1365-3156.2011.02814.x</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To compare (i) side effects associated with the simultaneous adminstration of praziquantel, albendazole and ivermectin with side affects associated with albendazole and ivermectin only and (ii) coverage by volunteers distributing three or two drugs.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Two-arm comparative study in northern Ghana integrated praziquantel distribution into an existing lymphatic filariasis and onchocerciasis control programme using Community Directed Distributors. The control arm continued to distribute only ivermectin and albendazole. Dosages of ivermectin and praziquantel were based on height. Treatment was directly observed, and all two/three drugs were co-administered. Adverse effects were recorded based on passive surveillance. Parasitological, anthropometric and haematological data were collected at baseline.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Prevalence of Schistosoma haematobium infection among 1001 (boys: 47.9% girls: 52.1%) school-age children (6-15 years) [intervention: 30.0% (CI: 23.1-34.2); control: 23.0% (CI: 18.9-27.0)], mean haemoglobin, weight and age were similar among the intervention and control groups. While 1676 (99.1%) compounds in the control area were visited and 15,020 (96.58%) people were treated, only 1375 (88.5%) compounds in the intervention area were visited and 8454 (80.97%) people treated (P < 0.001). The numbers of adverse effects were similar (intervention: 50/6896; control: 130/15,020). The most reported adverse effects was headache (intervention: 14/50; control: 13/130), followed by body weakness, which was reported more from the intervention group (intervention: 13/50, 95% CI: 14.6-40.3; control: 6/130, 95% CI: 1.7-9.8]. Sixty-six per cent (6896/10,441) of the eligible population received praziquantel.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Reported adverse events were mild and managed at the subdistrict level with no cases of hospitalization; intensive health education will, however, be required to improve coverage.</AbstractText><CopyrightInformation>© 2011 Blackwell Publishing Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Anto</LastName><ForeName>Francis</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Navrongo Health Research Centre, Navrongo, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Asoala</LastName><ForeName>Victor</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Anyorigiya</LastName><ForeName>Thomas</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Oduro</LastName><ForeName>Abraham</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Adjuik</LastName><ForeName>Martin</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Akweongo</LastName><ForeName>Patricia</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Aborigo</LastName><ForeName>Raymond</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Bimi</LastName><ForeName>Langbong</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Amankwa</LastName><ForeName>Joseph</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Hodgson</LastName><ForeName>Abraham</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>06</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Trop Med Int Health</MedlineTA><NlmUniqueID>9610576</NlmUniqueID><ISSNLinking>1360-2276</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005369">Filaricides</NameOfSubstance></Chemical><Chemical><RegistryNumber>6490C9U457</RegistryNumber><NameOfSubstance UI="D011223">Praziquantel</NameOfSubstance></Chemical><Chemical><RegistryNumber>70288-86-7</RegistryNumber><NameOfSubstance UI="D007559">Ivermectin</NameOfSubstance></Chemical><Chemical><RegistryNumber>F4216019LN</RegistryNumber><NameOfSubstance UI="D015766">Albendazole</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015766" MajorTopicYN="N">Albendazole</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004359" MajorTopicYN="N">Drug Therapy, Combination</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019353" MajorTopicYN="N">Endemic Diseases</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005369" MajorTopicYN="N">Filaricides</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005869" MajorTopicYN="N" Type="Geographic">Ghana</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006266" MajorTopicYN="N">Health Education</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007559" MajorTopicYN="N">Ivermectin</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009855" MajorTopicYN="N">Onchocerciasis</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011223" MajorTopicYN="N">Praziquantel</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012424" MajorTopicYN="N">Rural Population</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012552" MajorTopicYN="N">Schistosomiasis</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>6</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>6</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>1</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21689221</ArticleId><ArticleId IdType="doi">10.1111/j.1365-3156.2011.02814.x</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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