Galactolipids from Bauhinia racemosa as a new class of antifilarial agents against human lymphatic filarial parasite, Brugia malayi.
Identifieur interne : 002262 ( PubMed/Curation ); précédent : 002261; suivant : 002263Galactolipids from Bauhinia racemosa as a new class of antifilarial agents against human lymphatic filarial parasite, Brugia malayi.
Auteurs : Koneni V. Sashidhara [Inde] ; Suriya P. Singh ; Sweta Misra ; Jyoti Gupta ; Shailja Misra-BhattacharyaSource :
- European journal of medicinal chemistry [ 1768-3254 ] ; 2012.
Descripteurs français
- KwdFr :
- Animaux, Antihelminthiques (isolement et purification), Antihelminthiques (pharmacologie), Bauhinia (), Brugia malayi (), Diéthylcarbamazine (usage thérapeutique), Extraits de plantes (pharmacologie), Feuilles de plante (), Filaricides (isolement et purification), Filaricides (pharmacologie), Filariose lymphatique (parasitologie), Filariose lymphatique (traitement médicamenteux), Galactolipides (isolement et purification), Galactolipides (pharmacologie), Humains, Ivermectine (usage thérapeutique).
- MESH :
- isolement et purification : Antihelminthiques, Filaricides, Galactolipides.
- parasitologie : Filariose lymphatique.
- pharmacologie : Antihelminthiques, Extraits de plantes, Filaricides, Galactolipides.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Diéthylcarbamazine, Ivermectine.
- Animaux, Bauhinia, Brugia malayi, Feuilles de plante, Humains.
English descriptors
- KwdEn :
- Animals, Anthelmintics (isolation & purification), Anthelmintics (pharmacology), Bauhinia (chemistry), Brugia malayi (drug effects), Diethylcarbamazine (therapeutic use), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (parasitology), Filaricides (isolation & purification), Filaricides (pharmacology), Galactolipids (isolation & purification), Galactolipids (pharmacology), Humans, Ivermectin (therapeutic use), Plant Extracts (pharmacology), Plant Leaves (chemistry).
- MESH :
- chemical , isolation & purification : Anthelmintics, Filaricides, Galactolipids.
- chemical , pharmacology : Anthelmintics, Filaricides, Galactolipids, Plant Extracts.
- chemistry : Bauhinia, Plant Leaves.
- drug effects : Brugia malayi.
- drug therapy : Elephantiasis, Filarial.
- parasitology : Elephantiasis, Filarial.
- chemical , therapeutic use : Diethylcarbamazine, Ivermectin.
- Animals, Humans.
Abstract
Bioassay guided fractionation of ethanolic extract of the leaves of Bauhinia racemosa led to the isolation of galactolipid and catechin class of the compounds (1-7) from the most active n-butanol fraction (F4). Among the active galactolipids, 1 emerged as the lead molecule which was active on both forms of lymphatic filarial parasite, Brugia malayi. It was found to be better than the standard drug ivermectin and diethylcarbamazine (DEC) in terms of dose and efficacy.
DOI: 10.1016/j.ejmech.2012.01.057
PubMed: 22348826
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