Matrix metalloproteinase-2 governs lymphatic vessel formation as an interstitial collagenase.
Identifieur interne : 002184 ( PubMed/Curation ); précédent : 002183; suivant : 002185Matrix metalloproteinase-2 governs lymphatic vessel formation as an interstitial collagenase.
Auteurs : Benoit Detry [Belgique] ; Charlotte Erpicum ; Jenny Paupert ; Silvia Blacher ; Catherine Maillard ; Françoise Bruyère ; Hélène Pendeville ; Thibault Remacle ; Vincent Lambert ; Cédric Balsat ; Sandra Ormenese ; Françoise Lamaye ; Els Janssens ; Lieve Moons ; Didier Cataldo ; Frédéric Kridelka ; Peter Carmeliet ; Marc Thiry ; Jean-Michel Foidart ; Ingrid Struman ; Agnès NoëlSource :
- Blood [ 1528-0020 ] ; 2012.
Descripteurs français
- KwdFr :
- Animal génétiquement modifié, Animaux, Cellules cultivées, Collagenases (génétique), Collagenases (métabolisme), Collagenases (physiologie), Collagène de type I (métabolisme), Danio zébré, Embryon non mammalien, Femelle, Humains, Liquide extracellulaire (enzymologie), Liquide extracellulaire (métabolisme), Lymphangiogenèse (génétique), Matrix metalloproteinase 2 (génétique), Matrix metalloproteinase 2 (métabolisme), Matrix metalloproteinase 2 (physiologie), Mâle, Souris, Souris de lignée C57BL, Souris knockout, Vaisseaux lymphatiques (embryologie), Vaisseaux lymphatiques (métabolisme), Vaisseaux lymphatiques (physiologie).
- MESH :
- embryologie : Vaisseaux lymphatiques.
- enzymologie : Liquide extracellulaire.
- génétique : Collagenases, Lymphangiogenèse, Matrix metalloproteinase 2.
- métabolisme : Collagenases, Collagène de type I, Liquide extracellulaire, Matrix metalloproteinase 2, Vaisseaux lymphatiques.
- physiologie : Collagenases, Matrix metalloproteinase 2, Vaisseaux lymphatiques.
- Animal génétiquement modifié, Animaux, Cellules cultivées, Danio zébré, Embryon non mammalien, Femelle, Humains, Mâle, Souris, Souris de lignée C57BL, Souris knockout.
English descriptors
- KwdEn :
- Animals, Animals, Genetically Modified, Cells, Cultured, Collagen Type I (metabolism), Collagenases (genetics), Collagenases (metabolism), Collagenases (physiology), Embryo, Nonmammalian, Extracellular Fluid (enzymology), Extracellular Fluid (metabolism), Female, Humans, Lymphangiogenesis (genetics), Lymphatic Vessels (embryology), Lymphatic Vessels (metabolism), Lymphatic Vessels (physiology), Male, Matrix Metalloproteinase 2 (genetics), Matrix Metalloproteinase 2 (metabolism), Matrix Metalloproteinase 2 (physiology), Mice, Mice, Inbred C57BL, Mice, Knockout, Zebrafish.
- MESH :
- chemical , genetics : Collagenases, Matrix Metalloproteinase 2.
- chemical , metabolism : Collagen Type I, Collagenases, Matrix Metalloproteinase 2.
- chemical , physiology : Collagenases, Matrix Metalloproteinase 2.
- embryology : Lymphatic Vessels.
- enzymology : Extracellular Fluid.
- genetics : Lymphangiogenesis.
- metabolism : Extracellular Fluid, Lymphatic Vessels.
- physiology : Lymphatic Vessels.
- Animals, Animals, Genetically Modified, Cells, Cultured, Embryo, Nonmammalian, Female, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Zebrafish.
Abstract
Lymphatic dysfunctions are associated with several human diseases, including lymphedema and metastatic spread of cancer. Although it is well recognized that lymphatic capillaries attach directly to interstitial matrix mainly composed of fibrillar type I collagen, the interactions occurring between lymphatics and their surrounding matrix have been overlooked. In this study, we demonstrate how matrix metalloproteinase (MMP)-2 drives lymphatic morphogenesis through Mmp2-gene ablation in mice, mmp2 knockdown in zebrafish and in 3D-culture systems, and through MMP2 inhibition. In all models used in vivo (3 murine models and thoracic duct development in zebrafish) and in vitro (lymphatic ring and spheroid assays), MMP2 blockage or down-regulation leads to reduced lymphangiogenesis or altered vessel branching. Our data show that lymphatic endothelial cell (LEC) migration through collagen fibers is affected by physical matrix constraints (matrix composition, density, and cross-linking). Transmission electron microscopy and confocal reflection microscopy using DQ-collagen highlight the contribution of MMP2 to mesenchymal-like migration of LECs associated with collagen fiber remodeling. Our findings provide new mechanistic insight into how LECs negotiate an interstitial type I collagen barrier and reveal an unexpected MMP2-driven collagenolytic pathway for lymphatic vessel formation and morphogenesis.
DOI: 10.1182/blood-2011-12-400267
PubMed: 22490679
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002184
Links to Exploration step
pubmed:22490679Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Matrix metalloproteinase-2 governs lymphatic vessel formation as an interstitial collagenase.</title><author><name sortKey="Detry, Benoit" sort="Detry, Benoit" uniqKey="Detry B" first="Benoit" last="Detry">Benoit Detry</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Tumor and Development Biology, Groupe Interdisciplinaire de Génoprotéomique Appliqué-Recherche (GIGA-Cancer), University of Liège, Liège, Belgium;</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Tumor and Development Biology, Groupe Interdisciplinaire de Génoprotéomique Appliqué-Recherche (GIGA-Cancer), University of Liège, Liège</wicri:regionArea></affiliation></author><author><name sortKey="Erpicum, Charlotte" sort="Erpicum, Charlotte" uniqKey="Erpicum C" first="Charlotte" last="Erpicum">Charlotte Erpicum</name></author><author><name sortKey="Paupert, Jenny" sort="Paupert, Jenny" uniqKey="Paupert J" first="Jenny" last="Paupert">Jenny Paupert</name></author><author><name sortKey="Blacher, Silvia" sort="Blacher, Silvia" uniqKey="Blacher S" first="Silvia" last="Blacher">Silvia Blacher</name></author><author><name sortKey="Maillard, Catherine" sort="Maillard, Catherine" uniqKey="Maillard C" first="Catherine" last="Maillard">Catherine Maillard</name></author><author><name sortKey="Bruyere, Francoise" sort="Bruyere, Francoise" uniqKey="Bruyere F" first="Françoise" last="Bruyère">Françoise Bruyère</name></author><author><name sortKey="Pendeville, Helene" sort="Pendeville, Helene" uniqKey="Pendeville H" first="Hélène" last="Pendeville">Hélène Pendeville</name></author><author><name sortKey="Remacle, Thibault" sort="Remacle, Thibault" uniqKey="Remacle T" first="Thibault" last="Remacle">Thibault Remacle</name></author><author><name sortKey="Lambert, Vincent" sort="Lambert, Vincent" uniqKey="Lambert V" first="Vincent" last="Lambert">Vincent Lambert</name></author><author><name sortKey="Balsat, Cedric" sort="Balsat, Cedric" uniqKey="Balsat C" first="Cédric" last="Balsat">Cédric Balsat</name></author><author><name sortKey="Ormenese, Sandra" sort="Ormenese, Sandra" uniqKey="Ormenese S" first="Sandra" last="Ormenese">Sandra Ormenese</name></author><author><name sortKey="Lamaye, Francoise" sort="Lamaye, Francoise" uniqKey="Lamaye F" first="Françoise" last="Lamaye">Françoise Lamaye</name></author><author><name sortKey="Janssens, Els" sort="Janssens, Els" uniqKey="Janssens E" first="Els" last="Janssens">Els Janssens</name></author><author><name sortKey="Moons, Lieve" sort="Moons, Lieve" uniqKey="Moons L" first="Lieve" last="Moons">Lieve Moons</name></author><author><name sortKey="Cataldo, Didier" sort="Cataldo, Didier" uniqKey="Cataldo D" first="Didier" last="Cataldo">Didier Cataldo</name></author><author><name sortKey="Kridelka, Frederic" sort="Kridelka, Frederic" uniqKey="Kridelka F" first="Frédéric" last="Kridelka">Frédéric Kridelka</name></author><author><name sortKey="Carmeliet, Peter" sort="Carmeliet, Peter" uniqKey="Carmeliet P" first="Peter" last="Carmeliet">Peter Carmeliet</name></author><author><name sortKey="Thiry, Marc" sort="Thiry, Marc" uniqKey="Thiry M" first="Marc" last="Thiry">Marc Thiry</name></author><author><name sortKey="Foidart, Jean Michel" sort="Foidart, Jean Michel" uniqKey="Foidart J" first="Jean-Michel" last="Foidart">Jean-Michel Foidart</name></author><author><name sortKey="Struman, Ingrid" sort="Struman, Ingrid" uniqKey="Struman I" first="Ingrid" last="Struman">Ingrid Struman</name></author><author><name sortKey="Noel, Agnes" sort="Noel, Agnes" uniqKey="Noel A" first="Agnès" last="Noël">Agnès Noël</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22490679</idno><idno type="pmid">22490679</idno><idno type="doi">10.1182/blood-2011-12-400267</idno><idno type="wicri:Area/PubMed/Corpus">002184</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002184</idno><idno type="wicri:Area/PubMed/Curation">002184</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002184</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Matrix metalloproteinase-2 governs lymphatic vessel formation as an interstitial collagenase.</title><author><name sortKey="Detry, Benoit" sort="Detry, Benoit" uniqKey="Detry B" first="Benoit" last="Detry">Benoit Detry</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Tumor and Development Biology, Groupe Interdisciplinaire de Génoprotéomique Appliqué-Recherche (GIGA-Cancer), University of Liège, Liège, Belgium;</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Tumor and Development Biology, Groupe Interdisciplinaire de Génoprotéomique Appliqué-Recherche (GIGA-Cancer), University of Liège, Liège</wicri:regionArea></affiliation></author><author><name sortKey="Erpicum, Charlotte" sort="Erpicum, Charlotte" uniqKey="Erpicum C" first="Charlotte" last="Erpicum">Charlotte Erpicum</name></author><author><name sortKey="Paupert, Jenny" sort="Paupert, Jenny" uniqKey="Paupert J" first="Jenny" last="Paupert">Jenny Paupert</name></author><author><name sortKey="Blacher, Silvia" sort="Blacher, Silvia" uniqKey="Blacher S" first="Silvia" last="Blacher">Silvia Blacher</name></author><author><name sortKey="Maillard, Catherine" sort="Maillard, Catherine" uniqKey="Maillard C" first="Catherine" last="Maillard">Catherine Maillard</name></author><author><name sortKey="Bruyere, Francoise" sort="Bruyere, Francoise" uniqKey="Bruyere F" first="Françoise" last="Bruyère">Françoise Bruyère</name></author><author><name sortKey="Pendeville, Helene" sort="Pendeville, Helene" uniqKey="Pendeville H" first="Hélène" last="Pendeville">Hélène Pendeville</name></author><author><name sortKey="Remacle, Thibault" sort="Remacle, Thibault" uniqKey="Remacle T" first="Thibault" last="Remacle">Thibault Remacle</name></author><author><name sortKey="Lambert, Vincent" sort="Lambert, Vincent" uniqKey="Lambert V" first="Vincent" last="Lambert">Vincent Lambert</name></author><author><name sortKey="Balsat, Cedric" sort="Balsat, Cedric" uniqKey="Balsat C" first="Cédric" last="Balsat">Cédric Balsat</name></author><author><name sortKey="Ormenese, Sandra" sort="Ormenese, Sandra" uniqKey="Ormenese S" first="Sandra" last="Ormenese">Sandra Ormenese</name></author><author><name sortKey="Lamaye, Francoise" sort="Lamaye, Francoise" uniqKey="Lamaye F" first="Françoise" last="Lamaye">Françoise Lamaye</name></author><author><name sortKey="Janssens, Els" sort="Janssens, Els" uniqKey="Janssens E" first="Els" last="Janssens">Els Janssens</name></author><author><name sortKey="Moons, Lieve" sort="Moons, Lieve" uniqKey="Moons L" first="Lieve" last="Moons">Lieve Moons</name></author><author><name sortKey="Cataldo, Didier" sort="Cataldo, Didier" uniqKey="Cataldo D" first="Didier" last="Cataldo">Didier Cataldo</name></author><author><name sortKey="Kridelka, Frederic" sort="Kridelka, Frederic" uniqKey="Kridelka F" first="Frédéric" last="Kridelka">Frédéric Kridelka</name></author><author><name sortKey="Carmeliet, Peter" sort="Carmeliet, Peter" uniqKey="Carmeliet P" first="Peter" last="Carmeliet">Peter Carmeliet</name></author><author><name sortKey="Thiry, Marc" sort="Thiry, Marc" uniqKey="Thiry M" first="Marc" last="Thiry">Marc Thiry</name></author><author><name sortKey="Foidart, Jean Michel" sort="Foidart, Jean Michel" uniqKey="Foidart J" first="Jean-Michel" last="Foidart">Jean-Michel Foidart</name></author><author><name sortKey="Struman, Ingrid" sort="Struman, Ingrid" uniqKey="Struman I" first="Ingrid" last="Struman">Ingrid Struman</name></author><author><name sortKey="Noel, Agnes" sort="Noel, Agnes" uniqKey="Noel A" first="Agnès" last="Noël">Agnès Noël</name></author></analytic><series><title level="j">Blood</title><idno type="eISSN">1528-0020</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Animals, Genetically Modified</term><term>Cells, Cultured</term><term>Collagen Type I (metabolism)</term><term>Collagenases (genetics)</term><term>Collagenases (metabolism)</term><term>Collagenases (physiology)</term><term>Embryo, Nonmammalian</term><term>Extracellular Fluid (enzymology)</term><term>Extracellular Fluid (metabolism)</term><term>Female</term><term>Humans</term><term>Lymphangiogenesis (genetics)</term><term>Lymphatic Vessels (embryology)</term><term>Lymphatic Vessels (metabolism)</term><term>Lymphatic Vessels (physiology)</term><term>Male</term><term>Matrix Metalloproteinase 2 (genetics)</term><term>Matrix Metalloproteinase 2 (metabolism)</term><term>Matrix Metalloproteinase 2 (physiology)</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Zebrafish</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animal génétiquement modifié</term><term>Animaux</term><term>Cellules cultivées</term><term>Collagenases (génétique)</term><term>Collagenases (métabolisme)</term><term>Collagenases (physiologie)</term><term>Collagène de type I (métabolisme)</term><term>Danio zébré</term><term>Embryon non mammalien</term><term>Femelle</term><term>Humains</term><term>Liquide extracellulaire (enzymologie)</term><term>Liquide extracellulaire (métabolisme)</term><term>Lymphangiogenèse (génétique)</term><term>Matrix metalloproteinase 2 (génétique)</term><term>Matrix metalloproteinase 2 (métabolisme)</term><term>Matrix metalloproteinase 2 (physiologie)</term><term>Mâle</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Souris knockout</term><term>Vaisseaux lymphatiques (embryologie)</term><term>Vaisseaux lymphatiques (métabolisme)</term><term>Vaisseaux lymphatiques (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Collagenases</term><term>Matrix Metalloproteinase 2</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Collagen Type I</term><term>Collagenases</term><term>Matrix Metalloproteinase 2</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Collagenases</term><term>Matrix Metalloproteinase 2</term></keywords><keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Liquide extracellulaire</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Extracellular Fluid</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Lymphangiogenesis</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Collagenases</term><term>Lymphangiogenèse</term><term>Matrix metalloproteinase 2</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Extracellular Fluid</term><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Collagenases</term><term>Collagène de type I</term><term>Liquide extracellulaire</term><term>Matrix metalloproteinase 2</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Collagenases</term><term>Matrix metalloproteinase 2</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Animals, Genetically Modified</term><term>Cells, Cultured</term><term>Embryo, Nonmammalian</term><term>Female</term><term>Humans</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Zebrafish</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animal génétiquement modifié</term><term>Animaux</term><term>Cellules cultivées</term><term>Danio zébré</term><term>Embryon non mammalien</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Souris knockout</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphatic dysfunctions are associated with several human diseases, including lymphedema and metastatic spread of cancer. Although it is well recognized that lymphatic capillaries attach directly to interstitial matrix mainly composed of fibrillar type I collagen, the interactions occurring between lymphatics and their surrounding matrix have been overlooked. In this study, we demonstrate how matrix metalloproteinase (MMP)-2 drives lymphatic morphogenesis through Mmp2-gene ablation in mice, mmp2 knockdown in zebrafish and in 3D-culture systems, and through MMP2 inhibition. In all models used in vivo (3 murine models and thoracic duct development in zebrafish) and in vitro (lymphatic ring and spheroid assays), MMP2 blockage or down-regulation leads to reduced lymphangiogenesis or altered vessel branching. Our data show that lymphatic endothelial cell (LEC) migration through collagen fibers is affected by physical matrix constraints (matrix composition, density, and cross-linking). Transmission electron microscopy and confocal reflection microscopy using DQ-collagen highlight the contribution of MMP2 to mesenchymal-like migration of LECs associated with collagen fiber remodeling. Our findings provide new mechanistic insight into how LECs negotiate an interstitial type I collagen barrier and reveal an unexpected MMP2-driven collagenolytic pathway for lymphatic vessel formation and morphogenesis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22490679</PMID><DateCreated><Year>2012</Year><Month>05</Month><Day>25</Day></DateCreated><DateCompleted><Year>2012</Year><Month>08</Month><Day>07</Day></DateCompleted><DateRevised><Year>2012</Year><Month>05</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1528-0020</ISSN><JournalIssue CitedMedium="Internet"><Volume>119</Volume><Issue>21</Issue><PubDate><Year>2012</Year><Month>May</Month><Day>24</Day></PubDate></JournalIssue><Title>Blood</Title><ISOAbbreviation>Blood</ISOAbbreviation></Journal><ArticleTitle>Matrix metalloproteinase-2 governs lymphatic vessel formation as an interstitial collagenase.</ArticleTitle><Pagination><MedlinePgn>5048-56</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1182/blood-2011-12-400267</ELocationID><Abstract><AbstractText>Lymphatic dysfunctions are associated with several human diseases, including lymphedema and metastatic spread of cancer. Although it is well recognized that lymphatic capillaries attach directly to interstitial matrix mainly composed of fibrillar type I collagen, the interactions occurring between lymphatics and their surrounding matrix have been overlooked. In this study, we demonstrate how matrix metalloproteinase (MMP)-2 drives lymphatic morphogenesis through Mmp2-gene ablation in mice, mmp2 knockdown in zebrafish and in 3D-culture systems, and through MMP2 inhibition. In all models used in vivo (3 murine models and thoracic duct development in zebrafish) and in vitro (lymphatic ring and spheroid assays), MMP2 blockage or down-regulation leads to reduced lymphangiogenesis or altered vessel branching. Our data show that lymphatic endothelial cell (LEC) migration through collagen fibers is affected by physical matrix constraints (matrix composition, density, and cross-linking). Transmission electron microscopy and confocal reflection microscopy using DQ-collagen highlight the contribution of MMP2 to mesenchymal-like migration of LECs associated with collagen fiber remodeling. Our findings provide new mechanistic insight into how LECs negotiate an interstitial type I collagen barrier and reveal an unexpected MMP2-driven collagenolytic pathway for lymphatic vessel formation and morphogenesis.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Detry</LastName><ForeName>Benoit</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Laboratory of Tumor and Development Biology, Groupe Interdisciplinaire de Génoprotéomique Appliqué-Recherche (GIGA-Cancer), University of Liège, Liège, Belgium;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Erpicum</LastName><ForeName>Charlotte</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Paupert</LastName><ForeName>Jenny</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Blacher</LastName><ForeName>Silvia</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Maillard</LastName><ForeName>Catherine</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Bruyère</LastName><ForeName>Françoise</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Pendeville</LastName><ForeName>Hélène</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Remacle</LastName><ForeName>Thibault</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Lambert</LastName><ForeName>Vincent</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Balsat</LastName><ForeName>Cédric</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Ormenese</LastName><ForeName>Sandra</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Lamaye</LastName><ForeName>Françoise</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Janssens</LastName><ForeName>Els</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Moons</LastName><ForeName>Lieve</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Cataldo</LastName><ForeName>Didier</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Kridelka</LastName><ForeName>Frédéric</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Carmeliet</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Thiry</LastName><ForeName>Marc</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Foidart</LastName><ForeName>Jean-Michel</ForeName><Initials>JM</Initials></Author><Author ValidYN="Y"><LastName>Struman</LastName><ForeName>Ingrid</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Noël</LastName><ForeName>Agnès</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>04</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Blood</MedlineTA><NlmUniqueID>7603509</NlmUniqueID><ISSNLinking>0006-4971</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D024042">Collagen Type I</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.24.-</RegistryNumber><NameOfSubstance UI="D017364">Collagenases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.24.24</RegistryNumber><NameOfSubstance UI="D020778">Matrix Metalloproteinase 2</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D030801" MajorTopicYN="N">Animals, Genetically Modified</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D024042" MajorTopicYN="N">Collagen Type I</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017364" MajorTopicYN="N">Collagenases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004625" MajorTopicYN="N">Embryo, Nonmammalian</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045604" MajorTopicYN="N">Extracellular Fluid</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D042583" MajorTopicYN="N">Lymphangiogenesis</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D042601" MajorTopicYN="N">Lymphatic Vessels</DescriptorName><QualifierName UI="Q000196" MajorTopicYN="Y">embryology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020778" MajorTopicYN="N">Matrix Metalloproteinase 2</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018345" MajorTopicYN="N">Mice, Knockout</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015027" MajorTopicYN="N">Zebrafish</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>4</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>4</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>8</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22490679</ArticleId><ArticleId IdType="pii">blood-2011-12-400267</ArticleId><ArticleId IdType="doi">10.1182/blood-2011-12-400267</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002184 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 002184 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:22490679
|texte= Matrix metalloproteinase-2 governs lymphatic vessel formation as an interstitial collagenase.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:22490679" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |