Gemcitabine-associated "pseudocellulitis" and "pseudosepsis": a case report and review of the literature.
Identifieur interne : 002529 ( PubMed/Curation ); précédent : 002528; suivant : 002530Gemcitabine-associated "pseudocellulitis" and "pseudosepsis": a case report and review of the literature.
Auteurs : Karam M. Obeid [États-Unis] ; Anilrudh A. VenugopalSource :
- American journal of therapeutics [ 1536-3686 ] ; 2013.
Descripteurs français
- KwdFr :
- Antinéoplasiques antimétabolites (effets indésirables), Antinéoplasiques antimétabolites (usage thérapeutique), Cellulite sous-cutanée (diagnostic), Diagnostic différentiel, Désoxycytidine (analogues et dérivés), Désoxycytidine (effets indésirables), Désoxycytidine (usage thérapeutique), Femelle, Fièvre (), Fièvre (diagnostic), Humains, Maladies de la peau (), Maladies de la peau (diagnostic), Oedème (), Oedème (diagnostic), Sepsie (diagnostic), Sujet âgé, Tachycardie (), Tachycardie (diagnostic), Tumeurs du pancréas (traitement médicamenteux).
- MESH :
- analogues et dérivés : Désoxycytidine.
- diagnostic : Cellulite sous-cutanée, Fièvre, Maladies de la peau, Oedème, Sepsie, Tachycardie.
- effets indésirables : Antinéoplasiques antimétabolites, Désoxycytidine.
- traitement médicamenteux : Tumeurs du pancréas.
- usage thérapeutique : Antinéoplasiques antimétabolites, Désoxycytidine.
- Diagnostic différentiel, Femelle, Fièvre, Humains, Maladies de la peau, Oedème, Sujet âgé, Tachycardie.
English descriptors
- KwdEn :
- Aged, Antimetabolites, Antineoplastic (adverse effects), Antimetabolites, Antineoplastic (therapeutic use), Cellulitis (diagnosis), Deoxycytidine (adverse effects), Deoxycytidine (analogs & derivatives), Deoxycytidine (therapeutic use), Diagnosis, Differential, Edema (chemically induced), Edema (diagnosis), Female, Fever (chemically induced), Fever (diagnosis), Humans, Pancreatic Neoplasms (drug therapy), Sepsis (diagnosis), Skin Diseases (chemically induced), Skin Diseases (diagnosis), Tachycardia (chemically induced), Tachycardia (diagnosis).
- MESH :
- chemical , adverse effects : Antimetabolites, Antineoplastic, Deoxycytidine.
- chemical , analogs & derivatives : Deoxycytidine.
- chemical , therapeutic use : Antimetabolites, Antineoplastic, Deoxycytidine.
- chemically induced : Edema, Fever, Skin Diseases, Tachycardia.
- diagnosis : Cellulitis, Edema, Fever, Sepsis, Skin Diseases, Tachycardia.
- drug therapy : Pancreatic Neoplasms.
- Aged, Diagnosis, Differential, Female, Humans.
Abstract
Chemotherapeutic agents have been associated with sepsis and a variety of opportunistic and nonopportunistic infections. This was attributed to their immunosuppressive effects. Like all other chemotherapeutic agents, the use of gemcitabine has been associated with different infectious processes, yet many conditions that mimic infections have also been linked to its use. Pseudosepsis is a condition that should be added to these previously described conditions, such as gemcitabine-induced pseudocellulitis. We describe a patient who suffered from 2 different gemcitabine-induced adverse events including pseudocellulitis that was not related to prior lymphedema or radiation recall phenomenon and pseudosepsis wherein antibiotics have no role in the treatment, and the discontinuation of the offending agent resulted in the resolution of the patient's symptoms.
DOI: 10.1097/MJT.0b013e3182204ffe
PubMed: 21768869
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This was attributed to their immunosuppressive effects. Like all other chemotherapeutic agents, the use of gemcitabine has been associated with different infectious processes, yet many conditions that mimic infections have also been linked to its use. Pseudosepsis is a condition that should be added to these previously described conditions, such as gemcitabine-induced pseudocellulitis. We describe a patient who suffered from 2 different gemcitabine-induced adverse events including pseudocellulitis that was not related to prior lymphedema or radiation recall phenomenon and pseudosepsis wherein antibiotics have no role in the treatment, and the discontinuation of the offending agent resulted in the resolution of the patient's symptoms.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21768869</PMID><DateCreated><Year>2013</Year><Month>01</Month><Day>09</Day></DateCreated><DateCompleted><Year>2013</Year><Month>06</Month><Day>17</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1536-3686</ISSN><JournalIssue CitedMedium="Internet"><Volume>20</Volume><Issue>1</Issue><PubDate><Year>2013</Year><Month>Jan</Month></PubDate></JournalIssue><Title>American journal of therapeutics</Title><ISOAbbreviation>Am J Ther</ISOAbbreviation></Journal><ArticleTitle>Gemcitabine-associated "pseudocellulitis" and "pseudosepsis": a case report and review of the literature.</ArticleTitle><Pagination><MedlinePgn>118-20</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/MJT.0b013e3182204ffe</ELocationID><Abstract><AbstractText>Chemotherapeutic agents have been associated with sepsis and a variety of opportunistic and nonopportunistic infections. This was attributed to their immunosuppressive effects. Like all other chemotherapeutic agents, the use of gemcitabine has been associated with different infectious processes, yet many conditions that mimic infections have also been linked to its use. Pseudosepsis is a condition that should be added to these previously described conditions, such as gemcitabine-induced pseudocellulitis. We describe a patient who suffered from 2 different gemcitabine-induced adverse events including pseudocellulitis that was not related to prior lymphedema or radiation recall phenomenon and pseudosepsis wherein antibiotics have no role in the treatment, and the discontinuation of the offending agent resulted in the resolution of the patient's symptoms.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Obeid</LastName><ForeName>Karam M</ForeName><Initials>KM</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Internal Medicine, St John Hospital and Medical Center, Detroit, MI, USA. karam.obeid@stjohn.org</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Venugopal</LastName><ForeName>Anilrudh A</ForeName><Initials>AA</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Ther</MedlineTA><NlmUniqueID>9441347</NlmUniqueID><ISSNLinking>1075-2765</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000964">Antimetabolites, Antineoplastic</NameOfSubstance></Chemical><Chemical><RegistryNumber>0W860991D6</RegistryNumber><NameOfSubstance UI="D003841">Deoxycytidine</NameOfSubstance></Chemical><Chemical><RegistryNumber>B76N6SBZ8R</RegistryNumber><NameOfSubstance UI="C056507">gemcitabine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000964" MajorTopicYN="N">Antimetabolites, Antineoplastic</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002481" MajorTopicYN="N">Cellulitis</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003841" MajorTopicYN="N">Deoxycytidine</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003937" MajorTopicYN="N">Diagnosis, Differential</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004487" MajorTopicYN="N">Edema</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005334" MajorTopicYN="N">Fever</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010190" MajorTopicYN="N">Pancreatic Neoplasms</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018805" MajorTopicYN="N">Sepsis</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012871" MajorTopicYN="N">Skin Diseases</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013610" MajorTopicYN="N">Tachycardia</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>7</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>7</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>6</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21768869</ArticleId><ArticleId IdType="doi">10.1097/MJT.0b013e3182204ffe</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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